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  3. Bufatas 60 mg Injection 10 ml

Bufatas 60 mg Injection 10 ml, Pack of 1 INJECTION
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Composition :

BUSULFAN-60MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Bufatas 60 mg Injection

Bufatas 60 mg Injection belongs to a group of medicines called cytotoxics (also called chemotherapy). Busulfan is used for certain blood problems and cancers of the blood such as Chronic myeloid leukaemia, Polycythaemia vera, Thrombocythemia, and Myelofibrosis. On the other side, it can be used in bone marrow or stem cell transplant therapy. Blood cancers are cancers that develop in the blood. This can affect the production of blood cells and also how they work.

Bufatas 60 mg Injection contains Busulfan, which works by interfering with the production of blood cell DNA. Thus, it prevents the cells from growing and maturing, which ultimately leads to the death of these cells.

Bufatas 60 mg Injection should be administered to patients only in a hospital setting under the supervision of a physician qualified by training and experience to administer cancer chemotherapeutic agents. The most common adverse reactions that occur while on therapy are feeling or being sick, anaemia, bruising, bleeding gums or nosebleeds, headaches, tummy pain, constipation, diarrhoea, loss of appetite, liver changes, and increased risk of getting an infection, Symptoms include a change in temperature, aching muscles, headaches, feeling cold and shivery and generally unwell. Most of these side effects of Bufatas 60 mg Injection do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.

To treat your condition effectually, continue taking Bufatas 60 mg Injection for as long as your doctor has prescribed. It is expected to cause fetal harm when administered to a pregnant woman, so it should not be used in pregnant women. Both women and men using this Bufatas 60 mg Injection should use birth control to avoid pregnancy. Discontinue nursing while on therapy, considering the importance of the drug to the mother. Caution should be exercised while using Bufatas 60 mg Injection in patients with infections, hepatic, renal, heart dysfunction and or Lower-than-normal levels of blood count, so inform your doctor about all your medical conditions and medications you are currently taking.

Uses of Bufatas 60 mg Injection

Cancers of the blood, such as Chronic myeloid leukaemia, Polycythaemia vera, Thrombocythemia, and Myelofibrosis

Directions for Use

Bufatas 60 mg Injection should be administered to patients only in a hospital setting under the supervision of a physician qualified by training and experience to administer cancer chemotherapeutic agents.

Medicinal Benefits

Bufatas 60 mg Injection contains Busulfan, which belongs to a group of medicines called cytotoxics (also called chemotherapy). It works by interfering with the production of blood cell DNA. Thus, it prevents the cells from growing and maturing, which ultimately leads to the death of these cells. Thereby, it treats certain blood problems and cancers of the blood, such as Chronic myeloid leukaemia, Polycythaemia vera, Thrombocythemia, and Myelofibrosis.

Storage

Keep Bufatas 60 mg Injection out of reach and sight of children.
Side effects of Bufatas 60 mg Injection 10 ml
  • Eat well-cooked food to minimize infection risk.
  • Practice good hand hygiene to prevent infections.
  • Avoid crowds and people with illnesses to reduce exposure.
  • Wear a mask when necessary to lower infection risk.
  • Rest adequately to support your body's healing process.
  • Stay hydrated by drinking plenty of water.
  • Regularly monitor blood cell counts for changes.
  • Seek immediate medical help if symptoms like fever, chills, or fatigue occur.
  • Consult your doctor right away if concerning symptoms arise.
  • Follow your doctor's guidance on managing myelosuppression and infection prevention.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Maintaining adequate hydration will help you control your magnesium levels and improve your general health.
  • Maintain a diet high in magnesium-rich foods such as spinach, almonds, chickpeas and brown rice.
  • Limit your alcohol intake because too much of it lowers your magnesium levels.
  • Plan blood testing on a regular basis to monitor magnesium levels.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.

Drug Warnings

Before taking the Bufatas 60 mg Injection, let your doctor know about all your allergic or hypersensitivity reactions to medicines or food. Before taking Bufatas 60 mg Injection, inform your doctor about your medical history and other medications you are currently taking in order to rule out any potential negative effects. Bufatas 60 mg Injection may cause fertility problems in women if they take it. Please discuss this with their doctor before starting treatment. Women of childbearing age should use effective contraception during and up to 3 months after treatment with Bufatas 60 mg Injection. Avoid the consumption of alcoholic beverages. Busulfan may raise your chances of developing other types of cancer. Discuss the risks of receiving busulfan with your doctor. It is recommended not to take you. You have taken Busulfan before, and it did not work.

Drug-Drug Interactions

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BusulfanTofacitinib
Severe
BusulfanAdalimumab
Severe

Drug-Drug Interactions

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BusulfanTofacitinib
Severe
How does the drug interact with Bufatas 60 mg Injection 10 ml:
Coadministration of tofacitinib with Bufatas 60 mg Injection 10 ml may increase the risk of serious infections.

How to manage the interaction:
Taking Bufatas 60 mg Injection 10 ml with Tofacitinib together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, diarrhea, sore throat, muscle aches, shortness of breath, or burning during urination. Do not discontinue any medications without consulting your doctor.
BusulfanAdalimumab
Severe
How does the drug interact with Bufatas 60 mg Injection 10 ml:
Coadministration of Adalimumab with Bufatas 60 mg Injection 10 ml may increase the risk of developing infections.

How to manage the interaction:
Although taking Bufatas 60 mg Injection 10 ml and Adalimumab together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, diarrhea, sore throat, muscle aches, or pain while urinating, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
BusulfanDeferiprone
Severe
How does the drug interact with Bufatas 60 mg Injection 10 ml:
Coadministration of Deferiprone with Bufatas 60 mg Injection 10 ml can increase the risk of developing infections.

How to manage the interaction:
Taking Bufatas 60 mg Injection 10 ml with Deferiprone together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're having any of these symptoms, like fever, chills, sore throat, or muscle aches, contact your doctor immediately. Do not stop using any medications without a doctor's advice.
BusulfanNalidixic acid
Severe
How does the drug interact with Bufatas 60 mg Injection 10 ml:
Coadministration of Bufatas 60 mg Injection 10 ml with Nalidixic acid can increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Bufatas 60 mg Injection 10 ml and Nalidixic acid, you can take these medicines if prescribed by your doctor. Contact your doctor immediately if you notice unusual bruising, stomach discomfort, fever, or weakness. Do not stop using any medications without contacting your doctor.
BusulfanThiotepa
Severe
How does the drug interact with Bufatas 60 mg Injection 10 ml:
Combining Bufatas 60 mg Injection 10 ml with Thiotepa can increase the risk and severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Thiotepa and Bufatas 60 mg Injection 10 ml, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to your doctor.
BusulfanMetronidazole
Severe
How does the drug interact with Bufatas 60 mg Injection 10 ml:
Coadministration of Bufatas 60 mg Injection 10 ml and Metronidazole may increase the risk of side effects.

How to manage the interaction:
Taking Metronidazole and Bufatas 60 mg Injection 10 ml together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience unusual bruising or bleeding, fever, diarrhea, sore throat, muscle aches, shortness of breath, or burning during urination, contact a doctor immediately. Do not discontinue the medication without a doctor's advice.
BusulfanClozapine
Severe
How does the drug interact with Bufatas 60 mg Injection 10 ml:
Coadministration of Bufatas 60 mg Injection 10 ml with Clozapine can increase the risk of developing infection.

How to manage the interaction:
Although there is an interaction between Bufatas 60 mg Injection 10 ml and Clozapine, it can be taken if prescribed by a doctor. However, consult a doctor if you experience fever, diarrhea, sore throat, muscle pain, or pain while urinating, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
BusulfanLeflunomide
Severe
How does the drug interact with Bufatas 60 mg Injection 10 ml:
Coadministration of leflunomide with Bufatas 60 mg Injection 10 ml may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction between Bufatas 60 mg Injection 10 ml and Leflunomide, you can take these medicines together if prescribed by your doctor. However, if you experience fever, diarrhea, sore throat, muscle aches, body sores, or burning during urination, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
BusulfanBaricitinib
Severe
How does the drug interact with Bufatas 60 mg Injection 10 ml:
Coadministration of Baricitinib and Bufatas 60 mg Injection 10 ml can increase the risk of developing infections.

How to manage the interaction:
Although Baricitinib with Bufatas 60 mg Injection 10 ml can lead to an interaction, it can be taken if advised by the doctor. However, if you experience fever, sore throat, shortness of breath, body sores, or burning on urination, consult a doctor. Do not stop using any medications without talking to a doctor.
BusulfanThalidomide
Severe
How does the drug interact with Bufatas 60 mg Injection 10 ml:
Taking thalidomide together with Bufatas 60 mg Injection 10 ml may increase the risk of blood clots.

How to manage the interaction:
Although taking thalidomide and Bufatas 60 mg Injection 10 ml together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Side Effects of Bufatas 60 mg Injection

  • Anaemia

  • Bruising, bleeding gums or nosebleeds

  • Feeling or being sick

  • Headaches

  • Tiredness

  • Dizziness

  • Risk of infection

  • Inflammation of the food pipe

  • Constipation

  • Diarrhoea

  • Loss of appetite

  • Liver changes

  • High levels of substances in the blood

  • Change in temperature

  • Aching muscles

  • Hiccups

  • Headaches

  • Tummy pain

  • Swollen tummy

  • Generally unwell

  • High levels of creatinine in your blood

  • Joint, back or muscle pain

  • Loss of appetite

  • Feeling confused

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Bufatas 60 mg Injection Substitute

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 29, 2025 | 9:18 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Bufatas 60 mg Injection contains Busulfan, which works by interfering with the production of blood cell DNA. Thus, it prevents the cells from growing and maturing, which ultimately leads to the death of these cells.

Suppose you have polycythaemia vera (PV). Busulfan can control your blood count, which helps to reduce the risk of both blood clots and bleeding.

If you have essential thrombocythemia (ET), using busulfan to reduce and control platelet counts minimises the risk of blood clotting, bleeding and developing MF.

It is recommended not to be used in the population who are allergic to Busulfan or any other ingredients in this medication, is a pregnant woman, has too low blood cell counts, or suffers from severe liver or hepatic impairment.

Yes, Bufatas 60 mg Injection can cause a severe decrease in the number of blood cells in your bone marrow. Your doctor will monitor peripheral blood cell counts and adjust the dose as appropriate.

With a high dose of Busulfan, women's periods may stop, fertility may be compromised, and menopause may begin early. Please seek medical advice from your doctor if you have any concerns regarding this.

Drug-Drug Interactions Checker List

  • ADALIMUMAB
  • OZANIMOD
  • BCG VACCINE
  • DENGUE VACCINE
  • INFLUENZA VIRUS VACCINE LIVE
  • CLOZAPINE
  • DEUCRAVACITINIB
  • LEFLUNOMIDE

Special Advise

  • Pregnancy testing is recommended for females of reproductive potential prior to initiating treatment with Bufatas 60 mg Injection.
  • Bufatas 60 mg Injection should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking Bufatas 60 mg Injection.
  • Keep all appointments with your doctor and the laboratory. Your doctor will order laboratory tests before, during and after your treatment to check your body's response to busulfan to see if your blood cells are affected by this drug.
  • Do not donate sperm during treatment with Bufatas 60 mg Injection and for three months after your last dose.

Disease/Condition Glossary

Cancer: Cancer is a condition where cells in a specific body part grow and reproduce uncontrollably. The cancerous cells can invade and destroy surrounding healthy tissue, including organs. Cancer sometimes begins in one body part before spreading to other areas.

Chronic myeloid leukemia (CML) is also known as chronic myelogenous leukemia. It is a type of cancer that begins in the bone marrow's blood-forming cells.

Polycythemia vera is a form of blood cancer (pol-e-sy-THEE-me-uh VEER-uh). It causes your bone marrow to produce an abnormally large number of red blood cells. These extra cells thicken your blood, delaying its flow and even causing major complications like blood clots.

Essential thrombocythemia (ET) is a rare blood condition that causes an abnormally large amount of platelets to develop in the blood. These are blood cells that help with coagulation. Clotting is referred to as thrombosis, and blood cells are referred to as cythaemia.

Myelofibrosis (MF) is a rare type of blood cancer characterized by the formation of scar tissue, known as 'fibrosis,' in the bone marrow. As scar tissue grows, the bone marrow is unable to produce enough healthy blood cells.

Have a query?

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Alcohol

Caution

Avoid alcohol consumption while on treatment with Bufatas 60 mg Injection.

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Pregnancy

Unsafe

Bufatas 60 mg Injection should not be used during pregnancy because it can harm your fetus (newborn baby).

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Breast Feeding

Caution

Do not breastfeed during this treatment because the medicine may pass into your milk. Doctors normally advise against breastfeeding throughout this treatment and for a certain period of time after the final medication is taken.

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Driving

Caution

Bufatas 60 mg Injection may make you feel dizzy or tired. Do not drive or use machines if you feel tired or dizzy.

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Liver

Caution

This treatment may affect how your liver works. Please inform your doctor before prescribing Bufatas 60 mg Injection if you have liver impairment. Your doctor will weigh the benefits and potential risks before prescribing Bufatas 60 mg Injection.

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Kidney

Caution

This treatment may affect how your kidneys work. Please inform your doctor before prescribing Bufatas 60 mg Injection if you have kidney impairment. Your doctor will weigh the benefits and potential risks before prescribing Bufatas 60 mg Injection.

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Children

Caution

Talk to your care team about the use of this medication in children. Special care may be needed.

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Heart

Caution

Bufatas 60 mg Injection should be used with caution in patients with a history of heart disease. Inform your doctor if you have heart problems before receiving Bufatas 60 mg Injection.

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Geriatrics

Consult your doctor

Limited information is available. Please consult your doctor.

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