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Written By Urvashi Bharti , MBBS
Reviewed By Sunny S , MBBS
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Composition :

AZATHIOPRINE-50MG

Manufacturer/Marketer :

Heramb Healthcare

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Azorase-50 Tablet

Azorase-50 Tablet belongs to the class of medicine called 'immunosuppressant' that helps to reduce the pain/inflammation in rheumatoid arthritis conditions and keep the immune system from attacking new transplant organs like kidneys. Besides this, it also treats pain and inflammation in gastrointestinal issues like Crohn's disease, and ulcerative colitis, for patients who have undergone a kidney transplant. 

Azorase-50 Tablet contains 'Azathioprine' that works by reducing the function of the cells, causing inflammation, especially in the joint tissues thereby decreasing pain, inflammation, and slowing down the joint damage and disease progression over time. Besides this, after an organ transplant, your body will try to attack the new organ as it sees it as foreign. Azorase-50 Tablet helps stop your body from rejecting a new organ by suppressing your immune system. 

Take Azorase-50 Tablet as prescribed. Your doctor will advise you on how often you take Azorase-50 Tablet based on your medical condition. In some cases, you may experience certain common side-effects such as nausea, headaches, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, increase in liver enzymes, lowered resistance to infections, tingling sensation, stomach pain, leukopenia (decreased number of white blood cells), and sore throat. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Azorase-50 Tablet for as long as your doctor has prescribed. To avoid recurring symptoms, do not stop it midway. Do not take Azorase-50 Tablet if you are pregnant or planning for pregnancy. Azorase-50 Tablet should not be taken by breastfeeding mothers as it passes into breast milk. Azorase-50 Tablet should not be given to children as safety and efficacy have not been established. Azorase-50 Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of severe conditions such as fever, sore throat, breathlessness, jaundice, unexplained bleeding, or bruising. Avoid excessive exposure to sunlight, wear protective clothing, and use protective sunscreen with a high protection factor while using Azorase-50 Tablet . While taking Azorase-50 Tablet , do not contact anyone who has shingles, chickenpox, or measles. If you accidentally come in contact with any person having them, please inform your doctor immediately as it requires special treatment if you have not had these illnesses. Your doctor may advise you to undergo regular blood tests, kidney and liver tests to monitor your condition. Inform your doctor about your health condition and medicines to rule out any unpleasant side effects.

Uses of Azorase-50 Tablet

Rheumatoid arthritis, Immunosuppressant therapy after kidney transplant

Directions for Use

Swallow Azorase-50 Tablet as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Azorase-50 Tablet contains 'Azathioprine' which is an immunosuppressant that works by reducing the function of the cells, causing inflammation in the joint tissues. It reduces pain, inflammation, and slow joint damage and disease progression over time. Besides this, after an organ transplant, your body will try to attack the new organ as it sees it as foreign. Azorase-50 Tablet helps stop your body from rejecting a new organ by suppressing your immune system. Azorase-50 Tablet is also used to treat severe inflammatory diseases of the skin, Crohn's disease and ulcerative colitis, and some blood disorders.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Azorase-50 Tablet

  • Nausea
  • Headaches
  • Vomiting
  • Diarrhoea
  • Unusual fatigue
  • Dizziness
  • Headache
  • Loss of appetite
  • Increase in liver enzymes
  • Lowered resistance to infections
  • Tingling sensation
  • Stomach pain
  • Leukopenia (decreased number of white blood cells)
  • Sore throat

Drug Warnings

Do not take Azorase-50 Tablet if you are allergic to any immunosuppressant medicines or Azathioprine. Let your doctor know before using Azorase-50 Tablet if you have liver or kidney problems, serious blood disorders, immune system problems, bone marrow problems, serious infections, immunodeficiency syndrome, or if you have a condition where your body produces too little of a natural chemical called thiopurine methyltransferase (TPMT), received any vaccinations. Do not take Azorase-50 Tablet if you are pregnant or planning for pregnancy as Azorase-50 Tablet is a Pregnancy category risk D medicines which can cause serious congenital disabilities to the unborn baby. Azorase-50 Tablet should not be taken by breastfeeding mothers as it passes into breast milk. While taking Azorase-50 Tablet , do not contact anyone who has shingles, chickenpox, or measles. If you accidentally come in contact with any person having them, please inform your doctor immediately as it requires special treatment if you have not had these illnesses. Azorase-50 Tablet causes dizziness and drowsiness, so drive with caution. Azorase-50 Tablet should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol along with Azorase-50 Tablet as it could lead to increased dizziness. Your doctor may advise you to undergo regular blood tests, kidney and liver tests to monitor your condition. Using Azorase-50 Tablet for a long time can increase your chance of getting certain types of cancer, such as lymphoma (cancer of the spleen, thymus gland, and bone marrow), leukemia (blood cancer), and skin cancer. Avoid excessive exposure to sunlight, wear protective clothing, and use protective sunscreen with a high protection factor while using Azorase-50 Tablet .

Drug-Drug Interactions

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AzathioprineFebuxostat
Critical
AzathioprineCertolizumab
Severe

Drug-Drug Interactions

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AzathioprineFebuxostat
Critical
How does the drug interact with Azorase-50 Tablet:
Taking Azorase-50 Tablet and Febuxostat together can increase the blood levels of Azorase-50 Tablet

How to manage the interaction:
Taking Azorase-50 Tablet with Febuxostat is not recommended, but it can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
AzathioprineCertolizumab
Severe
How does the drug interact with Azorase-50 Tablet:
When Azorase-50 Tablet and Certolizumab are taken together, they may raise the risk of severe infections

How to manage the interaction:
Although there is a possible interaction between Azorase-50 Tablet and certolizumab, you can take these medicines together if prescribed by a doctor. However, if you have any of these symptoms- fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, blood in phlegm (a thick secretion in the airway during disease and inflammation), losing weight, or pain while peeing, make sure to contact a doctor immediately. Do not stop using any medications without a doctor's advice.
AzathioprineAdalimumab
Severe
How does the drug interact with Azorase-50 Tablet:
When Azorase-50 Tablet and Adalimumab are taken together, they may raise the risk of severe infections.

How to manage the interaction:
Although there is a possible interaction between Azorase-50 Tablet and Adalimumab, you can take these medicines together if prescribed by a doctor. However, if you have any of these symptoms- fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, blood in phlegm (a thick secretion in the airway during disease and inflammation), losing weight, or pain while peeing, make sure to contact a doctor immediately. Do not stop using any medications without a doctor's advice.
AzathioprineOlaratumab
Severe
How does the drug interact with Azorase-50 Tablet:
Using Azorase-50 Tablet together with olaratumab may increase the risk of serious infections.

How to manage the interaction:
Taking Olaratumab with Azorase-50 Tablet together can result in an interaction, but it can be taken if a doctor has advised it. If you need to take both medications together, it's important to closely monitor your health and get regular blood tests to check for any problems with your blood cells. If you notice any of these symptoms - like feeling weak, getting sick easily, having a fever or sore throat, or having trouble breathing - it's important to call a doctor right away. Do not stop using any medications without a doctor's advice.
AzathioprineVoclosporin
Severe
How does the drug interact with Azorase-50 Tablet:
Taking Azorase-50 Tablet with Voclosporin may lead to a higher chance of severe infections and certain cancers, such as skin cancer and lymph gland cancer (lymphoma).

How to manage the interaction:
Although taking Azorase-50 Tablet and Voclosporin together can cause an interaction, it can be taken if a doctor has suggested it. However, if you notice any symptoms like fever, chills, sore throat, muscle aches, blood in coughing fluid, red or inflamed skin, or body sores it is recommended to contact a doctor right away. Other symptoms such as weight loss, pain during urination, or difficulty breathing should also be reported promptly. Do not discontinue any medications without consulting a doctor.
AzathioprineEtanercept
Severe
How does the drug interact with Azorase-50 Tablet:
When Etanercept is used with Azorase-50 Tablet, the likelihood or severity of infection may increase.

How to manage the interaction:
Although there is a possible interaction between Azorase-50 Tablet and Etanercept, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
AzathioprineMercaptopurine
Severe
How does the drug interact with Azorase-50 Tablet:
Co-administration of Azorase-50 Tablet with Mercaptopurine can increase the risk of side effects.

How to manage the interaction:
Co-administration of Azorase-50 Tablet with Mercaptopurine can result in an interaction, but it can be taken if a doctor has advised it. However, contact a doctor immediately, if you experience any symptoms such as bruising or bleeding, fever, chills, sore throat, flu symptoms, mouth sores, black urine, severe stomach pain, jaundice (yellowing of the skin or eyes), or severe nausea, vomiting, or diarrhea. Do not stop using any medications without a doctor's advice.
AzathioprineTeriflunomide
Severe
How does the drug interact with Azorase-50 Tablet:
When Azorase-50 Tablet is taken with Teriflunomide, may raise the risk of side effects affecting bone marrow function, resulting in low levels of different types of blood cells. This can increase your chances of developing anemia, bleeding issues, or infections.

How to manage the interaction:
Taking Azorase-50 Tablet with Teriflunomide together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience paleness, exhaustion, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, or pain or burning during urination, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
AzathioprineFingolimod
Severe
How does the drug interact with Azorase-50 Tablet:
The use of fingolimod with Azorase-50 Tablet may raise the risk of severe infections.

How to manage the interaction:
Co-administration of Azorase-50 Tablet with Fingolimod can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you have a fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, and pain or burning during urination. Do not stop using any medications without talking to a doctor.
AzathioprineMercaptopurine
Severe
How does the drug interact with Azorase-50 Tablet:
The combined use of Azorase-50 Tablet with Mercaptopurine together can increase the risk of side effects.

How to manage the interaction:
Co-administration of Azorase-50 Tablet with Mercaptopurine can possibly result in an interaction, but it can be taken if a doctor has advised it. However, contact a doctor immediately, if you experience any symptoms such as bruising or bleeding, fever, chills, sore throat, flu symptoms, mouth sores, black urine, severe stomach pain, jaundice (yellowing of the skin or eyes), or severe nausea, vomiting, or diarrhea. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
  • Follow heat or cold therapy, apply a cold or hot compress on the joints for 15-20minutes regularly.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listen to soothing music.
  • Acupuncture, massage, and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes, and green tea.
  • Avoid smoking and alcohol consumption.

 

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS

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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Azorase-50 Tablet causes leukopenia (decreased number of white blood cells) and hence may make you more susceptible to infections. Consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding, or bruising.

Azorase-50 Tablet acts as an immunosuppressant, which helps in reducing inflammation and prevents joint stiffness, thereby provides relief from rheumatoid arthritis.

If you miss a dose of Azorase-50 Tablet , take the missed dose as soon as you remember it. However, if it's almost time for the next dose, do not take a double dose to make up for a missed one.

Diarrhoea might be a side-effect of Azorase-50 Tablet . Drink lots of fluids and eat food rich in fibre if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience excess diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.

Azorase-50 Tablet is a Category D pregnancy drug that is not recommended for pregnant women or given only when strictly guidance of the doctor as there is no clinical data available on use in pregnant women.

Drug-Drug Interactions Checker List

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  • ALLOPURINOL
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  • FOSINOPRIL
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  • INDOMETHACIN
  • TUBOCURARINE
  • PANCURONIUM
  • SUCCINYLCHOLINE

Special Advise

  • Use sunscreen while taking Azorase-50 Tablet , as it can make your skin more sensitive to sunlight and may cause skin cancer.
  • Long-term use of Azorase-50 Tablet may increase your risk of developing cancers like blood cancer, skin cancer and immune system cancer (lymphoma). 

Disease/Condition Glossary

Rheumatoid arthritis: It is an autoimmune disease (the body's immune system attacks its tissue) that leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, inflammation of joints, difficulty moving, and swelling.

Kidney transplant rejection: When you get a new kidney transplanted to your body, your body recognizes it as a foreign element and tries to attack, and reject it because it is not originally part of your body. So, immunosuppressant drugs like Azathioprine are given to such patients to suppress your immune system to attack a newly transplanted kidney. The ultimate goal is to adjust immunosuppressant to prevent rejection and to minimize any side effects of the drugs.

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