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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Composition :

BENDAMUSTINE-100MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Parenteral

Expires on or after :

Return Policy :

Not Returnable

About Benzz Injection

Benzz Injection belongs to a class of anti-cancer medicines used in the treatment of Leukemia. Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. This medicine is used in the treatment of Chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin’s leukemia (NHL) that has progressed during six months of treatment with rituximab or rituximab-containing treatment.

Benzz Injection contains Bendamustine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis.

Benzz Injection may cause certain side effects, such as nausea, vomiting, diarrhea, stomach pain, anorexia, decreased weight, constipation, fever, decreased platelet count, fatigue, cough, headache, rash, injection site reactions and pain at the site of injection. If the side effects bother you, inform your doctor. A trained healthcare professional will administer Benzz Injection. Hence, do not self-administer.

Benzz Injection should be avoided if you are allergic to it or any other components present in it. Before receiving this injection, inform your doctor if you have any pre-existing or a history of liver/kidney disease, cardiac disorders, cancer, active infections, skin problems, or any allergic conditions. Benzz Injection is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

Uses of Benzz Injection

Non-Hodgkin’s disease, Chronic Lymphocytic Leukaemia.

Directions for Use

A trained healthcare professional will administer Benzz Injection. Hence, do not self-administer. 

Key Benefits

Benzz Injection contains Bendamustine, which belongs to the class of alkylating agents. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This causes shrinkage of tumor cells and thereby prevents the growth and further spread of cancerous or non-cancerous cells. This medicine is used in the treatment of chronic lymphocytic leukemia and non-Hodgkin’s leukemia.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Benzz Injection should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before receiving this injection, inform your doctor if you have any history of liver/kidney disease, cardiac disorders, cancer, active infections, skin problems, or any allergic conditions. Benzz Injection may cause myelosuppression, active infections, severe skin reactions, tumor lysis syndrome (tumor cells release their contents into the bloodstream), other malignancies, and hypersensitivity reactions in some patients. Hence, careful monitoring should be done during the entire treatment. Benzz Injection may cause embryo-fetal toxicity. Hence, if you are pregnant or planning to become pregnant, inform your doctor beforehand. Before nursing, a breastfeeding mother should ask her oncologist whether this medicine is safe for use or not. Benzz Injection is not recommended for use in children as the safety and efficacy are not established.

Diet & Lifestyle Advise

  • After your treatment begins, dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast and fried food, processed meats, refined carbs and added sugars.

Side Effects of Benzz Injection

  • Diarrhoea
  • Back pain
  • Vomiting
  • Stomach pain
  • Cough
  • Bruising or bleeding gums
  • Pain at the site of injection
  • Fever
  • Anorexia
  • Constipation
  • Decreased platelet count
  • Rashes
  • Decreased weight
  • Injection site reactions

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

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FAQs

Drug-Drug Interactions Checker List

  • KETOCONAZOLE
  • CLOPIDOGREL
  • RITONAVIR
  • CLOZAPINE
  • CIMETIDINE
  • RIFAMPICIN
  • PHENYTOIN
  • ETANERCEPT
  • GOLIMUMAB
  • INFLIXIMAB
  • BARICITINIB

Special Advise

  • A blood test should be performed, such as a liver function test, or renal function test, to check for liver/kidney function.
  • Weekly blood tests should be done during the treatment to check for CBC (Complete blood count).

Disease/Condition Glossary

Indolent B-cell Non-Hodgkin’s Leukemia: Non-Hodgkin’s disease or Non-Hodgkin’s lymphoma is a blood cancer that affects your lymph system. It causes the uncontrollable growth of cancer cells in the lymph nodes. The lymph system is a part of the immune system which protects your body from disease and infections. In indolent B cell Non-Hodgkin’s lymphoma, the cancer cells grow slowly in the B lymphocytes. Symptoms include lymph node swelling, abdominal pain, chest pain, cough, fever, and night sweats.

Chronic Lymphocytic Leukaemia: It is a type of cancer that occurs in the bone marrow and blood. It increases the number of lymphocytes (a type of white blood cell). The symptoms include fever, enlarged liver, bone or joint pain, shortness of breath, weakness, and bleeding from gums or bruises.

Have a query?

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Alcohol

Safe if prescribed

Limit or avoid consumption of alcohol as it may worsen your condition.

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Pregnancy

Consult your doctor

Benzz Injection is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Benzz Injection. Use reliable methods of birth control while on treatment with Benzz Injection.

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Breast Feeding

Consult your doctor

If you are a nursing mother, inform your doctor before receiving Benzz Injection. You should not breastfeed while on treatment with Benzz Injection.

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Driving

Safe if prescribed

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Liver

Consult your doctor

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Benzz Injection. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition. Benzz Injection is not recommended for use in patients with severe liver disease.

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Kidney

Consult your doctor

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Benzz Injection. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition. This medicine should be avoided for patients with CrCl <40 ml/min.

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Children

Safe if prescribed

Benzz Injection is not recommended for use in children as the safety and efficacy is not established.

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