Esentra Injection belongs to a group of medicines called RANK ligand inhibitors used to treat osteoporosis in postmenopausal women and men who have an increased risk of fracture. Esentra Injection is also used to treat bone loss due to reduced hormone levels caused by surgery or due to treatment with medicines in patients with prostate cancer. It is also used to treat bone loss occurring due to long-term treatment with glucocorticoids in patients who are at an increased risk of fractures. Esentra Injection may also be used to reduce the risk of fractures in people with multiple myeloma, giant cell tumours of the bone and to treat high calcium levels caused due to cancer. Esentra Injection binds to a protein on RANK ligand on osteoclast (cells that cause bone breakdown) and inhibits their formation, functioning and survival. Thereby decreases bone breakdown, increases bone density, and strengthens the bone. Esentra Injection treats giant cell tumour of bone (GCTB) by blocking certain receptors in the tumour cells, thereby slows the tumour growth. Esentra Injection helps treat high calcium levels by decreasing bone breakdown as the breakdown of the bones releases calcium. Esentra Injection makes the bones stronger and less likely to break.

FAQs

How does Esentra Injection work?

Esentra Injection binds to a protein on RANK ligand on osteoclast (cells that cause bone breakdown) and inhibits their formation, functioning and survival. Thereby decreases bone breakdown, increases bone density, and strengthens the bone. Esentra Injection makes the bones stronger and less likely to break.

Does Esentra Injection cause osteonecrosis?

Osteonecrosis of the jaw (bone damage in the jaw) might be a side-effect of Esentra Injection. The risk increases in people taking Esentra Injection for longer durations. It might also occur upon discontinuation of the treatment. Maintain good dental hygiene and receive regular dental check-ups whilst on treatment with Esentra Injection. Inform your doctor if you have dental problems, gum disease, planned tooth extractions, cancer, if you smoke, or are taking bisphosphonates or corticosteroids.

Is Esentra Injection used to treat high calcium levels?

Breakdown of bones releases calcium and causes hypercalcemia (high calcium levels in the blood). Esentra Injection helps treat high calcium levels by decreasing bone breakdown.

Does Esentra Injection cause unusual thigh bone fractures?

Unusual thigh bone fractures might occur whilst on treatment with Esentra Injection. Consult your doctor if you experience new or unusual pain in the thigh, hip, or groin.

Is Esentra Injection used to treat giant cell tumours of the bone?

Esentra Injection treats giant cell tumour of bone (GCTB) by blocking certain receptors in the tumour cells, thereby slows the tumour growth. Giant cell tumour of the bone is a non-cancerous tumour that typically grows at the ends of long bones.

Does Esentra Injection cause skin infections?

Esentra Injection might cause skin infections. Consult your doctor immediately if you notice symptoms such as swollen skin, redness, cellulitis (hot and tender skin), commonly in the lower leg with feverish symptoms.