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About Ampril 5mg/5mg Tablet

Ampril 5mg/5mg Tablet belongs to the class of 'anti-hypertensive drugs' primarily used to treat hypertension (high blood pressure). Hypertension is a medical condition in which the blood exerts high pressure (force exerted by circulating blood) against the blood vessel's walls. This condition makes the heart work harder in pumping blood to the whole body. Hypertension can cause severe health complications, including stroke, heart failure, heart attack, and kidney failure.

The Ampril 5mg/5mg Tablet contains two medicines: Amlodipine (calcium channel blocker) and Enalapril (angiotensin-converting enzyme inhibitor). Amlodipine works by relaxing blood vessels to pass through them, thereby lowering the blood pressure easily. It also improves blood supply to the heart muscle to receive more oxygen and thus preventing chest pain. On the other hand, Enalapril works by relaxing and widening the blood vessels, making it easier for the heart to pump blood throughout the body, thereby lowering blood pressure. 

Take Ampril 5mg/5mg Tablet as prescribed by your doctor. You are advised to take Ampril 5mg/5mg Tablet for as long as your doctor has prescribed it for you, depending upon your medical condition. In some cases, you may experience blurred vision, sweating, confusion, tiredness, stomach upset, flushing (sense of warmth in the face, ears, neck, and trunk), dizziness, headache, and swelling of the ankles or feet. Most of these side effects of Ampril 5mg/5mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, please reach out to your doctor.

Do not stop taking Ampril 5mg/5mg Tablet without consulting your doctor since it may worsen your condition and increase the risk of future heart problems. Regular monitoring of blood pressure, electrolyte levels, and kidney functioning is advised while taking Ampril 5mg/5mg Tablet. Inform your doctor if you are suffering from kidney, liver, or heart diseases. Reducing the amount of table salt (sodium chloride) in your food often relieves the body's swelling. Let your doctor know if you use any prescription and non-prescription medications you are taking, including vitamins, before starting Ampril 5mg/5mg Tablet. If you are pregnant or breastfeeding, please tell your doctor so that the dosage of Ampril 5mg/5mg Tablet can be prescribed accordingly. 

Uses of Ampril 5mg/5mg Tablet

Hypertension (high blood pressure)

Directions for Use

Take Ampril 5mg/5mg Tablet with or without food as directed by your physician. Swallow it as a whole with a glass of water. Do not crush, chew, or break it. Try to take it at a fixed time every day. Do not double the dose if missed.

Medicinal Benefits

Ampril 5mg/5mg Tablet treats hypertension (high blood pressure), and consists of Amlodipine and Enalapril. Amlodipine is a 'calcium channel blocker,' primarily treats high blood pressure, Prinzmetal's or variant angina (chest pain), and other conditions caused by coronary artery disease. It relaxes blood vessels so that blood passes through them easily, thereby lowering blood pressure. It also treats chest pain by improving the blood supply to the heart muscle to receive more oxygen. Amlodipine also improves a person's tolerance to exercise and keeps the blood pressure at acceptable levels. Enalapril is an 'Angiotensin-Converting Enzyme (ACE) Inhibitor.' It relaxes and widens the blood vessels making it easier for the heart to pump blood throughout the body, thereby lowering blood pressure.  

Storage

Store in a cool and dry place away from sunlight

Side Effects of Ampril 5mg/5mg Tablet

  • Blurred vision
  • Sweating
  • Confusion
  • Tiredness
  • Stomach upset
  • Cough
  • Vomiting
  • Flushing (sense of warmth in the face, ears, neck, and trunk)
  • Dizziness (when getting up suddenly from a sitting position)
  • Headache
  • Swelling of the ankles or feet
  • Increase in the potassium levels

Drug Warnings

Do not use Ampril 5mg/5mg Tablet if you are allergic to Ampril 5mg/5mg Tablet or any of its components. Please inform your doctor if you are using any prescription and non-prescription medications you are taking, including vitamins, before starting Ampril 5mg/5mg Tablet. Let your doctor know if you have any history of severe heart, kidney, or liver diseases, high potassium levels (hyperkalemia), bone marrow suppression, and aortic stenosis (heart valve problem). It is essential to let your doctor know if you are a breastfeeding mother before using Ampril 5mg/5mg Tablet since Amlodipine may pass into the breast milk. Enalapril is not recommended during pregnancy since it has harmful effects on the unborn baby. Please ask your doctor if you plan to conceive or are pregnant before using Ampril 5mg/5mg Tablet. Ampril 5mg/5mg Tablet can increase the chances of light-headedness so rise slowly if you are sitting/lying and avoid operating any machine or doing any work that needs mental alertness.

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
EnalaprilAliskiren
Critical

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
How does the drug interact with Ampril 5mg/5mg Tablet:
Using Ampril 5mg/5mg Tablet together with dantrolene may increase the risk of hyperkalemia (high blood potassium).

How to manage the interaction:
Taking Ampril 5mg/5mg Tablet with Dantrolene can cause an interaction, consult a doctor before taking it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
EnalaprilAliskiren
Critical
How does the drug interact with Ampril 5mg/5mg Tablet:
Using aliskiren together with Ampril 5mg/5mg Tablet may increase the risk of serious side effects such as kidney problems, low blood pressure, and high potassium levels in the blood.

How to manage the interaction:
Taking Ampril 5mg/5mg Tablet with aliskiren is not recommended, but it can be taken together if your doctor advises. However, contact your doctor if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, or feelings of heaviness in the legs. Do not stop taking any medications without consulting a doctor.
AmlodipineLemborexant
Severe
How does the drug interact with Ampril 5mg/5mg Tablet:
Coadministration of lemborexant and Ampril 5mg/5mg Tablet may increase the blood levels of lemborexant.

How to manage the interaction:
Although co-administration of Ampril 5mg/5mg Tablet with Lemborexant can result in an interaction, it can be taken if a doctor has advised it. However, consult your doctor if you experience abnormal sleep patterns, worsening of depression, changes in heartbeat, or headache. Do not discontinue any medications without consulting a doctor.
AmlodipineCarbamazepine
Severe
How does the drug interact with Ampril 5mg/5mg Tablet:
Coadministration of Ampril 5mg/5mg Tablet and carbamazepine together may significantly reduce Ampril 5mg/5mg Tablet blood levels, making the medicine less effective.

How to manage the interaction:
Although there is an interaction between Ampril 5mg/5mg Tablet with carbamazepine, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms contact the doctor immediately. Do not stop using any medications without talking to a doctor.
AmlodipineDolasetron
Severe
How does the drug interact with Ampril 5mg/5mg Tablet:
Using dolasetron together with Ampril 5mg/5mg Tablet can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
There may be a possibility of interaction between Ampril 5mg/5mg Tablet and Dolasetron, but it can be taken if prescribed by a doctor. If you have any of these symptoms, like feeling dizzy, lightheaded, or your heart beating irregularly, it's important to call a doctor right away. Do not stop using any medications without a doctor's advice.
AmlodipineEnzalutamide
Severe
How does the drug interact with Ampril 5mg/5mg Tablet:
Using a combination of Ampril 5mg/5mg Tablet and enzalutamide may drastically lower Ampril 5mg/5mg Tablet blood levels, making the medicine less effective.

How to manage the interaction:
Taking Ampril 5mg/5mg Tablet with enzalutamide can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
AmlodipineSirolimus
Severe
How does the drug interact with Ampril 5mg/5mg Tablet:
Co-administration of Ampril 5mg/5mg Tablet can make Sirolimus may increase the risk of angioedema (a condition associated with swelling of the face, eyes, lips, tongue, throat, and occasionally also the hands and feet).

How to manage the interaction:
There may be a possibility of interaction between Ampril 5mg/5mg Tablet and Sirolimus, but it can be taken if prescribed by a doctor. However, consult the doctor if you notice any swelling of the face, eyes, lips, tongue, throat, hands and feet or have trouble breathing or swallowing. Do not stop using any medications without a doctor's advice.
AmlodipineNitisinone
Severe
How does the drug interact with Ampril 5mg/5mg Tablet:
Coadministration of Ampril 5mg/5mg Tablet and Nitisinone may increase the blood levels and effects of Nitisinone.

How to manage the interaction:
Taking Nitisinone with Ampril 5mg/5mg Tablet together can result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these symptoms or if you feel unwell after taking your medication, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
AmlodipineFosphenytoin
Severe
How does the drug interact with Ampril 5mg/5mg Tablet:
When Ampril 5mg/5mg Tablet is taken with Fosphenytoin, it may decrease the blood levels of Ampril 5mg/5mg Tablet, which may make Ampril 5mg/5mg Tablet less effective.

How to manage the interaction:
Although taking Ampril 5mg/5mg Tablet and Fosphenytoin together can cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without a doctor's advice.
AmlodipineMitotane
Severe
How does the drug interact with Ampril 5mg/5mg Tablet:
Using Ampril 5mg/5mg Tablet and mitotane together may drastically lower Ampril 5mg/5mg Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although co-administration of Ampril 5mg/5mg Tablet with mitotane can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Keep your weight under control with a body mass index (BMI) between 19.5 and 24.9.
  • Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you to lower your raised blood pressure by about 5 mm of Hg.
  • Limit sodium chloride intake (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.
  • If you are taking alcohol, use only one serving for women and two servings for men.
  • Quit smoking to lower the risk of heart disease.
  • Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress.
  • Monitor your blood pressure daily, and if you notice any fluctuations frequently, please contact your doctor immediately.
  • Try including heart-healthy omega-3 fatty acid-containing foods in your daily diet. You can also use low-fat cooking oils like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Ampril 5mg/5mg Tablet Substitute

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Ampril 5mg/5mg Tablet treats hypertension (high blood pressure) and consists of Amlodipine (calcium channel blocker) and Enalapril (angiotensin-converting enzyme inhibitor). Amlodipine relaxes blood vessels so that blood passes through them easily, thereby lowering the blood pressure. Enalapril relaxes and widens the blood vessels making it easier for the heart to pump blood throughout the body, thereby lowering the raised blood pressure.

Amlodipine in Ampril 5mg/5mg Tablet can cause ankle swelling upon long-term use. Please try to keep your feet at an elevated position when sitting for long hours. If the problem persists, please consult your doctor and do as advised.

Ampril 5mg/5mg Tablet may increase blood potassium levels in people with diabetes, poor kidney function, and patients using potassium-sparing diuretics or taking potassium supplements. Please consult your doctor before taking Ampril 5mg/5mg Tablet if you have diabetes.

Even though your blood pressure becomes normal after using Ampril 5mg/5mg Tablet, it may switch back to high ranges if you stop using it. Your doctor may change the dosing schedule based on your blood pressure range.

Ampril 5mg/5mg Tablet can cause dizziness as one of its side effects. If you feel dizzy, try getting up slowly from a sitting or lying position. If your dizziness is severe or unmanageable, please seek medical advice.

Before surgery, you should inform your doctor that you are taking Ampril 5mg/5mg Tablet as it can reduce your blood pressure when used along with anesthesia which is given before a major operation.

Drug-Drug Interactions Checker List

  • GOLD SODIUM THIOMALATE
  • ALISKIREN
  • LITHIUM
  • BENAZEPRIL
  • METOPROLOL
  • RAMIPRIL
  • HYDROCHLOROTHIAZIDE
  • ATORVASTATIN
  • SIMVASTATIN
  • SILDENAFIL
  • CLARITHROMYCIN
  • ERYTHROMYCIN
  • RIFAMPICIN
  • ITRACONAZOLE
  • KETOCONAZOLE
  • RITONAVIR
  • CARBAMAZEPINE
  • PHENYTOIN
  • PHENOBARBITAL
  • PRIMIDONE
  • CYCLOSPORINE
  • TACROLIMUS
  • IBUPROFEN
  • ASPIRIN

Special Advise

  • Monitor your blood pressure regularly and seek medical advice if you notice any drastic fluctuations.
  • Ampril 5mg/5mg Tablet may affect patients with hepatic impairment, and hence it is used cautiously, and Liver function monitoring and Liver Function Tests are advised to monitor the liver enzyme changes.
  • Your doctor may advise you to get a regular kidney function test, blood examinations for potassium levels and other electrolytes while using Ampril 5mg/5mg Tablet to rule out any renal impairment.

Disease/Condition Glossary

Hypertension: It is a chronic condition when blood pressure is too high. Blood pressure is defined as the amount of blood pumped by the heart and the amount of resistance exerted by the arteries against the blood flow. If the heart pumps more blood, then arteries become narrower, and in turn, blood pressure becomes high. If blood pressure becomes uncontrolled, it may lead to serious heart diseases, including stroke and heart attack. Additionally, high blood pressure can also cause brain damage (stroke) and kidney failure. Blood pressure is expressed as systolic and diastolic pressures. Systolic blood pressure represents the contraction and relaxation of the heart. Diastolic pressure is exerted in the blood vessels when the heart beats and is in the resting state. Ideal blood pressure should be between 90/60mmHg and 120/80mmHg. Hypertension is detected when systolic blood pressure is more than 140mmHg, and diastolic pressure is higher than 90mmHg. Some of the symptoms of hypertension include headache, nose bleed, vomiting, and chest pain.

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