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Written By Urvashi Bharti , MBBS
Reviewed By Sureshvarma D , MPharma
Non returnable*
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Composition :

FILGRASTIM-6MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Ciplastim 6 Injection

Ciplastim 6 Injection belongs to the class of medicine called 'hematopoietic agent' used to treat neutropenia, a lack of certain white blood cells caused by cancer, bone marrow transplant, receiving chemotherapy, bacterial infections or other conditions. Neutropenia is a condition in which the number of neutrophils (a type of white blood cell) in the blood is decreased. White blood cells (neutrophils) protect the body from infections. Without enough neutrophils, the body can not fight off bacteria which increases the risk of many types of infections.

Ciplastim 6 Injection contains ' Filgrastim ' that stimulates the bone marrow (the tissue where new blood cells are made) to produce more white blood cells that help fight infection. Ciplastim 6 Injection is used to improve white blood cells during cancer treatment (chemotherapy), bone marrow transplantation, severe chronic neutropenia (low number of a type of white blood cells), neutropenia in patients with HIV infection, and before stem cell donation.

You are advised to take Ciplastim 6 Injection for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as thrombocytopenia (low platelets level), anaemia (low red blood cell), headache, diarrhoea, vomiting, nausea, alopecia (unusual hair loss), tiredness, soreness, swelling of the digestive tract, fever. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Ciplastim 6 Injection for as long as your doctor has prescribed. To avoid recurring symptoms, do not stop it midway. Do not take Ciplastim 6 Injection if you are pregnant or planning for pregnancy. Ciplastim 6 Injection should not be taken by breastfeeding mothers unless prescribed. Ciplastim 6 Injection should be given to children under strict medical supervision. Please tell your doctor before using Ciplastim 6 Injection if you have sickle cell anaemia, as Ciplastim 6 Injection may cause sickle cell crisis and osteoporosis (bone disease). Regular blood tests will be taken to monitor the number of white blood cells in the body. Inform your doctor about your health condition and medicines to rule out unpleasant side effects. Ciplastim 6 Injection is a cold chain medicine, and so it has to be stored in the refrigerator between 2-8 degrees celsius else its efficacy might get lost. Do not store in the freezer or the fridge.

Uses of Ciplastim 6 Injection

Neutropenia (low number of white blood neutropenia cells),  Neutropenia during Chemotherapy,  Neutropenia after Bone marrow transplantation,  Neutropenia in patients with HIV infection,  peripheral blood stem cell mobilisation (to stimulate stem cells to enter the bloodstream to be collected and used in bone marrow transplantation)

Directions for Use

Ciplastim 6 Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Ciplastim 6 Injection contains ‘Filgrastim’ is a white blood cell growth factor. It belongs to a group of proteins called cytokines and is very similar to a natural protein (granulocyte-colony stimulating factor) produced by your body. Ciplastim 6 Injection works by stimulating the bone marrow (the tissue where new blood cells are made) to produce more white blood cells that help fight infection. Ciplastim 6 Injection is used to improve white blood cells during cancer treatment (chemotherapy), bone marrow transplantation, severe chronic neutropenia (low number of a type of white blood cells), neutropenia in patients with HIV infection and before stem cell donation.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Ciplastim 6 Injection if you are allergic to Ciplastim 6 Injection or any of its ingredients it may contain inactive ingredients (such as dry natural rubber/latex in the needle cover on the prefilled syringe), which can cause allergic reactions or other problems. Before starting treatment with Ciplastim 6 Injection , inform your doctor if you have sickle cell anaemia, osteoporosis (bone disease), kidney disease, liver disease, spleen problems, heart problems, and radiation treatment. Ciplastim 6 Injection can cause the spleen to become enlarged, and it could rupture (tear). Inform your doctor right away if you have sudden or severe pain in your left upper stomach spreading up to your shoulder. If you receive chemotherapy or bone marrow transplant, do not use Ciplastim 6 Injection within 24 hours before or 24 hours after you receive chemotherapy or bone marrow transplant.  Do not take Ciplastim 6 Injection if you are pregnant or breastfeeding unless prescribed by the doctor. Ciplastim 6 Injection can be given safely to children only when prescribed. Ciplastim 6 Injection may cause dizziness, so drive only if you are alert. Avoid consuming alcohol along with Ciplastim 6 Injection as it could lead to increased drowsiness. Keep your doctor informed about all the medicines you are taking, including prescription, non-prescription medicines and herbal supplements. 

Drug-Drug Interactions

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FilgrastimBexarotene
Severe
FilgrastimMitomycin
Severe

Drug-Drug Interactions

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FilgrastimBexarotene
Severe
How does the drug interact with Ciplastim 6 Injection 0.6 ml:
Coadministration of Ciplastim 6 Injection 0.6 ml with Bexarotene can alter the effect of Ciplastim 6 Injection 0.6 ml.

How to manage the interaction:
Although there is an interaction between Ciplastim 6 Injection 0.6 ml and bexarotene, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
FilgrastimMitomycin
Severe
How does the drug interact with Ciplastim 6 Injection 0.6 ml:
Using Ciplastim 6 Injection 0.6 ml together with mitomycin reduce the effects of Ciplastim 6 Injection 0.6 ml.

How to manage the interaction:
Co-administration of Ciplastim 6 Injection 0.6 ml with Mitomycin can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
FilgrastimLenalidomide
Severe
How does the drug interact with Ciplastim 6 Injection 0.6 ml:
Using Ciplastim 6 Injection 0.6 ml together with lenalidomide can reduce the effect of Ciplastim 6 Injection 0.6 ml.

How to manage the interaction:
Co-administration of Ciplastim 6 Injection 0.6 ml with Lenalidomide can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
FilgrastimRomidepsin
Severe
How does the drug interact with Ciplastim 6 Injection 0.6 ml:
Coadministration of Ciplastim 6 Injection 0.6 ml with Romidepsin can reduce the effect of Ciplastim 6 Injection 0.6 ml.

How to manage the interaction:
Although there is an interaction between Ciplastim 6 Injection 0.6 ml and Romidepsin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
FilgrastimAzacitidine
Severe
How does the drug interact with Ciplastim 6 Injection 0.6 ml:
Coadministration of Ciplastim 6 Injection 0.6 ml with Azacitidine can reduce the effects of Ciplastim 6 Injection 0.6 ml.

How to manage the interaction:
Although there is an interaction between Ciplastim 6 Injection 0.6 ml and azacitidine, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
FilgrastimBrentuximab
Severe
How does the drug interact with Ciplastim 6 Injection 0.6 ml:
Coadministration of Ciplastim 6 Injection 0.6 ml with Brentuximab can decrease the therapeutic effect of Ciplastim 6 Injection 0.6 ml.

How to manage the interaction:
Although there is an interaction between Ciplastim 6 Injection 0.6 ml and brentuximab, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
FilgrastimBusulfan
Severe
How does the drug interact with Ciplastim 6 Injection 0.6 ml:
Coadministration of Ciplastim 6 Injection 0.6 ml with Busulfan can reduce the effects of Ciplastim 6 Injection 0.6 ml.

How to manage the interaction:
Although there is a possible interaction between Ciplastim 6 Injection 0.6 ml and Busulfan, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without talking to your doctor.
FilgrastimMelphalan
Severe
How does the drug interact with Ciplastim 6 Injection 0.6 ml:
Co-administration of Ciplastim 6 Injection 0.6 ml together with Melphalan can reduce the effect of Ciplastim 6 Injection 0.6 ml.

How to manage the interaction:
Although taking Ciplastim 6 Injection 0.6 ml and Melphalan together can cause an interaction, it can be taken if a doctor has suggested it. Do not discontinue any medications without consulting a doctor.
FilgrastimBleomycin
Severe
How does the drug interact with Ciplastim 6 Injection 0.6 ml:
Combining Ciplastim 6 Injection 0.6 ml with Bleomycin can increase the risk of developing lung disorders.

How to manage the interaction:
There may be a possibility of interaction between Ciplastim 6 Injection 0.6 ml and Bleomycin, it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
FilgrastimImatinib
Severe
How does the drug interact with Ciplastim 6 Injection 0.6 ml:
Taking Ciplastim 6 Injection 0.6 ml together with Imatinib can reduce the effect of Ciplastim 6 Injection 0.6 ml.

How to manage the interaction:
There may be a possibility of interaction between Ciplastim 6 Injection 0.6 ml and Imatinib, but it can be taken if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a well-balanced and healthy diet, as it helps you to recover quickly. A dietitian will help you to create a diet plan based on your health condition. 

  • Avoid eating raw or undercooked food. 

  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes, and green tea.

  • Limit alcohol consumption and quit smoking. 

Habit Forming

No

Therapeutic Class

HEMATOPOIETIC

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Ciplastim 6 Injection contains 'Filgrastim' is a growth factor that stimulates the bone marrow to produce white blood cells. These cells protect the body against infections.

No, Ciplastim 6 Injection is not recommended to patients with spleen disorder. It may cause your spleen to become enlarged, and it could rupture. If you experience pain in the left upper stomach/abdominal area or left shoulder, contact your doctor immediately.

If you are being treated for severe chronic neutropenia for a longer period, Ciplastim 6 Injection may cause blood in your urine (haematuria). Your doctor may regularly test your urine if you experience this side effect or if a protein is found in your urine (proteinuria).

Ciplastim 6 Injection should be used with caution in patients with kidney diseases. Dose adjustments may be necessary. Ciplastim 6 Injection cause breathlessness (dyspnoea), tachycardia & wheeze, and even death. If you have had a history of asthma, the more possibility of these systemic allergic-like reactions. Please inform your doctor.

Ciplastim 6 Injection to be taken with caution, especially if you have had heart problems. The dose may have to be adjusted by your doctor. In some cases, Ciplastim 6 Injection causes inflammation of the aorta (the large blood vessel which transports blood from the heart to the body) symptoms can include fever, abdominal pain, malaise, back pain, and increased inflammatory markers. Tell your doctor if you experience those symptoms. Please inform your doctor before taking Ciplastim 6 Injection .

Yes, Ciplastim 6 Injection may interfere with certain lab tests such as bone imaging and blood tests (elevation in lactate dehydrogenase and alkaline phosphate), possibly causing false test results. Make sure your doctor and laboratory staff know you use Ciplastim 6 Injection .

Drug-Drug Interactions Checker List

  • ALTRETAMINE
  • BUSULFAN
  • CLADRIBINE
  • PROCARBAZINE
  • PEGFILGRASTIM
  • DACARBAZINE
  • GEMTUZUMAB
  • DINUTUXIMAB
  • BEVACIZUMAB
  • ALEMTUZUMAB
  • CARBOPLATIN
  • BENDAMUSTINE

Special Advise

  • Constantly monitors the number of blood cells in your blood, and your bone density level while you are receiving treatment with Ciplastim 6 Injection .

  • Do not take any kind of immunization or vaccination without your doctor's approval while using Ciplastim 6 Injection .

Disease/Condition Glossary

Neutropenia is a condition in which the number of neutrophils (a type of white blood cell) in the blood is decreased. White blood cells (neutrophils) protect the body from infections. Without enough neutrophils, the body can not fight off bacteria which increases the risk of many types of infections. It can be caused by diseases that damage the bone marrow like cancer chemotherapy, HIV or AIDS, infections or deficiencies in vitamins or minerals, such as vitamin B12, folate, or copper, and autoimmune diseases, including Crohn's disease, lupus, and rheumatoid arthritis. Severe chronic neutropenias arise from the failure of the bone marrow to produce adequate numbers of neutrophils that circulate in the blood. It appears that patients with severe chronic neutropenias are at greater risk of developing leukaemia (blood cancer) than are other people.

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