Combigan Ophthalmic Solution 5 ml

Written By Santoshini Reddy G , M Pharmacy

Reviewed By Hari Kumar , MBBS

MRP ₹535

(Inclusive of all Taxes)

₹80.3 Cashback (15%)

Provide Delivery Location

Non returnable*

Know More

COD available

Online payment accepted

Prescription drug

Whats That

About Combigan Ophthalmic Solution 5 ml

Combigan Ophthalmic Solution 5 ml is a combination medicine indicated for lowering elevated intraocular pressure in patients with glaucoma or ocular hypertension. Glaucoma is an eye disease that causes damage to the optic nerve and results in reduced vision. Ocular hypertension is increased pressure in the eye due to poor drainage of aqueous humour (fluid in the eye that maintains normal pressure by its continuous flow).

Combigan Ophthalmic Solution 5 ml contains Brimonidine tartrate (alpha-2 adrenergic receptor agonists), Timolol (beta-blocker), and Benzalkonium chloride (preservative). Brimonidine tartrate and timolol decrease the production of aqueous humour and increase the amount of fluid that is drained. Benzalkonium chloride acts as a preservative. Together, Combigan Ophthalmic Solution 5 ml helps lower the increased pressure in the eye.

You are advised to use Combigan Ophthalmic Solution 5 ml for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience common side effects such as burning sensation, eye redness, itching, irritation, and vision disturbances. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if the side effects persist or worsen.

Consult a doctor if you are pregnant or breastfeeding. Combigan Ophthalmic Solution 5 ml is not recommended for children below 17 years as safety and effectiveness have not been established. Combigan Ophthalmic Solution 5 ml might cause drowsiness; so, drive only if you are alert. Avoid touching the tip of the dropper as it may contaminate the contents. Keep your doctor informed about your health condition and the medicines you are taking to prevent any side effects/interactions.

Uses of Combigan Ophthalmic Solution 5 ml

Glaucoma and ocular hypertension

Directions for Use

Lie down and tilt your head backwards. Pull your lower eyelid gently with your index finger to form a pocket. Instil the number of drops advised by the doctor into the pocket of the lower eyelid. Close your eyes for 1-2 minutes.

Medicinal Benefits

Combigan Ophthalmic Solution 5 ml is a combination of three drugs, namely: Brimonidine tartrate, Timolol, and Benzalkonium chloride. Combigan Ophthalmic Solution 5 ml is indicated for lowering intraocular pressure in patients with glaucoma or ocular hypertension. Brimonidine tartrate belongs to a group of medicines called alpha-2 adrenergic receptor agonists, and Timolol belongs to a group of medicines called beta-blockers. They work by decreasing the production of aqueous humour and increasing the amount of liquid that is drained. Benzalkonium chloride acts as a preservative. Together, Combigan Ophthalmic Solution 5 ml helps lower the increased pressure in the eye.

Storage

Keep Combigan Ophthalmic Solution 5 ml out of reach and sight of children.

Drug Warnings

Do not use Combigan Ophthalmic Solution 5 ml if you are allergic to any of its contents, if you have/had bronchial asthma, severe chronic obstructive bronchitis, low heart rate, heartbeat disorder, heart failure, if you are taking anti-depressants or monoamine oxidase inhibitors. Inform your doctor if you have/had coronary heart disease, slow heartbeat, breathing problems, chronic obstructive pulmonary disease, poor blood circulation disease, diabetes, overactive thyroid, tumour of the adrenal gland, corneal disease, excess acidity in the blood, kidney or liver problems. If you are due to have any surgery or eye surgery, inform the doctor/surgeon that you are taking Combigan Ophthalmic Solution 5 ml. Consult a doctor if you are pregnant or breastfeeding. Combigan Ophthalmic Solution 5 ml is not recommended for children below 17 years. Combigan Ophthalmic Solution 5 ml might cause drowsiness, blurred vision; so, drive only if you are alert.

Drug-Drug Interactions

TimololAminophylline

Severe

TimololDiltiazem

Severe

Drug-Drug Interactions

Login/Sign Up

TimololAminophylline

Severe

How does the drug interact with Combigan Ophthalmic Solution 5 ml:
Co-administration of aminophylline with Combigan Ophthalmic Solution 5 ml can make Combigan Ophthalmic Solution 5 ml less effective and increase the effects of aminophylline.

How to manage the interaction:
Taking Aminophylline with Combigan Ophthalmic Solution 5 ml can lead to an interaction, however, it can be taken only if a doctor has advised it. If you experience symptoms such as nausea, vomiting, sleeplessness, restlessness, irregular heartbeats, or difficulty in breathing, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

TimololDiltiazem

Severe

How does the drug interact with Combigan Ophthalmic Solution 5 ml:
Co-administration of diltiazem with Combigan Ophthalmic Solution 5 ml can increase the risk or severity of side effects.

How to manage the interaction:
Taking diltiazem with Combigan Ophthalmic Solution 5 ml can lead to an interaction, however, it can be taken only if your doctor has advised it. If you experience symptoms such as fatigue, headache, fainting, swelling of the hands and legs, chest pain, increased or decreased heartbeat, or irregular heartbeats, or difficulty in breathing, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

TimololDisopyramide

Severe

How does the drug interact with Combigan Ophthalmic Solution 5 ml:
Co-administration of Combigan Ophthalmic Solution 5 ml together with disopyramide can increase the effects of disopyramide.

How to manage the interaction:
Although taking disopyramide and Combigan Ophthalmic Solution 5 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as dizziness, fainting, palpitations, slow or fast pulse, or irregular heartbeats, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.

TimololVerapamil

Severe

How does the drug interact with Combigan Ophthalmic Solution 5 ml:
Co-administration of verapamil with Combigan Ophthalmic Solution 5 ml can increase the risk or severity of side effects.

How to manage the interaction:
Although taking verapamil and Combigan Ophthalmic Solution 5 ml together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as fatigue, headache, fainting, swelling of the extremities, weight gain, shortness of breath, chest pain, increased or decreased heartbeat, or irregular heartbeat consult a doctor immediately. Do not discontinue any medications without consulting a doctor.

TimololClonidine

Severe

How does the drug interact with Combigan Ophthalmic Solution 5 ml:
Co-administration of Clonidine and Combigan Ophthalmic Solution 5 ml together may lower the blood pressure.

How to manage the interaction:
Although there is a possible interaction between Clonidine and Combigan Ophthalmic Solution 5 ml, you can take these medicines together if prescribed by your doctor. However, if you experience headaches, slow heartbeat, dizziness, or feeling like you might pass out, contact a doctor. Do not discontinue any medications without consulting a doctor.

TimololFormoterol

Severe

How does the drug interact with Combigan Ophthalmic Solution 5 ml:
Taking Combigan Ophthalmic Solution 5 ml with formoterol could reduce the benefits of both medications because they have opposite effects on the body.

How to manage the interaction:
Although taking formoterol and Combigan Ophthalmic Solution 5 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms, contact your doctor immediately. Do not stop using any medications without talking to your doctor.

TimololCeritinib

Severe

How does the drug interact with Combigan Ophthalmic Solution 5 ml:
Co-administration of ceritinib with Combigan Ophthalmic Solution 5 ml can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking certinib and Combigan Ophthalmic Solution 5 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as dizziness, lightheadedness, fainting, or irregular heartbeat, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.

TimololPirbuterol

Severe

How does the drug interact with Combigan Ophthalmic Solution 5 ml:
Co-administration of Pirbuterol with Combigan Ophthalmic Solution 5 ml can decrease the action of both the medications, can increase the risk or severity of side effects including increased risk of asthma, breathing problems.

How to manage the interaction:
Although taking pirbuterol and Combigan Ophthalmic Solution 5 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms consult a doctor immediately. Do not discontinue any medications without consulting a doctor.

TimololOlodaterol

Severe

How does the drug interact with Combigan Ophthalmic Solution 5 ml:
Co-administration of Olodaterol with Combigan Ophthalmic Solution 5 ml can decrease the action of both the medications, can increase the risk or severity of side effects including increased risk of asthma, breathing problems.

How to manage the interaction:
Although taking olodaterol and Combigan Ophthalmic Solution 5 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.

TimololSalmeterol

Severe

How does the drug interact with Combigan Ophthalmic Solution 5 ml:
Co-administration of Salmeterol with Combigan Ophthalmic Solution 5 ml can decrease the action of both the medications, can increase the risk or severity of side effects including increased risk of asthma, breathing problems.

How to manage the interaction:
Although taking salmeterol and Combigan Ophthalmic Solution 5 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms consult a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Login/Sign Up

Diet & Lifestyle Advise

Include fresh fruits and vegetables in your diet.
Avoid smoking and alcohol consumption.
Avoid intake of baked foods such as cakes, cookies, doughnuts or fried items such as french fries and stick margarine as these foods may worsen glaucoma and damage the optic nerve.
Cut down your coffee intake as it may increase pressure in the eye. Replace coffee with green tea.
Avoid exercises such as any position where the head is lower than the body, like an inverted yoga pose, as it may increase pressure in the eye. Doing selective exercises is advised for glaucoma patients.

Side Effects of Combigan Ophthalmic Solution 5 ml

Burning sensation
Eye redness
Eye itching
Irritation
Vision disturbances

Habit Forming

No

Therapeutic Class

OPHTHALMOLOGIC AGENTS

Author Details

Written By

Santoshini Reddy G

M Pharmacy

Reviewed By

Hari Kumar

MBBS

Last Updated

Jul 8, 2025 | 9:41 AM IST

We provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

Login/Sign Up

FAQs

How does Combigan Ophthalmic Solution 5 ml work?

Combigan Ophthalmic Solution 5 ml contains Brimonidine tartrate, Timolol, and Benzalkonium chloride. Brimonidine tartrate and timolol decrease the production of aqueous humour and increase the amount of fluid that is drained. Benzalkonium chloride acts as a preservative. Together, Combigan Ophthalmic Solution 5 ml helps lower the increased pressure in the eye.

Can I stop using Combigan Ophthalmic Solution 5 ml on my own?

Do not stop using Combigan Ophthalmic Solution 5 ml without consulting your doctor. Continue using Combigan Ophthalmic Solution 5 ml for as long as your doctor has prescribed it to you to treat your condition effectually. Consult the doctor if you experience any difficulty while using Combigan Ophthalmic Solution 5 ml.

Does Combigan Ophthalmic Solution 5 ml cause vision disturbances?

Combigan Ophthalmic Solution 5 ml might cause blurred vision and vision disturbances. So, avoid driving or operating machinery until your vision is clear to prevent any mishappening.

Can I wear contact lens while using Combigan Ophthalmic Solution 5 ml?

Combigan Ophthalmic Solution 5 ml contains benzalkonium chloride; it might discolour soft contact lenses. Therefore, do not wear contact lens while using Combigan Ophthalmic Solution 5 ml. Remove contact lenses before using Combigan Ophthalmic Solution 5 ml and put them back 15 minutes after using Combigan Ophthalmic Solution 5 ml.

I have high blood pressure; is it safe to use Combigan Ophthalmic Solution 5 ml?

Consult your doctor before using Combigan Ophthalmic Solution 5 ml if you have hypertension. Regularly monitor blood pressure levels while taking Combigan Ophthalmic Solution 5 ml to prevent unpleasant events.

Does Combigan Ophthalmic Solution 5 ml cause dry mouth?

Dry mouth could be a side-effect of Combigan Ophthalmic Solution 5 ml. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.

Can I use other eye medications with Combigan Ophthalmic Solution 5 ml?

Combigan Ophthalmic Solution 5 ml can be used with other eye medications if prescribed by the doctor. However, maintain a gap of 5-10minutes between Combigan Ophthalmic Solution 5 ml and other eye medications.

I am diabetic; can I use Combigan Ophthalmic Solution 5 ml?

Consult your doctor before using Combigan Ophthalmic Solution 5 ml if you are diabetic as Combigan Ophthalmic Solution 5 ml contains timolol; it might lower the blood glucose levels and may mask the symptoms of low blood sugar levels. Regular monitoring of blood glucose levels whilst taking Combigan Ophthalmic Solution 5 ml is advised.

Disease/Condition Glossary

Glaucoma: It is an eye condition that causes damage to the optic nerve (essential for good vision) due to abnormally increased pressure in the eye. If it is not treated in time, it may cause blindness. Usually, there are no symptoms for glaucoma initially, except the slow loss of vision gradually. However, some symptoms include visible rainbow-coloured circles around bright lights or blurred vision. Rarely, glaucoma can develop suddenly with intense pain in the eye, visual disturbance or nausea.

Ocular hypertension: It is a condition caused due to poor drainage of aqueous humour (fluid in the eye that maintains normal pressure by its continuous flow). This leads to a build-up of excess fluid in the eye resulting in increased pressure inside the eye. If ocular hypertension is not controlled, it may lead to glaucoma.