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  1. Home
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  3. Actilyse 50 mg Injection

Actilyse 50 mg Injection, Pack of 1 INJECTION
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Composition :

ALTEPLASE-50MG

Manufacturer/Marketer :

Boehringer Ingelheim India Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Actilyse 50 mg Injection

Actilyse 50 mg Injection belongs to the class of thrombolytics. It is used to treat various medical conditions, including Acute Ischemic Stroke (AIS), Acute Myocardial Infarction (AMI), to reduce mortality and incidence of heart failure. Besides this, it can be used in Acute Massive Pulmonary Embolism (PE) for lysis. Acute ischemic stroke (AIS) is the sudden loss of blood flow to an area of the brain with the resulting loss of neurologic function. A pulmonary embolism (PE) occurs when a clump of material, most often a blood clot, gets stuck in an artery in the lungs, blocking blood flow.

Actilyse 50 mg Injection contains Alteplase; it works by dissolving blood clots that block blood flow to the affected tissue, thereby effectively treating various medical conditions.

Actilyse 50 mg Injection is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. The most frequent adverse reactions of this therapy are bleeding and injection site reactions. Most of these side effects of Actilyse 50 mg Injection do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.

Before taking the Actilyse 50 mg Injection, let your doctor know about all your sensitivities and all medications you are using. And also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. The presence of additional medical issues may impact the use of this medication, so inform your doctor if you have any other medical problems, including active internal bleeding, recent intracranial or intraspinal surgery or serious head trauma, intracranial conditions that may increase the risk of bleeding, bleeding diathesis, current severe uncontrolled hypertension, current intracranial haemorrhage, subarachnoid haemorrhage and history of a recent stroke. It is recommended not to take alcohol while Actilyse 50 mg Injection therapy.

Uses of Actilyse 50 mg Injection

Acute Ischemic Stroke (AIS)Acute Myocardial Infarction (AMI) to reduce mortality and incidence of heart failure.Acute Massive Pulmonary Embolism (PE)

Directions for Use

The injection will be administered by a healthcare professional. Do not self-administer.

Medicinal Benefits

Actilyse 50 mg Injection plays a vital role in preventing the formation of harmful blood clots in your blood vessels. Thus, it helps to reduce the risk of Acute Ischemic Stroke (AIS) and Acute Myocardial Infarction (AMI) to reduce mortality and incidence of heart failure. On the other hand, it can treat acute massive pulmonary embolism (PE) in the lysis. It works by dissolving blood clots that block blood flow to the affected tissue.

Storage

Keep Actilyse 50 mg Injection out of the sight and reach of children.
Side effects of Actilyse 50 mg Injection
  • Your doctor may change or stop your medication to help manage your symptoms.
  • Your doctor may also prescribe medicine to lower stomach acid production or prevent blood flow to an injury.
  • Avoid taking pain relievers like NSAIDs or aspirin, as they can cause bleeding in your stomach.
  • Check with your doctor for safer pain relief options.
  • Do not smoke, as nicotine can make your symptoms worse by damaging blood vessels.
  • Avoid alcohol and caffeine, as they can irritate your stomach.
  • Eat a balanced diet with plenty of fruits, vegetables, lean meats, fish, low-fat dairy, and beans to help your body heal.
  • Drink extra fluids as recommended by your doctor.
  • Avoid massaging the bruise, as this might worsen the damage to the injured tissue.
  • Resting the affected area helps prevent more injury and aids healing.
  • Place a cloth-wrapped ice pack or cold compress on the affected area for 10 to 15 minutes.
  • If the bruise is extensive, severe, or accompanied by other symptoms like warmth, redness, or swelling, get medical help.

Drug Warnings

Before taking the Actilyse 50 mg Injection, let your doctor know you're allergic to any ingredient. Inform your doctor about your medical history and other medications you are currently taking to rule out any potential negative effects. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding or if you have any other medical conditions, including active internal bleeding, recent intracranial or intraspinal surgery or serious head trauma, current severe uncontrolled hypertension, current intracranial or subarachnoid haemorrhage and history of a recent stroke.

Drug-Drug Interactions

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AlteplaseHeparin
Critical
AlteplaseApixaban
Severe

Drug-Drug Interactions

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AlteplaseHeparin
Critical
How does the drug interact with Actilyse 50 mg Injection:
Taking Actilyse 50 mg Injection with Heparin can increase the risk of bleeding.

How to manage the interaction:
Taking Heparin with Actilyse 50 mg Injection is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you have unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
AlteplaseApixaban
Severe
How does the drug interact with Actilyse 50 mg Injection:
Coadministration of Actilyse 50 mg Injection and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Actilyse 50 mg Injection and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
AlteplaseCangrelor
Severe
How does the drug interact with Actilyse 50 mg Injection:
Co-administration of Cangrelor with Actilyse 50 mg Injection can increase the risk of bleeding.

How to manage the interaction:
There may be a possibility of interaction between Cangrelor and Actilyse 50 mg Injection, but it can be taken if prescribed by a doctor. If you notice any of these signs, it's important to contact a doctor right away: difficulty with bleeding, complications, bruising, feeling dizzy or lightheaded, dark or sticky stools, intense headache, weakness, or bleeding or vomiting. Do not discontinue any medications without consulting a doctor.
AlteplasePrasugrel
Severe
How does the drug interact with Actilyse 50 mg Injection:
Co-administration of Prasugrel with Actilyse 50 mg Injection can increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Actilyse 50 mg Injection and Prasugrel, you can take these medicines together if prescribed by a doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
AlteplaseIbrutinib
Severe
How does the drug interact with Actilyse 50 mg Injection:
Co-administration of Ibrutinib with Actilyse 50 mg Injection can increase the risk of bleeding.

How to manage the interaction:
Taking Ibrutinib with Actilyse 50 mg Injection together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
AlteplaseDabigatran etexilate
Severe
How does the drug interact with Actilyse 50 mg Injection:
Taking Dabigatran etexilate with Actilyse 50 mg Injection can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Dabigatran etexilate with Actilyse 50 mg Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
AlteplaseDasatinib
Severe
How does the drug interact with Actilyse 50 mg Injection:
Combining Dasatinib with Actilyse 50 mg Injection can increase the risk and severity of bleeding and hemorrhage.

How to manage the interaction:
Co-administration of Dasatinib with Actilyse 50 mg Injection can possibly result in an interaction, but it can be taken if your doctor has advised it. During your treatment, it's important to keep a close eye on any bleeding issues. If you notice any of these symptoms - like bleeding, bruising, dizziness, or black stools - make sure to contact your doctor right away. They will be able to help you and provide the necessary care. Do not discontinue any medications without first consulting your doctor.
AlteplaseFondaparinux
Severe
How does the drug interact with Actilyse 50 mg Injection:
Taking Actilyse 50 mg Injection with fondaparinux can increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between Actilyse 50 mg Injection and Fondaparinux, it can be taken if a doctor has advised it. However, if you experience bleeding or bruising, feeling dizzy or lightheaded, dark or bloody stools, headache, or weakness contact a doctor right away. Do not stop using any medications without talking to a doctor.
AlteplaseRivaroxaban
Severe
How does the drug interact with Actilyse 50 mg Injection:
Co-administration of Actilyse 50 mg Injection and Rivaroxaban can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Actilyse 50 mg Injection and Rivaroxaban can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, dark stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A low-cholesterol diet and a regular exercise regime effectively complement treatment with Actilyse 50 mg Injection.
  • Stick to a freshly prepared home-cooked meal and avoid processed, packed foods that contain hidden sugar and extra calories.
  • Replacing most of your saturated fats with unsaturated fats can quickly reduce total cholesterol and LDL cholesterol (bad cholesterol).
  • Foods like avocados, olive oil, fatty fish and nuts contain many heart-healthy unsaturated fats, so eating them regularly is beneficial.
  • Include a diet enriched in fats like fish oils, polyunsaturated oils, and omega-3 fatty acids, which are good for heart health.
  • Quit smoking and avoid excessive intake of alcohol.

Side Effects of Actilyse 50 mg Injection

Bleeding
Injection site reactions

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:48 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Actilyse 50 mg Injection contains Alteplase; it works by dissolving blood clots that block blood flow to the affected tissue, thereby effectively treating various medical conditions.

The most frequent adverse reaction associated with this therapy is bleeding. In most cases, this condition gradually resolves over time. However, if bleeding persists, contact your doctor.

The risk of stroke may outweigh the benefit produced by thrombolytic therapy in patients whose Acute Myocardial Infarction (AMI) puts them at low risk for death or heart failure.

Do not take anticoagulants; drugs that inhibit platelet function increase the risk of bleeding when administered with Alteplase therapy. And also recommended not to take concomitant angiotensin-converting enzyme inhibitors may increase the risk of angioedema.

Drug-Drug Interactions Checker List

  • WARFARIN
  • ASPIRIN
  • APIXABAN
  • ENALAPRIL
  • LISINOPRIL

Special Advise

  • As Actilyse 50 mg Injection tends to increase bleeding, try to avoid injuries, keep away from sharp objects, and inform your doctor if you have peptic ulcers or injuries.

Disease/Condition Glossary

Blood clot: A blood clot can occur in any part of the body, leading to a heart attack, stroke, and organ damage (even coma or death). Blood clots can reach your arteries or veins in the organs like the brain, kidney, heart, lungs, and limbs. Conditions like atherosclerosis, diabetes, heart failure, irregular heartbeat (arrhythmia), and obesity/overweight can trigger excessive blood clotting in the brain and heart. On the other hand, deep vein thrombosis (blood clot in veins), peripheral artery disease (narrowed arteries due to fat deposit or blood clot), and atherosclerosis (fat built upon the walls of the arteries) can cause a blood clot in your limbs.

Acute Ischemic Stroke (AIS): Acute ischemic stroke (AIS) is the sudden loss of blood flow to an area of the brain with the resulting loss of neurologic function. It is caused by thrombosis or embolism that occludes a cerebral vessel supplying a specific brain area.

Acute myocardial infarction: Acute myocardial infarction is myocardial necrosis resulting from acute obstruction of a coronary artery. Symptoms include chest discomfort with or without dyspnea, nausea, and/or diaphoresis.

Acute massive pulmonary embolism (PE): A pulmonary embolism (PE) occurs when a clump of material, most often a blood clot, gets stuck in an artery in the lungs, blocking blood flow. Acute massive pulmonary embolism (PE) is defined as Acute pulmonary emboli obstructing blood flow to a lobe or multiple lung segments. Acute pulmonary emboli are accompanied by unstable hemodynamics, e.g., failure to maintain blood pressure without supportive measures.

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