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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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Composition :

CEFUROXIME-125MG

Manufacturer/Marketer :

Glenmark Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About Altacef Suspension

Altacef Suspension belongs to the class of antibiotics known as cephalosporin, indicated for treating a wide range of bacterial infections. It helps in the treatment of urinary tract infections (UTI), Mild to moderate lower respiratory tract infections (bronchitis), severe lower respiratory tract infections (pneumonia), pyelonephritis (kidney inflammation due to the bacterial infection), uncomplicated gonorrhoea (sexually transmitted infection), Lyme disease (caused due to biting of infected black-legged tick insect) in adults and children above 12 years of age.

Altacef Suspension is a broad-spectrum antibiotic that kills a wide range of bacteria (bactericidal). It kills the bacterial cell by binding to the outer layer of the bacteria and blocking the activity of the enzyme that makes peptidoglycan (a vital component of the bacterial cell wall). As a result, the bacterial cell cannot grow and multiply and finally gets killed.

You should take Altacef Suspension only if your doctor has prescribed you. Altacef Suspension is available in various forms, such as oral tablets, dispersible tablets, and oral suspension. Most bacterial infections get treated within one week, while some conditions might take longer. So, it would be best if you tried to complete the dose your doctor prescribed for the specific bacterial infection. During the treatment with Altacef Suspension, you may observe some mild and transient nature of common side effects like headache, dizziness,  stomach upset, overgrowth of candida (fungal skin infection), unpleasant taste in the mouth, diaper rashes, and eosinophilia (increased disease-fighting cells WBCs). These side effects are usually in the initial phase and then resolved after some time. However, if these side effects persist, let your doctor know about them.

Overdosage of Altacef Suspension can cause brain problems (cerebral irritation with fits or convulsions attack). There is no clinical evidence of a Altacef Suspension effect on the mother or baby during pregnancy. However, one should take the Altacef Suspension with caution. Altacef Suspension is excreted in the breastmilk, so the nursing mother should cautiously take Altacef Suspension. This antibiotic may cause dizziness, so patients should be cautious while driving a motor vehicle or operating machinery. Altacef Suspension is not recommended for people allergic or hypersensitive to Altacef Suspension, penicillin, or other beta-lactam antibiotics. In the initial stage of the treatment, you might have diarrhoea and abdominal cramps due to loss of gut flora (good intestinal/gut bacteria that aids digestion). So, the doctor may prescribe you prebiotics or probiotics to increase the number of gut flora. You can drink alcoholic beverages while taking amoxicillin, as it does not interact with Altacef Suspension. Liver and kidney-affected people should take this medication with caution.

Uses of Altacef Suspension

Bacterial infections

Directions for Use

Tablet: Swallow it as a whole with water; do not crush, break or chew it.Suspension/Syrup: Shake the bottle well before use. Check the label for directions and take Altacef Suspension in doses as prescribed by your doctor with the help of a measuring cup.Dispersible Tablet: Check the label for directions before use. Disperse the tablet in the prescribed amount of water and swallow the whole contents.

Medicinal Benefits

Altacef Suspension treats a wide range of bacterial infections caused due to gram-positive and gram-negative bacteria. It helps treat respiratory tract infections, ear infections, skin infections, genitourinary infections, and bone infections. Besides this, Altacef Suspension also prevents in spreading of the infection after surgery and in the early treatment of Lyme disease caused by bacteria (Borrelia burgdorferi) in adults and children over the age of 12 years. The usual course of Altacef Suspension is seven days (5-10 days). But, your doctor might prescribe you Altacef Suspension for a longer duration depending on the condition of infection. Altacef Suspension has excellent antibacterial activity against gram-positive and gram-negative bacteria, including Staphylococcus aureus, Haemophilus para influenza, Streptococcus pneumonia, S. pyrogens, Haemophilus influenzae, Klebsiella pneumoniae, Moraxella catarrhalis, and Neisseria gonorrhoeae.

Storage

Store in a cool and dry place away from sunlight
Side effects of Altacef Suspension 30 ml
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Get plenty of fresh air.
  • Take regular sips of a cold drink.
  • Take ginger containing foods like ginger tea and ginger biscuits.
  • Do not take heavy meals at a time, take small and frequent meals.
  • Drink small sips of liquids frequently, especially water or oral rehydration solutions, to prevent dehydration, even if vomiting occurs.
  • Monitor urine output; frequent, light-colored urine is a sign of proper hydration.
  • Eat bland, easily digestible foods like toast, plain rice, applesauce, bananas, and crackers.
  • Avoid spicy, fatty, or greasy foods, dairy products, alcohol, and caffeine as these can irritate the stomach.
  • Eat smaller meals more often instead of large ones.
  • Get enough rest to allow your body to recover.
  • If you experience severe vomiting, bloody stools, diarrhea, high fever, significant dehydration, or signs of electrolyte imbalance, consult your doctor.
  • Focus on eating nutrient-rich foods such as citrus fruits, spinach, ginger, garlic, turmeric, and fermented foods to improve immunity and general health.
  • Drink plenty of water to stay hydrated, and think about taking probiotics, zinc, vitamin C, and vitamin D supplements.
  • Adopt healthful practices such as leading a balanced lifestyle and remaining at home when necessary.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.

Drug Warnings

Special care should be taken by the people taking Altacef Suspension who have allergic reactions to penicillin or other beta-lactam antibiotics. Use with other antibiotics may lead to a fungal skin infection known as Candida. Prolonged use of Altacef Suspension may also cause an overgrowth of other pathogens (like enterococci and Clostridium difficile), which can be prevented by stopping Altacef Suspension. The case of colitis (inflammatory bowel disease) has been reported using Altacef Suspension. Hence, it is important to consider the proper diagnosis of the patients who developed diarrhoea after taking Altacef Suspension. If the symptom of diarrhoea persists for a longer duration, the patient may experience abdominal cramps. In this situation, you should discontinue the intake of Altacef Suspension immediately. The Jarisch-Herxheimer reaction (caused due to toxins released by the death of bacteria within the body during antibiotic treatment) has been seen in the patients taking Altacef Suspension for the treatment of Lyme disease. Your ability to perform tasks that require judgment, cognitive, or body movement may be affected, and you may have dizziness. So patients taking Altacef Suspension should be warned to be cautious when driving or operating machinery.

Drug-Drug Interactions

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CefuroximeBCG vaccine
Severe
CefuroximeLepirudin
Severe

Drug-Drug Interactions

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CefuroximeBCG vaccine
Severe
How does the drug interact with Altacef Suspension 30 ml:
Co-administration of Altacef Suspension 30 ml may reduce the anti-tumor activity of BCG in the bladder.

How to manage the interaction:
Talk to your doctor before receiving BCG if you are currently being treated with Altacef Suspension 30 ml. To ensure adequate response to your treatment, you should not receive BCG until after you complete your antibiotic therapy. Do not discontinue the medication without consulting a doctor.
CefuroximeLepirudin
Severe
How does the drug interact with Altacef Suspension 30 ml:
The therapeutic efficacy of Lepirudin can be decreased when used in combination with Altacef Suspension 30 ml.

How to manage the interaction:
Although taking Altacef Suspension 30 ml and Lepirudin together can evidently cause an interaction, it can be taken if your doctor has suggested it. Do not stop using any medications without a doctor's advice.
How does the drug interact with Altacef Suspension 30 ml:
Co-administration of Dalteparin and Altacef Suspension 30 ml can increase the blood levels and effects of Dlateparin.

How to manage the interaction:
Taking Altacef Suspension 30 ml with Dalteparin together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Altacef Suspension 30 ml:
Taking these medications together might make it harder for your body to absorb atazanavir, which could make it less effective.

How to manage the interaction:
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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • It would be best to take probiotics after taking the full course of Altacef Suspension to restore some of the healthy bacteria in the intestine that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut and kimchi can help restore the intestine's good bacteria.
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria which helps stimulate their growth. Thus fibre foods may help restore healthy gut bacteria after taking a course of antibiotics. Whole grains like whole-grain bread, and brown rice, should be included in your diet.
  • Avoid taking too much calcium enriched foods and drinks as it might affect the working of Altacef Suspension.
  • Avoid intake of alcoholic beverages with Altacef Suspension as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid the Altacef Suspension in fighting off infections.

Habit Forming

No

Therapeutic Class

ANTI- BACTERIALS

Author Details

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Drug-Diseases Interactions

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CEFUROXIME-125MGOther gastroenteritis and colitis of infectious and unspecified origin
Severe
CEFUROXIME-125MGChronic kidney disease
Moderate

Drug-Diseases Interactions

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CEFUROXIME-125MGOther gastroenteritis and colitis of infectious and unspecified origin
Severe
How does the disease interact with Altacef Suspension 30 ml:
Colitis: In some cases the use of Altacef Suspension 30 ml may cause ranging from mild diarrhea to fatal colitis. Colitis is commonly Clostridioides difficile-associated diarrhea (CDAD). Discontinue therapy if signs of CDAD are confirmed.

How to manage the interaction:
Antibiotics may cause Clostridioides difficile-associated diarrhoea (CDAD), which may range from mild diarrhoea to fatal colitis. Altacef Suspension 30 ml should be used with caution in patients with a history of gastrointestinal disease, particularly colitis (inflammation of the colon) or pseudomembranous colitis (a severe inflammation of the inner lining of the large intestine). Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C difficile, and surgical evaluation is advised.
CEFUROXIME-125MGChronic kidney disease
Moderate
How does the disease interact with Altacef Suspension 30 ml:
Renal dysfunction: Altacef Suspension 30 ml is eliminated by the kidney in an unchanged form. Thus the plasma levels of the drug increase and prolongs the half-life. Adjust the doses of Altacef Suspension 30 ml as necessary.

How to manage the interaction:
The serum concentration may be increased in patients with impaired kidney function as most beta-lactam antibiotics are eliminated by the kidney. Dose adjustment may be necessary for patients with kidney dysfunction. Regular renal function tests are advised during prolonged or high-dose therapy.
CEFUROXIME-125MGDependence on enabling machines and devices, not elsewhere classified
Moderate
How does the disease interact with Altacef Suspension 30 ml:
Dialysis : Most of the antibiotics are eliminated by hemodialysis. Therefore, administer Altacef Suspension 30 ml after dialysis or an additional dosage to be administered.

How to manage the interaction:
Altacef Suspension 30 ml serum levels may be decreased by hemodialysis and peritoneal dialysis. Supplemental doses should be given at the end of each hemodialysis session.
CEFUROXIME-125MGConvulsions, not elsewhere classified
Moderate
How does the disease interact with Altacef Suspension 30 ml:
seizure disorders: In some patients, seizures were reported with whom renal dysfunction which incase of dosage adjustment was not done. Discontinue Altacef Suspension 30 ml if seizures are reported.

How to manage the interaction:
Cephalosporin antibiotics may trigger seizures. Altacef Suspension 30 ml should be discontinued if seizures associated with drug therapy occur.
CEFUROXIME-125MGOther diseases of liver
Moderate
How does the disease interact with Altacef Suspension 30 ml:
liver disease: With Altacef Suspension 30 ml, a transient increase in the AST, ALT, and alkaline phosphatase levels was observed. Use with caution and closely monitor for hepatic function is recommended.

How to manage the interaction:
Caution and monitoring is recommended in patients with liver disease as cases of hepatitis have been reported with the use of certain cephalosporins.
CEFUROXIME-125MGOther diseases of liver
Moderate
How does the disease interact with Altacef Suspension 30 ml:
Rarely, cephalosporins use may cause hypoprothrombinemia, with or without bleeding. Monitor for Prothrombin time.

How to manage the interaction:
Cephalosporins may be associated with reduced prothrombin activity/prolonged prothrombin time (blood takes too long to form a clot). Prothrombin time should be monitored in at-risk patients and managed as needed.

FAQs

Altacef Suspension is a broad-spectrum antibiotic that kills a wide range of bacteria (bactericidal). It kills the bacterial cell by binding to the outer layer of the bacteria and blocking the activity of the enzyme that makes peptidoglycan (a vital component of the bacterial cell wall). As a result, the bacterial cell cannot grow and multiply and finally gets killed.

No, it is a prescribed drug, given by a physician for preventing specific medical conditions. Taking it on your own can cause unwanted side-effects.

You should avoid taking Altacef Suspension with oral birth control pills, medicines that reduces gastric acidity (like antacids, omeprazole), immuno suppressing drugs (mycophenolate or mycophenolic), medicines used for reducing uric acid (probenecid), and some urinary glucose tests. Besides this, it also interacts with thyphoid and BCG vaccines.

Depending upon the severity of your medical condition your doctor may prescribe it to you daily for a specific duration. The usual dose ofAltacef Suspension is 7 days (5-10 days), but depending on your current infection state your doctor may extend your dose intake for more days.

Try to stay well hydrated by drinking at least 6 glass of water or other fluid per day. Keep your underwear clean and try to use underwear made of cotton to avoid the spread of infection. Always keep your bladder empty as much possible by peeing regularly. Your doctor may prescribe cranberry juice with antibiotics to treat urinary tract infection.

After taking an antibiotic you may need to wait for up to three hours for eating or drinking any dairy products include milk as well as butter, yoghurt, and cheese. Grapefruit juice and dietary supplements containing minerals like calcium may also work dampen the effect of antibiotics.

If you have taken accidently over dosage of Altacef Suspension, you may have diarrhoea, nausea or vomiting. In rare cases it can also cause convulsion or seizures (fits). Try to reach out to doctor in this case.

No. Altacef Suspension treats only bacterial infection. Cough, flu or cold are usually caused due to the viruses. So, you should consult doctor for these conditions.

Yes. Altacef Suspension may interact with birth control pills and lowers its efficiency. So, you should tell your doctor if your are using any birth control pills.

No. You should complete the full course of Altacef Suspension as your doctor prescribes. After completing the full course, the Altacef Suspension will work. You must take Altacef Suspension at the right dose, times, and for the right number of days.

Drug-Drug Interactions Checker List

  • OMEPRAZOLE
  • PROBENECID
  • MYCOPHENOLIC ACID

Disease/Condition Glossary

A bacterial infection is a condition in which harmful bacteria enter, multiply and infect our body. It can target any body part and multiple very quickly. When you get infected with bacteria, you can experience generalized symptoms like fevers, chills, and fatigue. Bacteria are of various forms comprising commonly spherical, rod, and spiral-shaped. Bacterial infections vary from minor illnesses like sore throat and ear infections to severe brain infections like meningitis and encephalitis. Few harmful bacteria that cause infections include Streptococcus, Staphylococcus, and E. coli. Anyone can become infected with a bacterial infection. But, people with weak immune systems or taking immunosuppressive medicine can make you more prone to bacterial infection.

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