Combimist-L Respules 5 x 2.5 ml

Written By Veda Maddala , M Pharmacy

Reviewed By Sunny S , MBBS

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About Combimist-L Respules 5 x 2.5 ml

Combimist-L Respules 5 x 2.5 ml is a combination medication primarily used to treat or prevent symptoms of chronic obstructive pulmonary disease (COPD) likes shortness of breath, coughing or wheezing (whistling sound while breathing). COPD is a group of lung diseases with emphysema (shortness of breath due to damaged air sac) and chronic bronchitis (inflammation and narrowing of the lining of airways or bronchial tubes).

Combimist-L Respules 5 x 2.5 ml is a combination of two bronchodilators, namely: Levosalbutamol and Ipratropium bromide. Combimist-L Respules 5 x 2.5 ml belongs to the class of bronchodilators that works by relaxing muscles and widening the airways of the lungs. Thereby, it allows us to breathe easily.

Use Combimist-L Respules 5 x 2.5 ml as prescribed. Your doctor will recommend how often you use Combimist-L Respules 5 x 2.5 ml based on your medical condition. Some people may experience headache, sore throat, dry mouth, runny or stuffy nose, pain, cough with mucus, sneezing, chest tightness, difficulty in breathing, dizziness, nervousness, tiredness, irregular heartbeats and vomiting. Most of these side effects of Combimist-L Respules 5 x 2.5 ml do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Combimist-L Respules 5 x 2.5 ml or any other medicines, pregnant or breastfeeding, or experience severe difficulty in breathing, please consult a doctor immediately. Do not use Combimist-L Respules 5 x 2.5 ml in more than the prescribed doses as it may lead to severe heart or lung problems. Regular monitoring of potassium levels is recommended while taking a prolonged intake of Combimist-L Respules 5 x 2.5 ml may cause low potassium levels in the blood. If you have high blood pressure, diabetes fits, enlarged prostate, glaucoma, thyroid or heart problems, bladder obstruction or other urinary problems, inform your doctor before taking Combimist-L Respules 5 x 2.5 ml. Please do not use or store Combimist-L Respules 5 x 2.5 ml near open flame or heat as it may burst the container.

Uses of Combimist-L Respules 5 x 2.5 ml

Chronic obstructive pulmonary disease (COPD)

Directions for Use

Inhaler/Transhaler: Shake the inhaler/Transhaler well and check the label for directions before using it. Hold the inhaler/Transhaler with the mouthpiece downwards. Put the mouthpiece between your teeth and seal the lips around it. Then, press down the inhaler once to release the medication. Breathe in slowly and hold your breath for 5 to 10 seconds. Breathe out slowly. Repeat the process until you have inhaled the number of puffs prescribed by the doctor. Rinse your mouth with water and spit it out after using inhaler/Transhaler to avoid fungal infections in the mouth and throat.Rotacaps/Transcaps/Respicaps: The capsule should be placed at the base of the rotahaler/Lupihaler/Respihaler and completely twist the mouthpiece until you hear a click sound. Then, breathe in through the mouthpiece deeply and hold your breath for 10 seconds. It is for inhalation only. Do not swallow the capsule.Respules/Transpules: Check the label for directions before using it. Twist the respule/transpule top, squeeze all the liquid into the nebulizer and use immediately after opening.

Medicinal Benefits

Combimist-L Respules 5 x 2.5 ml is a combination of two bronchodilators, namely: Levosalbutamol and Ipratropium bromide. Combimist-L Respules 5 x 2.5 ml belongs to the class of bronchodilators that works by relaxing muscles and widening the airways of the lungs. Thereby, allowing to breathe easily and provide relief from symptoms such as shortness of breath, coughing or wheezing (whistling sound while breathing).

Storage

Keep Combimist-L Respules 5 x 2.5 ml out of the sight and reach of children.

Side effects of Combimist-L Respules 5 x 2.5 ml

Cough

Here are the steps to manage the medication-triggered Cough:

Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.

Shortness Of Breath

Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):

Tell your doctor immediately if you experience shortness of breath after taking medication.
Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.

Inflammation Of Air Passages In Lungs

Managing Medication-Triggered Bronchitis (Inflammation of the bronchial tubes): A Step-by-Step Guide:

If you experience symptoms like coughing, wheezing, chest tightness, or difficulty breathing after taking medication, seek medical attention immediately.
Your healthcare provider will work with you to stop the medication causing the reaction, start alternative treatments, and provide supportive therapy.
To manage symptoms and prevent complications, follow your doctor's advice to use inhalers or nebulizers as prescribed, practice good hygiene, avoid irritants, stay hydrated, and get plenty of rest.
Regularly track your symptoms and report any changes or concerns to your healthcare provider.

Common Cold

Here are the steps to manage the medication-triggered Common Cold:

Inform your doctor about the common cold symptoms you're experiencing due to medication.
Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.

Common Cold

Here are the steps to manage the medication-triggered Upper respiratory tract infection:

Inform your doctor about the symptoms you're experiencing due to medication.
Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.

Sore Throat

Drink warm fluids such as warm water with honey, broth or herbal tea to soothe sore throat.
Gargle with warm salt water to decrease inflammation.
Suck on hard candies or lozenges to increase the production of saliva and soothe your throat.
Avoid smoking, spicy foods, and extremely hot fluids.
Rest your voice and get enough sleep.

Increased Phlegm

Drink plenty of fluids like water to thin mucus.
Use a humidifier to moisten the air.
Lie down in specific positions to help drain mucus from different areas of the lungs.
Inhale steam from a bowl of hot water, it can help loosen mucus.
Gargling with a saltwater solution can soothe a sore throat and help clear mucus.
Gentle exercise can help mobilize mucus and clear airways.
Limit exposure to smoke, dust, and other airborne irritants that can worsen mucus production.
Consult your doctor if the issue persists or is accompanied by other concerning symptoms.

Drug Warnings

If you are allergic to Combimist-L Respules 5 x 2.5 ml or any other medicines, pregnant or breastfeeding, experience severe difficulty in breathing, please consult a doctor immediately. Do not use Combimist-L Respules 5 x 2.5 ml in more than the prescribed doses as it may lead to severe heart or lung problems. Regular monitoring of potassium levels is recommended while taking Combimist-L Respules 5 x 2.5 ml as it may cause low potassium levels in the blood. However, if you experience irregular heartbeats, leg cramps, extreme thirst, constipation, increased urination, muscle weakness, numbness or tingling, please consult a doctor immediately as these might be signs of low potassium. If you have high blood pressure, diabetes, epilepsy (fits), enlarged prostate, glaucoma, thyroid or heart problems, bladder obstruction or other urinary problems, inform your doctor before taking Combimist-L Respules 5 x 2.5 ml. Do not use or store Combimist-L Respules 5 x 2.5 ml near open flame or heat as it may burst the container.

Drug-Drug Interactions

SalbutamolPapaverine

Severe

SalbutamolPindolol

Severe

Drug-Drug Interactions

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SalbutamolPapaverine

Severe

How does the drug interact with Combimist-L Respules 5 x 2.5 ml:
The combined use of Papaverine and Combimist-L Respules 5 x 2.5 ml can increase the risk of an irregular heart rhythm which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Co-administration of Papaverine and Combimist-L Respules 5 x 2.5 ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

SalbutamolPindolol

Severe

How does the drug interact with Combimist-L Respules 5 x 2.5 ml:
Using pindolol and Combimist-L Respules 5 x 2.5 ml together can increase the risk of narrowing of the airways.

How to manage the interaction:
The combined use of pindolol and Combimist-L Respules 5 x 2.5 ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience Coughing, wheezing, shortness of breath, and high-pitched breathing, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

SalbutamolPropranolol

Severe

How does the drug interact with Combimist-L Respules 5 x 2.5 ml:
Using propranolol and Combimist-L Respules 5 x 2.5 ml together can reduce the effects or increase the risk of narrowing of the airways.

How to manage the interaction:
The combined use of propranolol and Combimist-L Respules 5 x 2.5 ml can lead to an interaction, but they can be taken if advised by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.

SalbutamolMifepristone

Severe

How does the drug interact with Combimist-L Respules 5 x 2.5 ml:
Coadministration of mifepristone and Combimist-L Respules 5 x 2.5 ml can increase the risk of an irregular heart rhythm which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Combimist-L Respules 5 x 2.5 ml with mifepristone together is avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not discontinue any medications without consulting a doctor.

SalbutamolLabetalol

Severe

How does the drug interact with Combimist-L Respules 5 x 2.5 ml:
Co-administration of Salbutaml with Labetalol, the effectiveness of Combimist-L Respules 5 x 2.5 ml might be reduced.

How to manage the interaction:
Although taking Labetalol and Combimist-L Respules 5 x 2.5 ml together can possibly result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.

SalbutamolTimolol

Severe

How does the drug interact with Combimist-L Respules 5 x 2.5 ml:
Co-administration of Combimist-L Respules 5 x 2.5 ml with timolol can increase the risk of narrowing of the airways.

How to manage the interaction:
Although taking Combimist-L Respules 5 x 2.5 ml and timolol together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience Coughing, wheezing, shortness of breath, and high-pitched breathing, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

SalbutamolPenbutolol

Severe

How does the drug interact with Combimist-L Respules 5 x 2.5 ml:
Coadministration of Penbutolol and Combimist-L Respules 5 x 2.5 ml can reduce the effects of both medications and can cause narrowing of the airways.

How to manage the interaction:
Taking Penbutolol and Combimist-L Respules 5 x 2.5 ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience Coughing, wheezing, shortness of breath, and high-pitched breathing, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

SalbutamolLevobunolol

Severe

How does the drug interact with Combimist-L Respules 5 x 2.5 ml:
Using levobunolol and Combimist-L Respules 5 x 2.5 ml together can reduce the benefits of both drugs and can cause narrowing of the airways.

How to manage the interaction:
The combined use of levobunolol and Combimist-L Respules 5 x 2.5 ml can lead to an interaction, it can be taken if advised by your doctor. Don't forget to inform if you have any history of asthma, or severe chronic obstructive pulmonary disease (COPD), consult the doctor immediately. Do not stop using any medications without a doctor's advice.

SalbutamolCarvedilol

Severe

How does the drug interact with Combimist-L Respules 5 x 2.5 ml:
Coadministration of Carvedilol and Combimist-L Respules 5 x 2.5 ml may reduce the effects of both medications.

How to manage the interaction:
Although there is a possible interaction between Carvedilol and Combimist-L Respules 5 x 2.5 ml, they can be taken if your doctor advises. Consult your doctor if you experience shortness of breath, chest pain or any difficulties in breathing. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Eat foods rich in potassium such as tomatoes, bananas, asparagus, oranges, potatoes, avocados, dark leafy greens, and beetroots as potassium is important for lung function and a potassium deficiency may cause breathing problems.
Drink plenty of fluids every day to thin mucus which makes it easier to cough out.
Maintain a diet that includes complex carbohydrates such as lentils, beans, barley, oats, quinoa, bran, peas, and potatoes with skin.
Limit or avoid the intake of caffeinated drinks such as tea, coffee, soda, and energy drinks like red bull.
Eat protein-rich foods such as meat, fish (particularly salmon, sardines, and mackerel), eggs, and poultry.
Exercise regularly to strengthen your breathing muscles and boost your immune system. Learning breathing exercises will help you move more air in and out of your lungs.
Quit smoking as it may reduce the effectiveness of the Combimist-L Respules 5 x 2.5 ml and irritate the lungs worsening breathing problem.

Side Effects of Combimist-L Respules 5 x 2.5 ml

Headache
Sore throat
Dry mouth
Runny or stuffy nose
Chest tightness
Dizziness
Nervousness
Tiredness
Vomiting

Habit Forming

No

Therapeutic Class

BRONCHODILATOR

Author Details

Written By

Veda Maddala

M Pharmacy

Reviewed By

Sunny S

MBBS

Last Updated

Jul 8, 2025 | 9:30 AM IST

We provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Is Combimist-L Respules 5 x 2.5 ml safe for diabetic patients?

Combimist-L Respules 5 x 2.5 ml should be used with caution in diabetic patients if prescribed by a doctor. However, regular monitoring of blood sugar levels is recommended while taking Combimist-L Respules 5 x 2.5 ml as it may increase blood sugar levels.

Does Combimist-L Respules 5 x 2.5 ml cause blurred vision?

Yes, Combimist-L Respules 5 x 2.5 ml may cause blurred vision in some patients. It is not necessary for everyone taking Combimist-L Respules 5 x 2.5 ml to experience this side effect. Therefore, avoid driving if you notice any changes in vision after taking Combimist-L Respules 5 x 2.5 ml.

Can a hyperthyroid patient take Combimist-L Respules 5 x 2.5 ml?

Combimist-L Respules 5 x 2.5 ml should be used with caution in hyperthyroid (overactive thyroid) patients as it may worsen the condition. Inform your doctor if have hyperthyroidism before taking Combimist-L Respules 5 x 2.5 ml so that the dose may be adjusted appropriately. However, regular monitoring of thyroid hormone levels is recommended while taking Combimist-L Respules 5 x 2.5 ml.

Does Combimist-L Respules 5 x 2.5 ml cause dry mouth?

Yes, Combimist-L Respules 5 x 2.5 ml may cause dry mouth as a temporary side effect in some people. It is not necessary for everyone taking Combimist-L Respules 5 x 2.5 ml to experience this side effect. However, to avoid such side effects, drink plenty of water, regularly rinse your mouth, practice good oral hygiene and suck on sugarless candy. However, if the condition persists or worsens, please consult a doctor.

Can I stop taking Combimist-L Respules 5 x 2.5 ml on my own?

No, you are not recommended to stop taking Combimist-L Respules 5 x 2.5 ml without consulting your doctor as it may worsen the condition or cause recurring symptoms. Therefore, take Combimist-L Respules 5 x 2.5 ml for as long as your doctor has prescribed it, and if you experience any difficulty while taking Combimist-L Respules 5 x 2.5 ml, please consult your doctor.

Does Combimist-L Respules 5 x 2.5 ml relieve sudden symptoms?

No, Combimist-L Respules 5 x 2.5 ml does not relieve sudden symptoms such as shortness of breath. Therefore, it is advised to carry a rescue inhaler always to treat sudden symptoms.

Drug-Drug Interactions Checker List

SALMETEROL
ALBUTEROL
VILANTEROL
FORMOTEROL
TIOTROPIUM
BUDESONIDE
PREDNISONE
FUROSEMIDE
ONDANSETRON
ATROPINE

Special Advise

Avoid contact of Combimist-L Respules 5 x 2.5 ml with eyes, especially if you have glaucoma (damaged eye nerve due to increased eye pressure) as it may worsen the condition and cause eye irritation or blurred vision. A fungal infection might occur in your mouth and throat, so it is advisable to gargle with warm water after each inhalation of Combimist-L Respules 5 x 2.5 ml.

Disease/Condition Glossary

Chronic obstructive pulmonary disease (COPD): It is a group of lung diseases with emphysema (shortness of breath due to damaged air sacs) and chronic bronchitis (inflammation of the lining of bronchial tubes). The major cause of COPD is smoking tobacco and exposure to air pollutants like asbestos and chemicals/fumes. Also, long-term exposure to fumes and chemicals may lead to COPD. The symptoms include chronic cough, shortness of breath or wheezing (whistle sound while breathing).