APPLYGEN FORTE SOFTGEL VAGINAL SUPPOSITORIES 7'S belongs to the class of medications called 'vaginal antifungals' primarily used to treat vaginal infections caused by bacteria (bacterial vaginosis), yeast infection (candidiasis), and parasitic infections (trichomoniasis). Bacterial vaginosis is caused by the change in the average balance of vaginal bacteria. Vaginal yeast infection or Candidiasis is the infection of the vagina and tissues at the opening of the vagina (vulva). Trichomoniasis is a sexually transmitted infection caused by a parasite. Symptoms of a vaginal infection include itching, odour, and abnormal heavy white discharge from the vagina.

APPLYGEN FORTE SOFTGEL VAGINAL SUPPOSITORIES 7'S comprises three medicines: 'Clindamycin' (antibiotic), 'Clotrimazole' (antifungal), and 'Tinidazole'. Clindamycin belongs to the lincomycin antibiotic group that inhibits bacterial protein synthesis, which is required for the bacteria's survival. Tinidazole is an antibiotic or antiprotozoal which kills amoeba and parasites. On the other hand, Clotrimazole belongs to the imidazole antifungal group that kills fungi by causing holes in their cell membrane, thereby leaking all content. 

Common side effects of APPLYGEN FORTE SOFTGEL VAGINAL SUPPOSITORIES 7'S include burning sensation, irritation, and itching in the vaginal area. However, these side effects are mild and temporary in nature and sometimes go off after applying to the affected area. 

Inform your doctor if you are allergic to any antibacterial, antifungal, clotrimazole, clindamycin, or any of its components. It is essential to tell your doctor if you use any other azole antifungal or lincomycin antibiotics agents before using APPLYGEN FORTE SOFTGEL VAGINAL SUPPOSITORIES 7'S; otherwise, using other antifungal or antibacterial may lead to overdose and toxicity. Let your doctor know if have any liver, kidney, and gastrointestinal diseases (diarrhoea and colitis, an inflammation of the colon), allergic conditions (asthma, hay fever, eczema), diabetes, and immune system problems (HIV-AIDS). Clotrimazole and mineral oil additives in APPLYGEN FORTE SOFTGEL VAGINAL SUPPOSITORIES 7'S may weaken rubber products' activities of contraceptive devices, latex condoms, diaphragms, and cervical caps. Sometimes, antibiotic medications can cause antibiotic resistance. In such cases, your doctor may prescribe other antibiotics you are not resistant to.

APPLYGEN FORTE SOFTGEL VAGINAL SUPPOSITORIES 7'S is used to treat vaginal infections like bacterial vaginosis (BV), candidiasis, and trichomoniasis. It comprises three medicines: 'Clindamycin' (antibiotic), 'Tinidazole' (antibiotic), and 'Clotrimazole' (antifungal). Clindamycin is an antibiotic drug and works by inhibiting bacterial protein synthesis, which inhibits bacterial growth. It shows a bacteriostatic effect, which stops bacterial reproduction. Clotrimazole is an imidazole antifungal medication that prevents fungal growth by causing damage and leakage to the fungal cell membrane. Together APPLYGEN FORTE SOFTGEL VAGINAL SUPPOSITORIES 7'S treats vaginal infections caused by bacteria, yeast, and parasites preventing white discharge, itchiness, and inflammation in the genitourinary area. 

• Burning sensation
• Irritation 
• Itching in the vaginal area

Please inform your doctor if you use any prescription, non-prescription medicines, including vitamin and herbal supplements before using APPLYGEN FORTE SOFTGEL VAGINAL SUPPOSITORIES 7'S. Do not use APPLYGEN FORTE SOFTGEL VAGINAL SUPPOSITORIES 7'S if you are allergic to APPLYGEN FORTE SOFTGEL VAGINAL SUPPOSITORIES 7'S or any of its components. Let your doctor know if have any liver, kidney and gastrointestinal diseases (diarrhoea and colitis, an inflammation of the colon), allergic conditions (asthma, hay fever, eczema), diabetes, and immune system problems (HIV-AIDS). It is advised to use APPLYGEN FORTE SOFTGEL VAGINAL SUPPOSITORIES 7'S under your doctor's supervision if you use other azole antifungal medicines. Clotrimazole and mineral oil additive in APPLYGEN FORTE SOFTGEL VAGINAL SUPPOSITORIES 7'S may weaken rubber product's activity (such as latex condoms, diaphragms, cervical caps). 

 Drug-Drug Interaction: APPLYGEN FORTE SOFTGEL VAGINAL SUPPOSITORIES 7'S may interact with anaesthetic agents/skeletal muscle relaxants (atracurium, cisatracurium, doxacurium, mivacurium, pancuronium, pipecuronium, rapacuronium, rocuronium, vecuronium, succinylcholine, tubocurarine, and metocurine) and respiratory drugs (budesonide, formoterol). 

Drug-Food Interaction: No interaction found/established.

Drug-Disease Interaction: Before taking APPLYGEN FORTE SOFTGEL VAGINAL SUPPOSITORIES 7'S, let your doctor know if have any liver, kidney, and gastrointestinal diseases (diarrhoea and colitis, an inflammation of the colon), allergic conditions (asthma, hay fever, eczema), diabetes, and immune system problems (HIV-AIDS). 

• METOCURINE
• SUCCINYLCHOLINE
• TUBOCURARINE
• FORMOTEROL
• BUDESONIDE
• VECURONIUM
• ROCURONIUM
• ATRACURIUM
• CISATRACURIUM
• RAPACURONIUM
• PIPECURONIUM
• PANCURONIUM
• MIVACURIUM
• DOXACURIUM

• Avoid frequent douching to maintain the natural moisture in the vagina.
• Use mild soap while taking baths and prefer warm baths.
• Avoid harsh products on your skin.
• Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.
• Avoid or limit the intake of alcohol and caffeine.

• Ask your partner to use condoms during sexual intercourse, which will prevent the further spread of sexually transmitted infections like gonorrhea.
• Proper hygiene and regular cleaning/washing of the genitourinary area with anti-infective wash are advisable.
• If possible, you should wear cotton underwear and pantyhose with a cotton crotch, preventing vaginal inflammation and irritation.
• Do not take APPLYGEN FORTE SOFTGEL VAGINAL SUPPOSITORIES 7'S during the first trimester of pregnancy.
• Do not breast-feed while you are taking APPLYGEN FORTE SOFTGEL VAGINAL SUPPOSITORIES 7'S for at least 3 days after your last dose.

Vaginal infections: It is also referred to as ‘Vaginitis’ that can cause infection or inflammation of the vagina or external part of the vagina known as the vulva. Vaginal infections are generally caused due to bacteria, yeast, and parasites. White thick heavy discharge, foul odour, intense itchiness around the genitourinary area are the main characteristics of vaginal infections.

Vaginal bacterial infections: It causes greyish-white or yellow discharge with a fish-like odour that can be observed after sexual intercourse.

Vaginal yeast infections: It usually produces intense itching with sometimes white viscous discharge.

Vaginal Trichomoniasis: It is a parasitic infection that produces intense vaginal itching with a foul odour. Vaginal discharge colour is usually greenish-yellow.