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  3. Brinzagan Ophthalmic Suspension 5 ml

Brinzagan Ophthalmic Suspension 5 ml, Pack of 1 Suspension
Brinzagan Ophthalmic Suspension 5 ml, Pack of 1 Suspension
Brinzagan Ophthalmic Suspension 5 ml, Pack of 1 Suspension
Brinzagan Ophthalmic Suspension 5 ml, Pack of 1 Suspension
Brinzagan Ophthalmic Suspension 5 ml, Pack of 1 Suspension
Brinzagan Ophthalmic Suspension 5 ml, Pack of 1 Suspension
Written By Veda Maddala , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
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Composition :

BRINZOLAMIDE-1%W/V

Manufacturer/Marketer :

Allergan Healthcare India Pvt Ltd

Consume Type :

OPHTHALMIC

Return Policy :

Not Returnable

Expires on or after :

About Brinzagan Ophthalmic Suspension 5 ml

Brinzagan Ophthalmic Suspension 5 ml belongs to a class of anti-glaucoma agents called carbonic anhydrase inhibitors primarily used to treat increased pressure in eye conditions. Glaucoma is an eye condition that causes damage to the optic nerve (essential for good vision) due to abnormally increased pressure in the eye. Ocular hypertension is increased pressure in the eye due to poor drainage of aqueous humour (fluid in the eye that maintains normal pressure by its continuous flow).

Brinzagan Ophthalmic Suspension 5 ml contains Brinzolamide which works by inhibiting the action of carbonic anhydrase enzyme and decreasing bicarbonate production essential for the production of fluid in the eye (aqueous humour).  Thus it reduces the secretion of eye fluid called 'aqueous humour' that maintains pressure in the eyeball and in turn lowers the raised pressure in the eye by reducing aqueous humour entry into the eyeball. Thus, Brinzagan Ophthalmic Suspension 5 ml prevents eyes from getting blind in the conditions of open-angle type glaucoma and ocular hypertension. 

Use Brinzagan Ophthalmic Suspension 5 ml as prescribed. Brinzagan Ophthalmic Suspension 5 ml is only for use in the eyes. Do not swallow or inject Brinzagan Ophthalmic Suspension 5 ml. Your doctor will advise you on how many drops to instil based on your medical condition. In some cases, you may experience eye discharge, redness, itching, irritation or pain in the eyes, blurred vision, abnormal eye sensation and dry eyes. Most of these side effects of Brinzagan Ophthalmic Suspension 5 ml do not require medical attention and gradually resolve over time. However, if the side effects worsen or persist, please consult your doctor.

If you are allergic to Brinzagan Ophthalmic Suspension 5 ml or any other medicines, please tell your doctor. Brinzagan Ophthalmic Suspension 5 ml is not recommended for children below 18 years of age. You are not advised to use Brinzagan Ophthalmic Suspension 5 ml if you are pregnant, breastfeeding or have severe kidney problems or hyperchloraemic acidosis (excessive acidity in the blood). You are advised to remove soft contact lenses before using Brinzagan Ophthalmic Suspension 5 ml as it may cause discolouration of the soft contact lens. If you get any new eye problem, an eye infection or notice any allergic reactions such as itching or redness of the eye and skin rash, please consult your doctor immediately. You are advised to maintain a 5 minutes time gap between using Brinzagan Ophthalmic Suspension 5 ml and other eye drops. If you have dry eyes, cornea problems, narrow-angle glaucoma, pseudoexfoliative glaucoma or pigmentary glaucoma kidney or liver problems, before taking Brinzagan Ophthalmic Suspension 5 ml.

Uses of Brinzagan Ophthalmic Suspension 5 ml

Glaucoma (open-angle type), Ocular hypertension (high eye pressure)

Directions for Use

Lie down and tilt your head backward. Pull your lower eyelid gently with your index finger to form a pocket. Instill the number of drops as advised by the doctor into the pocket of the lower eyelid. Close your eyes for 1-2 minutes. Please do not touch the container tip to the eye, eyelids, or surrounding areas as it may contaminate Brinzagan Ophthalmic Suspension 5 ml and cause eye infections.

Medicinal Benefits

Brinzagan Ophthalmic Suspension 5 ml contains Brinzolamide used to treat increased pressure in the eye in conditions such as glaucoma (damage of optic nerve) and ocular hypertension (high fluid pressure inside the eye). Brinzagan Ophthalmic Suspension 5 ml inhibits the action of carbonic anhydrase enzyme and decreases bicarbonate production that is essential for the production of aqueous humour.  Thereby, it reduces the secretion of aqueous humour (a liquid that maintains normal pressure in the eyeball) and lowers the pressure in the eye by reducing aqueous humour entry into the eyeball.

Storage

Store in a cool and dry place away from sunlight
Side effects of Brinzagan Ophthalmic Suspension 5 ml
  • Bitter or bad taste can be managed by taking Vitamin B12 supplements only after your doctor's consultation.
  • Maintain good oral hygiene by using mouthwash frequently and cleaning your tongue while brushing.
  • Avoid eating foods that cause heartburn or stomach pain, as they can lead to a bitter taste in your mouth.
  • Do not smoke or drink alcohol, as it can worsen your condition.
  • Gently wash the eyelids using mild soap with lukewarm water to wash away dirt and bacteria.
  • Avoid rubbing the eyes or eyelids to prevent the inflammation.
  • Keep contact lenses clean and disinfected to avoid infection.
  • Follow the treatment plan and attend follow-up appointments to ensure full recovery.
  • See a doctor again if changes in your vision or eye symptoms occur.
  • Know your allergens that cause dermatitis and avoid them.
  • Use fragrance-free detergents and soaps.
  • Apply moisturizer after taking bath to retain moisture in the skin.
  • Apply cool, moist compresses to the rash.
  • Talk to your doctor about creams and ointments to manage your dermatitis.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Excessive blood flow needs immediate medical attention it should not be ignored.
  • Get an immediate physical examination and take necessary precautions.
  • Avoid anxiety and stress, as it can worsen your condition.
  • Consume more foods that are rich in Vitamin C and iron.
  • Stay hydrated and take necessary medication to control excess bleeding, as it can lead to critical conditions.
  • Wash your hands thoroughly before touching your eyes to prevent spreading the infection.
  • Gently wipe away discharge from the inner corner of your eye outwards using a clean, damp washcloth.
  • Apply warm compress to help loosen crusty build up and soothe irritation.
  • Take diet containing vitamins, minerals and proteins for the eye health.
  • Consult the doctor if the conjunctival discharge is excessive with severe pain.
  • Wear protective eye glasses to prevent infections.
  • Avoid rubbing and touching the eyes frequently.
  • Maintain eye hygiene by cleaning them with fresh water.
  • Take food rich in vitamin-A like carrots, fish and green leafy vegetables.

Drug Warnings

If you are allergic to Brinzagan Ophthalmic Suspension 5 ml or any other medicines, please tell your doctor. Brinzagan Ophthalmic Suspension 5 ml is not recommended for children below 18 years of age. You are not advised to use Brinzagan Ophthalmic Suspension 5 ml if you are pregnant, breastfeeding, or have severe kidney problems or hyperchloraemic acidosis (excessive acidity in the blood). You are advised to remove soft contact lenses before using Brinzagan Ophthalmic Suspension 5 ml as it may cause discoloration of the soft contact lens. If you get any new eye problem, an eye infection, or notice any allergic reactions such as itching or redness of the eye and skin rash, please consult your doctor immediately. You are advised to maintain a 5 minutes time gap between using Brinzagan Ophthalmic Suspension 5 ml and other eye drops. Please do not touch the container tip to the eye, eyelids, or surrounding areas as it may contaminate Brinzagan Ophthalmic Suspension 5 ml and cause eye infections. If you have dry eyes, cornea problems, narrow-angle glaucoma, pseudoexfoliative glaucoma, or pigmentary glaucoma kidney or liver problems, before taking Brinzagan Ophthalmic Suspension 5 ml.

Drug-Drug Interactions

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BrinzolamideSalsalate
Severe
BrinzolamideAspirin
Severe

Drug-Drug Interactions

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BrinzolamideSalsalate
Severe
How does the drug interact with Brinzagan Ophthalmic Suspension 5 ml:
Concomitant use of Brinzagan Ophthalmic Suspension 5 ml with salsalate can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction, Brinzagan Ophthalmic Suspension 5 ml should be used with salsalate only if prescribed by the doctor. Consult a doctor immediately if you experience ringing in the ears, vomiting, headache, dizziness, and fever. Do not stop using any medications without first talking to your doctor.
BrinzolamideAspirin
Severe
How does the drug interact with Brinzagan Ophthalmic Suspension 5 ml:
Coadministration of Brinzagan Ophthalmic Suspension 5 ml with Aspirin may cause side effects.

How to manage the interaction:
Although there is a possible interaction between aspirin and Brinzagan Ophthalmic Suspension 5 ml, you can take these medicines together if prescribed by a doctor. However, if you experience ringing in your ears, headache, vomiting, dizziness, or palpitations, please contact a doctor. Do not stop using any medications without talking to a doctor.
BrinzolamideDiflunisal
Severe
How does the drug interact with Brinzagan Ophthalmic Suspension 5 ml:
Coadministration of Brinzagan Ophthalmic Suspension 5 ml with diflunisal can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction, Brinzagan Ophthalmic Suspension 5 ml should be used with diflunisal only if prescribed by the doctor. Consult a doctor if you experience vomiting, headache, dizziness, or fever. Do not stop using any medications without first talking to your doctor.
BrinzolamideSodium salicylate
Severe
How does the drug interact with Brinzagan Ophthalmic Suspension 5 ml:
Concomitant use of Brinzagan Ophthalmic Suspension 5 ml with sodium salicylate may cause ringing in the ears, nausea, vomiting, headache, dizziness, confusion, hallucinations, rapid breathing, fever, and seizure (convulsions).

How to manage the interaction:
Although there is an interaction, Brinzagan Ophthalmic Suspension 5 ml should be used with sodium salicylate only if prescribed by the doctor. However, if you experience ringing in the ears, vomiting, headache, dizziness, or fever, contact your doctor immediately. Do not stop using any medications without consulting your doctor.
BrinzolamideCholine salicylate
Severe
How does the drug interact with Brinzagan Ophthalmic Suspension 5 ml:
Taking Brinzagan Ophthalmic Suspension 5 ml with Choline salicylate may increase the risk of side effects.

How to manage the interaction:
Although taking Brinzagan Ophthalmic Suspension 5 ml and Choline salicylate together can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience ringing in your ears, headache, vomiting, dizziness, or palpitations, consult a doctor. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid baked foods such as cakes, cookies, donuts, or fried items such as French fries and stick margarine as these foods may worsen glaucoma and damage the optic nerve.
  • Please cut down your coffee intake as it may increase pressure in the eye and replace coffee with green tea.
  • Avoid exercises such as any position where the head is lower than the body like inverted yoga poses as it may increase pressure in the eye. Doing selective exercises is advised for glaucoma patients.

Habit Forming

No

Therapeutic Class

ANTIGLAUCOMA AGENTS

Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Sunny S

Reviewed By

Sunny S

MBBS

Last Updated

Aug 20, 2024 | 12:52 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

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BRINZOLAMIDE-1%W/VAgranulocytosis
Severe
BRINZOLAMIDE-1%W/VDisorders of porphyrin and bilirubin metabolism
Severe

Drug-Diseases Interactions

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BRINZOLAMIDE-1%W/VAgranulocytosis
Severe
How does the disease interact with Brinzagan Ophthalmic Suspension 5 ml:
Applying Brinzagan Ophthalmic Suspension 5 ml ophthalmic to the skin, eyes, or mucosal membranes may cause systemic absorption. In addition to methemoglobinemia, sulfhemoglobinemia, leukopenia, granulocytopenia, eosinophilia, hemolytic anaemia, aplastic anaemia, purpura, coagulation problem, thrombocytopenia, hypofibrinogenemia, and hypoprothrombinemia, the usage of sulfonamides has also been linked to hematologic damage. Patients who already have blood dyscrasias or marrow suppression should use topical sulfonamide therapy with caution. During prolonged therapy (>2 weeks), complete blood counts should be taken on a regular basis, and patients should be instructed to report any indications or symptoms of a blood dyscrasia right away, such as fever, sore throat, local infection, bleeding, pallor, dizziness, or jaundice.

How to manage the interaction:
Brinzagan Ophthalmic Suspension 5 ml should be administered cautiously in patients with preexisting blood problems or bone marrow suppression. Complete blood count tests are advised regularly during prolonged therapy (>2 weeks). Consult the doctor if you notice signs or symptoms of blood problems such as fever, sore throat, local infection, bleeding, dizziness, or jaundice.
BRINZOLAMIDE-1%W/VDisorders of porphyrin and bilirubin metabolism
Severe
How does the disease interact with Brinzagan Ophthalmic Suspension 5 ml:
When sulfonamides are administered to the skin, eye, or mucosal membranes, they may be absorbed systemically. Patients with porphyria should use topical sulfonamide therapy with caution because these medications can cause an acute attack. Patients with porphyria are thought to be contraindicated for oral sulfonamide usage.

How to manage the interaction:
Therapy should be administered cautiously in patients with porphyria, since it may precipitate an acute attack.
BRINZOLAMIDE-1%W/VOther abnormal findings in urine
Moderate
How does the disease interact with Brinzagan Ophthalmic Suspension 5 ml:
When sulfonamides are administered to the skin, eye, or mucosal membranes, they may be absorbed systemically. Due to the sulfonamide and/or its N4-acetyl metabolite precipitating in the urinary tract, the usage of sulfonamides has been linked to crystalluria. There have been reports of renal toxicity, including hematuria, proteinuria, increased BUN and creatinine, uro- and nephrolithiasis, nephritis, toxic nephrosis, and more. During the use of sulfonamides, hydration and sufficient urine output (> 1.5 L/day) should be maintained. Patients who are dehydrated (for instance, as a result of severe diarrhoea or vomiting) may be more vulnerable to developing crystalluria and lithiasis, thus they should be encouraged to drink more liquids.

How to manage the interaction:
Dehydrated patients may be at increased risk for the development of crystalluria and lithiasis (formation of stones). Therefore, consume additional amounts of liquid. Hydration and adequate urinary output (> 1.5 L/day) should be maintained during administration of the medicine. Renal function tests and urinalysis should be performed regularly during prolonged therapy (> 2 weeks).
BRINZOLAMIDE-1%W/VOther diseases of liver
Moderate
How does the disease interact with Brinzagan Ophthalmic Suspension 5 ml:
Rarely have individuals using sulfonamides reported experiencing hepatotoxicity, including jaundice, diffuse hepatocellular necrosis, hypersensitivity hepatitis, and hepatic failure.

How to manage the interaction:
Therapy should be administered cautiously in patients with liver disease.
BRINZOLAMIDE-1%W/VOther disorders of kidney and ureter, not elsewhere classified
Moderate
How does the disease interact with Brinzagan Ophthalmic Suspension 5 ml:
Sulfonamide side effects may be more likely to occur in those with renal impairment because of decreased medication clearance. Sulfonamides can also result in toxic nephrosis, hematuria, proteinuria, increased BUN, and creatinine levels in addition to renal damage related to crystalluria.

How to manage the interaction:
Hydration and adequate urinary output (> 1.5 L/day) should be maintained during administration of the medicine in patients with kidney dysfunction. Renal function tests and urinalysis should be performed regularly during prolonged therapy (> 2 weeks).
BRINZOLAMIDE-1%W/VOther abnormal findings in urine
Moderate
How does the disease interact with Brinzagan Ophthalmic Suspension 5 ml:
When sulfonamides are administered to the skin, eye, or mucosal membranes, they may be absorbed systemically. Hematologic toxicity has been linked to the usage of sulfonamides.

How to manage the interaction:
A urinary output of at least 1.5 L/day should be maintained during therapy. Renal function tests and urinalysis should be performed regularly during prolonged therapy (> 2 weeks).

FAQs

Brinzagan Ophthalmic Suspension 5 ml contains Brinzolamide that works by inhibiting the action of carbonic anhydrase enzyme and decreases bicarbonate production that is essential for the production of aqueous humour. Thereby, it reduces the secretion of aqueous humour (a liquid that maintains normal pressure in the eyeball) and lowers the pressure in the eye by reducing aqueous humour entry into the eyeball.

You are recommended to wash your hands first and tilt your head back and gently pull the lower eyelid downwards. Then, press the bottom of the bottle gently by holding it upside down to instil one drop into the affected eye without touching the tip of the bottle to the eye or surrounding areas in order to avoid contamination. Finally, replace the cap tightly after use. After applying Brinzagan Ophthalmic Suspension 5 ml, you are advised to apply to the corner of the eye by pressing a finger to stop eye drops from spreading into the rest of the body.

No, you are not recommended to wear contact lenses while using Brinzagan Ophthalmic Suspension 5 ml as it contains benzalkonium chloride, a preservative that changes the colour of the contact lens as it may be absorbed by a soft contact lens. Benzalkonium chloride also causes irritation in the eye especially if you have disorders of the cornea (transparent layer at the front of the eye) or dry eyes. Therefore, you are advised to remove contact lenses before applying Brinzagan Ophthalmic Suspension 5 ml and reinsert after 15 minutes of using Brinzagan Ophthalmic Suspension 5 ml. Also, inform your doctor if you experience pain, stinging or abnormal sensation in the eye after using Brinzagan Ophthalmic Suspension 5 ml.

You are recommended to maintain a minimum of 5 minutes time gap between using Brinzagan Ophthalmic Suspension 5 ml and other eye drops and administer eye ointments in the last.

Yes, Brinzagan Ophthalmic Suspension 5 ml may cause temporary blurred vision. Therefore, you are recommended to wait until your vision is clear before driving or operating heavy machinery.

You are not recommended to stop using Brinzagan Ophthalmic Suspension 5 ml without consulting your doctor as it may increase pressure in the eyes and may lead to loss of vision. Therefore, use Brinzagan Ophthalmic Suspension 5 ml for as long as your doctor has prescribed it, and if you experience any difficulty while taking Brinzagan Ophthalmic Suspension 5 ml, please consult your doctor.

Drug-Drug Interactions Checker List

  • DORZOLAMIDE
  • ACETAZOLAMIDE

Special Advise

  • You are recommended to avoid wearing contact lenses while using Brinzagan Ophthalmic Suspension 5 ml as it may cause discoloration of soft contact lenses.
  • Do not use Brinzagan Ophthalmic Suspension 5 ml if you have used any steroid eye injection within six months, undergone any other intraocular surgery (like cataract surgery) within 6 months, or have had any laser surgery within 12 months.

Disease/Condition Glossary

Glaucoma: It is an eye condition that causes damage to the optic nerve (essential for good vision) due to abnormally increased pressure in the eye. If it is not treated in time, it may cause blindness. Usually, there are no symptoms of glaucoma initially except the slow loss of vision gradually. However, some symptoms include visible rainbow-colored circles around bright lights or blurred vision. Rarely, glaucoma can develop suddenly with intense pain in the eye, visual disturbance, or nausea.

Ocular hypertension: It is a condition caused due to poor drainage of aqueous humor (fluid in the eye that maintains normal pressure by its continuous flow). This leads to the build-up of excess fluid in the eye resulting in increased pressure inside the eye without any damage to the optic nerve. If ocular hypertension is not controlled, it may lead to glaucoma.

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