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Written By Urvashi Bharti , MBBS
Reviewed By Sunny S , MBBS
Non returnable*
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Composition :

BUPRENORPHINE-0.3MG

Manufacturer/Marketer :

Neon Laboratories Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Buprigesic Injection 2 ml

Buprigesic Injection 2 ml belongs to a class of drugs called 'opioid analgesic' primarily used to treat opioid addiction (narcotics) like morphine, heroin, etc. In some cases, it is also used to treat, prevent and treat moderate to severe pain. Drug addiction, also called substance use disorder, is a disease that affects a person's brain and behaviour and leads to an inability to control the use of a legal or illegal drug or medication.

Buprigesic Injection 2 ml contains 'Buprenorphine', an opioid partial agonist-antagonists that prevent withdrawal symptoms in patients who stop receiving opioid drugs by producing similar effects to these drugs. It has been approved for the treatment of narcotic-use disorders. A combination of buprenorphine and naloxone is prescribed for use in the treatment of opioid dependence. It also provides pain relief by acting on specific receptors in the brain and helps in relieving pain.

Buprigesic Injection 2 ml will be administered by a trained healthcare professional. Hence, do not self-administer. This medicine may cause certain side effects such as dry mouth, vomiting, blurred vision, constipation, dizziness, tiredness and injection site reactions. Most of these side effects of Buprigesic Injection 2 ml do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Buprigesic Injection 2 ml should be avoided if you are allergic to it. Do not use Buprigesic Injection 2 ml if you are pregnant or breastfeeding, as it may cause adverse effects on the baby. This medicine is not recommended for children below 18 years of age. Buprigesic Injection 2 ml is a habit-forming drug, and there is a risk of dependence on Buprigesic Injection 2 ml. Hence, do not stop receiving Buprigesic Injection 2 ml without consulting a doctor as it may cause withdrawal symptoms like anxiety, increased heart rate, tremors or general unwell feeling. Buprigesic Injection 2 ml may decrease fertility in men and women. Do not consume alcohol with Buprigesic Injection 2 ml as it may increase the risk of side effects. Inform your doctor if you have respiratory disorders, heart diseases, high blood pressure, and liver or kidney disease before starting treatment with Buprigesic Injection 2 ml.

Uses of Buprigesic Injection 2 ml

Opioid (drug) addiction, Pain

Directions for Use

Buprigesic Injection 2 ml will be administered by a trained healthcare professional. Do not self-administer.

Medicinal Benefits

The Buprigesic Injection 2 ml contains Buprenorphine as a substitution (replacement) treatment in patients addicted to opioid drugs (heroin and morphine, etc.). It prevents or reduces the unpleasant withdrawal symptoms experienced when addicts stop using opioid drugs. It also provides pain relief by acting on specific receptors in the brain and helps in relieving pain. Compared to other opioid analgesics like methadone, Buprigesic Injection 2 ml has the advantage of having less sedation (sleepiness), decreased respiratory depression, decreased risk of diversion, fewer withdrawal symptoms and lower risk of toxicity at higher doses. 

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Please do not stop receiving Buprigesic Injection 2 ml suddenly, as it may cause withdrawal symptoms. Avoid frequent or high doses as it may lead to addiction. If you are known to be allergic to Buprigesic Injection 2 ml or any other medicines, please tell your doctor.  Do not use Buprigesic Injection 2 ml if you are pregnant or breastfeeding, as it may cause adverse effects on the baby. Buprigesic Injection 2 ml is not recommended for children below 18 years of age.  Avoid consuming alcohol with Buprigesic Injection 2 ml as it may increase the risk of side effects. Do not use this medicine if you have used an MAO inhibitor (antidepressants) in the past 14 days, as a dangerous drug interaction could occur. Buprigesic Injection 2 ml should be used with extreme caution in patients who have a history of alcoholism or drug abuse. Inform your doctor if you have severe breathing problems, asthma, delirium tremens (confusion and shaking after stopping drinking alcohol), hallucinations (seeing and hearing things that are not there), kidney or liver problems, head injury or brain disease, low blood pressure, urinary disorders (especially linked to enlarged prostate), thyroid problems, adrenocortical disorder (Addison’s disease), depression or other conditions that are treated with antidepressants. 

Drug-Drug Interactions

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BuprenorphineAlvimopan
Critical

Drug-Drug Interactions

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BuprenorphineAlvimopan
Critical
How does the drug interact with Buprigesic Injection 2 ml:
Using alvimopan together with Buprigesic Injection 2 ml can cause side effects (abdominal pain, nausea, vomiting, and diarrhea).

How to manage the interaction:
Taking Alvimopan with Buprigesic Injection 2 ml is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Buprigesic Injection 2 ml:
Taking Ziprasidone with Buprigesic Injection 2 ml can increase the risk of serious side effects.

How to manage the interaction:
Taking Ziprasidone with Buprigesic Injection 2 ml is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, drowsiness, difficulty concentrating, and impairment in judgment. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Buprigesic Injection 2 ml:
Coadministration of Cyclobenzaprine with Buprigesic Injection 2 ml can increase the risk of developing side effects.

How to manage the interaction:
Coadministration of Buprigesic Injection 2 ml with cyclobenzaprine can result in an interaction, it can be taken if a doctor has advised it. Contact a doctor if you experience shortness of breath, chest discomfort, or palpitations. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Buprigesic Injection 2 ml:
Taking Buprigesic Injection 2 ml with mifepristone increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Buprigesic Injection 2 ml with mifepristone together is avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, weakness, tiredness, drowsiness, confusion, painful muscle cramping, nausea, or vomiting, constipation, abdominal cramping, chest pain, and/or swelling in the legs or feet, get medical attention. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Buprigesic Injection 2 ml:
Using ketamine together with Buprigesic Injection 2 ml may increase side effects.

How to manage the interaction:
Although taking Ketamine and Buprigesic Injection 2 ml together can cause an interaction, it can be taken if a doctor has suggested it. Keep an eye on your brain and breathing. If you notice any of these signs - feeling dizzy, sleepy, confused, having trouble focusing, feeling too relaxed, or having trouble breathing - reach out to a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Buprigesic Injection 2 ml:
Coadministration of Buprigesic Injection 2 ml with tranylcypromine may increase the risk of significant adverse effects such as respiratory depression(breathing problems), low blood pressure, fainting, unconsciousness

How to manage the interaction:
Concomitant administration of Buprigesic Injection 2 ml alongside tranylcypromine can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
BuprenorphineChloral hydrate
Severe
How does the drug interact with Buprigesic Injection 2 ml:
Using Buprigesic Injection 2 ml together with Chloral hydrate can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Co-administration of Buprigesic Injection 2 ml with Chloral hydrate can result in an interaction, but it can be taken if a doctor has advised it. It's important to keep an eye on your health and be aware of any changes. Doctor can recommend other options that won't cause any problems. If you experience trouble breathing, feeling too sleepy, or having difficulty with your nervous system - make sure to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Buprigesic Injection 2 ml:
When Buprigesic Injection 2 ml is used with topiramate, it may lead to significant adverse effects such as respiratory difficulties, unconsciousness.

How to manage the interaction:
Concomitant administration of Buprigesic Injection 2 ml alongside topiramate can result in an interaction, it can be taken if a doctor has advised it. Do not exceed the doses, frequency, or duration of usage advised by a doctor. You should avoid driving or operating hazardous machinery until you're aware of how these medications effect you. Consult a doctor if you have any questions or concerns. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Buprigesic Injection 2 ml:
Using Buprigesic Injection 2 ml together with Zonisamide may cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Concomitant administration of Buprigesic Injection 2 ml alongside Zonisamide can result in an interaction, it can be taken if a doctor has advised it. Do not exceed the doses, frequency, or duration of usage advised by a doctor. You should avoid driving or operating hazardous machinery until you're aware of how these medications affect you. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Buprigesic Injection 2 ml:
Coadministration of Buprigesic Injection 2 ml with primidone can increase the risk or severity of side effects such as breathing problems.

How to manage the interaction:
Although there is an interaction between Buprigesic Injection 2 ml and primidone, it can be taken if your doctor has advised it. However, if you experience abdominal cramping, loss of appetite, nausea, vomiting, diarrhea, weight loss, excessive sweating, goose bumps, fever, chills, watery eyes, runny nose, sneezing, or yawning, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Do regular exercise such as swimming or walking.
  • Drink plenty of water while on treatment with Buprigesic Injection 2 ml to avoid dry mouth.
  • Maintain a fibre-rich diet and eat plenty of fresh fruits and vegetables to avoid constipation while receiving Buprigesic Injection 2 ml.
  • Avoid consumption of alcohol and quit smoking.

Habit Forming

Yes

Therapeutic Class

OPIOID ANTAGONISTS

Buprigesic Injection 2 ml Substitute

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  • Buprigesic Injection 1 ml

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    27.00per tablet

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

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FAQs

Buprigesic Injection 2 ml consists of Buprenorphine is an opioid partial agonist. It prevents withdrawal symptoms in patients who stop receiving opioid drugs by producing similar effects to these drugs. It also provides pain relief by acting on specific receptors in the brain that change how your body feels and responds to pain.

Yes, Buprigesic Injection 2 ml may cause withdrawal symptoms such as sweating, feeling hot and cold, runny eyes and nose, feeling or being sick, diarrhoea, stomach cramps, poor sleep, and just feeling awful. Therefore, if you experience any difficulty while receiving Buprigesic Injection 2 ml, do not stop administration suddenly and consult your doctor so that the dose may be reduced gradually to avoid withdrawal symptoms.

Chronic use of opioids may cause reduced fertility (ability to have children) in females and males of reproductive potential. It is not known whether these effects on fertility are reversible. However, it is essential to talk to your doctor before starting treatment with Buprigesic Injection 2 ml if you think you may want to have a baby in the future.

No, you are not recommended to use Buprigesic Injection 2 ml with antidepressants (medicines used to treat depression), and antipsychotics (medicines used to treat bipolar disorder and psychosis) as co-administration of these medicines with Buprigesic Injection 2 ml may cause life-threatening respiratory depression and death have occurred. However, please consult a doctor before receiving Buprigesic Injection 2 ml with other medicines.

Yes, Buprigesic Injection 2 ml may cause addiction, especially if used for a prolonged time. Therefore, Buprigesic Injection 2 ml should be given only for a short duration under strict medical supervision, particularly to patients susceptible to drug abuse. Buprigesic Injection 2 ml should be administered only as advised by a doctor as overuse, or misuse of Buprigesic Injection 2 ml can lead to overdose or death.

Drug-Drug Interactions Checker List

  • DIAZEPAM
  • TEMAZEPAM
  • PENTAZOCIN
  • CODEINE
  • DIHYDROCODEINE
  • METHADONE
  • MORPHINE
  • MOCLOBEMIDE
  • TRANYLCYPROMINE
  • CITALOPRAM
  • ESCITALOPRAM
  • FLUOXETINE
  • FLUVOXAMINE
  • PAROXETINE
  • SERTRALINE
  • DULOXETINE
  • VENLAFAXINE
  • AMITRIPTYLINE
  • DOXEPIN
  • TRIMIPRAMINE
  • PROMETHAZINE
  • CHLORPHENIRAMINE
  • WARFARIN
  • ALPRAZOLAM
  • CARBAMAZEPINE
  • ONDANSETRON
  • KETOCONAZOLE
  • CIPROFLOXACIN
  • ERYTHROMYCIN
  • CERITINIB
  • LAPATINIB
  • FINGOLIMOD
  • DROPERIDOL
  • SAQUINAVIR

Special Advise

  • Do not receive Buprigesic Injection 2 ml for a prolonged time, as it may lead to mental or physical dependence on Buprigesic Injection 2 ml.
  • To avoid getting addicted to this drug, use it only in prescribed quantities and as directed by your doctor. Do not self-medicate.
  • Buprigesic Injection 2 ml causes drowsiness. Avoid doing activities that require your complete focus and attention, like driving when on this drug.
  • An abrupt stoppage of Buprigesic Injection 2 ml can lead to significant withdrawal symptoms. Always discuss with your doctor about decreasing the dosage before completely stopping its usage.
  • Avoid consuming alcohol while on this medication, as it can lead to dangerous side effects.

Disease/Condition Glossary

Drug addiction: It is also called substance use disorder. It is a psychological condition that affects a person's brain and behaviour and leads to an inability to control legal or illegal drug or medication use. Opioid analgesics, such as morphine or diamorphine (heroin), are often subject to abuse, leading to dependence (addiction). If you are addicted to these drugs, you need a regular dose to feel ‘normal’. Otherwise, you will develop withdrawal symptoms within a day or so of the last dose. Withdrawal symptoms include sweating, feeling hot and cold, runny eyes and nose, feeling or being sick, diarrhoea, stomach cramps, poor sleep, and just feeling awful.

Pain: Pain is an unpleasant emotion brought on by an illness or injury. Acute (short-term) or chronic pain both exist (long-term). It may be widespread (body-wide aches) or localised (pain in a specific body area). Since different people have varying pain tolerance levels, pain is highly subjective. Even though pain is uncomfortable and inconvenient, it can provide clues as to what is wrong with the body. Cramps, headaches, bone fractures, stomach pain, arthritis (swelling of one or more joints), muscle strain or overuse, cuts, the flu, fibromyalgia, and irritable bowel syndrome are a few conditions that can cause pain (muscle pain with stiffness and tenderness).

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