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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
COD available

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Composition :

BUPRENORPHINE-0.2MG

Manufacturer/Marketer :

Rusan Pharma Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Addnok 0.2 mg Tablet

Addnok 0.2 mg Tablet belongs to a class of drugs called 'opioid agonists' primarily used to treat opioid addiction (narcotics) like morphine, heroin, etc. It is also used to treat, prevent and treat moderate to severe pain. Drug addiction, also called substance use disorder, is a disease that affects a person's brain and behaviour and leads to an inability to control the use of a legal or illegal drug or medication.

Addnok 0.2 mg Tablet contains 'Buprenorphine', an opioid partial agonist-antagonists that prevent withdrawal symptoms in patients who stop taking opioid drugs by producing similar effects to these drugs. It has been approved for the treatment of narcotic-use disorders. A combination of buprenorphine and naloxone is prescribed for use in the treatment of opioid dependence. It also provides pain relief by acting on specific receptors in the brain and helps in relieving pain.

Addnok 0.2 mg Tablet should be used as prescribed by your doctor. The dose will be decided based on your medical condition. This medicine may cause certain side effects, in drowsiness, dry mouth, vomiting, blurred vision, constipation, dizziness or tiredness. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Addnok 0.2 mg Tablet should be avoided if you are allergic to it. Do not take Addnok 0.2 mg Tablet if you are pregnant or breastfeeding, as it may cause adverse effects on the baby. Addnok 0.2 mg Tablet is not recommended for children below 18 years of age. Addnok 0.2 mg Tablet is a habit-forming drug, and hence there is a risk of dependence on Addnok 0.2 mg Tablet . Therefore, before stopping Addnok 0.2 mg Tablet , contact a doctor as it may cause withdrawal symptoms like anxiety, increased heart rate, tremors or general unwell feeling. Addnok 0.2 mg Tablet may decrease fertility in men and women. Inform your doctor if you have respiratory disorders, heart diseases, high blood pressure, and liver or kidney disease before starting treatment with Addnok 0.2 mg Tablet . Avoid consuming alcohol along with Addnok 0.2 mg Tablet as it could lead to increased dizziness.

Uses of Addnok 0.2 mg Tablet

Opioid (drug) addiction, Pain

Directions for Use

Sublingual tablet: Place the tablet under your tongue and allow it to dissolve with your mouth closed. Do not chew the tablet or swallow it whole.

Medicinal Benefits

The Addnok 0.2 mg Tablet contains Buprenorphine as a substitution (replacement) treatment in patients addicted to opioid drugs (heroin and morphine, etc.). It prevents or reduces the unpleasant withdrawal symptoms experienced when addicts stop using opioid drugs. It also provides pain relief by acting on specific receptors in the brain and helps in relieving pain. Compared to other opioid analgesics like methadone, Addnok 0.2 mg Tablet has the advantage of having less sedation (sleepiness), decreased respiratory depression, decreased risk of diversion, fewer withdrawal symptoms and lower risk of toxicity at higher doses. 

Storage

Store in a cool and dry place away from sunlight

Side Effects of Addnok 0.2 mg Tablet

  • Weakness
  • Anxiety
  • Nervousness
  • Dizziness
  • Drowsiness
  • Headache
  • Orthostatic hypotension (a sudden dip of blood pressure on standing)
  • Constipation
  • Diarrhea
  • Nausea
  • Vomiting
  • Sweating

Drug Warnings

Please do not stop taking Addnok 0.2 mg Tablet suddenly, as it may cause withdrawal symptoms. Avoid frequent or high doses as it may lead to addiction. If you are known to be allergic to Addnok 0.2 mg Tablet or any other medicines, please tell your doctor.  Do not take Addnok 0.2 mg Tablet if you are pregnant or breastfeeding, as it may cause adverse effects on the baby. Addnok 0.2 mg Tablet is not recommended for children below 18 years of age.  Avoid consuming alcohol with Addnok 0.2 mg Tablet as it may increase the risk of side effects. Do not use this medicine if you have used an MAO inhibitor (antidepressants) in the past 14 days, as a dangerous drug interaction could occur. Addnok 0.2 mg Tablet should be taken with extreme caution in patients who have a history of alcoholism or drug abuse. Inform your doctor if you have severe breathing problems, asthma, delirium tremens (confusion and shaking after stopping drinking alcohol), hallucinations (seeing and hearing things that are not there), kidney or liver problems, head injury or brain disease, low blood pressure, urinary disorders (especially linked to enlarged prostate), thyroid problems, adrenocortical disorder (Addison’s disease), depression or other conditions that are treated with antidepressants. 

Drug-Drug Interactions

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BuprenorphineZiprasidone
Critical
BuprenorphineAlvimopan
Critical

Drug-Drug Interactions

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BuprenorphineZiprasidone
Critical
How does the drug interact with Addnok 0.2 mg Tablet:
Taking Ziprasidone with Addnok 0.2 mg Tablet can increase the risk of serious side effects.

How to manage the interaction:
Taking Ziprasidone with Addnok 0.2 mg Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, drowsiness, difficulty concentrating, and impairment in judgment. Do not discontinue any medications without consulting a doctor.
BuprenorphineAlvimopan
Critical
How does the drug interact with Addnok 0.2 mg Tablet:
Using alvimopan together with Addnok 0.2 mg Tablet can cause side effects (abdominal pain, nausea, vomiting, and diarrhea).

How to manage the interaction:
Taking Alvimopan with Addnok 0.2 mg Tablet is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
BuprenorphineCariprazine
Severe
How does the drug interact with Addnok 0.2 mg Tablet:
When Addnok 0.2 mg Tablet is used with cariprazine, it may possibly lead to side effects.

How to manage the interaction:
Concomitant administration of Addnok 0.2 mg Tablet alongside cariprazine can possibly result in an interaction, it can be taken if a doctor has advised it. Do not stop any medication without consulting a doctor. Do not discontinue any medications without consulting your doctor.
BuprenorphineSelegiline
Severe
How does the drug interact with Addnok 0.2 mg Tablet:
When Addnok 0.2 mg Tablet is taken with Selegiline, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in body).

How to manage the interaction:
There's an interaction between Addnok 0.2 mg Tablet alongside Selegiline that can result in an interaction but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
BuprenorphineEscitalopram
Severe
How does the drug interact with Addnok 0.2 mg Tablet:
Taking Addnok 0.2 mg Tablet with escitalopram increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Concomitant administration of Addnok 0.2 mg Tablet and escitalopram can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
BuprenorphinePhenobarbital
Severe
How does the drug interact with Addnok 0.2 mg Tablet:
Using phenobarbital along with Addnok 0.2 mg Tablet may lead to significant adverse effects (respiratory distress, and unconsciousness), and may drastically lower Addnok 0.2 mg Tablet levels in the blood, making the medicine less effective in treating disease.

How to manage the interaction:
Although taking phenobarbital and Addnok 0.2 mg Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience restlessness, irritability, anxiety, depression, pupil dilation, tremor, rapid heartbeat, body aches, involuntary shaking and kicking, abdominal pain, decreased hunger, nausea, vomiting, diarrhea, and weight loss, consult the doctor Do not stop using any medications without talking to a doctor.
BuprenorphineFlurazepam
Severe
How does the drug interact with Addnok 0.2 mg Tablet:
When Addnok 0.2 mg Tablet is used with flurazepam, it may lead to significant adverse effects (respiratory difficulties, unconsciousness).

How to manage the interaction:
Concomitant administration of Addnok 0.2 mg Tablet alongside flurazepam can result in an interaction, it can be taken if a doctor has advised it. Do not exceed the doses, frequency, or duration of usage advised by a doctor. You should avoid driving or operating hazardous machinery until you're aware of how these medications effect you. Do not discontinue any medications without consulting a doctor.
BuprenorphineGabapentin
Severe
How does the drug interact with Addnok 0.2 mg Tablet:
Co-administration of Addnok 0.2 mg Tablet and Gabapentin may cause central nervous system depression and lead to serious side effects (respiratory distress -build-up of fluid in the air sacs of the lungs).

How to manage the interaction:
Although there is a possible interaction between Gabapentin and Addnok 0.2 mg Tablet, you can take these medicines together if prescribed by a doctor. However, if you experience shortness of breath, fast heart rate, fast breathing, extreme tiredness, fever, cough with phlegm, or shallow breaths, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
BuprenorphineAlprazolam
Severe
How does the drug interact with Addnok 0.2 mg Tablet:
Using Alprazolam together with Addnok 0.2 mg Tablet can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although the combination of Alprazolam and Addnok 0.2 mg Tablet may cause an interaction, they can be used if prescribed by a doctor. Consult a doctor if you have any symptoms such as dizziness, drowsiness, difficulty concentrating, or impairment in judgment, reaction speed, or control of movements. Do not discontinue any medications without consulting a doctor.
BuprenorphinePentazocine
Severe
How does the drug interact with Addnok 0.2 mg Tablet:
When Addnok 0.2 mg Tablet is used with pentazocine, it may lead to significant adverse effects such as respiratory difficulties, unconsciousness.

How to manage the interaction:
Concomitant administration of Addnok 0.2 mg Tablet alongside pentazocine can result in an interaction, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Do regular exercise such as swimming or walking.
  • Drink plenty of water while taking Addnok 0.2 mg Tablet to avoid dry mouth.
  • Maintain a fibre-rich diet and eat plenty of fresh fruits and vegetables to avoid constipation while taking Addnok 0.2 mg Tablet .
  • Avoid consumption of alcohol and quit smoking.

Habit Forming

Yes

Therapeutic Class

OPIOID ANTAGONISTS

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Addnok 0.2 mg Tablet consists of Buprenorphine is an opioid partial agonist. It prevents withdrawal symptoms in patients who stop taking opioid drugs by producing similar effects to these drugs. It also provides pain relief by acting on specific receptors in the brain that change how your body feels and responds to pain.

Yes, Addnok 0.2 mg Tablet may cause withdrawal symptoms such as sweating, feeling hot and cold, runny eyes and nose, feeling or being sick, diarrhoea, stomach cramps, poor sleep, and just feeling awful. Therefore, if you experience difficulty while taking Addnok 0.2 mg Tablet , do not stop taking it suddenly and consult your doctor so that the dose may be reduced gradually to avoid withdrawal symptoms.

Chronic use of opioids may cause reduced fertility (ability to have children) in females and males of reproductive potential. It is not known whether these effects on fertility are reversible. However, it is essential to talk to your doctor before starting treatment with Addnok 0.2 mg Tablet if you think you may want to have a baby in the future.

No, you are not recommended to take Addnok 0.2 mg Tablet with antidepressants (medicines used to treat depression), and antipsychotics (medicines used to treat bipolar disorder and psychosis) as co-administration of these medicines with Addnok 0.2 mg Tablet may cause life-threatening respiratory depression and death have occurred. However, please consult a doctor before taking Addnok 0.2 mg Tablet with other medicines.

Yes, Addnok 0.2 mg Tablet may cause addiction, especially if taken for a prolonged time. Therefore, Addnok 0.2 mg Tablet should be given only for a short duration under strict medical supervision, particularly to patients susceptible to drug abuse. Take Addnok 0.2 mg Tablet only as advised by a doctor, as overuse or misuse of Addnok 0.2 mg Tablet can lead to overdose or death.

Some prescription-based opioid pain medications include codeine, fentanyl, hydromorphone, meperidine morphine, oxymorphone, oxycodone, hydrocodone and propoxyphene.

Drug-Drug Interactions Checker List

  • DIAZEPAM
  • CODEINE
  • MORPHINE
  • METHADONE
  • FLUOXETINE
  • ESCITALOPRAM
  • CITALOPRAM

Special Advise

  • Do not take Addnok 0.2 mg Tablet for a prolonged time, as it may lead to mental or physical dependence on Addnok 0.2 mg Tablet .
  • To avoid getting addicted to this drug, take it in prescribed quantities and as directed by your doctor. Do not self-medicate.
  • Addnok 0.2 mg Tablet causes drowsiness. Avoid doing activities that require your complete focus and attention, like driving when on this drug.
  • An abrupt stoppage of Addnok 0.2 mg Tablet can lead to significant withdrawal symptoms. Always discuss with your doctor about decreasing the dosage before completely stopping its usage.
  • Avoid consuming alcohol while on this medication, as it can lead to dangerous side effects.

Disease/Condition Glossary

Drug addiction: It is also called substance use disorder. It is a psychological condition that affects a person's brain and behaviour and leads to an inability to control legal or illegal drug or medication use. Opioid analgesics, such as morphine or diamorphine (heroin), are often subject to abuse, leading to dependence (addiction). If you are addicted to these drugs, you need a regular dose to feel ‘normal’. Otherwise, you will develop withdrawal symptoms within a day or so of the last dose. Withdrawal symptoms include sweating, feeling hot and cold, runny eyes and nose, feeling or being sick, diarrhoea, stomach cramps, poor sleep, and just feeling awful.

Pain: Pain is an unpleasant emotion brought on by an illness or injury. Acute (short-term) or chronic pain both exist (long-term). It may be widespread (body-wide aches) or localised (pain in a specific body area). Since different people have varying pain tolerance levels, pain is highly subjective. Even though pain is uncomfortable and inconvenient, it can provide clues as to what is wrong with the body. Cramps, headaches, bone fractures, stomach pain, arthritis (swelling of one or more joints), muscle strain or overuse, cuts, the flu, fibromyalgia, and irritable bowel syndrome are a few conditions that can cause pain (muscle pain with stiffness and tenderness).

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