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Reviewed By Sunny S , MBBS
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Composition :

AMANTADINE-129MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Amantrel ER 129 Tablet

Amantrel ER 129 Tablet contains a class of medication called dopamine agonist used to treat Parkinson's disease symptoms. It plays a vital role in treating symptoms such as difficulty moving, muscle stiffness, and tremors. Parkinson's disease is a nervous system disorder that causes movement, muscle control, balance, and other similar conditions.  In addition to this, it also prevents symptoms of influenza (a viral infection).

Amantrel ER 129 Tablet contains amantadine (dopamine agonist), which is an anti-Parkinson's drug. It helps treat Parkinson's disease by increasing dopamine (a chemical) level in the brain, responsible for improving body movement coordination. Thus, it effectively helps in performing daily functions in a better way and improving quality of life. Men are more likely to develop Parkinson's disease.

Amantrel ER 129 Tablet is taken with or without food in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to Amantrel ER 129 Tablet . In some cases, you may experience dry mouth, constipation, balance disorder (loss of balance), blurred vision, insomnia (difficulty sleeping), peripheral edema. Most of these side effects of Amantrel ER 129 Tablet are temporary, do not require medical attention, and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Consume only if the doctor prescribes you. Never encourage self-medication or suggest your medicine to someone else. You should not take Amantrel ER 129 Tablet if you are allergic to amandine or any of its ingredients, levocetirizine, or have severe liver or kidney problems, have epilepsy. Check with your doctor if you're pregnant, currently breastfeeding, or taking any other prescribed or non-prescribed medicines. Also, Amantrel ER 129 Tablet does not stop Amantrel ER 129 Tablet abruptly as it may lead to severe side effects. Inform your doctor, and he might lower your dose gradually.

Uses of Amantrel ER 129 Tablet

Parkinson’s disease

Directions for Use

Take Amantrel ER 129 Tablet with or without food as advised by a doctor. Swallow it as a whole with a glass of water. Do not crush, chew or break it.

Medicinal Benefits

Amantrel ER 129 Tablet contains amantadine (dopamine agonist), which is an anti-Parkinson's drug. It helps treat Parkinson's disease by increasing dopamine (a chemical) level in the brain, responsible for improving body movement coordination. Thus, it effectively helps in performing daily functions in a better way and improving quality of life. Parkinson's disease is more likely to occur in men.

Storage

Store in a cool and dry place away from sunlight
Side effects of Amantrel ER 129 Tablet
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
  • Do not stand up suddenly. Lie down and get up slowly only when you feel better.
  • Avoid alcohol and large meals.
  • Drink enough water before standing for long periods.
  • Exercise regularly; however, avoid exercising in extreme heat.
  • Eat small, low-carb meals.
  • Wear compression stockings.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Uncoordinated muscle movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Drug Warnings

Do not take Amantrel ER 129 Tablet if you are allergic to amantadine or any of its ingredients. Inform your doctor about all other OTC medications, vitamins, nutritional supplements, and herbal products you are taking or are planning to take. If you have kidney or liver disease, mental illness, glaucoma (increased pressure in the eye can lead to a gradual loss of vision), epilepsy, a sleep disorder, eczema (dry, itchy skin with red, scaly rashes), urinary tract infections, heart failure, hypotension (low blood pressure), or if you drink or have ever consumed large amounts of alcohol, Amantrel ER 129 Tablet should be taken with caution and only if a doctor prescribes you. Tell your doctor if you are pregnant or are breastfeeding before starting Amantrel ER 129 Tablet as a dose adjustment may be required if the benefits outweigh the risks. Amantrel ER 129 Tablet may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position, especially when you start taking Amantrel ER 129 Tablet so please get up gradually. Also, do not take any live vaccination for at least 48 hours after the last dose of Amantrel ER 129 Tablet . Avoid dairy products as it may cause disease progression, and take some calcium supplements to avoid their deficiency.

Drug-Drug Interactions

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AmantadineTramadol
Severe
AmantadineTrihexyphenidyl
Severe

Drug-Drug Interactions

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AmantadineTramadol
Severe
How does the drug interact with Amantrel ER 129 Tablet:
The combined use of Amantrel ER 129 Tablet with tramadol can increase the risk or severity of seizures (fits), The risk increases in elderly, patients undergoing alcohol or drug withdrawal, who have a history of seizures, brain tumors, or head trauma.

How to manage the interaction:
Taking Amantrel ER 129 Tablet and tramadol together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms such as seizures, dizziness, drowsiness, or difficulty concentrating, contact a doctor immediately. Do not discontinue the medication without a doctor's advice. Avoid activities requiring mental alertness such as driving or operating hazardous machinery while taking these medications.
AmantadineTrihexyphenidyl
Severe
How does the drug interact with Amantrel ER 129 Tablet:
Coadministration of Allopurinol with Trihexyphenidyl may increase side effects such as heat intolerance, dry mouth, confusion, constipation, difficulty urinating, and blurred vision especially in the elderly or those with a debilitating (physically weak) condition.

How to manage the interaction:
If you are supposed to take Allopurinol and Trihexyphenidyl together, your doctor may adjust the dose or monitor you more frequently to safely use both medications.
AmantadineAclidinium bromide
Severe
How does the drug interact with Amantrel ER 129 Tablet:
Coadministration of Amantrel ER 129 Tablet with Aclidinium bromide may increase the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Amantrel ER 129 Tablet and Aclidinium bromide, you can take these medicines together if prescribed by your doctor. However, if your side effects worsen, please consult your doctor.
AmantadineEsketamine
Severe
How does the drug interact with Amantrel ER 129 Tablet:
Taking Amantrel ER 129 Tablet with Esketamine can lead to or increase the risk or severity of developing side effects.

How to manage the interaction:
Taking Amantrel ER 129 Tablet with Esketamine together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, drowsiness, fainting, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AmantadineBupropion
Severe
How does the drug interact with Amantrel ER 129 Tablet:
Coadministration of Amantrel ER 129 Tablet with Bupropion may increase the risk of seizures (fits).

How to manage the interaction:
Taking Amantrel ER 129 Tablet with Bupropion together can result in an interaction, it can be taken if a doctor has advised it. However, if you have symptoms of seizures, hallucinations, muscle stiffness, fainting, fast or uneven heartbeat, shallow breathing, and chest pain or tightness, contact a doctor. Do not stop using any medications without talking to a doctor.
AmantadineMetrizamide
Severe
How does the drug interact with Amantrel ER 129 Tablet:
Coadministration of Amantrel ER 129 Tablet with Metrizamide may cause seizures (sudden, violent, uncontrollable contraction of a group of muscles).

How to manage the interaction:
Coadministration of Amantrel ER 129 Tablet with Metrizamide can cause an interaction, but it can be taken if prescribed by a doctor. However, if you experience Nausea, dizziness (lightheadedness), or insomnia (a condition that makes it hard to fall or stay asleep) call a doctor. Do not discontinue any medications without consulting a doctor.
AmantadineIopamidol
Severe
How does the drug interact with Amantrel ER 129 Tablet:
Coadministration of Amantrel ER 129 Tablet with Iopamidol may cause seizures (sudden, violent, uncontrollable contraction of a group of muscles).

How to manage the interaction:
There may be a possibility of interaction between Amantrel ER 129 Tablet and Iopamidol, but it can be taken if prescribed by a doctor. If you have seizures or a head injury, it's important to contact a doctor right away. Do not stop using any medications without talking to a doctor.
AmantadineIohexol
Severe
How does the drug interact with Amantrel ER 129 Tablet:
Coadministration of Amantrel ER 129 Tablet with Iohexol may cause seizures (sudden, violent, uncontrollable contraction of a group of muscles).

How to manage the interaction:
Although taking Amantrel ER 129 Tablet and Iohexol together can cause an interaction, it can be taken if your doctor has suggested it. If you have seizures or a head injury, it's important to contact a doctor right away. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Try to include heart-healthy omega 3 fatty acid containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil.
  • Include turmeric or yellow mustard in your diet to avoid constipation caused by Parkinson’s disease and increase the intake of fluids to stay hydrated.
  • Caffeine can help in slowing down the progression of the disease.
  • Take enough of Vitamin D and fresh air as it is known to improve the symptoms of Amantrel ER 129 Tablet .

Habit Forming

No

Therapeutic Class

ANTIPARKINSON AGENTS

Amantrel ER 129 Tablet Substitute

Substitutes safety advice
  • Parkitidin ER 129 Tablet 10's

    by Others

    22.50per tablet
  • Amantex ER 129 Tablet 10's

    by Others

    23.76per tablet
  • Amantad ER-129 Tablet 10's

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Drug-Diseases Interactions

verifiedApollotooltip
AMANTADINE-129MGDepressive episode
Severe
AMANTADINE-129MGOther disorders of kidney and ureter, not elsewhere classified
Severe

Drug-Diseases Interactions

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AMANTADINE-129MGDepressive episode
Severe
How does the disease interact with Amantrel ER 129 Tablet:
Amantrel ER 129 Tablet should be administered cautiously in patients with a history of psychiatric disorders, emotional instability, or substance abuse, and particularly if they are elderly.

How to manage the interaction:
Amantrel ER 129 Tablet should be used with caution in patients with a history of psychiatric disorders, emotional instability, or substance abuse, and particularly if they are elderly.
AMANTADINE-129MGOther disorders of kidney and ureter, not elsewhere classified
Severe
How does the disease interact with Amantrel ER 129 Tablet:
Amantrel ER 129 Tablet should be administered cautiously in patients with renal impairment.

How to manage the interaction:
Amantrel ER 129 Tablet should be used with caution in patients with kidney impairment. Dosage adjustments are recommended for patients with moderate to severe kidney failure.
AMANTADINE-129MGEpilepsy
Severe
How does the disease interact with Amantrel ER 129 Tablet:
Amantrel ER 129 Tablet may rarely precipitate or exacerbate seizure activity. Patients with epilepsy or predisposed to seizures should be monitored closely for increased seizure activity during therapy with Amantrel ER 129 Tablet.

How to manage the interaction:
Patients with epilepsy or at risk of developing seizures should be monitored closely for increased seizure activity during therapy with Amantrel ER 129 Tablet.
AMANTADINE-129MGHypotension
Severe
How does the disease interact with Amantrel ER 129 Tablet:
dopamine agonists should be monitored carefully in patients with Parkinson's disease since they may have an impaired ability to respond to an orthostatic challenge, and also in patients receiving antihypertensive drugs.

How to manage the interaction:
Amantrel ER 129 Tablet should be used carefully in patients with Parkinson's disease since they may have an impaired ability to respond to an orthostatic challenge, and also in patients receiving antihypertensive drugs (medicines used to treat high blood pressure).
AMANTADINE-129MGUnspecified nonorganic psychosis
Severe
How does the disease interact with Amantrel ER 129 Tablet:
Ordinarily, patients with major psychotic disorder should not be treated with dopaminergic antiparkinson agents, because of the risk of exacerbating psychosis.

How to manage the interaction:
Usually, patients with major psychotic disorder should not be treated with dopaminergic antiparkinson agents, because of the risk of worsening psychosis.
AMANTADINE-129MGOedema, not elsewhere classified
Moderate
How does the disease interact with Amantrel ER 129 Tablet:
Amantrel ER 129 Tablet may occasionally cause peripheral edema and, rarely, congestive heart failure. Patients with edema or congestive heart failure should be monitored closely for exacerbation of their condition. Dosage adjustments may be necessary.

How to manage the interaction:
Amantrel ER 129 Tablet may occasionally cause peripheral oedema (swelling in lower legs or hands) and, rarely, congestive heart failure. Patients with oedema or congestive heart failure should be monitored closely for worsening of their condition. Dosage adjustments may be necessary.
AMANTADINE-129MGHypotension
Moderate
How does the disease interact with Amantrel ER 129 Tablet:
Amantrel ER 129 Tablet may occasionally cause orthostatic hypotension. Patients with hypotension should be monitored for exacerbation of their condition during therapy with Amantrel ER 129 Tablet. Dosage adjustments may be necessary, and patients should be advised not to rise abruptly from a sitting or recumbent position.

How to manage the interaction:
Amantrel ER 129 Tablet may occasionally cause orthostatic hypotension (low blood pressure when standing up from sitting or lying down). Hence, patients using this medicine are advised not to rise suddenly from a sitting or lying position.

FAQs

No, Amantrel ER 129 Tablet should be taken in the dose and duration as advised by the doctor. If you take it in more than the recommended dose, it might cause unpleasant side effects. If you think your symptoms are not improving, please consult your doctor.

If you miss a dose of Amantrel ER 129 Tablet , take the missed dose as soon as you remember it. However, if it's almost time for the next dose, do not take a double dose to make up for a missed one.

No, Amantrel ER 129 Tablet should not be taken if you have epilepsy as it might increase your chances of seizures. Please consults your doctor before starting Amantrel ER 129 Tablet .

You should inform your doctor, and he might stop the use of Amantrel ER 129 Tablet before the surgery.

Do not stop taking Amantrel ER 129 Tablet without talking to your doctor. If you suddenly stop taking Amantrel ER 129 Tablet , you may experience confusion, fever, mental state changes, or severe muscle stiffness. Your doctor will probably decrease your dose gradually depending upon your disease condition.

Drug-Drug Interactions Checker List

  • BUSPIRONE
  • TRAMADOL
  • ASPIRIN
  • IBUPROFEN
  • CLONAZEPAM
  • DIAZEPAM
  • IODINE

Special Advise

Avoid alcoholic beverages with Amantrel ER 129 Tablet as it can make you dehydrated and may affect your sleep.

Disease/Condition Glossary

Parkinson’s Disease: It is a nervous system disorder that affects movement and coordination. The symptoms start slowly, sometimes with a simple tremor but eventually lead to a slowing movement and unable to coordinate movements. As the disease progresses, the symptoms may become worse.

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