APREPEP 125MG/80MG TABLET KIT belongs to a class of drugs called anti-emetics. It is used in combination with other medicines to prevent nausea and vomiting caused by chemotherapy (anti-cancer medicines) in adults and adolescents aged 12 years and above. Nausea is a feeling of uneasiness in the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth.

APREPEP 125MG/80MG TABLET KIT contains Aprepitant, a neurokinin 1 (NK1) receptor antagonist which works by blocking the neurokinin-1 receptor (causes the feeling of sickness) present in the vomiting centre in the brain. Thus, it helps prevent nausea and vomiting. 

Take APREPEP 125MG/80MG TABLET KIT as prescribed. You are recommended to take APREPEP 125MG/80MG TABLET KIT for as long as your doctor has advised it. In some cases, APREPEP 125MG/80MG TABLET KIT may cause common side effects such as headache, constipation, loss of appetite, tiredness, indigestion, and hiccups. Most of these side effects do not require medical attention and gradually resolve over time. However, consult your doctor immediately if the side effects persist or worsen. 

Please tell your doctor if you are allergic to APREPEP 125MG/80MG TABLET KIT or any other medicines. APREPEP 125MG/80MG TABLET KIT is not recommended for children below 12 years of age. If you are pregnant or breastfeeding, please inform your doctor before taking APREPEP 125MG/80MG TABLET KIT. Avoid driving or operating machinery if you feel dizzy or sleepy after taking APREPEP 125MG/80MG TABLET KIT. If you are taking other prescription or non-prescription medicines, inform your doctor before taking APREPEP 125MG/80MG TABLET KIT.

APREPEP 125MG/80MG TABLET KIT contains Aprepitant, an anti-emetic (a drug used to treat nausea and vomiting) that works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it is used in combination with other medicines to prevent nausea and vomiting caused by anti-cancer medicines in adults and adolescents from the age of 12 years. 

• Headache
• Constipation
• Loss of appetite
• Tiredness
• Indigestion
• Hiccups

Please tell your doctor if you are allergic to APREPEP 125MG/80MG TABLET KIT or any other medicines. APREPEP 125MG/80MG TABLET KIT is not recommended for children below 12 years of age. If you are pregnant or breastfeeding, please inform your doctor before taking APREPEP 125MG/80MG TABLET KIT. Avoid driving or operating machinery if you feel dizzy or sleepy after taking APREPEP 125MG/80MG TABLET KIT. If you are taking any other prescription or non-prescription medicines, inform your doctor before taking APREPEP 125MG/80MG TABLET KIT.

Drug-Drug Interactions: Avoid taking APREPEP 125MG/80MG TABLET KIT with antipsychotics (pimozide), antiallergic drugs (terfenadine, astemizole), and gastroprokinetic agents (cisapride). APREPEP 125MG/80MG TABLET KIT may interact with immunosuppressants (tacrolimus, everolimus, cyclosporine, sirolimus), pain killers (fentanyl, alfentanil), the medicine used to treat an irregular heartbeat (quinidine), anticancer medicines (etoposide, vinorelbine, irinotecan, ifosfamide), blood thinners (acenocoumarol, warfarin), antibiotics (clarithromycin, telithromycin, rifampicin), anticonvulsants (phenytoin, carbamazepine), medicines used to produce calmness or help you sleep (triazolam, phenobarbital, midazolam), antifungals (ketoconazole, voriconazole, posaconazole, itraconazole), antidepressant (nefazodone), corticosteroids (dexamethasone, methylprednisolone), anti-anxiety medicines (alprazolam), antidiabetic agent (tolbutamide) and medicines used to treat migraines and HIV infections.

Drug-Food Interactions: APREPEP 125MG/80MG TABLET KIT may interact with St. John’s Wort (herbal preparation used to treat depression).

Drug-Disease Interactions: If you have liver disease, inform your doctor before taking APREPEP 125MG/80MG TABLET KIT.

• PIMOZIDE
• TERFENADINE
• ASTEMIZOLE
• CISAPRIDE
• TACROLIMUS
• EVEROLIMUS
• CYCLOSPORINE
• SIROLIMUS
• FENTANYL
• ALFENTANIL
• QUINIDINE
• ETOPOSIDE
• IRINOTECAN
• ifosfamide
• ACENOCOUMAROL
• WARFARIN
• CLARITHROMYCIN
• TELITHROMYCIN
• RIFAMPICIN
• PHENYTOIN
• CARBAMAZEPINE
• TRIAZOLAM
• PHENOBARBITAL
• MIDAZOLAM
• KETOCONAZOLE
• VORICONAZOLE
• POSACONAZOLE
• ITRACONAZOLE
• NEFAZODONE
• DEXAMETHASONE
• METHYLPREDNISOLONE
• ALPRAZOLAM
• TOLBUTAMIDE

• Eat a healthy and low-fat diet that includes lots of fruits and vegetables, lean meats, skinless poultry, nuts, fish, whole grains, and plant-based oils, especially in small portions, as it will be easy for digestion.
• Avoid eating over-sweet food and include more salty food, especially if you have been vomiting. 
• Increase the intake of fluids. Drink a small amount of water after small intervals to stay hydrated. 
• Avoid taking greasy or oily foods, as these foods trigger nausea and vomiting. 
• If the smell of food makes you feel sick (vomit), do not cook food, as it may worsen your condition. Let someone else do the cooking or use prepared food from the freezer.

Nausea and vomiting: Nausea is an uneasiness in the stomach that usually precedes vomiting. Vomiting, on the other hand, is a normal bodily response in which a person desires to evacuate stomach contents from the mouth aggressively. In brief, nausea and vomiting are symptoms of a variety of disorders, including infections, motion sickness, an early stage of pregnancy, and gastroparesis (slow stomach emptying). Vomiting is controlled by a receptor in the brain known as the chemoreceptor trigger zone (CTZ). After chemotherapy and radiation therapy, nausea and vomiting are common side effects. It can also arise as a side effect of an operation or surgery. Controlling vomiting and nausea in cancer patients is critical for conducting daily tasks. It can cause mental abnormalities, lack of appetite, malnutrition, and dehydration if not managed.