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  3. Axytef 250mg Tablet

Axytef 250mg Tablet, Pack of 1 Tablet
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
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Composition :

CLARITHROMYCIN-250MG

Manufacturer/Marketer :

Axyzen Life Scineces

Consume Type :

ORAL

Return Policy :

Not Returnable

About Axytef 250mg Tablet

Axytef 250mg Tablet belongs to a group of medicine called macrolide antibiotics derived from Saccharopolyspora erythraea (originally called Streptomyces erythreus), used to treat a wide range of bacterial infections, including chest infections such as bronchitis and pneumonia, skin problems such as cellulitis (potentially serious bacterial skin infection. The affected skin appears swollen and red and is typically painful and warm to the touch), and ear infections. Besides this, Axytef 250mg Tablet is also used in combination with other medicines to treat duodenal ulcers caused by H. pylori. A bacterial infection is a condition in which bacteria grow in the body and cause infection. It can target any body part and multiple very quickly. Antibiotics inhibit the growth of microorganisms given to treat such kinds of conditions.

Axytef 250mg Tablet contains Clarithromycin (antibiotic). It inhibits the protein synthesis process required for the growth of the bacterial cell. As a result, bacterial cells are not able to reproduce and grow. Thus, Axytef 250mg Tablet helps in the prevention of infections.

Axytef 250mg Tablet should only be if your doctor has prescribed you. Axytef 250mg Tablet should not be stopped even if you feel better as it is an antibiotic medication, and completing the full course if very necessary; otherwise, the infection might re-appear in a more severe form. Like all medicines, Axytef 250mg Tablet may cause some common side effects, including feeling sick (nausea), diarrhoea and being sick (vomiting), losing your appetite, bloating and indigestion, headaches and difficulty sleeping. These side effects are temporary and may get resolve after some time; however, if this side persists, let your doctor know about this if you notice any sudden wheeziness, tightness in the chest or throat, difficulty in breathing, swelling of the eyelids, face or lips, rash or itching (especially affecting your whole body) STOP TAKING your medicine and go to a doctor immediately.

Do not take Axytef 250mg Tablet if allergic to azithromycin, other macrolide antibiotics, or any components present in Axytef 250mg Tablet. Axytef 250mg Tablet isn't normally recommended during pregnancy and while breastfeeding. But your doctor may prescribe it if the benefits of you taking it are greater than the risks. Do not consume alcohol as it may cause excessive drowsiness when taken along with Axytef 250mg Tablet. Before using the Axytef 250mg Tablet, tell your doctor if you ever had an allergy to Axytef 250mg Tablet have kidney problems, liver problems, swollen food pipe (oesophagitis), lupus disease (an autoimmune disease), or muscle disease (myasthenia gravis). Do not drink alcohol with Axytef 250mg Tablet as it may increase the unpleasant side effects like drowsiness and dizziness.

Uses of Axytef 250mg Tablet

Bacterial infections

Directions for Use

Tablet/capsule: Swallow it as a whole with water; do not crush, break or chew it.Dispersible Tablet: Check the label for directions before use. Disperse the tablet in the prescribed amount of water and swallow the contents. Do not crush, chew or swallow as a whole.Oral Suspension/Syrup: Shake the bottle well before use. Check the label for directions and take Axytef 250mg Tablet in doses as prescribed by your doctor with the help of a measuring cup.Powder/granules: Check the label for directions before use. Mix the powder/granules in water, mix well and drink immediately.

Medicinal Benefits

Axytef 250mg Tablet is a type of macrolide class of antibiotic which is effective against a wide range of bacteria, including gram-negative, gram-positive bacteria, anaerobes, and some parasites (like Balantidium coli and Entamoeba species). It is prescribed for treating various bacterial infections including chest infections such as pneumonia, skin problems such as cellulitis, and ear infections; on the other hand, It is also used in combination with other medicines to treat duodenal ulcers caused by H. pylori (Helicobacter pylori). Axytef 250mg Tablet is sometimes used by people who have an allergy to penicillin and antibiotics similar to penicillin, such as amoxicillin.

Storage

Store in a cool and dry place away from sunlight
Side effects of Axytef 250mg Tablet
  • Drink plenty of fluids and consider oral rehydration solutions.
  • Eat bland, easily digestible foods like bananas, rice, toast, and applesauce.
  • Avoid trigger foods like greasy, spicy, fatty, acidic, and caffeinated foods.
  • Gradually reintroduce fiber-rich foods as symptoms improve.
  • Get adequate sleep and rest.
  • Practice relaxation techniques to manage stress.
  • Maintain regular bowel habits.
  • Avoid overexertion and take breaks when needed.
  • Consult a doctor if your gastrointestinal symptoms are severe, persistent, or accompanied by fever, bloody stools, dehydration, or last for more than a few days.
  • Regularly brush and floss your teeth.
  • Rinse your mouth with water and baking soda a solution to neutralize acid in the mouth. This makes your food taste as it should.
  • Drink plenty of water or non-caffeinated drinks to prevent dry mouth which may lead to altered taste.
  • Try ginger, peppermint, fruit or green teas, lemonade, ginger ale or fruit juice to help mask unpleasant tastes.
  • Try sucking on sugar-free ice pops or ice cubes to prevent dry mouth.
  • Use a warm compress on the affected area to help reduce discomfort.
  • Elevate the affected limb above heart level.
  • Remove the IV catheter (if applicable) and reinsert at a different site.
  • Consult your healthcare provider if symptoms are severe or persist.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.

Drug Warnings

Iron and antacid (like magnesium hydroxide and aluminium hydroxide) may bind to Axytef 250mg Tablet in the gastrointestinal tract, lowering its efficiency. So, a gap of at least 2 hours should be maintained between intake of Axytef 250mg Tablet and iron supplements and antacids. Besides this, in some cases, the use of Axytef 250mg Tablet causes antibiotic-associated diarrhoea. Axytef 250mg Tablet may cause sensitive skin to sunlight and ultraviolet rays, causing an exaggerated sunburn reaction. Hence it is advisable to apply sunscreen before going outside. Its use has also been associated with an increased risk of fungal skin infections like (vaginal candidiasis - thrush). Tetracycline and Axytef 250mg Tablet can form a stable calcium complex in bone-forming tissue, thereby affecting the growth of fibula bones in young children and bone development in the foetus. Using a Axytef 250mg Tablet with isotretinoin should be avoided as it has been reported to cause pseudotumor cerebri (increased pressure inside the brain). Long-term use of Axytef 250mg Tablet may affect your blood, kidney, and liver health, so yearly diagnostics test of these parameters is recommended.

Drug-Drug Interactions

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ClarithromycinTerfenadine
Critical
ClarithromycinQuinidine
Critical

Drug-Drug Interactions

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ClarithromycinTerfenadine
Critical
How does the drug interact with Axytef 250mg Tablet:
When Terfenadine is taken with Axytef 250mg Tablet, the amount of Terfenadine in the blood can go up.

How to manage the interaction:
Co-administration of Axytef 250mg Tablet and Terfenadine can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinQuinidine
Critical
How does the drug interact with Axytef 250mg Tablet:
When Quinidine is taken with Axytef 250mg Tablet, can increase the blood levels and effects of Quinidine. This may increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Axytef 250mg Tablet and Quinidine can lead to an interaction, it can be taken if advised by a doctor. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or fast or pounding heartbeats. However, if you experience any symptoms like headache, confusion, vomiting, diarrhea, ringing in the ears, hearing loss, blurred or double vision, or sensitivity to light, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinLurasidone
Critical
How does the drug interact with Axytef 250mg Tablet:
Using Lurasidone together with Axytef 250mg Tablet may result in significantly higher Lurasidone blood levels. This may increase the possibility of side effects like Parkinson's disease. (It is a brain disorder that produces uncontrollable movements.)

How to manage the interaction:
While Lurasidone and Axytef 250mg Tablet may interact, they can be used if prescribed by a doctor. Consult a doctor if you have any abnormal muscle activity, fits, high blood sugar, high sugars, high cholesterol, heat intolerance or heat stroke, dizziness, lightheadedness, headache, flushing, fainting, or heart palpitations. Do not discontinue any medications without consulting a doctor.
ClarithromycinNaloxegol
Critical
How does the drug interact with Axytef 250mg Tablet:
When Naloxegol is taken with Axytef 250mg Tablet, the amount of Naloxegol in the blood can go up.

How to manage the interaction:
Co-administration of Axytef 250mg Tablet and Naloxegol can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like sweating, tearing, runny nose, chills, diarrhea, abdominal pain, anxiety, insomnia, irritability, restlessness, and yawning, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinDronedarone
Critical
How does the drug interact with Axytef 250mg Tablet:
When Dronedarone is taken with Axytef 250mg Tablet, can increase the blood levels of dronedarone and cause an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Axytef 250mg Tablet with Dronedarone can result in an interaction, it should be taken only if a doctor has advised it. However, if you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitation, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ClarithromycinBepridil
Critical
How does the drug interact with Axytef 250mg Tablet:
Co-administration of Bepridil with Axytef 250mg Tablet may increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Axytef 250mg Tablet with Bepridil is not recommended as it can result in an interaction, it should be taken only if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
ClarithromycinZiprasidone
Critical
How does the drug interact with Axytef 250mg Tablet:
Taking Axytef 250mg Tablet with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Co-administration of Axytef 250mg Tablet and Ziprasidone can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinLovastatin
Critical
How does the drug interact with Axytef 250mg Tablet:
Taking Axytef 250mg Tablet with Lovastatin can increase the risk of muscle problems.

How to manage the interaction:
Co-administration of Axytef 250mg Tablet and Lovastatin can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark-colored urine, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinErgotamine
Critical
How does the drug interact with Axytef 250mg Tablet:
When Ergotamine is taken with Axytef 250mg Tablet, the amount of Ergotamine in the blood can go up.

How to manage the interaction:
Taking Axytef 250mg Tablet with Ergotamine can result in an interaction, it should be taken only if a doctor has advised it. However, if you experience abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, irregular heartbeat, severe headache, shortness of breath, blurred vision, confusion, and/or slurred speech, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ClarithromycinAlprazolam
Critical
How does the drug interact with Axytef 250mg Tablet:
The combination of Alprazolam and Axytef 250mg Tablet may considerably increase the risk of side effects.

How to manage the interaction:
Despite the fact that there is an interaction between Alprazolam and Axytef 250mg Tablet, it can be used if prescribed by a doctor. Consult a doctor if you have excessive drowsiness, problems with movement, memory loss, anxiety, hallucinations (illogical thoughts), or breathing issues (particularly if you have asthma or obstructive sleep apnea). Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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CLARITHROMYCIN-250MGGrapefruit and Grapefruit Juice
Mild

Drug-Food Interactions

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CLARITHROMYCIN-250MGGrapefruit and Grapefruit Juice
Mild
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Grapefruit juice may delay the gastrointestinal absorption of Axytef 250mg Tablet. Avoid grapefruit juice while on treatment with Axytef 250mg Tablet.

Diet & Lifestyle Advise

  • Probiotics and prebiotics can also help to reduce the side effects of antibiotics.
  • Include more fibre-enriched food in your diet, as it can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fibre foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread and brown rice should be included in your diet. 
  • Eating grapefruit during antibiotics treatment can prevent the body from utilizing Axytef 250mg Tablet properly. So, avoid intake of grapefruit or grapefruit juice with the antibiotic. 
  • Avoid taking too much calcium, iron-enriched foods and drinks as it might affect the working of Axytef 250mg Tablet. 
  • Avoid intake of alcoholic beverages with Axytef 250mg Tablet as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid the Axytef 250mg Tablet in fighting off infections.

Habit Forming

No

Therapeutic Class

ANTI- BACTERIALS

Axytef 250mg Tablet Substitute

Substitutes safety advice

Product Substitutes

Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Sunny S

Reviewed By

Sunny S

MBBS

Last Updated

Jul 8, 2025 | 9:29 AM IST

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Drug-Diseases Interactions

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CLARITHROMYCIN-250MGOther bacterial intestinal infections
Severe
CLARITHROMYCIN-250MGToxic liver disease
Moderate

Drug-Diseases Interactions

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CLARITHROMYCIN-250MGOther bacterial intestinal infections
Severe
How does the disease interact with Axytef 250mg Tablet:
Almost all antibacterial medications have been associated with cases of Clostridioides difficile-associated diarrhoea (CDAD), formerly known as pseudomembranous colitis. It can vary from mild diarrhoea to deadly colitis. Clindamycin and lincomycin are two of the most frequent those involved.

How to manage the interaction:
Anti-bacterial medicines may cause Clostridioides difficile-associated diarrhea (CDAD) ranging from mild diarrhoea to colitis. Therapy should be administered with caution in patients with history of gastrointestinal disease, particularly colitis and pseudomembranous colitis. Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C difficile is advised.
CLARITHROMYCIN-250MGToxic liver disease
Moderate
How does the disease interact with Axytef 250mg Tablet:
Patients on Axytef 250mg Tablet have been reported to experience hepatic dysfunction, including elevated liver enzymes, cholestatic and/or hepatocellular hepatitis, with or without jaundice. Using this medication to patients with hepatic impairment requires caution and close monitoring. If hepatitis signs and symptoms appear, treatment must be stopped.

How to manage the interaction:
Caution and monitoring is advised if Axytef 250mg Tablet is used in patients with liver impairment. Treatment must be discontinued immediately if signs and symptoms of hepatitis such as anorexia, jaundice, dark urine, pruritus, or tender abdomen occur. The use of Axytef 250mg Tablet is contraindicated in patients with a history of cholestatic jaundice or liver impairment associated with the prior use of Axytef 250mg Tablet.
CLARITHROMYCIN-250MGOther disorders of kidney and ureter, not elsewhere classified
Moderate
How does the disease interact with Axytef 250mg Tablet:
The kidney and liver are the organs that eliminate of Axytef 250mg Tablet the most. In individuals with severe renal impairment (CrCl 30 mL/min), a lower dose or longer dosing intervals are advised. Patients with mild to moderate renal impairment often do not require dosage modifications, while medication accumulation may happen if there is concurrent liver illness. It is suggested to monitor.

How to manage the interaction:
Dose adjustment may be needed in patients with severe kidney impairment. Monitoring is advised in patients with mild to moderate kidney impairment.
CLARITHROMYCIN-250MGMyasthenia gravis and other myoneural disorders
Moderate
How does the disease interact with Axytef 250mg Tablet:
Myasthenia gravis symptoms have been observed to worsen and new myasthenic syndrome symptoms appear when macrolide antibiotics are used, according to reports. In patients who have a history of myasthenia gravis, therapy with these medicines should be used with caution.

How to manage the interaction:
Therapy should be administered cautiously in patients with a history of myasthenia gravis as the use of macrolide antibiotics has been reported to exacerbate symptoms of myasthenia gravis.
CLARITHROMYCIN-250MGAbnormal results of function studies
Moderate
How does the disease interact with Axytef 250mg Tablet:
Macrolides have been associated with an increase in the QT interval and occasional cases of arrhythmia. Patients with known QT interval prolongation, ventricular cardiac arrhythmia, including torsades de pointes, patients with proarrhythmic conditions like untreated hypokalemia or hypomagnesemia, clinically significant bradycardia, or patients taking other drugs that prolong the QT interval should avoid taking Axytef 250mg Tablet and erythromycin.

How to manage the interaction:
Axytef 250mg Tablet should be avoided in patients with known prolongation of the QT interval, abnormal heart rhythm, uncorrected low potassium or low magnesium, clinically significant slow heart rate, or receiving other drugs that prolong the QT interval.

FAQs

Drug-Drug Interactions Checker List

  • AZITHROMYCIN
  • AMOXICILLIN+CLAVULANIC ACID
  • SIMVASTATIN
  • ATORVASTATIN
  • WARFARIN
  • BUDESONIDE+FORMOTEROL
  • CARBAMAZEPINE
  • PHENYTOIN
  • ERGOTAMINE
  • DIHYDROERGOTAMINE

Special Advise

  • Probiotics should be taken after taking the full course of Axytef 250mg Tablet in order to restore some of the healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut, kombucha and kimchi can help restore the intestine's good bacteria.

Disease/Condition Glossary

Bacterial infections: A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect our body. It can target any body part and multiple very quickly. When you get infected with bacteria, you can experience generalized symptoms like fevers, chills, and fatigue. Bacteria are of various forms comprising commonly spherical, rod, and spiral-shaped. Bacterial infections vary from minor illnesses like sore throat and ear infections to severe brain infections like meningitis and encephalitis. Few harmful bacteria that cause infections include Streptococcus, Staphylococcus, and E. coli. Anyone can become infected with a bacterial infection. But, people with weak immune systems or taking immunosuppressive medicine can make you more prone to bacterial infection.

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