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Written By Urvashi Bharti , MBBS
Reviewed By Sunny S , MBBS
Non returnable*
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Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About Cilamin-250 Capsule 10's

Cilamin-250 Capsule 10's belongs to the group of medicines called ‘chelating agents’ used to treat severe rheumatoid arthritis, Wilsons disease, and cystinuria. Rheumatoid arthritis is a joint disorder in which our immune system attacks our body cells. Wilson disease is a genetic problem characterized by excess copper deposited in body parts like the eye, brain, and liver leading to metal toxicity. Cystinuria is the excess build-up of an amino acid called cystine in the urinary bladder and kidney, leading to harmful effects. 

Cilamin-250 Capsule 10's contains Penicillamine which works by blocking the action of certain chemical messengers responsible for inflammation and slows the progress of the condition with certain joint diseases. It works in Wilson's disease by binding to the extra copper in the body and causing it to leave the body through the urine. Decreasing copper levels improves liver function, and mental, mood, and nerve problems (like confusion, and difficulty speaking or walking) caused due to Wilson's disease. Besides this, Cilamin-250 Capsule 10's is also used to treat cystinuria (kidney and bladder stone) and lead poisoning.

Take Cilamin-250 Capsule 10's exactly as prescribed by your doctor. You are advised to take Cilamin-250 Capsule 10's for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side effects such as protein in the urine, low blood platelets, stomach upset or throwing up, diarrhoea, change in taste, loss of appetite,  mouth irritation, and mouth sores. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Cilamin-250 Capsule 10's for as long as your doctor has prescribed. To avoid recurring symptoms, do not stop it midway. Do not take Cilamin-250 Capsule 10's if you are pregnant or planning for pregnancy as Cilamin-250 Capsule 10's causes serious congenital disabilities. Cilamin-250 Capsule 10's should not be taken by breastfeeding mothers as it passes into breast milk. Your doctor may advise you to undergo regular blood tests, and kidney and liver tests to monitor your condition. Inform your doctor about your health condition and medicines to rule out any unpleasant side effects.

Uses of Cilamin-250 Capsule 10's

Rheumatoid arthritis, Wilson's disease, Cystinuria, Lead poisoning

Directions for Use

Take Cilamin-250 Capsule 10's as advised by the doctor. Swallow it as a whole with a glass of water; do not break, or chew it.

Medicinal Benefits

Cilamin-250 Capsule 10's contains Penicillamine primarily used to treat Wilson's disease (copper builds up in the body and may result in serious symptoms) and cystinuria (kidney stones). It is also used in combination with other treatments to treat severe rheumatoid arthritis. The treatment of rheumatoid arthritis Cilamin-250 Capsule 10's reduces pain, inflammation, and slow joint damage and disease progression over time; hence Cilamin-250 Capsule 10's is known as a disease-modifying anti-rheumatic drug (DMARD). In Wilson's disease, Cilamin-250 Capsule 10's works by binding to the extra copper in the body and causing it to leave the body through the urine. Decreasing copper levels improves liver function and the mental, mood, and nerve problems (such as confusion, and difficulty speaking/walking) caused by Wilson's disease. In cystinuria, it helps decrease the amount of a certain substance (cystine) by binding to that substance which can cause kidney stones and prevent it from building up and forming stones. Besides this, Cilamin-250 Capsule 10's is also used to treat lead poisoning.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Cilamin-250 Capsule 10's

  • Protein in urine
  • Low blood platelets
  • Stomach upset 
  • Diarrhoea
  • Change in taste
  • Loss of appetite
  • Mouth irritation
  • Mouth sores

Drug Warnings

Do not take Cilamin-250 Capsule 10's if you are allergic (hypersensitive) to penicillamine or any of the other ingredients in it. Inform your doctor if you have severe kidney problems, lupus erythematosus (an auto-immune disorder), agranulocytosis (a low white cell blood count), aplastic anaemia (symptoms including feeling tired, breathless, having pale skin and more susceptible to infection) or thrombocytopenia (a blood disorder which causes bleeding into your skin, bruising and bleeding more than normal). Do not take Cilamin-250 Capsule 10's if you are pregnant or planning to get pregnant and breastfeeding. This medicine may cause harm to the unborn baby if you take it while you are pregnant. Caution should be required while taking Cilamin-250 Capsule 10's by elderly patients as they may be at greater risk of suffering side effects if you are taking Cilamin-250 Capsule 10's over a long time, especially if you are on a restricted diet, as this medicine increases the requirement for pyridoxine (Vitamin B6) so your doctor may also prescribe this vitamin for you. If you are taking iron tablets, antacids, or digoxin (used to treat heart failure), please maintain two hours gap between these tablets and Cilamin-250 Capsule 10's. Low blood cell counts have happened while taking Cilamin-250 Capsule 10's. If blood cell counts get very low, this can lead to bleeding problems, infections, or anaemia, and sometimes, these have been deadly. 

Drug-Drug Interactions

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PenicillamineIodamide
Severe
PenicillamineIoversol
Severe

Drug-Drug Interactions

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PenicillamineIodamide
Severe
How does the drug interact with Cilamin-250 Capsule:
Using iodamide together with Cilamin-250 Capsule can cause an increased risk of kidney problems.

How to manage the interaction:
Although there is a drug interaction between Cilamin-250 Capsule and iodamide, they can be taken together if advised by the doctor. If you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm consult your doctor immediately. Do not discontinue medications without consulting a doctor.
PenicillamineIoversol
Severe
How does the drug interact with Cilamin-250 Capsule:
Using ioversol together with Cilamin-250 Capsule can cause an increased risk of kidney problems.

How to manage the interaction:
Although there is a drug interaction between Cilamin-250 Capsule and ioversol, they can be taken together if advised by the doctor. If you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm consult your doctor immediately. Do not discontinue medications without consulting a doctor.
PenicillamineTenofovir alafenamide
Severe
How does the drug interact with Cilamin-250 Capsule:
Taking Cilamin-250 Capsule and tenofovir alafenamide can increase the risk of kidney problems.

How to manage the interaction:
Taking Cilamin-250 Capsule and Tenofovir alafenamide together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
PenicillamineMetrizamide
Severe
How does the drug interact with Cilamin-250 Capsule:
Taking Cilamin-250 Capsule together with metrizamide can cause severe kidney problems.

How to manage the interaction:
Although taking Cilamin-250 Capsule and Metrizamide together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
PenicillamineLeflunomide
Severe
How does the drug interact with Cilamin-250 Capsule:
Using Cilamin-250 Capsule with leflunomide can increase the risk of low blood levels.

How to manage the interaction:
There may be a possibility of interaction between Leflunomide and Cilamin-250 Capsule, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
PenicillamineCladribine
Severe
How does the drug interact with Cilamin-250 Capsule:
Taking cladribine with Cilamin-250 Capsule can increase the risk of developing serious infections.

How to manage the interaction:
Taking Cladribine with Cilamin-250 Capsule together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
PenicillamineClozapine
Severe
How does the drug interact with Cilamin-250 Capsule:
Taking Cilamin-250 Capsule with Clozapine can increase the risk of low blood levels.

How to manage the interaction:
Taking Cilamin-250 Capsule with Clozapine together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
PenicillamineSodium aurothiomalate
Severe
How does the drug interact with Cilamin-250 Capsule:
Using Cilamin-250 Capsule together with sodium aurothiomalate can increase the severity of adverse effects of Cilamin-250 Capsule.

How to manage the interaction:
There may be a possibility of interaction between Sodium aurothiomalate and Cilamin-250 Capsule, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without talking to your doctor.
PenicillamineTenofovir disoproxil
Severe
How does the drug interact with Cilamin-250 Capsule:
Coadministration of Tenofovir disoproxil with Cilamin-250 Capsule can increase the risk of developing kidney problems.

How to manage the interaction:
Taking Tenofovir disoproxil with Cilamin-250 Capsule can possibly result in an interaction, it can be taken when your doctor has advised it. However, if you experience vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, shortness of breath, muscle cramps, dizziness, and irregular heart rhythm contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
PenicillamineDeferiprone
Severe
How does the drug interact with Cilamin-250 Capsule:
Deferiprone when taken with Cilamin-250 Capsule can cause an increased risk of low blood levels.

How to manage the interaction:
Co-administration of Cilamin-250 Capsule with Deferiprone can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination contact your doctor immediately. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
  • Follow heat or cold therapy, apply a cold or hot compress on the joints for 15-20minutes regularly.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listen to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Drink plenty of fluids.
  • Limit consumption of spinach, wheat bran, nuts, beets and dairy products.
  • Avoid high salt intake and foods containing baking soda.
  • Follow work safety regulations if you are at risk of occupational exposure. Wear necessary protective gear while working and do not take any contaminated material such as clothing or work gear to home. 
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

CHELATING AGENTS

Cilamin-250 Capsule 10's Substitute

Substitutes safety advice
  • Penicitin Capsule 10's

    by Others

    14.76per tablet
  • Aaramine-250mg Tablet 10's

    by Others

    15.57per tablet
  • ATRMIN 250MG CAPSULE

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    13.68per tablet
  • ARTAMIN 250MG CAPSULE

    by Others

    15.21per tablet

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • GOLD SODIUM THIOMALATE
  • DIGOXIN
  • ALUMINIUM HYDROXIDE
  • IBUPROFEN
  • INDOMETHACIN
  • NAPROXEN
  • OXYPHENBUTAZONE
  • PHENYLBUTAZONE
  • CHLOROQUINE
  • HYDROXYCHLOROQUINE
  • CLOZAPINE
  • LEVODOPA
  • AZATHIOPRINE
  • CYCLOPHOSPHAMIDE
  • MYCOPHENOLATE MOFETIL
  • CYCLOSPORINE
  • ZINC SULFATE
  • CARBONYL IRON
  • HEME IRON POLYPEPTIDE
  • AURANOFIN
  • AUROTHIOGLUCOSE
  • ZINC ACETATE
  • ZINC GLUCONATE

Special Advise

  • Your doctor may advise you to take blood and urine tests while using Cilamin-250 Capsule 10's to examine your health condition and ensure that this medicine treats your condition.
  • People with Wilson disease should avoid using copper-containing foods like shellfish, nuts, chocolate, mushroom, and organ meats. 
  • Avoid using copper containers for drinking, cooking and eating. Ensure running water you drink should be reduced copper level up to the minimum. 
  • If you are using any nutritional supplements or herbal supplements which contains copper tell your doctor about this. Your doctor may suggest any other alternative to this. 

Disease/Condition Glossary

Rheumatoid arthritis: It is an autoimmune disease (the body's immune system attacks its tissue), leading to joint pain and damage. Symptoms of rheumatoid arthritis include pain, inflammation of joints, difficulty moving, and swelling.

Wilson’s disease: It is a rare genetic disorder that causes excess copper in the body. Copper plays an important role in developing healthy nerves, bones, collagen, and the skin pigment melanin. Normally, copper is absorbed from the food; the liver filters out excess copper and releases it through urine. In People with Wilson’s disease, the liver cannot remove the extra copper properly, and the extra copper then builds up in organs such as the brain, liver, and eyes.

Cystinuria: It is the condition in which the amino acid called cystine in the urine, leading to the formation of cystine stones in the kidneys, ureters, and bladder. Cystinuria symptoms are usually sharp pain in the lower back or side of the abdomen (renal colic), blood in the urine (hematuria), obstruction of the urinary tract, and infections of the urinary tract. 

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