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  3. Bortecine Injection

Bortecine Injection, Pack of 1 Injection
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Sureshvarma D , MPharma
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Composition :

BORTEZOMIB-2MG

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Bortecine Injection

Bortecine Injection belongs to a group of anti-cancer medicines used to treat adult patients with multiple myeloma and mantle cell lymphoma who have received at least one prior therapy. Multiple myeloma, also known as myeloma, is a type of bone marrow cancer it affects several areas of the body, such as the spine, skull, pelvis, and ribs. Mantle cell lymphoma (MCL) is a rare type of non-Hodgkin lymphoma (NHL). It develops when B-cells (also called B-lymphocytes) become abnormal. B-cells are white blood cells that fight infection.

Bortecine Injection contains 'Bortezomibx' that works by interfering with how proteasomes work, which may cause cancer cells to die and may stop cancer from growing and eventually kills them.

Bortecine Injection is prescribed by a doctor experienced in the use of medications to treat cancer. It is administered by a healthcare professional as an injection into your vein (intravenously or IV) or under your skin (subcutaneously or SC). Bortecine Injection must not be administered into your spinal fluid (intrathecally). You may experience nausea, diarrhoea, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), peripheral neuropathy (nerves malfunction), fatigue, neuralgia, anaemia, leukopenia, constipation, vomiting, lymphopenia, rash, pyrexia, and anorexia. Most of these side effects of Bortecine Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

To treat your condition effectually, continue taking Bortecine Injection for as long as your doctor has prescribed. Do not stop the Bortecine Injection midway. Talk to your doctor before taking Bortecine Injection if you have allergies or if you are suffering from peripheral neuropathy (nerves malfunction), hypotension, cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), hepatic disorders. Avoid taking Bortecine Injection if you are pregnant or breastfeeding because this Bortecine Injection can cause harmful effects on the unborn baby. Both women and men using this Bortecine Injection should use birth control to avoid pregnancy.

Uses of Bortecine Injection

Multiple myeloma and Mantle cell lymphoma.

Directions for Use

Bortecine Injection will be administered by a qualified healthcare professional. Kindly do not self-administer.

Medicinal Benefits

Bortecine Injection contains the active substance bortezomib, also-called ‘proteasome inhibitor. Proteasomes play an important role in controlling cell function and growth. By interfering with their function, thereby it can kill cancer cells. Bortecine Injection is used to treat multiple myeloma (a cancer of the bone marrow) and mantle cell lymphoma (a type of cancer affecting the lymph nodes) in 18 years or older patients. It can be used alone or together with other medicines.

Storage

Keep Bortecine Injection out of the sight and reach of children.
Side effects of Bortecine Injection
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Nourish your body with a balanced diet with protein-rich foods like fish, eggs, and beans. Fruits, vegetables, and nuts provide essential vitamins and minerals. If necessary, consider vitamin B12 and folate supplements.
  • Practice good hygiene to protect yourself from infections. Wash your hands often, stay up-to-date on vaccinations, avoid crowded areas, and take care when handling food, pets, and diapers.
  • Aim for a good night's sleep, targeting 8 hours of sleep. Find calm through stress-reducing practices like yoga, meditation, or deep breathing. Regular physical activity can also help.
  • Stay healthy by drinking plenty of water, eating probiotic-rich foods like yoghurt, and limiting processed foods and sugars. Consult your doctor, if you are having difficulties or concerns.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Drug Warnings

To treat your condition effectually, continue taking Bortecine Injection for as long as your doctor has prescribed. Do not stop the Bortecine Injection midway. Talk to your doctor before taking Bortecine Injection if you have allergies or if you are suffering from peripheral neuropathy (nerves malfunction), hypotension, cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), hepatic disorders. And also, inform your doctor if you have diabetes because this medicine can affect your blood glucose levels. Your doctor may require close monitoring of your blood glucose levels and change your diabetes medicine dose while being treated with Bortecine Injection. Avoid taking Bortecine Injection if you are pregnant because this Bortecine Injection can cause harmful effects on the unborn baby. Both women and men using this Bortecine Injection should use birth control to avoid pregnancy and for at least six months following treatment. Do not breastfeed during treatment with Bortecine Injection and four months after your final dose of Bortecine Injection.

Drug-Drug Interactions

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BortezomibLomitapide
Severe
BortezomibPrimidone
Severe

Drug-Drug Interactions

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BortezomibLomitapide
Severe
How does the drug interact with Bortecine Injection:
Coadministration of lomitapide and Bortecine Injection can increases the risk of liver problems.

How to manage the interaction:
Although using Bortecine Injection and Lomitapide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, joint pain or swelling, skin rash, itching, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes. Do not stop taking any medications without consulting a doctor.
BortezomibPrimidone
Severe
How does the drug interact with Bortecine Injection:
Coadministration of Bortecine Injection and primidone may reduce the blood levels of Bortecine Injection, which may make the medication less effective in treating your condition.

How to manage the interaction:
Although using Bortecine Injection and Primidone together can possibly result in an interaction, they can be taken together if prescribed by your doctor. Do not discontinue any medications without consulting a doctor.
BortezomibCertolizumab
Severe
How does the drug interact with Bortecine Injection:
Coadministration of certolizumab and Bortecine Injection may increase the risk of infections.

How to manage the interaction:
Although using Bortecine Injection and Certolizumab together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhoea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibSamarium (153sm) lexidronam
Severe
How does the drug interact with Bortecine Injection:
Using samarium (153sm) lexidronam together with Bortecine Injection may increase the risk of side effects

How to manage the interaction:
Co-administration of Bortecine Injection with Samarium (153sm) lexidronam can possibly result in an interaction; they can be taken if your doctor has advised it. However, consult a doctor if you experience fatigue, dizziness, fever, chills, diarrhea, sore throat, muscle aches, red or inflamed skin, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
BortezomibTofacitinib
Severe
How does the drug interact with Bortecine Injection:
Taking tofacitinib and Bortecine Injection may increase the risk of infections.

How to manage the interaction:
Although using Bortecine Injection and Tofacitinib together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibCladribine
Severe
How does the drug interact with Bortecine Injection:
Coadministration of cladribine and Bortecine Injection may increase the risk of infections.

How to manage the interaction:
Although using Bortecine Injection and Cladribine together can possibly result in an interaction, they can be taken together if advised by your doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscle pains, red or irritated skin, body sores, and a burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
BortezomibRifapentine
Severe
How does the drug interact with Bortecine Injection:
Coadministration of bortezumib and rifapentine may reduce the blood levels of Bortecine Injection, which may make the medication less effective in treating your condition.

How to manage the interaction:
Although using Bortecine Injection and Rifapentine together can possibly result in an interaction, they can be taken together if advised by your doctor. Do not stop taking any medications without consulting a doctor.
BortezomibTalimogene laherparepvec
Severe
How does the drug interact with Bortecine Injection:
Taking Bortecine Injection together with talimogene laherparepvec increases the risk of developing infection.

How to manage the interaction:
Although using Bortecine Injection and Talimogene laherparepvec together can possibly result in an interaction, they can be taken together if advised by your doctor. Do not stop taking any medications without consulting a doctor.
BortezomibAdalimumab
Severe
How does the drug interact with Bortecine Injection:
Coadministration of adalimumab and Bortecine Injection may increase the risk of infections.

How to manage the interaction:
Although using Bortecine Injection and Adalimumab together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience any symptoms of infection, such as fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, discomfort, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibMitotane
Severe
How does the drug interact with Bortecine Injection:
Coadministration of Bortecine Injection and mitotane may reduce the blood levels of Bortecine Injection, which may make the medication less effective in treating your condition.

How to manage the interaction:
Although using Bortecine Injection and Mitotane together can possibly result in an interaction, they can be taken together if advised by your doctor. However, consult your doctor if your condition worsens. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

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BORTEZOMIB-2MGCaffeine containing foods/drinks, Fiber rich foods
Moderate

Drug-Food Interactions

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BORTEZOMIB-2MGCaffeine containing foods/drinks, Fiber rich foods
Moderate
Common Foods to Avoid:
Green Tea, Oranges

How to manage the interaction:
Vitamin C or vitamin-containing foods and green tea diminish the effectiveness of Bortecine Injection Avoid or limit the consumption of Vitamin C or vitamin-containing foods and green tea.

Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs in your diet.
  • Get optimal sleep, and rest well.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Avoid smoking and alcohol consumption.
  • Avoid fast, fried, processed meats, refined carbs, and added sugars.

Side Effects of Bortecine Injection

  • Nausea
  • Diarrhoea
  • Thrombocytopenia (low blood platelet count)
  • Neutropenia (too few neutrophils)
  • Peripheral neuropathy (nerves malfunction)
  • Fatigue (overtired)
  • Neuralgia (pain in the head or face)
  • Muscle pain, bone pain
  • Anaemia (low red blood cell Count)
  • Leukopenia (Low White Blood Cell Count)
  • High blood pressure
  • Constipation
  • Dehydration
  • Vomiting
  • Loss of appetite
  • Lymphopenia (Low lymphocytes Count)
  • Rash
  • Pyrexia (raised body temperature)
  • Anorexia (lack or loss of appetite for food)
  • Infections, including pneumonia, respiratory infections, bronchitis, fungal infections, coughing with phlegm, flu-like illness

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Bortecine Injection Substitute

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Sureshvarma D

Reviewed By

Sureshvarma D

MPharma

Last Updated

Jul 8, 2025 | 9:37 AM IST

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Bortecine Injection contains the active substance bortezomib, also-called ‘proteasome inhibitor. Proteasomes play an important role in controlling cell function and growth. By interfering with their function, thereby it can kill cancer cells.

Bortecine Injection is prescribed by a doctor experienced in the use of medications to treat cancer. It is administered by a healthcare professional as an injection into your vein (intravenously or IV) or under your skin (subcutaneously, or SC). Bortecine Injection must not be administered into your spinal fluid (intrathecally).

Yes, Bortecine Injection can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or believe you have an infection.

Avoid taking Bortecine Injection if you are pregnant because Bortecine Injection can cause harmful effects on the unborn baby. Females should follow effective birth control methods during treatment and at least six months after the final dose of Bortecine Injection.

Before you receive treatment with Bortecine Injection, tell your doctor about all of your medical conditions. You should not receive Bortecine Injection if you are allergic to bortezomib or any contents in Bortecine Injection.

If not given an inappropriate dose, Bortecine Injection can cause toxic effects, although not everyone gets it. So, Bortecine Injection is prescribed by a doctor experienced in using medications to treat cancer only.

Drug-Drug Interactions Checker List

  • KETOCONAZOLE
  • RITONAVIR
  • RIFAMPICIN
  • CARBAMAZEPINE
  • PHENYTOIN
  • PHENOBARBITAL

Special Advise

  • Bortecine Injection should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking Bortecine Injection.
  • Your doctor may get routine blood tests done to monitor your liver function, electrolyte levels, blood cell count in your blood.
  • Avoid unnecessary or prolonged exposure to sunlight and UV light (such as tanning booths) and wear protective clothing, sunglasses, and sunscreen. Bortecine Injection may make your skin sensitive to sunlight.

Disease/Condition Glossary

Multiple myeloma, also known as myeloma, is a type of bone marrow cancer it affects several areas of the body, such as the spine, skull, pelvis, and ribs.

Mantle cell lymphoma (MCL) is a rare type of non-Hodgkin lymphoma (NHL). It develops when B-cells (also called B-lymphocytes) become abnormal. B-cells are white blood cells that fight infection.

Cancer is a condition where cells in a specific body part grow and reproduce uncontrollably. The cancerous cells can invade and destroy surrounding healthy tissue, including organs.

Have a query?

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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Bortecine Injection. It could lead to avoiding unpleasant side effects.

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Pregnancy

Unsafe

Bortecine Injection should not be used during pregnancy because it causes harm to the fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking Bortecine Injection and at least six months afterwards. Please discuss with your doctor any concerns regarding this.

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Breast Feeding

Unsafe

Bortecine Injection should not be taken during breastfeeding as it passes into the breastmilk and may harm the nursing baby. It is contraindicated in breastfeeding mothers.

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Driving

Caution

Bortecine Injection may affect your reactions and your ability to drive. Possible side effects of chemotherapy with Bortecine Injection may occur, such as nausea and vomiting. If you are affected by these side effects, you should not drive and/or operate machines that require you to be alert.

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Liver

Caution

If you have a history or evidence of liver-related diseases, inform the doctor before prescribing the Bortecine Injection. Your doctor will weigh the benefits and potential risks before prescribing them.

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Kidney

Caution

If you have a history or evidence of kidney-related diseases, inform the doctor before prescribing the Bortecine Injection. Your doctor will weigh the benefits and potential risks before prescribing them.

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Children

Unsafe

Bortecine Injection should not be used by children below 18 years of age, as efficacy and safety have not been established.

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