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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

About ABCIXIREL 10MG INJECTION 5ML

ABCIXIREL 10MG INJECTION 5ML belongs to the group of medicines called 'antiplatelet agents' used to prevent the formation of blood clots, thereby reducing the chance of Myocardial infarction. ABCIXIREL 10MG INJECTION 5ML is used as an adjunct during percutaneous coronary intervention (PCI) procedure in patients with unstable angina not responding to conventional medical therapy when PCI procedure is planned within 24 hours.

ABCIXIREL 10MG INJECTION 5ML contains Abciximab, which belongs to the monoclonal anti-glycoprotein IIb/IIIa receptor antibodies class. It works by blocking the glycoprotein IIb/IIIa receptor's activity, thereby preventing platelet aggregation. This causes inhibition of fibrinogen binding, reducing the chance of blood clot formation. ABCIXIREL 10MG INJECTION 5ML results in reducing the risk of cardiovascular events like myocardial infarction (heart attack), repeat coronary revascularization, and stent thrombosis (ST).

ABCIXIREL 10MG INJECTION 5ML may cause certain side effects such as bleeding, nausea, headache, abdominal pain, hypotension, vomiting, dizziness, back pain, and pain at the site of injection. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. A trained healthcare professional will administer ABCIXIREL 10MG INJECTION 5ML. So, do not self-administer. Your doctor will decide the dose of the medicine based on your health condition.

ABCIXIREL 10MG INJECTION 5ML should be avoided if you are allergic to it. It is contraindicated in patients who have active internal bleeding, thrombocytopenia, severe uncontrolled hypertension, had recent major surgery or trauma, a history of cerebrovascular accident within the last two years, or recent gastrointestinal or genitourinary bleeding, intracranial neoplasm, aneurysm, used dextran before PCI procedure, and history of vasculitis as it can cause serious adverse effects. ABCIXIREL 10MG INJECTION 5ML is administered along with aspirin and heparin. Hence, close monitoring of patients is needed for any bleeding conditions. Talk to your doctor before receiving ABCIXIREL 10MG INJECTION 5ML, have/had a recent severe injury or surgery due to risk of severe bleeding problems. If you are pregnant or breastfeeding, inform your doctor before receiving this medicine. ABCIXIREL 10MG INJECTION 5ML is not recommended for children below 12 years of age as efficacy and safety have not been established.

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Non returnable*
COD available

Online payment accepted

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

Uses of ABCIXIREL 10MG INJECTION 5ML

Myocardial infarction (heart attack)

Medicinal Benefits

ABCIXIREL 10MG INJECTION 5ML contains Abciximab, which belongs to the monoclonal anti-glycoprotein IIb/IIIa receptor antibodies class. It works by blocking the glycoprotein IIb/IIIa receptor's activity, thereby preventing platelet aggregation. This causes inhibition of fibrinogen binding, reducing the chance of blood clot formation. ABCIXIREL 10MG INJECTION 5ML results in reducing the risk of cardiovascular events like myocardial infarction (heart attack), repeat coronary revascularization, and stent thrombosis (ST). This medicine is always administered along with aspirin and heparin.

Side Effects of ABCIXIREL 10MG INJECTION 5ML

  • Bleeding
  • Nausea
  • Headache
  • Abdominal pain
  • Hypotension
  • Vomiting
  • Dizziness
  • Back pain
  • Pain at the site of injection

Directions for Use

A trained healthcare professional will administer ABCIXIREL 10MG INJECTION 5ML. Hence, do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not receive ABCIXIREL 10MG INJECTION 5ML if you are allergic to it. This medicine is contraindicated in patients having active internal bleeding, thrombocytopenia, recent major surgery or trauma, severe uncontrolled hypertension, history of cerebrovascular accident within two years, or recent gastrointestinal or genitourinary bleeding, intracranial neoplasm, aneurysm, use of dextran before PCI procedure, and history of vasculitis as it can cause serious adverse effects. ABCIXIREL 10MG INJECTION 5ML is administered along with aspirin and heparin. Hence, close monitoring of patients is needed for any bleeding conditions. Talk to your doctor before receiving ABCIXIREL 10MG INJECTION 5ML if you have/had a recent severe injury or surgery due to the risk of severe bleeding problems. If you are pregnant or breastfeeding, inform your doctor before receiving this medicine. ABCIXIREL 10MG INJECTION 5ML is not recommended for children below 12 years of age as efficacy and safety have not been established.

Therapeutic Class

ANTICOAGULANT/ANTITHROMBOTIC

Drug-Drug Interactions

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AbciximabCangrelor
Severe
AbciximabDabigatran etexilate
Severe

Drug-Drug Interactions

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AbciximabCangrelor
Severe
How does the drug interact with ABCIXIREL 10MG INJECTION 5ML:
Co-administration of ABCIXIREL 10MG INJECTION 5ML with Cangrelor can increase the risk of bleeding.

How to manage the interaction:
Co-administration of Cangrelor with ABCIXIREL 10MG INJECTION 5ML can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these signs, it's important to contact a doctor right away: difficulty with bleeding, complications, bruising, feeling dizzy or lightheaded, dark or sticky stools, intense headache, weakness, or bleeding or vomiting. Do not stop using any medications without talking to a doctor.
AbciximabDabigatran etexilate
Severe
How does the drug interact with ABCIXIREL 10MG INJECTION 5ML:
Taking Dabigatran etexilate with ABCIXIREL 10MG INJECTION 5ML can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Dabigatran etexilate with ABCIXIREL 10MG INJECTION 5ML together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
AbciximabWarfarin
Severe
How does the drug interact with ABCIXIREL 10MG INJECTION 5ML:
Coadministration of Warfarin with ABCIXIREL 10MG INJECTION 5ML can increase the effect of Warfarin.

How to manage the interaction:
Although there is a possible interaction between Warfarin and ABCIXIREL 10MG INJECTION 5ML, you can take these medicines together if prescribed by a doctor. However, if you experience unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, contact a doctor. Do not discontinue any medications without a doctor's advice.
AbciximabDalteparin
Severe
How does the drug interact with ABCIXIREL 10MG INJECTION 5ML:
The combined use of ABCIXIREL 10MG INJECTION 5ML with Dalteparin can increase the risk of bleeding.

How to manage the interaction:
Taking ABCIXIREL 10MG INJECTION 5ML with Dalteparin together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as bleeding, severe bleeding, bruising, dark or black stools, severe headache, weakness, bleeding, or vomiting. Do not discontinue any medications without consulting a doctor.
AbciximabApixaban
Severe
How does the drug interact with ABCIXIREL 10MG INJECTION 5ML:
Coadministration of ABCIXIREL 10MG INJECTION 5ML and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining ABCIXIREL 10MG INJECTION 5ML and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
AbciximabHeparin
Severe
How does the drug interact with ABCIXIREL 10MG INJECTION 5ML:
Taking ABCIXIREL 10MG INJECTION 5ML with Heparin may increase the risk of bleeding.

How to manage the interaction:
Co-administration of ABCIXIREL 10MG INJECTION 5ML with Heparin can result in an interaction, but it can be taken if a doctor has advised it. However, if you notice any of these signs - bleeding, bruising, vomiting, headache, dizziness, weakness, or blood in your urine or stools, it's important to contact a doctor immediately. Do not stop using any medications without talking to a doctor.
AbciximabNepafenac
Severe
How does the drug interact with ABCIXIREL 10MG INJECTION 5ML:
Using Nepafenac and ABCIXIREL 10MG INJECTION 5ML can interfere with clotting and cause bleeding, especially when used regularly or for prolonged periods.

How to manage the interaction:
Although taking Nepafenac and ABCIXIREL 10MG INJECTION 5ML together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood, severe headache, and weakness call a doctor right away. Do not discontinue any medications without consulting a doctor.
AbciximabDasatinib
Severe
How does the drug interact with ABCIXIREL 10MG INJECTION 5ML:
Using Dasatinib together with ABCIXIREL 10MG INJECTION 5ML may increase the risk of bleeding.

How to manage the interaction:
Taking ABCIXIREL 10MG INJECTION 5ML with Dasatinib together can result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these signs, it's important to contact a doctor right away - bruising, feeling dizzy or lightheaded, dark stools, intense headaches. Do not stop using any medications without talking to a doctor.
AbciximabProtamine
Severe
How does the drug interact with ABCIXIREL 10MG INJECTION 5ML:
Coadministration of protamine and ABCIXIREL 10MG INJECTION 5ML can increase the risk of bleeding.

How to manage the interaction:
Co-administration of Protamine with ABCIXIREL 10MG INJECTION 5ML can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without first talking to your doctor.
AbciximabFondaparinux
Severe
How does the drug interact with ABCIXIREL 10MG INJECTION 5ML:
Taking ABCIXIREL 10MG INJECTION 5ML with fondaparinux can increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between ABCIXIREL 10MG INJECTION 5ML and Fondaparinux, it can be taken if prescribed by a doctor. However, if you experience bleeding, bruising, feeling dizzy or lightheaded, dark or black stools, severe headache, weakness, bleeding, or vomiting contact a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • ASPIRIN
  • IBUPROFEN
  • CELECOXIB
  • CLOPIDOGREL
  • ENOXAPARIN
  • CAPTOPRIL
  • ENALAPRIL
  • NIFEDIPINE
  • CILNIDIPINE
  • ATENOLOL
  • SOTALOL
  • WARFARIN
  • HEPARIN

Diet & Lifestyle Advise

  • Eat a diet rich in whole grains, vegetables, fruits, skinless poultry, fish, eggs, and low-fat dairy products.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight with proper diet and exercise.
  • Managing stress with meditation, yoga, and massage.
  • Avoid eating fried food, fast food, boxed food, canned food, and processed frozen meals.

Habit Forming

No

Special Advise

  • Before administration of ABCIXIREL 10MG INJECTION 5ML, a blood test for platelet count, prothrombin time, ACT and APTT should be done to check for any hemostatic abnormalities.
  • As ABCIXIREL 10MG INJECTION 5ML will be administered along with heparin and aspirin, it is always important to check the patient for any bleeding conditions.

Disease/Condition Glossary

Blood clot: Platelets are small cell particles that circulate in the blood. When the blood vessel is damaged or cut, the platelets clump together and lead to the formation of a clot. Thus, it prevents bleeding. The formation of clots in arteries can cut off the blood supply, leading to heart attack, stroke or death. Clot formation in the arteries that supply blood to the heart may cause reduced blood flow, leading to unstable angina (chest pain).

Myocardial infarction: Myocardial infarction, also known as a heart attack or stroke, could occur due to the lack of blood and oxygen supply in the heart. Symptoms include chest pain, upper body pain, sweating, weakness, trouble breathing, lightheadedness and nausea.

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