Cosklot MF Tablet 10's

Written By Santoshini Reddy G , M Pharmacy

Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

MRP ₹378.5

(Inclusive of all Taxes)

₹56.8 Cashback (15%)

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Whats That

About Cosklot MF Tablet

Cosklot MF Tablet is a combination medicine used to treat dysmenorrhea (period pain) and menorrhagia (heavy menstrual bleeding). Besides this, Cosklot MF Tablet is also used to treat severe blood loss, swelling in various body parts, fever, inflammation, and migraine headache. Menstrual cramps, also known as dysmenorrhea, are characterized by cramps and pain during menstruation. Menorrhagia is a condition with abnormally heavy or prolonged bleeding during menstruation/periods.

Cosklot MF Tablet is a combination of two drugs: Tranexamic acid (anti-fibrinolytic) and Mefenamic acid (NSAID). Tranexamic acid helps the body's natural blood clot process by preventing fibrin's breakdown, this stops fibrinolysis, a process that stops blood clot formation. Mefenamic acid works by blocking the effect of chemical messengers that cause pain.

You are advised to take Cosklot MF Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as nausea, vomiting, diarrhoea, indigestion, heartburn, and headache. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Consult your doctor if you are pregnant or breastfeeding. Cosklot MF Tablet may cause dizziness, so drive with caution. Cosklot MF Tablet should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol along with Cosklot MF Tablet as it could lead to increased drowsiness and dizziness, it might also increase the risk of stomach bleeding. Keep your doctor informed about your health condition and medicines to rule out any side-effects/interactions.

Uses of Cosklot MF Tablet

Dysmenorrhea (period pain) and menorrhagia (heavy menstrual bleeding).

Directions for Use

Take Cosklot MF Tablet with food to prevent stomach upset. Swallow Cosklot MF Tablet as a whole with a glass of water, do not chew, or break it.

Medicinal Benefits

Cosklot MF Tablet is a combination of two drugs, namely: Tranexamic acid and Mefenamic acid. Cosklot MF Tablet is used to treat abdominal pain, dysmenorrhea (period pain), and menorrhagia (heavy menstrual bleeding). Additionally, Cosklot MF Tablet is also used to treat severe blood loss, swelling in various body parts, fever, inflammation, and migraine headache. Tranexamic acid is an anti-fibrinolytic agent that helps the body's natural blood clot process by preventing fibrin's breakdown, this stops fibrinolysis, a process that stops blood clot formation. Mefenamic acid is an NSAID that works by blocking the effect of a chemical messenger in the body, known as cyclo-oxygenase (COX) enzymes that make other chemical prostaglandins. By blocking the COX enzyme's effect, lesser prostaglandins are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Together, Cosklot MF Tablet helps treat heavy bleeding and pains/cramps during periods.

Storage

Keep Cosklot MF Tablet out of reach and sight of children.

Side effects of Cosklot MF Tablet

Constipation

Here are the steps to cope with constipation as a side effect of medication:

Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Indigestion

Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:

Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.

Gas Or Fart

Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:

Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.

Gastric Ulcers

Ulcer In The Duodenum

Stay hydrated to promote healthy digestion and general well-being.
Nonsteroidal anti-inflammatory medications (NSAIDs) have the potential to make worse ulcers by irritating the stomach lining.
Avoiding or consuming alcohol is advised because it can irritate the stomach lining and slow down the healing process.
limit intake of hot foods, caffeine, and acidic foods such as citrus and tomatoes, as they can worsen the ulcer.

Anemia

Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
Consume vitamin C-rich foods as they aid iron absorption.
Limit tea, cocoa, and coffee as these can slow iron absorption.
Exercise regularly; however, do not overdo it.

It Takes A Long Time For The Blood To Clot

Drug Warnings

Do not take Cosklot MF Tablet if you are allergic to any of its contents or if you have severe heart failure. Inform your doctor if you have/had deep vein thrombosis, pulmonary embolism (block a blood vessel in the lungs), coagulopathy (formation of blood clots), epilepsy, irregular periods, heart, kidney, or liver problems. Consult your doctor if you are pregnant or breastfeeding. Cosklot MF Tablet may cause dizziness and drowsiness, so drive only if you are alert. Cosklot MF Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Cosklot MF Tablet as it could lead to increased drowsiness and can increase the risk of stomach bleeding. Do not take any other NSAIDs for pain relief along with Cosklot MF Tablet unless prescribed.

Drug-Drug Interactions

Tranexamic acidEtonogestrel

Critical

Tranexamic acidDrospirenone

Critical

Drug-Drug Interactions

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Tranexamic acidEtonogestrel

Critical

How does the drug interact with Cosklot MF Tablet:
Co-administration of Cosklot MF Tablet may cause blood clotting when taken with Etonogestrel.

How to manage the interaction:
Taking Cosklot MF Tablet with Etonogestrel is not recommended, as it can lead to an interaction but can be taken if prescribed by the doctor. However, If you suffer from chest discomfort, shortness of breath, blood in the urine, blood in the cough, sudden loss of vision, and pain, redness, or swelling in your arm or leg, consult your doctor immediately.

Tranexamic acidDrospirenone

Critical

How does the drug interact with Cosklot MF Tablet:
Taking drospirenone with Cosklot MF Tablet may increase the risk of blood clot formation.

How to manage the interaction:
Taking Cosklot MF Tablet with Drospirenone is not recommended, as it can lead to an interaction but can be taken if prescribed by the doctor. However, If you suffer from chest discomfort, shortness of breath, blood in the urine, blood in the cough, sudden loss of vision, and pain, redness, or swelling in your arm or leg, consult your doctor immediately.

Tranexamic acidMedroxyprogesterone

Critical

How does the drug interact with Cosklot MF Tablet:
Taking Medroxyprogesterone acetate with Cosklot MF Tablet may increase the risk of blood clots.

How to manage the interaction:
Taking Medroxyprogesterone with Cosklot MF Tablet is not recommended but can be taken if prescribed by a doctor. Consult your doctor immediately if you experience symptoms such as chest pain, shortness of breath, coughing up blood, blood in the urine, sudden loss of vision, and pain, redness, or swelling in your arm or leg. Do not stop using any medications without talking to your doctor.

Tranexamic acidLevonorgestrel

Critical

How does the drug interact with Cosklot MF Tablet:
Taking Levonorgestrel with Cosklot MF Tablet may increase the risk of blood clot formation which can lead to serious conditions such as heart problems and kidney failure.

How to manage the interaction:
Taking Cosklot MF Tablet with Levonorgestrel may leads to an interaction but can be taken if prescribed by the doctor. However, if you experience chest pain; shortness of breath; coughing up blood; blood in the urine; sudden loss of vision; and pain, redness, or swelling in your arm or leg, consult the doctor immediately. Do not stop using any medications without talking to a doctor.

Tranexamic acidEthinylestradiol

Critical

How does the drug interact with Cosklot MF Tablet:
Taking Ethinylestradiol with Cosklot MF Tablet may increase the risk of blood clot formation.

How to manage the interaction:
Taking Ethinylestradiol with Cosklot MF Tablet is not recommended, as it can lead to an interaction, but can be taken if a doctor has prescribed it. However, if you suffer from chest discomfort, shortness of breath, blood in the urine, blood in the cough, sudden loss of vision, and pain, redness, or swelling in your arm or leg, consult doctor immediately. Do not stop using any medications without talking to a doctor.

Mefenamic acidMeloxicam

Critical

How does the drug interact with Cosklot MF Tablet:
Co-administration of Cosklot MF Tablet with Meloxicam together can increase the risk or severity of bleeding.

How to manage the interaction:
Taking Cosklot MF Tablet with Meloxicam together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking a doctor.

Mefenamic acidKetorolac

Critical

How does the drug interact with Cosklot MF Tablet:
Coadministration of Cosklot MF Tablet with Ketorolac can increase the risk or severity of gastric bleeding and ulcers.

How to manage the interaction:
Taking Cosklot MF Tablet with Ketorolac together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Tranexamic acidNorethisterone

Severe

How does the drug interact with Cosklot MF Tablet:
Using Cosklot MF Tablet together with norethindrone may increase the risk of blood clots.

How to manage the interaction:
Taking norethisterone with Cosklot MF Tablet can lead to an interaction, however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, coughing up blood, blood in the urine, sudden loss of vision, and pain, redness, or swelling in your arm or leg, contact a doctor immediately .Do not discontinue any medications without consulting a doctor.

Tranexamic acidCarfilzomib

Severe

How does the drug interact with Cosklot MF Tablet:
Co-administration of Carfilzomib with Cosklot MF Tablet can increase the risk of blood clots.

How to manage the interaction:
Taking carfilzomib with Cosklot MF Tablet is not recommended due to its increased effects, however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, and numbness or weakness on one side of the body contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Tranexamic acidEstrone

Severe

How does the drug interact with Cosklot MF Tablet:
Co-administration of Estrone with Cosklot MF Tablet can increase the risk of blood clots.

How to manage the interaction:
Taking Estrone with Cosklot MF Tablet can possibly lead to an interaction, however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, and numbness or weakness on one side of the body contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Follow a healthy diet. Include vegetables, fruits, and whole grains in your meals.
Stay hydrated; drink plenty of water.
Cut down on sugars, salts, spicy food, coffee, and alcohol.
A heating pad can help ease the pain by placing it on the belly or lower back.
Exercise can help ease the pain of menstrual cramps.
Avoid stress by performing meditation or yoga.
Massage your lower back or abdomen to relieve the pain.
Take proper rest.

Side Effects of Cosklot MF Tablet

Nausea
Vomiting
Diarrhoea
Indigestion
Heartburn
Headache
Musculoskeletal pain
Stomach pain

Habit Forming

No

Therapeutic Class

ANTIFIBRINOLYTIC AGENTS

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Author Details

Written By

Santoshini Reddy G

M Pharmacy

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 8, 2025 | 9:34 AM IST

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Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

How does Cosklot MF Tablet work?

Cosklot MF Tablet contains Tranexamic acid and Mefenamic acid. Tranexamic acid helps the body's natural blood clot process by preventing the breakdown of fibrin, this stops fibrinolysis, a process that stops blood clot formation. Mefenamic acid works by blocking the effect of chemical messengers that cause pain.

Does Cosklot MF Tablet cause diarrhoea?

Diarrhoea might be a side-effect of Cosklot MF Tablet . Drink enough fluids and eat non-spicy food if you experience diarrhoea. Consult your doctor if you experience severe diarrhoea or if you find blood in stools.

Can I take Cosklot MF Tablet for longer durations?

Cosklot MF Tablet should not be taken for longer durations unless prescribed by the doctor. Cosklot MF Tablet is usually prescribed for a few days at the time of heavy bleeding and cramps.

Is Cosklot MF Tablet used to treat period pain?

Cosklot MF Tablet is used to treat dysmenorrhea (period pain), pain due to heavy bleeding during periods, and menstrual cramps. Take Cosklot MF Tablet only as prescribed and do not overdose.

Is it safe to take contraceptives along with Cosklot MF Tablet ?

Consult your doctor before taking contraceptive pills along with Cosklot MF Tablet . When taken together, there is an increased risk of deep vein thrombosis (blood clot in the deep vein, usually legs).

Can I take Cosklot MF Tablet if I have heart problems?

Cosklot MF Tablet contains mefenamic acid, an NSAID which might increase the risk of cardiovascular thrombotic events, myocardial infarction, and stroke. Therefore, avoid taking Cosklot MF Tablet if you have heart-related problems unless prescribed by the doctor.

Drug-Drug Interactions Checker List

IBUPROFEN
CELECOXIB
DULOXETINE
FLUOXETINE
SERTRALINE

Disease/Condition Glossary

Menorrhagia: Menorrhagia is a condition with abnormally heavy or prolonged bleeding during menstruation/periods. The exact cause of menorrhagia is unknown, but it could be due to hormonal imbalance, dysfunction of the ovaries, uterine fibroids, polyps, inherited bleeding disorders, intrauterine devices, or medications. Symptoms include socking through one/more sanitary pads/tampons for every hour, needing to use double sanitary protection to control the flow, needing to wake up during the night to change the pad, bleeding for more than a week, passing blood clots, unable to do daily activities due to heavy flow, tiredness, and fatigue.

Dysmenorrhea: Menstrual cramps, also known as dysmenorrhea, is characterised by cramps and pain during menstruation due to heavy flow. Pain, cramps, and discomfort during periods are normal. However, excessive pain during periods is not normal and requires medication. Symptoms of dysmenorrhea include intense throbbing pain in the lower abdomen, dull, continuous aches, pain in the lower back and thighs, nausea, headache, and dizziness. The pain usually starts 1-3 days prior to the period, peaks one day before the period starts, and subsides 2-3days after the onset of the period.