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Reviewed By Sunny S , MBBS
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Manufacturer/Marketer

Fusion Health Care Pvt Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Advastat Cv 20/75mg Capsule

Advastat Cv 20/75mg Capsule is a combination drug composed of a blood-thinning agent and cholesterol-lowering agent, primarily used to prevent heart attack and stroke in the future. It lowers the raised level of cholesterol and fats (triglycerides) in our body. A heart attack is a condition in which your coronary arteries (blood vessel supplying blood and oxygen to the heart) becomes blocked due to build-up of fats (plaque) including cholesterol. These plaques narrow the arteries, leading to atherosclerosis and coronary artery disease, mainly for most heart attacks.

Advastat Cv 20/75mg Capsule is composed of two medicines, namely: Rosuvastatin and Clopidogrel. Rosuvastatin is a lipid-lowering medication that blocks the enzyme required to make cholesterol in the body. As a result, it lowers the bad cholesterol (low-density lipoproteins or LDL), triglycerides (TG) and increases the levels of good cholesterol (high-density lipoproteins or HDL). Clopidogrel is a blood thinner (anticoagulant) that collectively prevents a clot in the blood vessels. Together Advastat Cv 20/75mg Capsule reduces the increased levels of bad cholesterol (low-density lipoprotein and triglycerides) and prevents blood clots, thereby reducing and preventing the risk of heart attack, stroke and heart-related chest pain (angina).

Take Advastat Cv 20/75mg Capsule exactly as directed by your doctor. The dose and duration of Advastat Cv 20/75mg Capsule may differ depending on the reason why you're taking it and your responses to treatment. In some cases, you may experience headaches, ankle swelling due to fluid retention (oedema), slow heart rate, and nausea. Advastat Cv 20/75mg Capsule is known to cause dizziness, so driving should be avoided. Most of these side effects of Advastat Cv 20/75mg Capsule do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking Advastat Cv 20/75mg Capsule of your own. Suddenly stopping Advastat Cv 20/75mg Capsule may worsen your condition and increase your risk of a future heart attack. Inform your doctor know if you are allergic to rosuvastatin, clopidogrel, or have any active liver disease (liver enzymes abnormalities), active bleeding issues (like peptic ulcer, brain haemorrhage), or muscle problem (myopathy, rhabdomyolysis). The patient should inform the doctor that they are taking Advastat Cv 20/75mg Capsule before any surgery is scheduled or any new medicine is taken. Rosuvastatin present in Advastat Cv 20/75mg Capsule is a pregnancy category X drug, so it should not be given to pregnant women. It may cause harm to the fetus if administered to pregnant or breastfeeding women.

Uses of Advastat Cv 20/75mg Capsule

Hyperlipidemia (Increased cholesterol), Prevention of heart attack, Prevention of stroke

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Rosuvastatin is a lipid-lowering medication that blocks the enzyme required to make cholesterol in the body. As a result, it lowers the bad cholesterol (low-density lipoproteins or LDL), triglycerides (TG) and increases the levels of good cholesterol (high-density lipoproteins or HDL). Clopidogrel is a blood thinner (anticoagulant) that collectively prevents a clot in the blood vessels. Together Advastat Cv 20/75mg Capsule reduces the increased levels of bad cholesterol (low-density lipoprotein and triglycerides) and prevents blood clots, thereby reducing the risk of heart attack, stroke, and heart-related chest pain (angina).

Storage

Store in a cool and dry place away from sunlight

Side Effects of Advastat Cv 20/75mg Capsule

  • Stomach bleeding
  • Gastrointestinal bleeding
  • Nose bleeding
  • Rash
  • Diarrhoea
  • Stomach ulcer
  • Muscle disease (myopathy, rhabdomyolysis)
  • Abdominal pain

Drug Warnings

Tell your doctor if you are allergic to rosuvastatin, clopidogrel, or any of its ingredients. If you have any active liver disease, active bleeding issues (like peptic ulcers, brain haemorrhage), pregnant, or plan to become pregnant or breastfeeding, do not take Advastat Cv 20/75mg Capsule until prescribed. The patient should inform the doctor that they are taking Advastat Cv 20/75mg Capsule before any surgery is scheduled or any new medicine is taken. Rosuvastatin present in Advastat Cv 20/75mg Capsule is a pregnancy category X drug, so it is contraindicated in pregnant women. As it may cause harm to the fetus if administered to pregnant women. The risk of muscle problems might increase if Advastat Cv 20/75mg Capsule is taken with an antibiotic (clarithromycin), anti-HIV drugs (ritonavir, lopinavir, darunavir, atazanavir, indinavir) and antifungal (itraconazole). Coadministration with anticoagulants like warfarin may cause gastric bleeding and other bleeding problems. So, if you are using any blood-thinning agents, let your doctor know about this. Advastat Cv 20/75mg Capsule contains rosuvastatin, which can cause muscle problems like myopathy and rhabdomyolysis. Patients with active liver disease should use the Advastat Cv 20/75mg Capsule with caution. Safety and effectiveness of Advastat Cv 20/75mg Capsule have not been established, so its use should be avoided in paediatric patients less than ten years of age. Discontinuation of Advastat Cv 20/75mg Capsule may lead to cardiovascular events like heart attack, stroke, and angina (heart-related chest pain). Hence, you should consult a doctor before stopping the dose of Advastat Cv 20/75mg Capsule .

Drug-Drug Interactions

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ClopidogrelMifepristone
Critical
ClopidogrelSelexipag
Critical

Drug-Drug Interactions

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ClopidogrelMifepristone
Critical
How does the drug interact with Advastat CV 20 mg/75 mg Capsule:
Taking Advastat CV 20 mg/75 mg Capsule together with mifepristone increases the risk of vaginal bleeding in women.

How to manage the interaction:
Although taking Advastat CV 20 mg/75 mg Capsule with mifepristone is not recommended, that would certainly result in interaction, it can be taken if a doctor prescribes it. If you experience prolonged and heavy bleeding, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
ClopidogrelSelexipag
Critical
How does the drug interact with Advastat CV 20 mg/75 mg Capsule:
When Selexipag and Advastat CV 20 mg/75 mg Capsule are taken together, the body's ability to break down Selexipag may be reduced.

How to manage the interaction:
Taking Advastat CV 20 mg/75 mg Capsule with Selexipag is not recommended, please consult your doctor before taking it. They can be taken if prescribed by your doctor.
ClopidogrelRepaglinide
Severe
How does the drug interact with Advastat CV 20 mg/75 mg Capsule:
Advastat CV 20 mg/75 mg Capsule increases the blood levels of Repaglinide, which results in increased effectiveness of Repaglinide. When these medicines are taken together, you may experience low blood sugar (hypoglycemia).

How to manage the interaction:
Although taking Advastat CV 20 mg/75 mg Capsule with Repaglinide may result in interaction, it can be taken if prescribed by a doctor. However, if you experience any signs of hypoglycemia (low blood sugar), consult your doctor immediately. Common symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, weakness, tremor, nausea, hunger, sweating, and palpitation. It is advised to monitor your blood sugar levels if you experience the above symptoms. Do not discontinue any medication without consulting a doctor.
ClopidogrelPioglitazone
Severe
How does the drug interact with Advastat CV 20 mg/75 mg Capsule:
Taking Pioglitazone with Advastat CV 20 mg/75 mg Capsule can increases the blood levels of Pioglitazone, when these medicines are taken together, you may experience hypoglycemia (low blood sugar).

How to manage the interaction:
Taking Advastat CV 20 mg/75 mg Capsule together with Pioglitazone may lead to interaction, but it can be taken if prescribed by your doctor. Consult a doctor immediately if you experience headache, dizziness, drowsiness, nervousness, weakness, shaking, or sweating. Do not discontinue any medication without consulting the doctor.
ClopidogrelArgatroban
Severe
How does the drug interact with Advastat CV 20 mg/75 mg Capsule:
Taking Advastat CV 20 mg/75 mg Capsule together with argatroban can increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between Advastat CV 20 mg/75 mg Capsule and Apixaban, they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience any unusual bleeding or have other signs of bleeding, like feeling dizzy or lightheaded, red or black, sticky stools, or severe headaches. Do not discontinue any medications without consulting your doctor.
ClopidogrelDabigatran etexilate
Severe
How does the drug interact with Advastat CV 20 mg/75 mg Capsule:
Taking Advastat CV 20 mg/75 mg Capsule with Dabigatran may increase the risk of bleeding.

How to manage the interaction:
Although there may be an interaction between Advastat CV 20 mg/75 mg Capsule and Apixaban, they can be taken together if advised by your doctor. However, consult your doctor immediately if you experience any unusual bleeding, dizziness or lightheadedness, red or black, sticky stools, or headaches. Do not discontinue any medication without consulting your doctor.
ClopidogrelDalteparin
Severe
How does the drug interact with Advastat CV 20 mg/75 mg Capsule:
Using dalteparin together with Advastat CV 20 mg/75 mg Capsule may increase the risk of bleeding.

How to manage the interaction:
There may be a possible interaction between Advastat CV 20 mg/75 mg Capsule and Dalteparin, but they can be taken together if prescribed by your doctor. However, If you experience any unusual bleeding or have other signs of bleeding like feeling dizzy or lightheaded, red or black, sticky stools, or having a headache consult your doctor without any delay. Do not discontinue any medication without consulting your doctor.
ClopidogrelEnoxaparin
Severe
How does the drug interact with Advastat CV 20 mg/75 mg Capsule:
Taking enoxaparin with Advastat CV 20 mg/75 mg Capsule can increase the risk of bleeding.

How to manage the interaction:
There may be a possibility of interaction between Advastat CV 20 mg/75 mg Capsule and Enoxaparin, but they can be taken together if prescribed by a doctor. However, If you experience any unusual bleeding or have other signs of bleeding like feeling dizzy or lightheaded, red or black, sticky stools, or headache, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
ClopidogrelAbciximab
Severe
How does the drug interact with Advastat CV 20 mg/75 mg Capsule:
Coadministration of Advastat CV 20 mg/75 mg Capsule with Abciximab it increases the risk of bleeding.

How to manage the interaction:
Although there is a interaction between Advastat CV 20 mg/75 mg Capsule and Abciximab, but it can be taken if prescribed by a doctor. However, consult your doctor immediately if you experience unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, and weakness. Do not discontinue any medications without consulting your doctor.
ClopidogrelFluconazole
Severe
How does the drug interact with Advastat CV 20 mg/75 mg Capsule:
Co-administration of Advastat CV 20 mg/75 mg Capsule with fluconazole can reduce the effectiveness of Advastat CV 20 mg/75 mg Capsule.

How to manage the interaction:
Advastat CV 20 mg/75 mg Capsule and Fluconazole may interact, but you can take these medications together if a doctor has advised it. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A low cholesterol diet and a regular exercise regime effectively complement treatment with Advastat Cv 20/75mg Capsule .
  • Stick to a freshly prepared home-cooked meal and avoid processed, packed foods that contain hidden sugar and extra calories.
  • Try to replace most of your saturated fats with unsaturated fats to reduce total cholesterol and LDL cholesterol (bad cholesterol) quickly.
  • Foods like avocados, olive oil, fatty fish, and nuts contain too many heart-healthy unsaturated fats, so eating them regularly is beneficial.
  • Include a diet enriched in fats like fish oils, polyunsaturated oils, and omega-3 fatty acids, which are good for heart health.
  • Quit smoking and avoid excessive intake of alcohol.

Habit Forming

No

Therapeutic Class

ANTICOAGULANT/ANTITHROMBOTIC

Advastat Cv 20/75mg Capsule Substitute

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Advastat Cv 20/75mg Capsule is composed of two medicines, namely: Rosuvastatin and Clopidogrel. Rosuvastatin is a lipid-lowering medication that blocks the enzyme required to make cholesterol in the body. As a result, it lowers the bad cholesterol (low-density lipoproteins or LDL), triglycerides (TG) and increases the levels of good cholesterol (high-density lipoproteins or HDL). Clopidogrel is a blood thinner (anticoagulant) that collectively prevents a clot in the blood vessels. Together Advastat Cv 20/75mg Capsule reduces the increased levels of bad cholesterol (low-density lipoprotein and triglycerides) and prevents blood clots, thereby reducing and preventing the risk of heart attack, stroke and heart-related chest pain (angina).

Yes, Advastat Cv 20/75mg Capsule contains clopidogrel that prevents blood clotting. It works by preventing platelets (a type of blood cell) from sticking together and forming clots, preventing heart attack and stroke.

No, Advastat Cv 20/75mg Capsule contains Rosuvastatin, pregnancy category X medicine, and can harm both pregnant mother and unborn baby. Even if you are planning for pregnancy, tell your doctor that you are using Advastat Cv 20/75mg Capsule .

If you accidentally take an overdose of Advastat Cv 20/75mg Capsule , you may have liver problems (increased secretion of liver enzymes) and bleeding complications. If problems persist, you should immediately go to the nearby clinic or hospital.

It would be best if you had total lipid profile (TG, HDL, LDL, VLDL, TC) and Blood coagulation tests like Complete blood count (CBC), Factor V assay, Fibrinogen Test, Prothrombin time (PT or PT-INR), Platelet count, Thrombin time and Bleeding time to analyze your blood clot timing and cholesterol level.

Do not drink grapefruit juice while taking Advastat Cv 20/75mg Capsule . Grapefruit juice may increase the blood-thinning effect of your medicine.

Yes, prolonged use of Advastat Cv 20/75mg Capsule may cause muscle diseases like myopathy and rhabdomyolysis. So if you feel any musculoskeletal pain after taking Advastat Cv 20/75mg Capsule , consult your doctor about this issue.

Drinking alcohol with Advastat Cv 20/75mg Capsule may damage your liver and increase liver enzymes like transaminase. So, Advastat Cv 20/75mg Capsule should be used with caution who consume alcohol and/or have a liver disease history.

Yes, taking Advastat Cv 20/75mg Capsule can increase bleeding risk as it contains aspirin and clopidogrel, which belongs to a class of blood-thinning agents. So, please be very cautious while shaving, cutting fingernails or toenails, or using sharp objects to avoid bleeding. Before going through any surgical procedure, let your doctor know that you are taking the Advastat Cv 20/75mg Capsule .

Drug-Drug Interactions Checker List

  • ERYTHROMYCIN
  • CLARITHROMYCIN
  • RITONAVIR
  • LOPINAVIR
  • DARUNAVIR
  • ATAZANAVIR
  • INDINAVIR
  • ITRACONAZOLE
  • WARFARIN
  • HEPARIN
  • COLCHICINE
  • DIGOXIN
  • CYCLOSPORINE

Disease/Condition Glossary

Heart attack: Heart attack is when your coronary arteries (blood vessels supplying blood and oxygen to the heart) become blocked due to the build-up of fats (plaque), including cholesterol. These plaques narrow the arteries, leading to atherosclerosis and coronary artery disease, mainly for most heart attacks.

Stroke: Stroke occurs when the blood and oxygen supply to the brain is blocked or minimized. As a result, the brain tissue is deprived of getting oxygen and nutrients. After a few minutes, brain cells (neurons) start to die. A stroke is a medical emergency; immediate treatment is required; else can cause brain damage, coma or even death. 

Atherosclerosis: Atherosclerosis occurs when fats, cholesterol, and other substances known as plaque deposit on your artery walls that restrict blood flow. This plaque formation triggers blood clots, narrows the artery's size, and hardens it. This, in turn, can lead to various heart complications like atherosclerosis, heart attack, heart-related chest pain (angina), and stroke. However, it can also affect the body's arteries apart from the heart.

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