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Written By Divya L , PharmaD
Reviewed By Sureshvarma D , MPharma

About Combisaf Tablet 1's

Combisaf Tablet 1's belongs to the class of 'antibiotics', primarily used to treat vaginal infections, such as bacterial vaginosis (BV), candidiasis, trichomoniasis, and mixed infections with chlamydia and Neisseria. Bacterial vaginosis is caused by the change in the normal balance of vaginal bacteria. Vaginal yeast infection or Candidiasis is the infection of the vagina and tissues at the opening of the vagina (vulva). Trichomoniasis is a sexually transmitted infection caused by a parasite. Chlamydia is a sexually transmitted infection caused by bacteria. Symptoms of a vaginal infection include itching, odour and abnormal vaginal discharge.

Combisaf Tablet 1's comprises three medicines: Azithromycin (antibiotic), Fluconazole (antifungal), and Secnidazole (antibiotic). Azithromycin belongs to the class of 'macrolide antibiotics'. It works by inhibiting bacterial protein synthesis, which inhibits bacterial growth. Fluconazole belongs to the class of 'azole antifungal' agents. It stops the growth of fungi by causing damage and leakage to the fungal cell membrane. Secnidazole is an antibiotic that belongs to the class of 'amoebicides'. It works by stopping the growth of infection-causing bacteria.

Use Combisaf Tablet 1's as prescribed by the doctor. Common side effects of Combisaf Tablet 1's include taste changes, vomiting, headache, dizziness, stomach pain, nausea, indigestion, diarrhoea, and loss of appetite. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Inform your doctor if you are allergic to Combisaf Tablet 1's or any of its components. It is essential to tell your doctor if you use any other azole antifungal agents before using Combisaf Tablet 1's. Let your doctor know if you have any liver, kidney, gastrointestinal diseases (diarrhoea and colitis, inflammation of the colon), allergic conditions, ulcers or blisters, and urination problems. Pregnant and breastfeeding women should consult their doctor before starting Combisaf Tablet 1's. It is advised to avoid alcohol intake while using Combisaf Tablet 1's to prevent any undesirable effects.

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Non returnable*
COD available

Online payment accepted

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

Uses of Combisaf Tablet 1's

Vaginal infections, bacterial vaginosis (BV), candidiasis, and trichomoniasis. 

Medicinal Benefits

Combisaf Tablet 1's is used to treat vaginal infections, such as bacterial vaginosis (BV), candidiasis, trichomoniasis, and mixed infections with chlamydia and Neisseria. It comprises three medicines: Azithromycin, Fluconazole, and Secnidazole. Azithromycin is an antibiotic that works by inhibiting bacterial protein synthesis, which further inhibits bacterial growth. Fluconazole is an antifungal drug that stops fungi growth by causing damage and leakage to the fungal cell membrane. Secnidazole is an antibiotic works by stopping the growth of infection-causing bacteria. It effectively treats vaginal infection (bacterial vaginosis).

Side Effects of Combisaf Tablet 1's

  • Taste changes
  • Vomiting
  • Headache
  • Dizziness
  • Stomach pain
  • Nausea
  • Indigestion
  • Diarrhoea
  • Loss of appetite 

Directions for Use

Take Combisaf Tablet 1's with food as prescribed by your doctor. Swallow Combisaf Tablet 1's as a whole with a glass of water, do not chew, break or crush it.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Please inform your doctor if you use any prescription, non-prescription medicines, including vitamin and herbal supplements before using Combisaf Tablet 1's. Do not use Combisaf Tablet 1's if you are allergic to Combisaf Tablet 1's or any of its components. Let your doctor know if you have any liver, kidney, gastrointestinal diseases (diarrhea and colitis, an inflammation of the colon), allergic conditions, ulcers or blisters, and urination problems. Combisaf Tablet 1's is not recommended in case of severe renal impairment. It is advised to use Combisaf Tablet 1's under your doctor's supervision if you use other azole antifungal medicines. It is better to avoid Combisaf Tablet 1's during the first trimester of pregnancy. Combisaf Tablet 1's should be used with caution and only under a doctor's advice if you are a nursing mother. Do not drive or operate machinery if you experience dizziness or other side effects that may affect your mental ability to drive. Avoid alcohol consumption along with Combisaf Tablet 1's to avoid undesirable effects like flushing, increased heartbeat, nausea, thirst, chest pain, and low blood pressure. Do not take any antacids containing magnesium or aluminum for up to two hours after using Combisaf Tablet 1's.

Therapeutic Class

ANTIBIOTIC COMBINATION

Drug-Drug Interactions

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AceclofenacAtenolol
Severe
ParacetamolTeriflunomide
Severe

Drug-Drug Interactions

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AceclofenacAtenolol
Severe
How does the drug interact with Combisaf Tablet 1's:
Co-administration of Atenolol with Combisaf Tablet 1's could increase the risk of low blood pressure.

How to manage the interaction:
Although there is a possible interaction between Atenolol and Combisaf Tablet 1's, you can take these medicines together if prescribed by a doctor. Consult a doctor if you experience excessive sweating, shortness of breath, palpitations, or chest discomfort. Do not discontinue any medications without consulting a doctor.
ParacetamolTeriflunomide
Severe
How does the drug interact with Combisaf Tablet 1's:
Co-administration of Teriflunomide with Combisaf Tablet 1's may increase the risk or severity of Liver problems.

How to manage the interaction:
Taking Combisaf Tablet 1's with Teriflunomide together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
ParacetamolKetamine
Severe
How does the drug interact with Combisaf Tablet 1's:
Co-administration of ketamine and Combisaf Tablet 1's may decrease the effectiveness of Ketamine which could result in a higher blood level.

How to manage the interaction:
Although taking Ketamine and Combisaf Tablet 1's together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you're feeling very sleepy or having trouble breathing, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.
ParacetamolKetoconazole
Severe
How does the drug interact with Combisaf Tablet 1's:
Co-administration of Combisaf Tablet 1's and Ketoconazole may increase the risk of liver injury.

How to manage the interaction:
Although there is a possible interaction between Combisaf Tablet 1's and Ketoconazole, you can take these medicines together if prescribed by a doctor. However, if you have joint pain or swelling, fever, chills, unusual bleeding or bruising, skin rash, itching, over-tiredness, nausea, vomiting, loss of appetite, stomach pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact a doctor immediately as these may be signs and symptoms of liver damage. Do not discontinue the medication without consulting a doctor.
ParacetamolOxazepam
Severe
How does the drug interact with Combisaf Tablet 1's:
Co-administration of Combisaf Tablet 1's may decrease the excretion rate of Oxazepam which could result in a higher serum level.

How to manage the interaction:
Although there is a possible interaction between Oxazepam and Combisaf Tablet 1's, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolLeflunomide
Severe
How does the drug interact with Combisaf Tablet 1's:
Co-administration of Combisaf Tablet 1's and Leflunomide may increase the risk of liver problems.

How to manage the interaction:
Although there is a possible interaction between Combisaf Tablet 1's and Leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ParacetamolValdecoxib
Severe
How does the drug interact with Combisaf Tablet 1's:
Co-administration of Combisaf Tablet 1's and Valdecoxib may increase the risk or severity of adverse effects.

How to manage the interaction:
Although there is a possible interaction between Combisaf Tablet 1's and Valdecoxib, you can take these medicines together if prescribed by a doctor. However, if the side effects worsen, please consult a doctor.
ParacetamolLomitapide
Severe
How does the drug interact with Combisaf Tablet 1's:
Co-administration of Lomitapide and Combisaf Tablet 1's may increase the risk of severity of liver injury.

How to manage the interaction:
Although there is a possible interaction between Combisaf Tablet 1's and Lomitapide, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolMipomersen
Severe
How does the drug interact with Combisaf Tablet 1's:
Co-administration of Mipomersen with Combisaf Tablet 1's may increase the risk or severity of liver injury.

How to manage the interaction:
There may be a possibility of interaction between Combisaf Tablet 1's and Mipomersen, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • DIGOXIN
  • TRIAZOLAM
  • CYCLOSPORINE
  • TACROLIMUS
  • CARBAMAZEPINE
  • PHENYTOIN
  • RIFAMPICIN
  • RIFABUTIN
  • THEOPHYLLINE
  • ASTEMIZOLE

Diet & Lifestyle Advise

  • Avoid frequent douching to maintain the natural moisture in the vagina.
  • Use mild soap while taking baths and prefer warm baths.
  • Avoid harsh products on your skin.
  • Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.
  • Avoid or limit the intake of alcohol and caffeine.

Habit Forming

No

Special Advise

It is advised to reach out to your doctor if the infection symptoms persist or worsen after two weeks of treatment. 

Author Details

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Disease/Condition Glossary

Bacterial vaginosis: It is a type of vaginal infection caused by the change in the normal balance of vaginal bacteria.

Vaginal yeast infection or Candidiasis is the infection of the vagina and tissues at the opening of the vagina (vulva). 

Trichomoniasis is a sexually transmitted infection caused by a parasite. Symptoms of a vaginal infection include itching, odor, and abnormal vaginal discharge.

Combisaf Tablet 1's Substitute

Substitutes safety advice
  • Isp Kit Tablet 1's

    by AYUR

    135.00per tablet
  • Fas 3 Kit

    31.27per tablet
  • BTC+Kit Combikit Tablet 4's

    28.57per tablet
  • LGI-3 Kit Tablet 4's

    28.13per tablet
  • Shie Kit Tablet 4's

    28.80per tablet
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