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Reviewed By Sureshvarma D , MPharma
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Composition :

EVEROLIMUS-0.25MG

Manufacturer/Marketer :

Biocon Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Advacan 0.25 mg Tablet

Advacan 0.25 mg Tablet belongs to the group of medicine called ‘anti-cancer’. It is primarily used to treat breast cancer, pancreatic cancer, lung cancer and kidney cancer. Breast cancer is a type of cancer that develops in breast cells stimulated by the female sex hormone known as estrogen. Pancreatic cancer is described as a cancerous growth in the pancreas which normally begins in the cells that generate the juices that help break down food and the hormones which help in controlling blood sugar levels. Lung cancer is the uncontrolled growth of abnormal cells in one or both lungs. 

Advacan 0.25 mg Tablet contains 'Everolimus' which belongs to the group of medicines known as 'kinase inhibitors'. It works by decreases the activity of the immune system of the body and prevents rejection of the transplanted organ. It works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. In this way, it stops the spread of cancerous cells.

Take Advacan 0.25 mg Tablet as prescribed by your doctor. You are advised to take Advacan 0.25 mg Tablet for as long as your doctor has prescribed it for you depending on your medical conditions. You may experience weakness, infection, sinus inflammation, cough, diarrhea, fever, fatigue, otitis media (infection of the ear), stomatitis (Inflammation of the mouth) and upper respiratory tract infection. Most of these side effects of Advacan 0.25 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

To treat your condition effectually, continue taking Advacan 0.25 mg Tablet for as long as your doctor has prescribed. If you are known to be allergic to Advacan 0.25 mg Tablet or any other medicines, please tell your doctor. Do not take Advacan 0.25 mg Tablet if you are pregnant or planning for pregnancy as Advacan 0.25 mg Tablet may harm the unborn baby. Advacan 0.25 mg Tablet should not be taken by breastfeeding mothers as it may cause harm to the newborn baby. Advacan 0.25 mg Tablet causes tiredness, thus, it is advisable not to drive unless you are alert. Elderly people are more sensitive to medicine so they may adjust the dosage according to their condition.

Uses of Advacan 0.25 mg Tablet

Breast cancer, pancreatic cancer, lung cancer and kidney cancer.

Directions for Use

Take Advacan 0.25 mg Tablet with or without food as advised by the doctor. Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Advacan 0.25 mg Tablet is indicated to the patients dealing with breast cancer, pancreatic cancer, lung cancer, kidney cancer and stomach/ intestinal cancer. Cancer of this type tends to spread quickly in other parts of the body. Advacan 0.25 mg Tablet travels through the bloodstream and effectively destroys cancerous cells and other parts of the body. It works by decreases the activity of the immune system of the body and prevents rejection of the transplanted organ. It works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. In this way, it stops the spread of cancerous cells. Besides this, it is also effective in people with genetic disorders to treat some types of tumors in the brain or kidney.

Storage

Store in a cool and dry place away from sunlight
Side effects of Advacan 0.25 mg Tablet
  • Eat more plant based foods like vegetables, fruits and whole grains.
  • Reduce intake of foods containing high fat such as dairy, oil and red meat.
  • Exercise for at least 30 minutes 5 days a week.
  • Aim for weight loss and maintain healthy weight.
  • Quit smoking.
  • Control blood sugar and blood pressure.
  • Stay hydrated by taking fluids like water, juices and soups etc.
  • Eat fruits and vegetables which contain vitamins.
  • Take iron rich food like dry fruits, green leafy vegetables and sea food etc.
  • Reduce intake of milk, cheese, yogurt, soy, chocolate, ice cream, Grapes, Popcorn, canned salmon, pomegranate.
  • Regular exercise like walking, jogging is helpful.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Get plenty of rest and avoid activities that tire you out to allow your body fight the infection.
  • Drink lots of fluids to help loosen mucus in the lungs.
  • Use over-the-counter medications like paracetamol or ibuprofen to manage fever.
  • Use a humidifier as it helps soothe irritated airways.
  • Do not make changes to your medication schedule or take over-the-counter medicines without consulting your doctor.
  • Eat a healthy balanced diet.
  • Reduce stress with relaxation techniques such as yoga or meditation.
  • Keep track of your menstrual cycle any irregularities.
  • Have regular check ups to exclude other health problems.
  • Exercise but do not exercise to the extent of overheating.
  • Hydrate well, eat well (particularly iron and vitamins).
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
Managing Medication-Triggered Epistaxis (Nosebleed): A Step-by-Step Guide:
  • If you experience nosebleeds or unusual bleeding after taking medication, seek medical attention right away and schedule an appointment to discuss your symptoms with your doctor.
  • Your doctor may adjust your treatment plan by changing the dosage, switching to a different medication, or stopping the medication.
  • If your doctor advises, take steps to manage bleeding and promote healing, such as applying pressure, using saline nasal sprays, or applying a cold compress, using humidifiers, avoiding blowing or picking your nose, and applying petroleum jelly to the nostrils.
  • Schedule follow-up appointments with your doctor to monitor progress, adjust treatment plans, and prevent future episodes.

Drug Warnings

If you are known to be allergic to Advacan 0.25 mg Tablet or any other medicines, please tell your doctor. Advacan 0.25 mg Tablet should not be taken in the conditions like liver disease, diabetes and high level of cholesterol. Do not take Advacan 0.25 mg Tablet if you have recent surgery, infection and hepatitis B. Advacan 0.25 mg Tablet may weaken your immune system, inform your doctor before taking Advacan 0.25 mg Tablet . Advacan 0.25 mg Tablet may also impair your kidney function. Therefore, monitor your kidney function regularly while taking Advacan 0.25 mg Tablet . Advacan 0.25 mg Tablet may cause cough, fever and shortness of breathing, thereby inform your doctor while taking your Advacan 0.25 mg Tablet . Advacan 0.25 mg Tablet may cause skin cancer, if you observe night sweating, weight loss, or change in color and size of the mole inform your doctor. Do not take Advacan 0.25 mg Tablet if you are pregnant or planning for pregnancy as Advacan 0.25 mg Tablet may harm the unborn baby. Advacan 0.25 mg Tablet should not be taken by breastfeeding mothers as it may cause harm to the newborn baby. Advacan 0.25 mg Tablet causes tiredness, thus, it is advisable not to drive unless you are alert. Elderly people are more sensitive to medicine so they may adjust the dosage according to their condition.

Drug-Drug Interactions

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EverolimusMetrizamide
Severe
EverolimusRifapentine
Severe

Drug-Drug Interactions

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EverolimusMetrizamide
Severe
How does the drug interact with Advacan 0.25 mg Tablet:
Injections of metrizamide and related contrast agents can occasionally cause kidney damage, and mixing them with other medication that might adversely harm the kidney, such as Advacan 0.25 mg Tablet, may enhance the risk.

How to manage the interaction:
Although taking Advacan 0.25 mg Tablet and Metrizamide together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor immediately. Drink lots of fluid after the procedure to stay hydrated and to flush the contrast agent out of your kidneys. Do not stop using any medications without talking to a doctor.
EverolimusRifapentine
Severe
How does the drug interact with Advacan 0.25 mg Tablet:
When Advacan 0.25 mg Tablet is taken with Rifapentine, it may lower Advacan 0.25 mg Tablet blood levels, making it less effective in treating the illness.

How to manage the interaction:
Taking Advacan 0.25 mg Tablet with Rifapentine together can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without a doctor's advice.
How does the drug interact with Advacan 0.25 mg Tablet:
Taking Advacan 0.25 mg Tablet and Polymyxin b together may increase the risk of kidney problems.

How to manage the interaction:
There may be a possibility of interaction between Advacan 0.25 mg Tablet and Polymyxin b, but it can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, swelling, difficulty breathing, bone pain, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Advacan 0.25 mg Tablet:
When Advacan 0.25 mg Tablet is taken with Efavirenz, the effect of Advacan 0.25 mg Tablet is reduced.

How to manage the interaction:
Co-administration of Advacan 0.25 mg Tablet with Efavirenz can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without a doctor's advice.
EverolimusZafirlukast
Severe
How does the drug interact with Advacan 0.25 mg Tablet:
When Advacan 0.25 mg Tablet is taken with Zafirlukast, the amount of Advacan 0.25 mg Tablet in the blood can go up.

How to manage the interaction:
Co-administration of Zafirlukast with Advacan 0.25 mg Tablet can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Advacan 0.25 mg Tablet:
Coadministration of Phenytoin and Advacan 0.25 mg Tablet may decrease the blood levels of Advacan 0.25 mg Tablet, which may make Advacan 0.25 mg Tablet less effective.

How to manage the interaction:
Although taking Phenytoin and Advacan 0.25 mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. Without consulting a doctor, never stop taking any drugs.
EverolimusEnzalutamide
Severe
How does the drug interact with Advacan 0.25 mg Tablet:
Taking Enzalutamide with Advacan 0.25 mg Tablet may decrease the blood levels of Advacan 0.25 mg Tablet, which may make Advacan 0.25 mg Tablet less effective in treating the condition.

How to manage the interaction:
Although taking Enzalutamide and Advacan 0.25 mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Advacan 0.25 mg Tablet:
Using Advacan 0.25 mg Tablet and Flurbiprofen can increase the risk of kidney problems.

How to manage the interaction:
Although taking Advacan 0.25 mg Tablet and Flurbiprofen together can cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Advacan 0.25 mg Tablet:
Advacan 0.25 mg Tablet may cause kidney problems, and combining it with gentamicin may increase that risk.

How to manage the interaction:
Although there is a possible interaction, gentamicin can be taken with Advacan 0.25 mg Tablet if prescribed by the doctor. Consult the doctor if you experience symptoms of kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm.
EverolimusFosamprenavir
Severe
How does the drug interact with Advacan 0.25 mg Tablet:
Taking Advacan 0.25 mg Tablet with Fosamprenavir can considerably raise blood levels of Advacan 0.25 mg Tablet, increasing the risk of serious side effects (pneumonitis - lung inflammation, infection, mouth ulcers, anemia, or bleeding).

How to manage the interaction:
Taking Advacan 0.25 mg Tablet with Fosamprenavir together can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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EVEROLIMUS-0.25MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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EVEROLIMUS-0.25MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Taking Advacan 0.25 mg Tablet with grapefruit juice can raise blood levels and enhance the effects of Advacan 0.25 mg Tablet. Since the co-administration of Advacan 0.25 mg Tablet along with grapefruit juice can lead to an interaction, You should not consume grapefruit juice or eat grapefruits while taking Advacan 0.25 mg Tablet.

Diet & Lifestyle Advise

  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yogurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs and spices in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep, rest well.
  • Performing yoga and other relaxation techniques may also improve physical and mental health and may reduce your stress levels.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Advacan 0.25 mg Tablet is an anticancer medicine. It belongs to a group of medicines known as a kinase inhibitor. It works by lowering the blood supply to the tumor, which reduces the growth and spread of cancer cells.

There is no specific duration of treatment with Advacan 0.25 mg Tablet . Advacan 0.25 mg Tablet is continued till benefit is seen or undesirable toxicity or side effects occur.

You should prevent grapefruit or grapefruit juice while taking Advacan 0.25 mg Tablet . This is because taking them together may rise the levels of Advacan 0.25 mg Tablet in your blood to toxic levels. Avoid the use of live vaccinations and any probable contact with people who have received live vaccinations.

Advacan 0.25 mg Tablet can lead to serious side effects that consist of severe allergic reactions, angioedema (painless swelling under the skin) and kidney failure which can be dangerous and can lead to death. It is possible that you may develop an infection or problems associated to lungs like breathing problems.

It usually takes three to six months for most types of lung cancer to double their size. It will take a long time for lung cancer to reach a size that could be diagnosed in X-Ray.

Drug-Drug Interactions Checker List

  • KETOCONAZOLE
  • ITRACONAZOLE
  • VORICONAZOLE
  • CLARITHROMYCIN
  • TELITHROMYCIN
  • ERYTHROMYCIN
  • RITONAVIR
  • EFAVIRENZ
  • RAMIPRIL
  • VERAPAMIL
  • DILTIAZEM
  • DRONEDARONE
  • IMATINIB
  • PHENYTOIN
  • CARBAMAZEPINE
  • PHENOBARBITAL
  • FLUCONAZOLE

Special Advise

  • Advacan 0.25 mg Tablet should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking Advacan 0.25 mg Tablet .
  • Do not have immunizations/vaccinations without a doctor's advice.
  • Avoid contact with people who have recently received live vaccines.

Disease/Condition Glossary

Breast cancer: It is a type of cancer that develops in breast cells that are stimulated by a female sex hormone called estrogen. Breast cancer may form in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), in the fatty tissue or the fibrous connective tissue within the breast. The tumor cells invade other healthy breast cells and can travel to lymph nodes which are a primary pathway for the cancer cells to move to other parts of the body. 

Lung cancer: It happens when cells in the lung begin to grow in an uncontrolled manner. The most common form of lung cancer is non-small cell lung cancer (NSCLC). It happens when cells that form the lining of the lung start growing uncontrollably. Persons who smoke are at high risk of lung cancer. A common symptom of lung cancer is a cough that does not go easily followed by shortness of breath. Cancerous cells of the lung spread off and travel through the bloodstream to distant regions of the body and grow.

Pancreatic cancer: It is described as a cancerous growth in the pancreas which normally begins in the cells that generate the juices. Juices are produced by the pancreas ( a gland present behind your stomach) help in the breakdown of food and hormones which help in controlling blood sugar levels.

Kidney cancer: Kidneys are the organs on either side of your backbone directly above your waist. The tubes present inside clean and filter your blood, taking out waste foods and making urine. Kidney cancer produces in the lining of tiny tubes inside your kidneys.

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