Lastinem 500mg/500mg Injection is a combination of two drugs, namely: Cilastatin (dehydropeptidase inhibitor) and Imipenem (antibacterial). Lastinem 500mg/500mg Injection is used to treat severe bacterial infections of the lungs, heart, bladder, skin, kidneys, bones, joints, blood, stomach, and female reproductive organs. Lastinem 500mg/500mg Injection may also be used in the management of patients with low white blood cell count who have a fever, which is suspected to be due to bacterial infection. Cilastatin inhibits the dehydropeptidase enzyme, which causes the breakdown of Imipenem, thereby helps imipenem to stay active for a longer duration. Imipenem prevents the formation of the bacterial protective covering, which is necessary for the survival of the bacteria. Together, Lastinem 500mg/500mg Injection helps to treat bacterial infections. Imipenem is a broad-spectrum antibiotic that is effective against a wide range of aerobic and anaerobic bacteria.

FAQs

How does Lastinem 500mg/500mg Injection work?

Lastinem 500mg/500mg Injection is a combination of two drugs, namely: Cilastatin and Imipenem. Cilastatin inhibits the dehydropeptidase enzyme, which causes the breakdown of Imipenem, thereby helps imipenem to stay active for a longer duration. Imipenem prevents the formation of the bacterial protective covering, which is necessary for the survival of the bacteria. Together, Lastinem 500mg/500mg Injection helps to treat bacterial infections.

Does Lastinem 500mg/500mg Injection cause diarrhoea?

Diarrhoea might be a side-effect of Lastinem 500mg/500mg Injection. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience prolonged diarrhoea with abdominal pain, consult your doctor. Do not take anti-diarrheal medicine on your own.

Can I take Probenecid with Lastinem 500mg/500mg Injection?

Concomitant administration of Probenecid (used to treat gout and hyperuricemia) along with Lastinem 500mg/500mg Injection is not recommended as it might result in an increase of plasma levels and half-life of Imipenem.

Is it safe to take Ganciclovir along with Lastinem 500mg/500mg Injection?

Ganciclovir (anti-viral) should not be co-administered along with Lastinem 500mg/500mg Injection unless benefits outweigh the risks as generalised seizures have been reported when taken together.

Does Lastinem 500mg/500mg Injection cause discolouration of urine?

Lastinem 500mg/500mg Injection may cause changes in urine colour and amount of urine. Do not worry and consult your doctor if you have any concerns regarding this.

Does Lastinem 500mg/500mg Injection cause thrush?

Lastinem 500mg/500mg Injection may rarely cause thrush or candidiasis, which is a fungal infection occurring due to the overgrowth of yeast-like fungus in the mouth or throat. Regularly rinse your mouth with water to prevent the growth of fungus.