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  3. Combitide 25/125 mcg Starhaler Inhaler 120 mdi

Written By Divya L , PharmaD
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

INHALATION

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Not Returnable

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About Combitide 25/125 mcg Starhaler Inhaler 120 mdi

Combitide 25/125 mcg Starhaler Inhaler 120 mdi is a respiratory medication primarily used to treat and prevent respiratory disorders like asthma attacks and chronic obstructive pulmonary diseases (COPD). Asthma is a breathing problem in which airways narrow, swell, and produce extra mucus, leading to difficulty breathing. COPD is a group of lung diseases with emphysema (shortness of breath) and chronic bronchitis (inflammation of the lining of your bronchial tubes).

Combitide 25/125 mcg Starhaler Inhaler 120 mdi is a combination of two medicines, namely: Salmeterol (bronchodilator) and Fluticasone. Salmeterol is a long-acting bronchodilator that relaxes the muscles in the airways and increases airflow to the lungs. It makes breathing easier by widening the airways. Fluticasone belongs to the class of corticosteroids. It acts by blocking prostaglandins' production (chemical messengers) that cause inflammation (swelling) of the airways.

Your doctor will advise on how often you take Combitide 25/125 mcg Starhaler Inhaler 120 mdi based on your medical condition. The common side effects of Combitide 25/125 mcg Starhaler Inhaler 120 mdi include nausea, vomiting, respiratory tract infection, headache, sore throat, cough, bone, muscle or joint pain, increased heart rate, chills, black or tarry stools, and noisy breathing. Most of these side effects of Combitide 25/125 mcg Starhaler Inhaler 120 mdi do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking this medicine of your own. Brief your medical history to the doctor if you have heart, liver, kidney diseases, hypokalaemia (low potassium levels in the blood), hyperadrenocorticism (high levels of cortisol), eye disorders like cataract and glaucoma, seizure (fits), osteoporosis (weak and brittle bones), and diabetes before taking Combitide 25/125 mcg Starhaler Inhaler 120 mdi. Therapy with nasal or inhaled corticosteroids like Fluticasone should be cautiously administered in patients with a fungal, bacterial, parasitic, or viral infection and tuberculosis since there are chances of developing a secondary infection. Please check with your doctor if you are pregnant, currently breastfeeding, or taking any other prescribed or non-prescribed medicines.

Uses of Combitide 25/125 mcg Starhaler Inhaler 120 mdi

Chronic Obstructive Pulmonary Disease (COPD), Bronchitis, Asthma, and Emphysema.

Directions for Use

Inhaler: Hold the inhaler with the mouthpiece facing downwards. Form a tight seal by placing your lips around the mouthpiece. Start breathing slowly with your mouth and push down the inhaler once. Remove the inhaler and breathe normally.Rotacap/Transcap:Rotacap/Transcap is a capsule with powdered medication which is placed in Rotahaler. It is for inhalation only. Do not swallow the capsule. Rotahaler/Transhaler is a plastic inhalation device that releases the medication when you breathe. The capsule should be placed at the base of the rotahaler/transhaler and completely twist the mouthpiece until you hear a click sound. Then, breathe in through the mouthpiece deeply and hold your breath for 10 seconds. Remove the device and breathe out normally.Respicap/Instacaps: Please read the instruction leaflet before usage and use in the dose and duration suggested by your doctor.Autohaler: Autohaler is a breath-activated device that releases the medication when you inhale. Shake the autohaler well before using it. Hold it upright and push the lever up. Place the mouthpiece in your mouth and seal your lips around it. Breathe in slowly and deeply to release the medication from the device. Hold your breath for 10 seconds and breathe out normally. Push the lever down and replace the cap.Inhalation Capsule: The capsule is meant for inhalation only; do not swallow the capsule. Check the instructions leaflet before use. Place it at the base of the inhaler and twist the mouthpiece until you hear a click sound. Breathe deeply through the mouthpiece and hold your breath for 10 seconds.Oral inhalation (Powder): Check the label for directions to use. Inhale the powder by mouth using an inhaler.Rotadisk: Rotadisk is a silver-coloured aluminium foil disk that contains four blisters to place the medication. The medicine is to be inhaled through the mouth from the Rotadisk using a plastic device called Diskhaler.

Medicinal Benefits

Combitide 25/125 mcg Starhaler Inhaler 120 mdi is used to treat and prevent respiratory disorders like asthma attacks and chronic obstructive pulmonary diseases (COPD). Combitide 25/125 mcg Starhaler Inhaler 120 mdi improves pulmonary function and effectively treats and prevents the worsening of emphysema (shortness of breath) and chronic bronchitis (inflammation of the lining of your bronchial tubes). Combitide 25/125 mcg Starhaler Inhaler 120 mdi is a combination of Salmeterol (bronchodilator) and Fluticasone (corticosteroid). Salmeterol relaxes the muscles in the airways and increases airflow to the lungs. It makes breathing easier by widening the airways. Fluticasone acts by blocking prostaglandins' production (chemical messengers) that cause inflammation (swelling) of the airways. Fluticasone has potent vasoconstrictive (narrowing of the blood vessels) and anti-inflammatory activity.

Storage

Keep out of sight and reach of children.
Side effects of Combitide 25/125 mcg Starhaler Inhaler 120 mdi
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • A blocked nose can be relieved by drinking more water, which helps clear fluids.
  • Use saline nasal spray available over the counter to relieve blockage or blow harder to remove the mucus.
  • Use nasal strips that can be placed on the nose to widen nostrils and increase airflow.
  • Keep a humidifier around to moisten air at home/workplace.
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
  • Regular exercise, like swimming, walking, and yoga, can help reduce bone pain by strengthening muscles and releasing natural pain relievers.
  • Physical therapy, including stretching, strengthening exercises, TENS (a type of therapy using electrical pulses), and massage, can help ease bone pain and improve movement.
  • Mind-body techniques, like relaxation, meditation, and hypnosis, can reduce pain and help control muscle tension that comes with bone pain.
  • Acupuncture may help reduce bone pain by triggering the release of natural painkillers and easing nerve discomfort.
  • Avoid sitting for long periods; take short walks or stretch regularly.
  • Herbs like turmeric and ginger might help with bone pain.
  • Eat a diet rich in calcium, vitamin D, and protein for strong bones and muscles.
  • Quit smoking and limit alcohol.

Drug Warnings

Do not stop taking this medicine of your own unless advised by your doctor. Before taking Combitide 25/125 mcg Starhaler Inhaler 120 mdi, let your doctor know if have a history of heart, liver, kidney diseases, hyperadrenocorticism (high levels of cortisol), eye disorders like cataracts and glaucoma, seizure (fits), osteoporosis (weak and brittle bones), and diabetes. Combitide 25/125 mcg Starhaler Inhaler 120 mdi causes hypokalemia (low potassium levels in the blood), therefore should be used with caution in patients with hypokalaemia to prevent any cardiovascular effects.  Special precautions should be taken in patients with a fungal, bacterial, parasitic, or viral infection and tuberculosis since nasal or inhaled corticosteroids like Fluticasone can cause secondary infections. Combitide 25/125 mcg Starhaler Inhaler 120 mdi can cause a rise in blood glucose levels. Hence monitor your blood glucose levels regularly if you are diabetic. Please let your doctor know if you plan to become pregnant or are already pregnant and a lactating mother. Do not drive or operate machinery if you experience drowsiness and increased/uneven heart rate while using Combitide 25/125 mcg Starhaler Inhaler 120 mdi. Avoid drinking alcohol while taking this medicine as it can worsen your side effects.

Drug-Drug Interactions

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SalmeterolConivaptan
Severe

Drug-Drug Interactions

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How does the drug interact with Combitide 25/125 mcg Starhaler Inhaler 120 mdi:
Co-administration of Combitide 25/125 mcg Starhaler Inhaler 120 mdi with Mifepristone may make Combitide 25/125 mcg Starhaler Inhaler 120 mdi less effective as a therapy.

How to manage the interaction:
Taking Combitide 25/125 mcg Starhaler Inhaler 120 mdi with Mifepristone is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
SalmeterolConivaptan
Severe
How does the drug interact with Combitide 25/125 mcg Starhaler Inhaler 120 mdi:
Conivaptan may significantly increase the blood levels of Combitide 25/125 mcg Starhaler Inhaler 120 mdi. High blood levels of Combitide 25/125 mcg Starhaler Inhaler 120 mdi can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there is a possible interaction between Combitide 25/125 mcg Starhaler Inhaler 120 mdi and Conivaptan, you can take these medicines together if prescribed by a doctor. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without a doctor's advice.
How does the drug interact with Combitide 25/125 mcg Starhaler Inhaler 120 mdi:
Taking Ketoconazole and Combitide 25/125 mcg Starhaler Inhaler 120 mdi (oral inhalation) together can increase the blood levels and effects of Combitide 25/125 mcg Starhaler Inhaler 120 mdi which may lead to a serious abnormal heart rhythm.

How to manage the interaction:
Taking Ketoconazole and Combitide 25/125 mcg Starhaler Inhaler 120 mdi together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
SalmeterolTelithromycin
Severe
How does the drug interact with Combitide 25/125 mcg Starhaler Inhaler 120 mdi:
Telithromycin may significantly increase the blood levels of Combitide 25/125 mcg Starhaler Inhaler 120 mdi. High blood levels of Combitide 25/125 mcg Starhaler Inhaler 120 mdi can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there is a possible interaction between Combitide 25/125 mcg Starhaler Inhaler 120 mdi and Telithromycin, you can take these medicines together if prescribed by a doctor. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
SalmeterolAmprenavir
Severe
How does the drug interact with Combitide 25/125 mcg Starhaler Inhaler 120 mdi:
Co-administration of Amprenavir and Combitide 25/125 mcg Starhaler Inhaler 120 mdi together can increase the irregular heart rhythm.

How to manage the interaction:
Although taking Combitide 25/125 mcg Starhaler Inhaler 120 mdi and Amprenavir together can cause an interaction, it can be taken if a doctor has suggested it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without a doctor's advice.
SalmeterolNefazodone
Severe
How does the drug interact with Combitide 25/125 mcg Starhaler Inhaler 120 mdi:
Nefazodone may significantly increase the blood levels of Combitide 25/125 mcg Starhaler Inhaler 120 mdi. High blood levels of Combitide 25/125 mcg Starhaler Inhaler 120 mdi can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
There may be a possibility of interaction between Combitide 25/125 mcg Starhaler Inhaler 120 mdi and Nefazodone, but it can be taken if prescribed by a doctor. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
SalmeterolTroleandomycin
Severe
How does the drug interact with Combitide 25/125 mcg Starhaler Inhaler 120 mdi:
The combined use of Troleandomycin and Combitide 25/125 mcg Starhaler Inhaler 120 mdi can increase the risk of irregular heart rhythm.

How to manage the interaction:
Co-administration of Combitide 25/125 mcg Starhaler Inhaler 120 mdi with Troleandomycin can result in an interaction, but it can be taken if your doctor has advised it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
SalmeterolDelavirdine
Severe
How does the drug interact with Combitide 25/125 mcg Starhaler Inhaler 120 mdi:
The combined use of Delavirdine and Combitide 25/125 mcg Starhaler Inhaler 120 mdi can increase the risk of irregular heart rhythm.

How to manage the interaction:
Co-administration of Combitide 25/125 mcg Starhaler Inhaler 120 mdi with Delavirdine can result in an interaction, but it can be taken if a doctor has advised it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
SalmeterolCobicistat
Severe
How does the drug interact with Combitide 25/125 mcg Starhaler Inhaler 120 mdi:
Cobicistat may significantly increase the blood levels of Combitide 25/125 mcg Starhaler Inhaler 120 mdi. High blood levels of Combitide 25/125 mcg Starhaler Inhaler 120 mdi can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Co-administration of Combitide 25/125 mcg Starhaler Inhaler 120 mdi with Cobicistat can result in an interaction, but it can be taken if your doctor has advised it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without a doctor's advice.
How does the drug interact with Combitide 25/125 mcg Starhaler Inhaler 120 mdi:
Using sotalol together with Combitide 25/125 mcg Starhaler Inhaler 120 mdi may reduce the effects of both medications, which can lead to low treatment outcomes.

How to manage the interaction:
There may be a possibility of interaction between sotalol and Combitide 25/125 mcg Starhaler Inhaler 120 mdi, but it can be taken if prescribed by a doctor. If you experience any symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Take the medication as directed by the doctor and at regular intervals. Do not use other over the counter medications, herbal or vitamin supplements without informing your pharmacist or doctor when you take Combitide 25/125 mcg Starhaler Inhaler 120 mdi.
  • Know your triggers like allergens, such as pollen, dust, and food items that make your asthma severe.
  • Quit smoking and avoid passive smoking. Smoking also reduces the effectiveness of the medicine.
  • Eat a healthy diet and exercise regularly to strengthen your breathing muscles and boost your immune system.
  • Learning breathing exercises will help you move more air in and out of your lungs.

Side Effects of Combitide 25/125 mcg Starhaler Inhaler 120 mdi

  • Nausea
  • Vomiting
  • Respiratory tract infection
  • Headache
  • Sore throat
  • Cough
  • Bone, muscle or joint pain
  • Increased heart rate
  • Chills
  • Black or tarry stools
  • Noisy breathing

Habit Forming

No

Therapeutic Class

RESPIRATORY STIMULANTS

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Combitide 25/125 mcg Starhaler Inhaler 120 mdi is used to treat and prevent respiratory disorders like asthma attacks and chronic obstructive pulmonary diseases (COPD). Combitide 25/125 mcg Starhaler Inhaler 120 mdi consists of Salmeterol (bronchodilator) and Fluticasone (Fluticasone). Salmeterol relaxes the muscles in the airways and increases airflow to the lungs. Fluticasone acts by blocking prostaglandins' production (chemical messengers) that cause inflammation (swelling) of the airways.

Combitide 25/125 mcg Starhaler Inhaler 120 mdi should be cautiously administered under the doctor's guidance in seizures since bronchodilators like Salmeterol can cause central nervous system stimulation that can lead to other adverse conditions. Please consult your doctor before using Combitide 25/125 mcg Starhaler Inhaler 120 mdi if you have seizures.

Combitide 25/125 mcg Starhaler Inhaler 120 mdi contains bronchodilator (Fluticasone), which can cause a rise in blood glucose levels. Hence therapy with Combitide 25/125 mcg Starhaler Inhaler 120 mdi is cautiously administered in patients with diabetes. Please monitor your blood glucose levels regularly and inform your doctor so that the dose can be adjusted accordingly.

Bronchodilator (Salmeterol) in Combitide 25/125 mcg Starhaler Inhaler 120 mdi may decrease the potassium levels in your body, therefore should be used with caution. Please consult your doctor before taking Combitide 25/125 mcg Starhaler Inhaler 120 mdi since low potassium levels can lead to other cardiovascular problems in patients with hypokalaemia.

Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule.

Drug-Drug Interactions Checker List

  • FUROSEMIDE
  • BUDESONIDE
  • VILANTEROL
  • FORMOTEROL
  • ALBUTEROL
  • IPRATROPIUM
  • METOPROLOL

Special Advise

  • It is advised to undergo blood examination to keep a check on your potassium levels since Combitide 25/125 mcg Starhaler Inhaler 120 mdi can cause low potassium levels in the blood (hypokalaemia).
  • Regularly monitor your blood sugar levels while using Combitide 25/125 mcg Starhaler Inhaler 120 mdi since bronchodilators like Salmeterol can cause low blood glucose levels.
  • Consult your diabetologist if you have diabetes before using Combitide 25/125 mcg Starhaler Inhaler 120 mdi so that your insulin or other diabetic medication can be adjusted accordingly to maintain your blood sugar levels.

Disease/Condition Glossary

Asthma: It is a chronic (long-term) respiratory condition in which airways narrow, swell, and produce extra mucus, leading to difficulty in breathing. The symptoms of asthma include wheezing (whistling sound while breathing), shortness of breath, chest tightness and cough, especially at night. The symptoms of mild persistent asthma may occur more than 2 times in a week and up to 4 nights in a month whereas, in case of severe persistent asthma, the symptoms occur several times every day and most nights. The treatment for asthma includes medication, breathing exercises and self-care.

Chronic obstructive pulmonary disease (COPD): It is a group of lung diseases with emphysema (shortness of breath) and chronic bronchitis (inflammation of the lining of bronchial tubes). The major cause of COPD is smoking tobacco. Also, long-term exposure to fumes and chemicals may also lead to COPD. The symptoms include chronic cough, shortness of breath or wheezing (whistle sound while breathing).

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Alcohol

Caution

Avoid drinking alcohol while taking this medicine as it can worsen your side effects.

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Pregnancy

Caution

Please consult your doctor if you are planning to conceive or are already pregnant before starting Combitide 25/125 mcg Starhaler Inhaler 120 mdi.

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Breast Feeding

Caution

There is limited data on how Combitide 25/125 mcg Starhaler Inhaler 120 mdi affects breastfeeding. Please consult your doctor before starting Combitide 25/125 mcg Starhaler Inhaler 120 mdi.

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Driving

Caution

Do not drive or operate machinery if you experience drowsiness and increased/uneven heart rate while using Combitide 25/125 mcg Starhaler Inhaler 120 mdi. This may affect your ability to drive. Seek medical attention if the symptoms persist longer.

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Liver

Caution

Combitide 25/125 mcg Starhaler Inhaler 120 mdi should be used with caution in patients with liver diseases. Let your doctor know if you have any history of liver diseases or hepatic impairment. Your doctor will weigh the benefits and potential risks before prescribing Combitide 25/125 mcg Starhaler Inhaler 120 mdi.

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Kidney

Caution

Combitide 25/125 mcg Starhaler Inhaler 120 mdi should be used with caution in patients with kidney diseases. Let your doctor know if you have any history of kidney diseases. Your doctor will weigh the benefits and potential risks before prescribing Combitide 25/125 mcg Starhaler Inhaler 120 mdi.

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Children

Caution

Combitide 25/125 mcg Starhaler Inhaler 120 mdi is not recommended for use for children less than four years of age. The dose may have to be adjusted by your doctor depending upon the condition of the child's disease and age.

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