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  3. Comclin 300mg Capsule

Comclin 300mg Capsule, Pack of 1 Capsule
Comclin 300mg Capsule, Pack of 1 Capsule
Written By Divya L , PharmaD
Reviewed By Veda Maddala , M Pharmacy
Non returnable*
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Whats That

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Composition :

CLINDAMYCIN-300MG

Manufacturer/Marketer :

Murentia Pharmaceuticals

Consume Type :

ORAL

Return Policy :

Not Returnable

About Comclin 300mg Capsule

Comclin 300mg Capsule belongs to the class of ‘antibiotics’, primarily used to treat bacterial infections. Bacterial infection occurs when harmful bacteria grow in the body and causes illness. It can infect any part of the body and multiply very quickly. Comclin 300mg Capsule will not work for viral infections, such as common cold and flu.

Comclin 300mg Capsule contains 'Clindamycin' that works by preventing bacterial protein synthesis, leading to the inhibition of bacterial growth. It shows a bacteriostatic effect that stops bacterial reproduction. Comclin 300mg Capsule effectively treats infections caused by gram-positive and anaerobic (living without air) bacteria, including susceptible strains of Staphylococcus aureus, Streptococcus pneumoniae, and Clostridium perfringens.

Take Comclin 300mg Capsule as advised by a doctor. Comclin 300mg Capsule may cause side effects, although not everybody gets them. Common side effects of Comclin 300mg Capsule include stomach pain, nausea, vomiting, diarrhoea, heartburn, skin rash, and vaginal itching or discharge. Most of these side effects do not require medical attention and gradually resolve over time. If these side effects persist longer, please consult your doctor.

Inform the doctor if you are allergic to any of the components in Comclin 300mg Capsule. Let your doctor know if you have any liver disease, kidney disease, gastrointestinal diseases (colitis, an inflammation of the colon), yellow food dye allergy, and allergic conditions (asthma, hay fever, eczema). Do not use Comclin 300mg Capsule while getting vaccinated with live bacterial vaccines (typhoid vaccine) since Comclin 300mg Capsule may affect vaccine activity. Comclin 300mg Capsule should be used only with a doctor's advice during pregnancy and breastfeeding.

Uses of Comclin 300mg Capsule

Bacterial infections.

Directions for Use

Tablet/capsule: Swallow the tablet/capsule as a whole with a glass of water. Do not chew, crush or break it.Oral liquid: Measure the liquid with a measuring cup and take it as advised by the doctor.

Medicinal Benefits

Comclin 300mg Capsule is an antibiotic that treats bacterial infections. It works by inhibiting bacterial protein synthesis, which inhibits bacterial growth. It shows a bacteriostatic effect, which stops bacterial reproduction but doesn't kill them. Comclin 300mg Capsule effectively treats infections caused by gram-positive and anaerobic (living without air) bacteria, including susceptible strains of Staphylococcus aureus, Streptococcus pneumoniae, and Clostridium perfringens.

Storage

Store in a cool and dry place away from sunlight
Side effects of Comclin 300mg Capsule
  • Take cold water baths avoiding soap.
  • Avoid scratching and scrubbing to prevent infections while itching.
  • Use nets to prevent insects and mosquitoes.
  • Stop using lotions and creams that cause irritation.
  • Avoid alcohol and caffeine intake.
  • Abnormal liver function requires immediate medical attention. Your doctor may recommend lifestyle modifications along with needed medication.
  • Avoid intake of alcohol as it has a direct impact on liver functioning.
  • Prevent medications like paracetamol, over-the-counter painkillers or those mentioned by your doctor, as they may have issues getting metabolised in your body.
  • If you have overweight issues, losing weight can be a good thing to manage abnormal liver function.
  • Cut down the number of fatty foods that are taken daily.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.

Drug Warnings

Do not use Comclin 300mg Capsule if you are allergic to any of its components. Let your doctor know if you have any liver or kidney diseases, gastrointestinal diseases (colitis, Clostridium difficile-associated diarrhoea), yellow food dye allergy, and allergic conditions (asthma, hay fever, eczema). Do not use Comclin 300mg Capsule while getting vaccinated with live bacterial vaccines (typhoid vaccine) since Comclin 300mg Capsule may affect vaccine activity. Pregnant and breastfeeding women should consult their doctor before taking Comclin 300mg Capsule. Comclin 300mg Capsule should be used in children only when prescribed by a doctor.

Drug-Drug Interactions

verifiedApollotooltip
ClindamycinGentamicin
Severe
ClindamycinItraconazole
Severe

Drug-Drug Interactions

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ClindamycinGentamicin
Severe
How does the drug interact with Comclin 300mg Capsule:
Co-administration of of Comclin 300mg Capsule with gentamicin may increase the risk of kidney and/or nerve damage.

How to manage the interaction:
Although there is a possible interaction, Comclin 300mg Capsule can be taken with gentamicin if prescribed by the doctor. Consult the prescriber if you experience signs and symptoms of kidney damage such as sudden weight gain or weight loss, nausea, vomiting, fluid retention, loss of appetite, increased or decreased urination, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. If you develop diarrhea or vomiting during treatment with these medications, drink plenty of fluids to prevent dehydration, as dehydration may also harm the kidney.
ClindamycinItraconazole
Severe
How does the drug interact with Comclin 300mg Capsule:
Concomitant use of Comclin 300mg Capsule with itraconazole can reduce the metabolism and increase the levels of Comclin 300mg Capsule in the body. This may increase the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction, Comclin 300mg Capsule can be taken with itraconazole if prescribed by the doctor. Consult a doctor immediately if you experience persistent vomiting, nausea, abdominal pain, or diarrhea. Do not stop using any medications without first talking to your doctor.
ClindamycinBoceprevir
Severe
How does the drug interact with Comclin 300mg Capsule:
Co-administration of Boceprevir together with Comclin 300mg Capsule can increase the effects of Comclin 300mg Capsule.

How to manage the interaction:
Although there is a possible interaction between Comclin 300mg Capsule and Boceprevir, you can take these medicines together if prescribed by your doctor. If you have ongoing feelings of sickness, throwing up, having loose stools, or pain in your stomach, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.
ClindamycinFosphenytoin
Severe
How does the drug interact with Comclin 300mg Capsule:
When Comclin 300mg Capsule is taken with Fosphenytoin, it can cause the body to process Comclin 300mg Capsule faster.

How to manage the interaction:
Although there is a possible interaction between Comclin 300mg Capsule and Fosphenytoin, you can take these medicines together if prescribed by your doctor. If you notice any symptoms like sudden drowsiness, fatigue, confusion, itching, burning, or tingling sensation, abnormal body movements, or loss of coordination, make sure to contact your doctor right away. Do not stop using any medications without first talking to your doctor.
ClindamycinCholera, live attenuated
Severe
How does the drug interact with Comclin 300mg Capsule:
Co-administration of Comclin 300mg Capsule may reduce the activity of the cholera vaccine.

How to manage the interaction:
Talk to your doctor before receiving the Cholera vaccine if you are currently being treated with Comclin 300mg Capsule or have been treated within the last 14 days. To ensure adequate vaccine response, you should not receive cholera vaccine until at least 14 days after you complete antibiotic therapy. Do not discontinue the medication without consulting a doctor.
ClindamycinBalsalazide
Severe
How does the drug interact with Comclin 300mg Capsule:
Co-administration of Comclin 300mg Capsule with Balsalazide may reduce the effectiveness of Balsalazide.

How to manage the interaction:
Although there is a possible interaction, Comclin 300mg Capsule can be taken with balsalazide if prescribed by the doctor. Consult the prescriber if you have any concerns, the doctor may prescribe alternatives that do not interact, dose adjustment, or more frequent monitoring to safely use both medications. Do not discontinue the medication without consulting a doctor.
ClindamycinClarithromycin
Severe
How does the drug interact with Comclin 300mg Capsule:
Taking Comclin 300mg Capsule with clarithromycin may increase the effects of Comclin 300mg Capsule.

How to manage the interaction:
Although there is a possible interaction, Comclin 300mg Capsule can be taken with clarithromycin if prescribed by the doctor. Consult the prescriber if you experience persistent vomiting, nausea, abdominal pain, or diarrhea. Do not discontinue the medication without consulting a doctor.
ClindamycinEstradiol
Severe
How does the drug interact with Comclin 300mg Capsule:
When taken in combination, Comclin 300mg Capsule can lower the amount or action of estradiol.

How to manage the interaction:
Co-administration of Estradiol with Comclin 300mg Capsule can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without a doctor's advice.
ClindamycinIndinavir
Severe
How does the drug interact with Comclin 300mg Capsule:
Concomitant use of Comclin 300mg Capsule with indinavir may increase the effects of Comclin 300mg Capsule.

How to manage the interaction:
Although there is a possible interaction, Comclin 300mg Capsule can be taken with indinavir if prescribed by the doctor. Consult the prescriber if you experience persistent vomiting, nausea, abdominal pain, or diarrhoea.
ClindamycinAmprenavir
Severe
How does the drug interact with Comclin 300mg Capsule:
Co-administration of Amprenavir together with Comclin 300mg Capsule can increase the effects of Comclin 300mg Capsule.

How to manage the interaction:
Co-administration of Comclin 300mg Capsule with Amprenavir can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have ongoing feelings of sickness, throwing up, having loose stools, or pain in your stomach, it's important to contact your doctor right away. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include whole-grain foods like multigrain bread and brown rice in your diet. 
  • Taking probiotics after an antibiotic treatment reduces the risk of antibiotic-associated diarrhoea. 
  • Try taking yoghurt, cheese, sauerkraut, and kimchi that help restore the intestine's good bacteria.
  • Include more fibre-enriched food in your diet that is easily digested by your gut bacteria. Fibre foods may also help restore healthy gut bacteria after a course of antibiotics. 
  • Avoid intake of alcoholic beverages as it can make you dehydrated and affect your sleep. 
  • Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep. 

Habit Forming

No

Therapeutic Class

ANTIBIOTICS

Comclin 300mg Capsule Substitute

Substitutes safety advice

  • Dalacin C 300 mg Capsule 10's

    by Others

    ₹26.18per tablet

  • Clindatec 300 mg Capsule 8's

    by Others

    ₹25.31per tablet

  • Clindasure 300mg Capsule 10's

    by AYUR

    ₹26.78per tablet

  • Clincin 300 mg Capsule 10's

    by Others

    ₹26.78per tablet

  • Camyda 300 Capsule 10's

    by AYUR

    ₹26.78per tablet

Product Substitutes

Author Details

Doctor image

Written By

Divya L

PharmaD

Veda MaddalaDoctor badge

Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Aug 20, 2024 | 1:14 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

verifiedApollotooltip
CLINDAMYCIN-300MGOther bacterial intestinal infections
Severe
CLINDAMYCIN-300MGDisorders related to short gestation and low birth weight, not elsewhere classified
Severe

Drug-Diseases Interactions

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CLINDAMYCIN-300MGOther bacterial intestinal infections
Severe
How does the disease interact with Comclin 300mg Capsule:
Almost all antibacterial medications have been associated with reports of Clostridioides difficile-associated diarrhoea (CDAD), formerly known as pseudomembranous colitis. It can vary from mild diarrhoea to deadly colitis.

How to manage the interaction:
Clostridioides difficile-associated diarrhea (CDAD) ranging from mild diarrhoea to colitis has been reported during treatment with antibacterial agents. Therapy should be administered cautiously in patients with history of gastrointestinal disease, particularly colitis and pseudomembranous colitis. Appropriate fluid and electrolyte management, protein supplementation, and antibacterial treatment of C difficile is advised.
CLINDAMYCIN-300MGDisorders related to short gestation and low birth weight, not elsewhere classified
Severe
How does the disease interact with Comclin 300mg Capsule:
Benzyl alcohol is frequently used as a preservative in the formulation of multidose vials for parenteral medicines. Manufacturers of pharmaceuticals believe that using them in neonates, especially preterm and underweight newborns, is contraindicated. In low birth weight preterm newborns, the use of benzyl alcohol in bacteriostatic saline intravascular flush and endotracheal tube lavage solutions has been linked to mortality and serious respiratory and metabolic problems.

How to manage the interaction:
Parenteral medications containing benzyl alcohol as a preservative are contraindicated in neonates, particularly premature infants and infants of low birth weight.
CLINDAMYCIN-300MGOther diseases of liver
Moderate
How does the disease interact with Comclin 300mg Capsule:
The liver is the primary site of Comclin 300mg Capsule metabolism. Patients with significantly impaired hepatic function may have a rise in the blood concentration of Comclin 300mg Capsule and a prolongation of the half-life. Additionally, the drug's usage may result in abnormal liver enzyme levels and jaundice. Patients with liver problems should receive Comclin 300mg Capsule therapy with caution. When given every 8 hours, dosage modifications might not be required. However, with high-dose therapy, serum concentrations should be observed, and during prolonged therapy, regular liver function tests should be carried out.

How to manage the interaction:
Comclin 300mg Capsule is primarily metabolized by the liver. Therapy with Comclin 300mg Capsule should be administered cautiously in patients with liver disease. Serum concentrations should be monitored during high-dose therapy, and periodic liver function tests should be performed during prolonged therapy.
CLINDAMYCIN-300MGOther disorders of kidney and ureter, not elsewhere classified
Moderate
How does the disease interact with Comclin 300mg Capsule:
Comclin 300mg Capsule is partially removed by the kidney. Comclin 300mg Capsule should be used with caution in individuals with significantly impaired renal function. Dosage changes are probably to be required. Serum Comclin 300mg Capsule concentrations should be monitored throughout high-dose therapy, and renal function tests should be conducted on a regular basis during extended medication.

How to manage the interaction:
Therapy with Comclin 300mg Capsule should be administered cautiously in patients with severely impaired renal function. Serum Comclin 300mg Capsule concentrations should be monitored during high-dose therapy, and periodic renal function tests should be performed during prolonged therapy.
CLINDAMYCIN-300MGOther disorders of kidney and ureter, not elsewhere classified
Moderate
How does the disease interact with Comclin 300mg Capsule:
Comclin 300mg Capsule is partially removed by the kidney. Comclin 300mg Capsule should be used with caution in individuals with significantly impaired renal function. Dosage changes are probably to be required. Serum Comclin 300mg Capsule concentrations should be monitored throughout high-dose therapy, and renal function tests should be conducted on a regular basis during extended medication.

How to manage the interaction:
Therapy with Comclin 300mg Capsule should be administered cautiously in patients with severely impaired renal function. Serum Comclin 300mg Capsule concentrations should be monitored during high-dose therapy, and periodic renal function tests should be performed during prolonged therapy.

FAQs

Comclin 300mg Capsule is an antibiotic that treats bacterial infections. It works by inhibiting bacterial protein synthesis, which retards bacterial growth.

Comclin 300mg Capsule should be used with proper caution and doctor consultation if you have any liver disease, kidney disease, gastrointestinal diseases (colitis, an inflammation of the colon), yellow food dye allergy, and allergic conditions (asthma, hay fever, eczema).

Comclin 300mg Capsule can affect the live vaccines like typhoid vaccine and decrease its effectiveness. Please consult a doctor before you start Comclin 300mg Capsule if you are due to undergo any vaccinations.

Comclin 300mg Capsule may cause abnormal liver function tests as one of its side effects. Please consult your doctor before starting Comclin 300mg Capsule if you have any history of liver problems.

It is recommended to complete the course of Comclin 300mg Capsule even if you feel better as it is an antibiotic, and stopping it midway may lead to recurring infections.

Diarrhoea can be a side-effect of Comclin 300mg Capsule. Drink enough fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or experience severe diarrhoea, consult your doctor. Do not take anti-diarrhoeal medicine on your own.

Drug-Drug Interactions Checker List

  • ERYTHROMYCIN
  • WARFARIN
  • CARBAMAZEPINE
  • RIFAMPICIN
  • PHENYTOIN

Special Advise

  • Liver function monitoring (Liver function tests) is recommended in patients with severe liver disease.
  • Clostridium difficile-associated diarrhoea (CDAD) is reported during the usage of antibiotics. Please consult your doctor if you experience prolonged diarrhoea.
  • Coagulation (blood clotting) tests are recommended when Comclin 300mg Capsule is used along with anticoagulants.

Disease/Condition Glossary

Bacterial infection: It occurs when harmful bacteria grow in the body and causes illness. It can infect any part of the body and multiply very quickly. Bacteria may be gram-positive (have a thick cell wall) or gram-negative (do not have a cell wall). Some common symptoms of a bacterial infection include cough, fever, shortness of breath, chills, muscle pain, fatigue, and tiredness. Untreated bacterial infections may lead to serious life-threatening conditions like sepsis.

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