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  3. COMBITIDE 250MCG STARHALER

COMBITIDE 250MCG STARHALER , Pack of 1
Written By Divya L , PharmaD
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Non returnable*
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Composition :

FLUTICASONE-250MCG + SALMETEROL-25MCG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

INHALATION

Return Policy :

Not Returnable

Expires on or after :

About COMBITIDE 250MCG STARHALER

COMBITIDE 250MCG STARHALER is a respiratory medication primarily used to treat and prevent respiratory disorders like asthma attacks and chronic obstructive pulmonary diseases (COPD). Asthma is a breathing problem in which airways narrow, swell, and produce extra mucus, leading to difficulty breathing. COPD is a group of lung diseases with emphysema (shortness of breath) and chronic bronchitis (inflammation of the lining of your bronchial tubes).

COMBITIDE 250MCG STARHALER is a combination of two medicines, namely: Salmeterol (bronchodilator) and Fluticasone. Salmeterol is a long-acting bronchodilator that relaxes the muscles in the airways and increases airflow to the lungs. It makes breathing easier by widening the airways. Fluticasone belongs to the class of corticosteroids. It acts by blocking prostaglandins' production (chemical messengers) that cause inflammation (swelling) of the airways.

Your doctor will advise on how often you take COMBITIDE 250MCG STARHALER based on your medical condition. The common side effects of COMBITIDE 250MCG STARHALER include nausea, vomiting, respiratory tract infection, headache, sore throat, cough, bone, muscle or joint pain, increased heart rate, chills, black or tarry stools, and noisy breathing. Most of these side effects of COMBITIDE 250MCG STARHALER do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking this medicine of your own. Brief your medical history to the doctor if you have heart, liver, kidney diseases, hypokalaemia (low potassium levels in the blood), hyperadrenocorticism (high levels of cortisol), eye disorders like cataract and glaucoma, seizure (fits), osteoporosis (weak and brittle bones), and diabetes before taking COMBITIDE 250MCG STARHALER . Therapy with nasal or inhaled corticosteroids like Fluticasone should be cautiously administered in patients with a fungal, bacterial, parasitic, or viral infection and tuberculosis since there are chances of developing a secondary infection. Please check with your doctor if you are pregnant, currently breastfeeding, or taking any other prescribed or non-prescribed medicines.

Uses of COMBITIDE 250MCG STARHALER

Chronic Obstructive Pulmonary Disease (COPD), Bronchitis, Asthma, and Emphysema.

Directions for Use

Inhaler: Hold the inhaler with the mouthpiece facing downwards. Form a tight seal by placing your lips around the mouthpiece. Start breathing slowly with your mouth and push down the inhaler once. Remove the inhaler and breathe normally.Rotacap/Transcap:Rotacap/Transcap is a capsule with powdered medication which is placed in Rotahaler. It is for inhalation only. Do not swallow the capsule. Rotahaler/Transhaler is a plastic inhalation device that releases the medication when you breathe. The capsule should be placed at the base of the rotahaler/transhaler and completely twist the mouthpiece until you hear a click sound. Then, breathe in through the mouthpiece deeply and hold your breath for 10 seconds. Remove the device and breathe out normally.Respicap/Instacaps: Please read the instruction leaflet before usage and use in the dose and duration suggested by your doctor.Autohaler: Autohaler is a breath-activated device that releases the medication when you inhale. Shake the autohaler well before using it. Hold it upright and push the lever up. Place the mouthpiece in your mouth and seal your lips around it. Breathe in slowly and deeply to release the medication from the device. Hold your breath for 10 seconds and breathe out normally. Push the lever down and replace the cap.Inhalation Capsule: The capsule is meant for inhalation only; do not swallow the capsule. Check the instructions leaflet before use. Place it at the base of the inhaler and twist the mouthpiece until you hear a click sound. Breathe deeply through the mouthpiece and hold your breath for 10 seconds.Oral inhalation (Powder): Check the label for directions to use. Inhale the powder by mouth using an inhaler.Rotadisk: Rotadisk is a silver-coloured aluminium foil disk that contains four blisters to place the medication. The medicine is to be inhaled through the mouth from the Rotadisk using a plastic device called Diskhaler.

Medicinal Benefits

COMBITIDE 250MCG STARHALER is used to treat and prevent respiratory disorders like asthma attacks and chronic obstructive pulmonary diseases (COPD). COMBITIDE 250MCG STARHALER improves pulmonary function and effectively treats and prevents the worsening of emphysema (shortness of breath) and chronic bronchitis (inflammation of the lining of your bronchial tubes). COMBITIDE 250MCG STARHALER is a combination of Salmeterol (bronchodilator) and Fluticasone (corticosteroid). Salmeterol relaxes the muscles in the airways and increases airflow to the lungs. It makes breathing easier by widening the airways. Fluticasone acts by blocking prostaglandins' production (chemical messengers) that cause inflammation (swelling) of the airways. Fluticasone has potent vasoconstrictive (narrowing of the blood vessels) and anti-inflammatory activity.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not stop taking this medicine of your own unless advised by your doctor. Before taking COMBITIDE 250MCG STARHALER , let your doctor know if have a history of heart, liver, kidney diseases, hyperadrenocorticism (high levels of cortisol), eye disorders like cataracts and glaucoma, seizure (fits), osteoporosis (weak and brittle bones), and diabetes. COMBITIDE 250MCG STARHALER causes hypokalemia (low potassium levels in the blood), therefore should be used with caution in patients with hypokalaemia to prevent any cardiovascular effects.  Special precautions should be taken in patients with a fungal, bacterial, parasitic, or viral infection and tuberculosis since nasal or inhaled corticosteroids like Fluticasone can cause secondary infections. COMBITIDE 250MCG STARHALER can cause a rise in blood glucose levels. Hence monitor your blood glucose levels regularly if you are diabetic. Please let your doctor know if you plan to become pregnant or are already pregnant and a lactating mother. Do not drive or operate machinery if you experience drowsiness and increased/uneven heart rate while using COMBITIDE 250MCG STARHALER . Avoid drinking alcohol while taking this medicine as it can worsen your side effects.

Drug-Drug Interactions

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FluticasoneMifepristone
Critical
SalmeterolCarvedilol
Severe

Drug-Drug Interactions

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FluticasoneMifepristone
Critical
How does the drug interact with Combitide 250 Starhaler:
Co-administration of Combitide 250 Starhaler with Mifepristone may make Combitide 250 Starhaler less effective as a therapy.

How to manage the interaction:
Taking Combitide 250 Starhaler with Mifepristone is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
SalmeterolCarvedilol
Severe
How does the drug interact with Combitide 250 Starhaler:
Taking Carvedilol and Combitide 250 Starhaler may reduce the effects of both medications.

How to manage the interaction:
There may be a possibility of interaction between Combitide 250 Starhaler and Carvedilol, but it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
SalmeterolConivaptan
Severe
How does the drug interact with Combitide 250 Starhaler:
Conivaptan may significantly increase the blood levels of Combitide 250 Starhaler. High blood levels of Combitide 250 Starhaler can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there is a possible interaction between Combitide 250 Starhaler and Conivaptan, you can take these medicines together if prescribed by a doctor. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without a doctor's advice.
SalmeterolItraconazole
Severe
How does the drug interact with Combitide 250 Starhaler:
Co-administration of Combitide 250 Starhaler and itraconazole can increase the risk of developing an irregular heartbeat.

How to manage the interaction:
Combitide 250 Starhaler and itraconazole have the potential to interact, however, they can still be used if a doctor prescribes them. If you suffer any of the following symptoms, seek medical attention: dizziness, lightheadedness, fainting, shortness of breath, or racing heartbeats. Never discontinue taking a drug without consulting a doctor.
SalmeterolClarithromycin
Severe
How does the drug interact with Combitide 250 Starhaler:
Taking Clarithromycin may boost the blood levels of Combitide 250 Starhaler increasing the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there is a possible interaction, clarithromycin can be taken with Combitide 250 Starhaler if prescribed by the doctor. Consult the prescriber if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications. Do not stop using any medications without a doctor's advice.
SalmeterolPropranolol
Severe
How does the drug interact with Combitide 250 Starhaler:
Using propranolol together with Combitide 250 Starhaler may reduce the benefits of both medications, since they have opposing effects in the body. In addition, propranolol can sometimes cause breathing problems.

How to manage the interaction:
Although taking Propranolol together with Combitide 250 Starhaler can result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
SalmeterolNelfinavir
Severe
How does the drug interact with Combitide 250 Starhaler:
Nelfinavir may significantly increase the blood levels of Combitide 250 Starhaler. High blood levels of Combitide 250 Starhaler can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Co-administration of Combitide 250 Starhaler with Nelfinavir can result in an interaction, but it can be taken if your doctor has advised it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without a doctor's advice.
SalmeterolKetoconazole
Severe
How does the drug interact with Combitide 250 Starhaler:
Taking Ketoconazole and Combitide 250 Starhaler (oral inhalation) together can increase the blood levels and effects of Combitide 250 Starhaler which may lead to a serious abnormal heart rhythm.

How to manage the interaction:
Taking Ketoconazole and Combitide 250 Starhaler together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
SalmeterolBoceprevir
Severe
How does the drug interact with Combitide 250 Starhaler:
Co-administration of Boceprevir and Combitide 250 Starhaler together can increase the irregular heart rhythm.

How to manage the interaction:
Although taking Combitide 250 Starhaler and Boceprevir together can cause an interaction, it can be taken if a doctor has suggested it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
SalmeterolSaquinavir
Severe
How does the drug interact with Combitide 250 Starhaler:
Saquinavir may significantly increase the blood levels of Combitide 250 Starhaler. High blood levels of Combitide 250 Starhaler can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
There may be a possibility of interaction between Combitide 250 Starhaler and Saquinavir, but it can be taken if prescribed by a doctor. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Take the medication as directed by the doctor and at regular intervals. Do not use other over the counter medications, herbal or vitamin supplements without informing your pharmacist or doctor when you take COMBITIDE 250MCG STARHALER .
  • Know your triggers like allergens, such as pollen, dust, and food items that make your asthma severe.
  • Quit smoking and avoid passive smoking. Smoking also reduces the effectiveness of the medicine.
  • Eat a healthy diet and exercise regularly to strengthen your breathing muscles and boost your immune system.
  • Learning breathing exercises will help you move more air in and out of your lungs.

Habit Forming

No

Therapeutic Class

RESPIRATORY STIMULANTS

Author Details

Doctor image

Written By

Divya L

PharmaD

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 8, 2025 | 9:32 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

COMBITIDE 250MCG STARHALER is used to treat and prevent respiratory disorders like asthma attacks and chronic obstructive pulmonary diseases (COPD). COMBITIDE 250MCG STARHALER consists of Salmeterol (bronchodilator) and Fluticasone (Fluticasone). Salmeterol relaxes the muscles in the airways and increases airflow to the lungs. Fluticasone acts by blocking prostaglandins' production (chemical messengers) that cause inflammation (swelling) of the airways.

COMBITIDE 250MCG STARHALER should be cautiously administered under the doctor's guidance in seizures since bronchodilators like Salmeterol can cause central nervous system stimulation that can lead to other adverse conditions. Please consult your doctor before using COMBITIDE 250MCG STARHALER if you have seizures.

COMBITIDE 250MCG STARHALER contains bronchodilator (Fluticasone), which can cause a rise in blood glucose levels. Hence therapy with COMBITIDE 250MCG STARHALER is cautiously administered in patients with diabetes. Please monitor your blood glucose levels regularly and inform your doctor so that the dose can be adjusted accordingly.

Bronchodilator (Salmeterol) in COMBITIDE 250MCG STARHALER may decrease the potassium levels in your body, therefore should be used with caution. Please consult your doctor before taking COMBITIDE 250MCG STARHALER since low potassium levels can lead to other cardiovascular problems in patients with hypokalaemia.

Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule.

Drug-Drug Interactions Checker List

  • FUROSEMIDE
  • BUDESONIDE
  • VILANTEROL
  • FORMOTEROL
  • ALBUTEROL
  • IPRATROPIUM
  • METOPROLOL

Special Advise

  • It is advised to undergo blood examination to keep a check on your potassium levels since COMBITIDE 250MCG STARHALER can cause low potassium levels in the blood (hypokalaemia).
  • Regularly monitor your blood sugar levels while using COMBITIDE 250MCG STARHALER since bronchodilators like Salmeterol can cause low blood glucose levels.
  • Consult your diabetologist if you have diabetes before using COMBITIDE 250MCG STARHALER so that your insulin or other diabetic medication can be adjusted accordingly to maintain your blood sugar levels.

Disease/Condition Glossary

Asthma: It is a chronic (long-term) respiratory condition in which airways narrow, swell, and produce extra mucus, leading to difficulty in breathing. The symptoms of asthma include wheezing (whistling sound while breathing), shortness of breath, chest tightness and cough, especially at night. The symptoms of mild persistent asthma may occur more than 2 times in a week and up to 4 nights in a month whereas, in case of severe persistent asthma, the symptoms occur several times every day and most nights. The treatment for asthma includes medication, breathing exercises and self-care.

Chronic obstructive pulmonary disease (COPD): It is a group of lung diseases with emphysema (shortness of breath) and chronic bronchitis (inflammation of the lining of bronchial tubes). The major cause of COPD is smoking tobacco. Also, long-term exposure to fumes and chemicals may also lead to COPD. The symptoms include chronic cough, shortness of breath or wheezing (whistle sound while breathing).

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