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  3. Busuphan 2mg Tablet

Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
COD available

Online payment accepted

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Composition :

BUSULFAN-2MG

Manufacturer/Marketer :

Elder Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Busuphan 2mg Tablet

Busuphan 2mg Tablet belongs to a group of medicines called cytotoxics (also called chemotherapy). Busulfan is used for certain blood problems and cancers of the blood such as Chronic myeloid leukaemia, Polycythaemia vera, Thrombocythemia, and Myelofibrosis. On the other side, it can be used in bone marrow or stem cell transplant therapy. Blood cancers are cancers that develop in the blood. This can affect the production of blood cells and also how they work.

Busuphan 2mg Tablet contains Busulfan, which works by interfering with the production of blood cell DNA. Thus, it prevents the cells from growing and maturing, which ultimately leads to the death of these cells.

Busuphan 2mg Tablet is a prescription-only medicine. Take Busuphan 2mg Tablet as prescribed. The most common adverse reactions that occur while on therapy are feeling or being sick, anaemia, bruising, bleeding gums or nosebleeds, headaches, tummy pain, constipation, diarrhoea, loss of appetite, liver changes, and increased risk of getting an infection, Symptoms include a change in temperature, aching muscles, headaches, feeling cold and shivery and generally unwell. Most of these side effects of Busuphan 2mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.

To treat your condition effectually, continue taking Busuphan 2mg Tablet for as long as your doctor has prescribed. It is expected to cause fetal harm when administered to a pregnant woman, so it should not be used in pregnant women. Both women and men using this Busuphan 2mg Tablet should use birth control to avoid pregnancy. Discontinue nursing while on therapy, considering the importance of the drug to the mother. Caution should be exercised while using Busuphan 2mg Tablet in patients with infections, hepatic, renal, heart dysfunction and or Lower-than-normal levels of blood count, so inform your doctor about all your medical conditions and medications you are currently taking.

Uses of Busuphan 2mg Tablet

Cancers of the blood, such as Chronic myeloid leukaemia, Polycythaemia vera, Thrombocythemia, and Myelofibrosis

Directions for Use

Take Busuphan 2mg Tablet as directed by the physician. Swallow it as a whole with a glass of water. Do not crush, chew or break it.

Medicinal Benefits

Busuphan 2mg Tablet contains Busulfan, which belongs to a group of medicines called cytotoxics (also called chemotherapy). It works by interfering with the production of blood cell DNA. Thus, it prevents the cells from growing and maturing, which ultimately leads to the death of these cells. Thereby, it treats certain blood problems and cancers of the blood, such as Chronic myeloid leukaemia, Polycythaemia vera, Thrombocythemia, and Myelofibrosis.

Storage

Store in a cool and dry place away from sunlight
Side effects of Busuphan 2mg Tablet
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • High levels of bilirubin in blood leads to yellow discolouration of skin and eyes which is a significant liver issue that needs immediate medical attention.
  • Eating a balanced diet can help manage such side effects and must be taken as a dietician suggests.
  • Exercise regularly to maintain a good metabolism in your body.
  • Avoid alcohol consumption as it can affect liver functioning and worsen if there is a yellow discolouration of the skin and eyes.
  • Prevent toxins from chemicals that can be touched and inhaled. Ensure to manage your medications carefully.
  • Maintain a healthy diet with fruits, whole grains, and vegetables.
  • Include easy-to-digest and antioxidant-rich food in your diet.
  • Drink plenty of water and unsweetened liquids.
  • Limit sugary foods, alcohol, refined carbs and fried foods.

Drug Warnings

Before taking the Busuphan 2mg Tablet, inform your doctor about all your allergic or hypersensitivity reactions to medicines or food. Before taking Busuphan 2mg Tablet, tell your doctor about your medical history and other medications you are currently taking to rule out any potential negative effects. Busuphan 2mg Tablet may cause fertility problems in women if they take it. Please discuss this with their doctor before starting treatment. Women of childbearing age should use effective contraception during and up to 3 months after treatment with Busuphan 2mg Tablet. Avoid the consumption of alcoholic beverages. Busulfan may raise your chances of developing other types of cancer. Discuss the risks of receiving Busulfan with your doctor. It is recommended not to take you. You have taken Busulfan before, and it did not work.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Busuphan 2mg Tablet:
Coadministration of Busuphan 2mg Tablet and Infliximab can increase the risk or severity of developing infections.

How to manage the interaction:
Although taking Busuphan 2mg Tablet and Infliximab together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, or burning while peeing contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Busuphan 2mg Tablet:
Co-administration of Cyclophosphamide with Busuphan 2mg Tablet can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Busuphan 2mg Tablet and Cyclophosphamide, they can be taken together if prescribed by a doctor. However, if you experience any vomiting, diarrhea, mouth sores, or stomach pain, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
How does the drug interact with Busuphan 2mg Tablet:
Coadministration of leflunomide with Busuphan 2mg Tablet may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction between Busuphan 2mg Tablet and Leflunomide, you can take these medicines together if prescribed by your doctor. However, if you experience fever, diarrhea, sore throat, muscle aches, body sores, or burning during urination, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
How does the drug interact with Busuphan 2mg Tablet:
Combining Cladribine with Busuphan 2mg Tablet can increase the risk of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Cladribine and Busuphan 2mg Tablet, but it can be taken if prescribed by a doctor. However, consult a doctor if you experience fever, diarrhea, sore throat, muscle aches, and pain or burning urination. Do not stop using any medications without talking to your doctor.
How does the drug interact with Busuphan 2mg Tablet:
Coadministration of Busuphan 2mg Tablet with Nalidixic acid can increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Busuphan 2mg Tablet and Nalidixic acid, you can take these medicines if prescribed by your doctor. Contact your doctor immediately if you notice unusual bruising, stomach discomfort, fever, or weakness. Do not stop using any medications without contacting your doctor.
How does the drug interact with Busuphan 2mg Tablet:
Taking thalidomide together with Busuphan 2mg Tablet may increase the risk of blood clots.

How to manage the interaction:
Although taking thalidomide and Busuphan 2mg Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Busuphan 2mg Tablet:
Coadministration of Adalimumab with Busuphan 2mg Tablet may increase the risk of developing infections.

How to manage the interaction:
Although taking Busuphan 2mg Tablet and Adalimumab together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, diarrhea, sore throat, muscle aches, or pain while urinating, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Busuphan 2mg Tablet:
Coadministration of Filgrastim with Busuphan 2mg Tablet can reduce the effects of Filgrastim.

How to manage the interaction:
Although there is a possible interaction between Filgrastim and Busuphan 2mg Tablet, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without talking to your doctor.
How does the drug interact with Busuphan 2mg Tablet:
Taking these two medications may raise the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Busuphan 2mg Tablet and Natalizumab, you can take these medicines together if prescribed by your doctor. It is important to be aware of any symptoms such as infections, neurological problems, fever, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, weakness on one side of the body, clumsiness, vision problems, or confusion. If you experience any of these symptoms, contact your doctor right away. Do not stop using any medications without talking to your doctor.
How does the drug interact with Busuphan 2mg Tablet:
Combining Busuphan 2mg Tablet with Thiotepa can increase the risk and severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Thiotepa and Busuphan 2mg Tablet, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast, fried, processed meats, refined carbs, and added sugars.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Drug-Drug Interactions Checker List

  • ADALIMUMAB
  • OZANIMOD
  • BCG VACCINE
  • DENGUE VACCINE
  • INFLUENZA VIRUS VACCINE LIVE
  • CLOZAPINE
  • DEUCRAVACITINIB
  • LEFLUNOMIDE

Special Advise

  • Pregnancy testing is recommended for females of reproductive potential before initiating treatment with Busuphan 2mg Tablet.
  • Busuphan 2mg Tablet should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking Busuphan 2mg Tablet.
  • Keep all appointments with your doctor and the laboratory. Your doctor will order laboratory tests before, during and after your treatment to check your body's response to busulfan to see if your blood cells are affected by this drug.
  • Do not donate sperm during treatment with Busuphan 2mg Tablet for three months after your last dose.

Disease/Condition Glossary

Cancer: Cancer is a condition where cells in a specific body part grow and reproduce uncontrollably. The cancerous cells can invade and destroy surrounding healthy tissue, including organs. Cancer sometimes begins in one body part before spreading to other areas.

Chronic myeloid leukemia (CML) is also known as chronic myelogenous leukemia. It is a type of cancer that begins in the bone marrow's blood-forming cells.

Polycythemia vera is a form of blood cancer (pol-e-sy-THEE-me-uh VEER-uh). It causes your bone marrow to produce an abnormally large number of red blood cells. These extra cells thicken your blood, delaying its flow and even causing major complications like blood clots.

Essential thrombocythemia (ET) is a rare blood condition that causes an abnormally large amount of platelets to develop in the blood. These are blood cells that help with coagulation. Clotting is referred to as thrombosis, and blood cells are referred to as cythaemia.

Myelofibrosis (MF) is a rare type of blood cancer characterized by the formation of scar tissue, known as 'fibrosis,' in the bone marrow. As scar tissue grows, the bone marrow is unable to produce enough healthy blood cells.

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