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Written By Veda Maddala , M Pharmacy
Reviewed By Sunny S , MBBS
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Composition :

APIXABAN-2.5MG

Manufacturer/Marketer :

Micro Labs Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Apivas-2.5 Tablet

Apivas-2.5 Tablet belongs to a class of drugs called 'anticoagulants' (blood thinners) primarily used to prevent and treat deep vein thrombosis (blood clots in leg veins) and pulmonary embolism (blood clots in the lung). Additionally, Apivas-2.5 Tablet is used to prevent blood clots in patients with atrial fibrillation (irregular heartbeat). Deep vein thrombosis is a condition in which blood clots form in deep veins usually in the legs. Pulmonary embolism is a condition in which a blood clot blocks the arteries in the lungs. Atrial fibrillation is a condition that causes irregular, often fast heartbeat.

Apivas-2.5 Tablet contains Apixaban that works by inhibiting the action of blood clotting factor (X a) which is an important element of blood clotting. Thereby, it prevents the conversion of fibrinogen (soluble protein) to fibrin (insoluble protein) and helps in preventing blood clot formation.

Take Apivas-2.5 Tablet as prescribed. Your doctor will advise you how often you take Apivas-2.5 Tablet based on your medical condition. Some people may experience nausea, anemia (lack of blood), and unusual bleeding, including swelling and bruising. Most of these side effects of Apivas-2.5 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Apivas-2.5 Tablet or any other medicines, please tell your doctor. If you are pregnant or a nursing mother, it is advised to consult a doctor before using Apivas-2.5 Tablet . If you have a stomach ulcer, recent bleeding in the brain, kidney or liver problems, high blood pressure, or bleeding problems, inform your doctor before taking Apivas-2.5 Tablet . Your doctor may suggest a blood test called 'international normalized ratio' (INR) to check how quickly your blood's clotting. This test result will help your doctor to decide exactly when you should start taking Apivas-2.5 Tablet .

Uses of Apivas-2.5 Tablet

Prevention of blood clot

Directions for Use

Take Apivas-2.5 Tablet with or without food as advised by the doctor. Swallow it as a whole with a glass of water. Do not chew or break it. If you have difficulty swallowing the whole tablet, crush it and mix with water, 5 % dextrose in water, apple puree, or juice.

Medicinal Benefits

Apivas-2.5 Tablet is primarily used to prevent and treat blood clots in the body by inhibiting the action of clotting factor Xa which is important element of blood clotting. Thereby, prevents conversion of fibrinogen to fibrin (a protein that binds platelets together and forms a clot) and helps in preventing blood clots formation.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Apivas-2.5 Tablet

  • Nausea
  • Anaemia (lack of blood)
  • Bleeding including swelling and bruising

Drug Warnings

Apivas-2.5 Tablet should not be used in children. Blood tests are advised before and while taking Apivas-2.5 Tablet to monitor kidney and liver functioning. If you are pregnant or breastfeeding, please inform your doctor before taking Apivas-2.5 Tablet . If you have a stomach ulcer, recent bleeding in the brain, kidney or liver problems, high blood pressure or bleeding problems, antiphospholipid syndrome (an immune system disorder that causes an increased risk of blood clots), inform your doctor before taking Apivas-2.5 Tablet .

Drug-Drug Interactions

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ApixabanMifepristone
Critical
ApixabanDefibrotide
Critical

Drug-Drug Interactions

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ApixabanMifepristone
Critical
How does the drug interact with Apivas-2.5 Tablet:
Mifepristone and Apivas-2.5 Tablet co-administration have been associated with more severe vaginal bleeding in women.

How to manage the interaction:
Taking Apivas-2.5 Tablet with Mifepristone together is not generally recommended as it may lead to an interaction, but it can be taken if prescribed by a doctor. However, if you experience persistent, excessive bleeding, consult the doctor. Without consulting a doctor, never stop taking any medication.
ApixabanDefibrotide
Critical
How does the drug interact with Apivas-2.5 Tablet:
Coadministration of Defibrotide and Apivas-2.5 Tablet co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Defibrotide and Apivas-2.5 Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanMeclofenamic acid
Severe
How does the drug interact with Apivas-2.5 Tablet:
Coadministration of Meclofenamic acid and Apivas-2.5 Tablet co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Meclofenamic acid and Apivas-2.5 Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanClopidogrel
Severe
How does the drug interact with Apivas-2.5 Tablet:
Coadministration of Clopidogrel and Apivas-2.5 Tablet may raise the risk of bleeding.

How to manage the interaction:
Although there is an interaction between Clopidogrel and Apivas-2.5 Tablet, it can be taken if prescribed by a doctor. However, consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), bruising, dizziness, lightheadedness, or headache. Do not discontinue any medications without consulting a doctor
ApixabanTenecteplase
Severe
How does the drug interact with Apivas-2.5 Tablet:
Coadministration of Tenecteplase and Apivas-2.5 Tablet co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Tenecteplase and Apivas-2.5 Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanEpoprostenol
Severe
How does the drug interact with Apivas-2.5 Tablet:
Coadministration of Epoprostenol and Apivas-2.5 Tablet co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Epoprostenol and Apivas-2.5 Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanIloprost
Severe
How does the drug interact with Apivas-2.5 Tablet:
Coadministration of Iloprost and Apivas-2.5 Tablet co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Iloprost and Apivas-2.5 Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanIndometacin
Severe
How does the drug interact with Apivas-2.5 Tablet:
Coadministration of Indomethacin and Apivas-2.5 Tablet may raise the risk of bleeding.

How to manage the interaction:
Taking Indomethacin and Apivas-2.5 Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
ApixabanEnoxaparin
Severe
How does the drug interact with Apivas-2.5 Tablet:
Coadministration of Apivas-2.5 Tablet and Enoxaparin co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Enoxaparin and Apivas-2.5 Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanPhenobarbital
Severe
How does the drug interact with Apivas-2.5 Tablet:
Apivas-2.5 Tablet's blood levels can be considerably lowered by taking it along with Phenobarbital, This can decrease the medication's ability to treat and prevent blood clots.

How to manage the interaction:
Although Co-administration of Phenobarbital and Apivas-2.5 Tablet can lead to interaction, they can be taken in case a doctor advises it to. Never discontinue taking a medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid vitamin K rich foods such as coriander, cabbage, spinach, broccoli, collard greens, kale (leaf cabbage), black liquorice, turnip greens, avocados, Brussels sprouts as they may decrease the effectiveness of Apivas-2.5 Tablet .
  • Do regular exercise as it helps to dissolve blood clots especially in obese people.
  • Do not consume more than 14 units of alcohol per week as excess alcohol intake may increase the risk of bleeding and quit smoking.

Habit Forming

No

Therapeutic Class

ANTICOAGULANT/ANTITHROMBOTIC

Apivas-2.5 Tablet Substitute

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Author Details

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Drug-Diseases Interactions

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APIXABAN-2.5MGHaemorrhage, not elsewhere classified
Severe
APIXABAN-2.5MGHepatic failure, not elsewhere classified
Moderate

Drug-Diseases Interactions

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APIXABAN-2.5MGHaemorrhage, not elsewhere classified
Severe
How does the disease interact with Apivas-2.5 Tablet:
Factor Xa inhibitors should not be used in individuals who have active pathological bleeding since they raise the risk of bleeding and have the potential to result in serious or fatal haemorrhages. Factor Xa inhibitors should only be prescribed with caution to patients who are at a higher risk of bleeding, such as those who are undergoing procedures where bleeding could result in life-threatening consequences.

How to manage the interaction:
Apivas-2.5 Tablet therapy is not recommended for patients with a history of bleeding disorder since it can worsen the condition, which can be fatal. It can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
APIXABAN-2.5MGHepatic failure, not elsewhere classified
Moderate
How does the disease interact with Apivas-2.5 Tablet:
In individuals with moderate or severe liver impairment (Child-Pugh B or C), the use of factor Xa inhibitors (including Apivas-2.5 Tablet and edoxaban) is not advised because these patients may have intrinsic coagulation problems.

How to manage the interaction:
Apivas-2.5 Tablet therapy is generally avoided in patients with a history of liver diseases since it can worsen the condition, which can be fatal. It can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, Skin and eyes that appear yellowish, abdominal pain and swelling, dizziness, lightheadedness, red or black tarry stools, dark urine, coughing up or vomiting blood, severe headache, and weakness, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
APIXABAN-2.5MGNonrheumatic aortic valve disorders
Moderate
How does the disease interact with Apivas-2.5 Tablet:
Patients who have artificial heart valves shouldn't use some factor Xa inhibitors, such as Apivas-2.5 Tablet, edoxaban, and rivaroxaban, as their safety and effectiveness have not been proven in this population.

How to manage the interaction:
Apivas-2.5 Tablet therapy is generally avoided in patients with a history of heart disease since it can worsen the condition, which can be fatal. It can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, palpitations, chest pain or discomfort, and weakness, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
APIXABAN-2.5MGOther coagulation defects
Moderate
How does the disease interact with Apivas-2.5 Tablet:
In individuals with antiphospholipid syndrome (APS), direct-acting oral anticoagulants such as factor Xa inhibitors and some thrombin inhibitors like dabigatran are not advised. Increased rates of recurrent thrombotic events have been linked to the use of these medications, particularly in individuals with triple-positive APS.

How to manage the interaction:
Apivas-2.5 Tablet therapy is generally avoided in patients with a history of bleeding disorder since it can worsen the condition, which can be fatal. It can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, dark urine, coughing up or vomiting blood, severe headache, and weakness, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.

FAQs

No, you are not recommended to take ibuprofen with Apivas-2.5 Tablet as co-administration of these two medicines may increase the risk of bleeding more easily. However, if you notice blood in urine or stools, dizziness, unusual bleeding or bruising, red or black tarry stools, vomiting, weakness or headache, please consult a doctor immediately. If you are supposed to use these medicines together, you are advised to contact your doctor so that the dose may be adjusted appropriately to use safely.

No, you are usually not advised to have a tattoo or body piercing while taking Apivas-2.5 Tablet as it may increase the risk of bleeding and infection. If you still wish to proceed further, contact your doctor so that the dose may be adjusted or any antibiotics may be prescribed and let the piercer or tattooist know in advance that you are on treatment with a blood thinner.

Yes, you are advised to stop taking Apivas-2.5 Tablet a few days before surgery or procedure as Apivas-2.5 Tablet may increase the risk of bleeding. Therefore, before having any procedure or any surgery, please inform your doctor that you are taking Apivas-2.5 Tablet .

Yes, Apivas-2.5 Tablet helps in reducing the risk of stroke and heart attack by preventing blood clots. Stroke is caused as blood clots break off and travel to brain.

No, you are not recommended to stop taking Apivas-2.5 Tablet without consulting your doctor as it may worsen the condition. Therefore, take Apivas-2.5 Tablet for as long as your doctor has prescribed it.

Drug-Drug Interactions Checker List

  • ASPIRIN
  • CLOPIDOGREL
  • DILTIAZEM
  • HEPARIN
  • IBUPROFEN
  • NAPROXEN
  • RIVAROXABAN

Special Advise

Complete blood count (CBC), INR test, prothrombin tests are advised before and while taking Apivas-2.5 Tablet .

Disease/Condition Glossary

Deep vein thrombosis (blood clots in legs) is a medical condition in which blood clots form in deep veins usually in legs. The symptoms include leg pain or swelling.

Pulmonary embolism (blood clots in lung) is a condition which occurs as the blood clots break and travel to lungs from deep veins in the legs or other parts of the body. The symptoms of pulmonary embolism include cough, chest pain and shortness of breath. Quick medication is advised to reduce the risk of serious conditions due to blood clots.

Atrial fibrillation is a condition that causes irregular, often fast heartbeat. In atrial fibrillation condition, blood clots are formed as blood is pooled in the upper chambers of heart.

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