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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

About Benzz Injection 1's

Benzz Injection 1's belongs to a class of anti-cancer medicines used in the treatment of Leukemia. Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. This medicine is used in the treatment of Chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin’s leukemia (NHL) that has progressed during six months of treatment with rituximab or rituximab-containing treatment.

Benzz Injection 1's contains Bendamustine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis.

Benzz Injection 1's may cause certain side effects, such as nausea, vomiting, diarrhea, stomach pain, anorexia, decreased weight, constipation, fever, decreased platelet count, fatigue, cough, headache, rash, injection site reactions and pain at the site of injection. If the side effects bother you, inform your doctor. A trained healthcare professional will administer Benzz Injection 1's. Hence, do not self-administer.

Benzz Injection 1's should be avoided if you are allergic to it or any other components present in it. Before receiving this injection, inform your doctor if you have any pre-existing or a history of liver/kidney disease, cardiac disorders, cancer, active infections, skin problems, or any allergic conditions. Benzz Injection 1's is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

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Whats That

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Non returnable*
COD available

Online payment accepted

Synonym

BENDAMUSTINE HYDROCHLORIDE

Consume Type

PARENTERAL

Return Policy

3 Days Returnable

Expires on or after

Apr-24

for this medicine

Uses of Benzz Injection 1's

Non-Hodgkin’s disease, Chronic Lymphocytic Leukaemia.

Medicinal Benefits

Benzz Injection 1's contains Bendamustine, which belongs to the class of alkylating agents. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This causes shrinkage of tumor cells and thereby prevents the growth and further spread of cancerous or non-cancerous cells. This medicine is used in the treatment of chronic lymphocytic leukemia and non-Hodgkin’s leukemia.

Side Effects of Benzz Injection 1's

  • Diarrhoea
  • Back pain
  • Vomiting
  • Stomach pain
  • Cough
  • Bruising or bleeding gums
  • Pain at the site of injection
  • Fever
  • Anorexia
  • Constipation
  • Decreased platelet count
  • Rashes
  • Decreased weight
  • Injection site reactions

Directions for Use

A trained healthcare professional will administer Benzz Injection 1's. Hence, do not self-administer. 

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Benzz Injection 1's should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before receiving this injection, inform your doctor if you have any history of liver/kidney disease, cardiac disorders, cancer, active infections, skin problems, or any allergic conditions. Benzz Injection 1's may cause myelosuppression, active infections, severe skin reactions, tumor lysis syndrome (tumor cells release their contents into the bloodstream), other malignancies, and hypersensitivity reactions in some patients. Hence, careful monitoring should be done during the entire treatment. Benzz Injection 1's may cause embryo-fetal toxicity. Hence, if you are pregnant or planning to become pregnant, inform your doctor beforehand. Before nursing, a breastfeeding mother should ask her oncologist whether this medicine is safe for use or not. Benzz Injection 1's is not recommended for use in children as the safety and efficacy are not established.

Therapeutic Class

ANTINEOPLASTIC

Drug-Drug Interactions

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BendamustineCladribine
Severe
BendamustineBaricitinib
Severe

Drug-Drug Interactions

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BendamustineCladribine
Severe
How does the drug interact with Benzz Injection 1's:
Combining Cladribine with Benzz Injection 1's can increase the risk of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Benzz Injection 1's and Cladribine, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
BendamustineBaricitinib
Severe
How does the drug interact with Benzz Injection 1's:
Combining Benzz Injection 1's with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Benzz Injection 1's and Baricitinib together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
BendamustineLeflunomide
Severe
How does the drug interact with Benzz Injection 1's:
Combining Benzz Injection 1's with Leflunomide can increase the likelihood of negative side effects.

How to manage the interaction:
There may be a possibility of interaction between Benzz Injection 1's and Leflunomide, but it can be taken if prescribed by a doctor. If you have any of these symptoms - like an infection, complications, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - contact your doctor right away. Do not stop using any medications without a doctor's advice.
BendamustineClozapine
Severe
How does the drug interact with Benzz Injection 1's:
Combining Benzz Injection 1's with Clozapine can increase the risk of neutropenia.

How to manage the interaction:
Although there is a possible interaction between Benzz Injection 1's and Clozapine, you can take these medicines together if prescribed by your doctor. However, consult your doctor immediately If you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without talking to a doctor.
BendamustineInfliximab
Severe
How does the drug interact with Benzz Injection 1's:
When Benzz Injection 1's is taken with Infliximab, it can cause the metabolism of Benzz Injection 1's to speed up. This can increase the risk of developing serious infections.

How to manage the interaction:
Taking Benzz Injection 1's with Infliximab together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you urinate, contact a doctor right away. Do not stop using any medications without talking to a doctor.
BendamustineTofacitinib
Severe
How does the drug interact with Benzz Injection 1's:
Using tofacitinib together with Benzz Injection 1's may increase the risk of developing serious infections.

How to manage the interaction:
Taking Tofacitinib with Benzz Injection 1's together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • KETOCONAZOLE
  • CLOPIDOGREL
  • RITONAVIR
  • CLOZAPINE
  • CIMETIDINE
  • RIFAMPICIN
  • PHENYTOIN
  • ETANERCEPT
  • GOLIMUMAB
  • INFLIXIMAB
  • BARICITINIB

Diet & Lifestyle Advise

  • After your treatment begins, dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast and fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Special Advise

  • A blood test should be performed, such as a liver function test, or renal function test, to check for liver/kidney function.
  • Weekly blood tests should be done during the treatment to check for CBC (Complete blood count).

Disease/Condition Glossary

Indolent B-cell Non-Hodgkin’s Leukemia: Non-Hodgkin’s disease or Non-Hodgkin’s lymphoma is a blood cancer that affects your lymph system. It causes the uncontrollable growth of cancer cells in the lymph nodes. The lymph system is a part of the immune system which protects your body from disease and infections. In indolent B cell Non-Hodgkin’s lymphoma, the cancer cells grow slowly in the B lymphocytes. Symptoms include lymph node swelling, abdominal pain, chest pain, cough, fever, and night sweats.

Chronic Lymphocytic Leukaemia: It is a type of cancer that occurs in the bone marrow and blood. It increases the number of lymphocytes (a type of white blood cell). The symptoms include fever, enlarged liver, bone or joint pain, shortness of breath, weakness, and bleeding from gums or bruises.

Benzz Injection 1's Substitute

Substitutes safety advice
  • BENDIT 100MG INJECTION

    2987.30per tablet
  • BIMODE 100MG INJECTION 20ML

    106.03per tablet
  • ZUMUSTIN 100MG INJECTION

    6350.90per tablet
  • Adben 100 mg Injection 1's

    3280.82per tablet
  • Bizisa Injection 1's

    5740.00per tablet
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