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Reviewed By Sunny S , MBBS
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About Cohist Syrup

Cohist Syrup belongs to a group of medicines called expectorants and cough products used to provide relief from cough. Additionally, Cohist Syrup may also help in providing relief from allergies and nasal congestion due to colds. Coughing (dry or productive) is the body's way of clearing irritants (like allergens, mucus or smoke) from airways, thereby preventing respiratory infection.
 
Cohist Syrup combines three drugs: Diphenhydramine, Ammonium chloride, and Sodium citrate. Diphenhydramine works by blocking the action of a chemical substance called histamine, which is responsible for causing allergic reactions. Ammonium chloride helps remove phlegm/mucus from the airways by decreasing its stickiness. Sodium citrate helps reduce congestion, making it easier to cough out through the mouth. Together, Cohist Syrup provides relief from cough.
 
Take Cohist Syrup as prescribed. Depending on your medical condition, you are advised to take Cohist Syrup for as long as your doctor has prescribed it for you. Sometimes, you may experience certain common side effects such as headache, stomach upset, dizziness, tiredness, and dry mouth. Most of these side effects do not require medical attention and resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult your doctor before taking Cohist Syrup if you are pregnant or breastfeeding. Cohist Syrup may cause dizziness, so drive only if you are alert. Cohist Syrup should be given to children only if prescribed by the doctor. Avoid consuming alcohol with Cohist Syrup as it could lead to increased dizziness. Inform your doctor about all the prescription, non-prescription and herbal medicines you take to rule out any side effects/interactions.

Uses of Cohist Syrup

Cough, Allergies

Directions for Use

Cohist Syrup should be swallowed as a whole with water, do not chew, break or crush the tablet.

Medicinal Benefits

Cohist Syrup is a combination of three drugs: Diphenhydramine, Ammonium chloride and Sodium citrate. Cohist Syrup is used to relieve a cough accompanied by cold symptoms such as sore throat, runny nose, watery eyes, and sneezing. Additionally, Cohist Syrup helps in providing relief from allergies. Diphenhydramine is an antihistamine that works by blocking the action of a chemical substance called histamine, which is responsible for causing allergic reactions. Ammonium chloride is an expectorant that helps remove phlegm/mucus from the airways by decreasing its stickiness. Sodium citrate is a mucolytic agent that helps loosen the congestion, making it easier to cough out through the mouth. Together, Cohist Syrup provides relief from cough.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Cohist Syrup if you are allergic to any of its contents. Inform your doctor before taking Cohist Syrup if you have asthma, prostate problems, narrow-angle glaucoma, stomach or bowel ulcers, glucose-galactose malabsorption, sucrase-isomaltase deficiency, fructose intolerance, kidney or liver problems; if you are taking antidepressants or anti-Parkinson drugs or have taken them in the last 14days. Consult your doctor before taking Cohist Syrup if you are pregnant, planning for pregnancy or breastfeeding. Cohist Syrup may cause dizziness, so drive only if you are alert. Avoid consuming alcohol along with Cohist Syrup as it could lead to increased dizziness.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Cohist Syrup:
When Thioridazine is taken with Cohist Syrup, it can slow down the way Cohist Syrup is broken down in the body.

How to manage the interaction:
Taking Cohist Syrup with Thioridazine is not recommended, please consult your doctor before taking it. It can be taken if your doctor advises it. Do not stop taking any medication without consulting your doctor.
How does the drug interact with Cohist Syrup:
Taking Cohist Syrup with Potassium chloride can increase the risk of stomach ulcers.

How to manage the interaction:
Taking Cohist Syrup with Potassium chloride is not recommended, as it can lead to an interaction, but it can be taken if a doctor has prescribed it. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, contact your doctor. Do not stop taking any medication without consulting your doctor.
DiphenhydramineEliglustat
Critical
How does the drug interact with Cohist Syrup:
When Cohist Syrup is taken with Eliglustat, it can cause a decrease in metabolism.

How to manage the interaction:
Taking Cohist Syrup with Eliglustat is not recommended, please consult your doctor before taking it. It can be taken if prescribed by your doctor. Do not stop taking any medication without consulting your doctor.
DiphenhydramineSodium oxybate
Critical
How does the drug interact with Cohist Syrup:
Taking Cohist Syrup with Sodium oxybate can enhance the sedative effects on the central nervous system.

How to manage the interaction:
Taking Cohist Syrup with Sodium oxybate is not recommended, but it can be taken if prescribed by a doctor. However contact your doctor if you experience shortness of breath, increased sweating, palpitations, or confusion. Do not stop using any medications without consulting a doctor.
DiphenhydraminePotassium citrate
Critical
How does the drug interact with Cohist Syrup:
Taking Cohist Syrup and Potassium citrate together can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Cohist Syrup with Potassium citrate is not recommended, as it may lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Cohist Syrup:
Topiramate can induce elevated body temperature and decreased sweating, which can be exacerbated when combined with drugs that have similar effects, such as Cohist Syrup.

How to manage the interaction:
Although taking Cohist Syrup with Topiramate can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is essential to stay hydrated by drinking enough fluids, especially in hot weather and when doing physical activity. Contact your doctor immediately if you notice decreased sweating, fever, dizziness, drowsy, or lightheadedness. Do not discontinue using any medications without consulting a doctor.
DiphenhydramineBrexpiprazole
Severe
How does the drug interact with Cohist Syrup:
Cohist Syrup increases the blood levels of Brexpiprazole. This increases the risk of Side effects.

How to manage the interaction:
Taking Cohist Syrup with Brexpiprazole together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms - feeling tired, unusual muscle movements, muscle spasms, shaking or jerking in your arms and legs, feeling dizzy or lightheaded, or fainting - contact your doctor right away. Do not stop using any medications without talking to a doctor.
How does the drug interact with Cohist Syrup:
Coadministration of Zonisamide with Cohist Syrup can induce elevated body temperature and decreased sweating.

How to manage the interaction:
Although taking Cohist Syrup with Zonisamide can result in an interaction, they can be taken together if prescribed by your doctor. It is essential to stay hydrated by drinking enough fluids, especially in hot weather and when doing physical activity. Contact a doctor immediately if you notice decreased sweating, fever, dizziness, drowsy, or lightheadedness. Do not discontinue using any medications without consulting a doctor.
DiphenhydramineEsketamine
Severe
How does the drug interact with Cohist Syrup:
Taking Cohist Syrup with Esketamine can increase the risk of adverse effects.

How to manage the interaction:
Co-administration of Cohist Syrup with Esketamine can result in an interaction, but it can be taken if your doctor has advised it. However, contact your doctor if you experience drowsiness, confusion, or difficulty concentrating. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Cohist Syrup:
Cohist Syrup reduces the blood levels and effectiveness of tamoxifen.

How to manage the interaction:
Although taking Cohist Syrup with Tamoxifen can possibly reduce the effectiveness of Tamoxifen, they can be taken together if prescribed by your doctor. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Gargle with salt water for relief from sore throat.
  • Avoid smoking and consumption of alcohol.
  • Avoid dairy products such as milk, as it may increase mucus production. Also, avoid processed or refined foods. Replace baked foods, fried foods, white bread, white pasta, french fries, sugary desserts and chips with green leafy vegetables.
  • Drink plenty of fluids to avoid a dry throat while you have a cough. It also helps loosen mucus.
  • Avoid citrus fruits as they may worsen the cough. Eat fruits rich in water content, such as pears, watermelon, peaches and pineapples.

Habit Forming

No

Therapeutic Class

ANTIHISTAMINE AND ANTITUSSIVE ANTIHISTAMINES

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Cohist Syrup is a combination drug containing three medicines: Diphenhydramine, Ammonium Chloride and Sodium Citrate. Diphenhydramine blocks a natural substance (histamine) during an allergic reaction. Ammonium chloride decreases mucus stickiness, and sodium citrate being mucolytic, loosens the mucus and makes it easier to cough out. Together it helps relieve allergy symptoms like sneezing, running nose, watery eyes, itching, swelling, congestion, or stiffness.

You should not take Cohist Syrup if you have asthma, as it might worsen your condition and lead to breathing problems.

Do not take Cohist Syrup if you have breathing problems like asthma, chronic bronchitis, vision problems like glaucoma or difficulty in peeing due to an enlarged prostate gland. Besides this, if you are taking alcohol, peptic ulcer, sleeping pills, or antianxiety pills, immediately stop taking Cohist Syrup as it might induce drowsiness and dizziness.

Cohist Syrup is known to cause drowsiness and sleepiness, so it is recommended not to drive a car or operate any machinery which requires concentration. Also, do not consume alcohol as it might increase drowsiness.

The most common side effects of Cohist Syrup are sleepiness, impaired coordination, stomach pain, dizziness, and thickened respiratory tract secretions. These side effects usually go away during the treatment.

Dry mouth could be a side-effect of Cohist Syrup. Limiting caffeine intake, avoiding smoking, drinking water regularly and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.

Drug-Drug Interactions Checker List

  • ISOCARBOXAZID
  • PHENELZINE
  • SELEGILINE
  • RASAGILINE
  • TRANYLCYPROMINE

Special Advise

  • If you have diabetes, please monitor your blood sugar level regularly.
  • It is advised to avoid contact with known allergens (allergy-causing agents) such as pollen, dust, etc. Certain food items are known to cause allergies to you.

Disease/Condition Glossary

Allergy: Allergy is an immune system response to foreign elements typically not harmful to your body. These foreign elements are known as ‘allergens.’ Allergic condition varies from person to person. Some might be allergic to certain foods and seasonal allergies like hay fever. At the same time, others might be allergic to pollen or pet dander. One of the symptoms of allergy is cough.

Cough: Coughing is the body's way of clearing irritants (like allergens, mucus or smoke) from airways and preventing infection. Cough can be dry or productive. A productive cough (wet cough) develops sputum (phlegm or mucus) from the lungs. Cough is commonly caused as a response to allergy or viral infection but coughing up mucus is possibly an indication of infection in the respiratory tract. If you are coughing out thick, solid white mucus, it indicates that you may have a bacterial infection in the airways. Clear or light-coloured mucus indicates allergies or minor infections in the respiratory tract, and yellow or green mucus indicates a respiratory infection.

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