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Written By Veda Maddala , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
COD available

Online payment accepted

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Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Clofranil 25 Tablet

Clofranil 25 Tablet belongs to a class of drugs called 'antidepressant' used to treat obsessive-compulsive disorder (OCD), depression, panic and anxiety disorder. OCD is a mental disorder with symptoms such as excessive thoughts or ideas (obsessions), leading to repetitive behaviours (compulsions). Depression is a mood disorder associated with symptoms such as sadness, unable to sleep properly or enjoy life as you used to do. Panic or anxiety disorder is linked to anxiety with sudden feelings of unnecessary fear or worries even when there is no danger in reality.

Clofranil 25 Tablet contains Clomipramine which works by increasing the activity of serotonin and noradrenaline (chemical messengers) in the brain involved in regulating mood, behaviour and emotions. Thereby, Clofranil 25 Tablet helps relieve depression, lighten the mood and relieve anxiety symptoms such as fear and panic.

Take Clofranil 25 Tablet with food as prescribed by your doctor and swallow whole with a glass of water. Do not break, crush or chew it. Your doctor will advise you how often you take Clofranil 25 Tablet based on your medical condition. Some people may experience dizziness, headache, drowsiness, dry mouth, nausea, weight gain, increased sweating, constipation, shaking, blurred vision, erectile dysfunction or difficulty in urination. Most of these side effects of Clofranil 25 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Clofranil 25 Tablet or any other medicines, please tell your doctor. Clofranil 25 Tablet is not recommended for children below 17 years of age. Avoid taking Clofranil 25 Tablet if you are pregnant as it may cause harm to the foetus. Avoid breastfeeding while taking Clofranil 25 Tablet as it may be excreted in human milk and cause adverse effects in the baby. If you have any self-harming or suicidal thoughts before taking Clofranil 25 Tablet , inform your doctor as they may worsen in the initial days of taking Clofranil 25 Tablet .

Uses of Clofranil 25 Tablet

Obsessive-compulsive disorder (OCD), Depression, Panic disorder, Anxiety disorder

Directions for Use

Take Clofranil 25 Tablet with food or as advised by a doctor. Swallow it as a whole with a glass of water. Do not break, crush or chew it.

Medicinal Benefits

Clofranil 25 Tablet contains Clomipramine, an antidepressant used to treat obsessive-compulsive disorder (OCD), depression, and panic disorder. Clofranil 25 Tablet increases the activity of serotonin and noradrenaline (chemical messengers) in the brain that are involved in regulating mood, behavior, and emotions. Thereby, Clofranil 25 Tablet helps in relieving depression, lighten the mood and relieve anxiety symptoms such as fear and panic. Clofranil 25 Tablet in combination with other medicines may be used to treat cataplexy (a disorder that causes muscle weakness) which usually affects people suffering from narcolepsy (uncontrollable sleepiness during daytime).

Storage

Store in a cool and dry place away from sunlight

Side Effects of Clofranil 25 Tablet

  • Dizziness
  • Headache
  • Drowsiness
  • Dry mouth
  • Nausea
  • Weight gain
  • Increased sweating
  • Constipation
  • Shaking
  • Blurred vision
  • Erectile dysfunction
  • Difficulty in urination

Drug Warnings

If you are allergic to Clofranil 25 Tablet or any other medicines, please tell your doctor. Clofranil 25 Tablet is not recommended for children below 17 years of age. Avoid taking Clofranil 25 Tablet if you are pregnant as it may cause harm to the fetus. Avoid breastfeeding while taking Clofranil 25 Tablet as Clofranil 25 Tablet may be excreted in human milk and cause adverse effects in the baby. Therefore, please consult a doctor if you are pregnant, planning for pregnancy, or breastfeeding. Clofranil 25 Tablet should be used with caution in elderly patients as there is an increased risk of low sodium levels in the blood.  If you have any self-harming or suicidal thoughts before taking Clofranil 25 Tablet , inform your doctor as they may worsen in the initial days of taking Clofranil 25 Tablet . Do not take Clofranil 25 Tablet with monoamine oxidase inhibitors (MAOIs) such as moclobemide, tranylcypromine and phenelzine used to treat depression as it may cause severe adverse effects. Also, avoid taking Clofranil 25 Tablet with buprenorphine as it may cause a serious life-threatening condition. If you have fits, low blood pressure, mania, glaucoma, difficulty in urination, a blood disorder, hyperthyroidism (overactive thyroid gland), severe constipation, pheochromocytoma (tumor of the adrenal gland), low potassium levels in blood, kidney, liver, or heart problems, inform your doctor before taking Clofranil 25 Tablet .

Drug-Drug Interactions

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ClomipramineSparfloxacin
Critical
ClomipramineFurazolidone
Critical

Drug-Drug Interactions

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ClomipramineSparfloxacin
Critical
How does the drug interact with Clofranil 25 Tablet:
When Clofranil 25 Tablet is taken with Sparfloxacin, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
There may be a possibility of interaction between Clofranil 25 Tablet and Sparfloxacin, but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
ClomipramineFurazolidone
Critical
How does the drug interact with Clofranil 25 Tablet:
When Clofranil 25 Tablet is taken with Furazolidone, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
There may be a possibility of interaction between Clofranil 25 Tablet and Furazolidone, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea-call a doctor right away. Do not stop using any medications without a doctor's advice.
ClomipramineTranylcypromine
Critical
How does the drug interact with Clofranil 25 Tablet:
Taking tranylcypromine with Clofranil 25 Tablet can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Clofranil 25 Tablet with Tranylcypromine is not recommended but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination (seeing and hearing things that do not exist), fits, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
ClomipramineDronedarone
Critical
How does the drug interact with Clofranil 25 Tablet:
When Clofranil 25 Tablet is taken with Dronedarone, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
There may be a possibility of interaction between Clofranil 25 Tablet and Dronedarone, but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
ClomipramineThioridazine
Critical
How does the drug interact with Clofranil 25 Tablet:
When Thioridazine is taken with Clofranil 25 Tablet, can increase the side effects.

How to manage the interaction:
There may be a possibility of interaction between Clofranil 25 Tablet and Thioridazine, but it can be taken if prescribed by a doctor. If you notice any of these signs - like extreme drowsiness, confusion, agitation, vomiting, blurred vision, feeling hot or cold, sweating, muscle stiffness, fainting, seizure (convulsions), call a doctor right away. Do not stop using any medications without a doctor's advice.
ClomipramineSelegiline
Critical
How does the drug interact with Clofranil 25 Tablet:
Co-administration of Selegiline can increase the effects of Clofranil 25 Tablet on serotonin levels (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Selegiline with Clofranil 25 Tablet together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as confusion, hallucination, fits, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
ClomipramineMethylene blue
Critical
How does the drug interact with Clofranil 25 Tablet:
When Clofranil 25 Tablet is taken with Methylene blue, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
There may be a possibility of interaction between Clofranil 25 Tablet and Methylene blue, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea-contact a doctor immediately. Do not stop using any medications without a doctor's advice.
ClomipramineProcarbazine
Critical
How does the drug interact with Clofranil 25 Tablet:
When Clofranil 25 Tablet is taken with Procarbazine, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
There may be a possibility of interaction between Clofranil 25 Tablet and Procarbazine, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea-call a doctor right away. Do not stop using any medications without a doctor's advice.
ClomipramineLinezolid
Critical
How does the drug interact with Clofranil 25 Tablet:
When Clofranil 25 Tablet is taken with Linezolid, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
There may be a possibility of interaction between Clofranil 25 Tablet and Linezolid, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea-contact a doctor immediately. Do not stop using any medications without a doctor's advice.
ClomipramineMoclobemide
Critical
How does the drug interact with Clofranil 25 Tablet:
When Clofranil 25 Tablet is taken with Moclobemide, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
There may be a possibility of interaction between Clofranil 25 Tablet and Moclobemide, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea-contact a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a diet rich in fruits, vegetables, and whole grains. Avoid fried foods, high-fat dairy products, pastries, and processed foods as they may worsen anxiety. Include foods rich in omega fatty acids such as fish, nuts, fresh fruits, vegetables, and olive oils.
  • Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help in proper maintenance of neurotransmitters.
  • Complex carbohydrates help in stimulating serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges, and pears.
  • Exercising helps in the production of the body’s natural antidepressants. It also helps in relieving stress, improving mood, boosting self-esteem, and providing restful sleep.
  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.
  • Regularly attend therapy sessions.
  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIDEPRESSANT

Clofranil 25 Tablet Substitute

Substitutes safety advice
  • Clonil-25 Tablet 15's

    by Others

    6.27per tablet
  • Clonil-25 Tablet 10's

    by Others

    5.58per tablet
  • Clomip 25 mg Tablet 10's

    by Others

    4.97per tablet
  • D.D. Pramine 25 Tablet 10's

    by AYUR

    6.26per tablet
  • Prumpin 25 mg Tablet 10's

    by Others

    6.21per tablet

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • SELEGILINE
  • LEVODOPA
  • PENTAMIDINE
  • RIFAMPICIN
  • PIMOZIDE
  • BUPRENORPHINE
  • MORPHINE
  • CODEINE
  • WARFARIN
  • MOCLOBEMIDE
  • PHENELZINE
  • TRANYLCYPROMINE
  • FLUVOXAMINE
  • FLUOXETINE
  • AMITRIPTYLINE
  • SERTRALINE
  • VENLAFAXINE
  • DOTHIEPIN
  • LITHIUM
  • PHENYTOIN
  • CARBAMAZEPINE
  • PHENOBARBITAL
  • VALPROATE
  • ASPIRIN
  • CIMETIDINE
  • FUROSEMIDE
  • TERFENADINE
  • RESERPINE
  • GUANETHIDINE
  • CLONIDINE
  • ISOPRENALINE
  • AMIODARONE
  • QUINIDINE
  • DISOPYRAMIDE
  • PROCAINAMIDE
  • EPINEPHRINE
  • DILTIAZEM
  • VERAPAMIL
  • RITONAVIR
  • INDINAVIR
  • MAPROTILINE
  • BETANIDINE

Special Advise

  • Regular blood tests are recommended while taking Clofranil 25 Tablet to monitor liver and heart functioning.
  • Regular dental check-ups are also advised while taking Clofranil 25 Tablet as it may cause dry mouth, which may increase the risk of tooth decay.

Disease/Condition Glossary

Obsessive-compulsive disorder (OCD): It is a mental disorder with symptoms such as excessive thoughts or ideas (obsessions) leading to repetitive behaviors (compulsions).

Depression: It is a mood disorder associated with symptoms such as sadness, unable to sleep properly, or enjoy life as you used to do. Depression can also influence some chronic health conditions and relationships. The exact cause of depression is unknown, but it may be associated with mental problems, trauma, family history, drug use, and medical conditions.

Panic disorder: It is linked to anxiety with sudden feelings of fear when there is no danger in reality.

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