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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Hari Kumar , MBBS
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About Coversyl-AM 8/5 Tablet

Coversyl-AM 8/5 Tablet belongs to the group of anti-hypertensive medicines used to treat high blood pressure (hypertension). Additionally, it is also used to treat stable coronary artery disease. High blood pressure is a condition in which the blood exerts increased pressure on the walls of blood vessels. Stable coronary artery disease is a condition in which the blood supply to the heart is blocked or reduced.
 
Coversyl-AM 8/5 Tablet is a combination of two drugs, namely: Amlodipine and Perindopril erbumine. Amlodipine relaxes the blood vessels, thereby improves blood flow. Perindopril erbumine widens the blood vessels, making it easier for the heart to pump blood through them. Together, Coversyl-AM 8/5 Tablet helps lower the blood pressure, thereby reduces the chances of heart problems such as heart attack and stroke.  
 
You are advised to take Coversyl-AM 8/5 Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as oedema, headache, dizziness, nausea, and abdominal pain. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if the side effects persist or worsen.
 
Coversyl-AM 8/5 Tablet is not recommended during early pregnancy and should not be taken when more than 3months pregnant as it may cause serious harm to the baby. Coversyl-AM 8/5 Tablet is not recommended for breastfeeding mothers and children. Coversyl-AM 8/5 Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Inform your doctor about all the medicines you are taking and your health condition to rule out any unpleasant side effects.

Uses of Coversyl-AM 8/5 Tablet

Hypertension (high blood pressure), stable coronary artery disease

Directions for Use

Take Coversyl-AM 8/5 Tablet before a meal. Swallow Coversyl-AM 8/5 Tablet as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Coversyl-AM 8/5 Tablet is a combination of two drugs, namely: Amlodipine and Perindopril erbumine. Coversyl-AM 8/5 Tablet belongs to the group of anti-hypertensive medicines used to treat high blood pressure (hypertension) and/or stable coronary artery disease. Amlodipine is a calcium channel blocker that relaxes the blood vessels, thereby improving blood flow. Perindopril erbumine is an angiotensin-converting enzyme inhibitor that widens the blood vessels; this makes it easier for the heart to pump blood through them. Together, Coversyl-AM 8/5 Tablet helps treat hypertension, thereby reducing the chances of heart problems such as heart attack and stroke.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Coversyl-AM 8/5 Tablet if you are allergic to any of its contents; if you have angioedema, severe water retention, low blood pressure, or low blood potassium. Inform your doctor if you have diabetes, heart problems, gout, parathyroid gland problems, heart failure, collagen disease, atherosclerosis (hardening of arteries), excess acid in the blood, liver/kidney problems, if you are on a low-salt diet, if you are taking lithium/potassium-sparing diuretics, or if you are taking any other blood pressure-lowering medicines. Coversyl-AM 8/5 Tablet is not recommended during early pregnancy and should not be taken when more than 3 months pregnant as it may cause serious harm to the baby. Coversyl-AM 8/5 Tablet is not recommended for breastfeeding mothers and children. Coversyl-AM 8/5 Tablet may cause dizziness, so drive with caution. Keep your doctor informed about your health condition and medications to rule out any interactions.

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
PerindoprilAliskiren
Critical

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
How does the drug interact with Coversyl-AM 8/5 Tablet:
Using Coversyl-AM 8/5 Tablet together with dantrolene may increase the risk of hyperkalemia (high blood potassium).

How to manage the interaction:
Taking Coversyl-AM 8/5 Tablet with Dantrolene can cause an interaction, consult a doctor before taking it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
PerindoprilAliskiren
Critical
How does the drug interact with Coversyl-AM 8/5 Tablet:
Combining Aliskiren with Coversyl-AM 8/5 Tablet can increase the risk of low blood pressure, high potassium levels, and kidney damage.

How to manage the interaction:
Taking Coversyl-AM 8/5 Tablet with Aliskiren is not recommended, but can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
AmlodipinePrimidone
Severe
How does the drug interact with Coversyl-AM 8/5 Tablet:
Using Coversyl-AM 8/5 Tablet and primidone together may lower Coversyl-AM 8/5 Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although co-administration of Coversyl-AM 8/5 Tablet with primidone can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
AmlodipineRifampicin
Severe
How does the drug interact with Coversyl-AM 8/5 Tablet:
Coadministration of Coversyl-AM 8/5 Tablet and rifampicin together may lower Coversyl-AM 8/5 Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although there is an interaction between Coversyl-AM 8/5 Tablet and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
AmlodipineSimvastatin
Severe
How does the drug interact with Coversyl-AM 8/5 Tablet:
Taking simvastatin with Coversyl-AM 8/5 Tablet may result in considerably higher blood levels of simvastatin and may increase the risk of side effects (liver damage and rhabdomyolysis - an uncommon but serious illness characterized by the breakdown of skeletal muscle tissue).

How to manage the interaction:
Although taking Coversyl-AM 8/5 Tablet with simvastatin can result in an interaction, it can be taken if a doctor has advised it. If you have unexplained muscular pain, soreness, or weakness while using simvastatin, especially if these symptoms are accompanied by fever or dark-colored urine, consult the doctor immediately. However, if you develop a fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes, consult the doctor. Do not stop using any medications without a doctor's advice.
AmlodipineEnzalutamide
Severe
How does the drug interact with Coversyl-AM 8/5 Tablet:
Using a combination of Coversyl-AM 8/5 Tablet and enzalutamide may drastically lower Coversyl-AM 8/5 Tablet blood levels, making the medicine less effective.

How to manage the interaction:
Taking Coversyl-AM 8/5 Tablet with enzalutamide can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
AmlodipineItraconazole
Severe
How does the drug interact with Coversyl-AM 8/5 Tablet:
Coadministration of Coversyl-AM 8/5 Tablet with itraconazole may significantly raise the blood levels and effects of Coversyl-AM 8/5 Tablet.

How to manage the interaction:
Coversyl-AM 8/5 Tablet and itraconazole may interact, but if prescribed by a doctor, they can be used together. Consult a doctor if you develop chest discomfort, trouble breathing, dizziness or fainting, swelling of the hands, ankles, or feet, or any other of these symptoms. Without consulting a doctor, never stop taking any medication.
AmlodipineNitisinone
Severe
How does the drug interact with Coversyl-AM 8/5 Tablet:
Coadministration of Coversyl-AM 8/5 Tablet and Nitisinone may increase the blood levels and effects of Nitisinone.

How to manage the interaction:
Taking Nitisinone with Coversyl-AM 8/5 Tablet together can result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these symptoms or if you feel unwell after taking your medication, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
AmlodipineLemborexant
Severe
How does the drug interact with Coversyl-AM 8/5 Tablet:
Coadministration of lemborexant and Coversyl-AM 8/5 Tablet may increase the blood levels of lemborexant.

How to manage the interaction:
Although co-administration of Coversyl-AM 8/5 Tablet with Lemborexant can result in an interaction, it can be taken if a doctor has advised it. However, consult your doctor if you experience abnormal sleep patterns, worsening of depression, changes in heartbeat, or headache. Do not discontinue any medications without consulting a doctor.
AmlodipineMitotane
Severe
How does the drug interact with Coversyl-AM 8/5 Tablet:
Using Coversyl-AM 8/5 Tablet and mitotane together may drastically lower Coversyl-AM 8/5 Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although co-administration of Coversyl-AM 8/5 Tablet with mitotane can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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AMLODIPINE-5MG+PERINDOPRIL ERBUMINE-8MGPotassium rich foods
Moderate

Drug-Food Interactions

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AMLODIPINE-5MG+PERINDOPRIL ERBUMINE-8MGPotassium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
Taking Coversyl-AM 8/5 Tablet with potassium-containing salt substitutes or potassium supplements can cause high levels of potassium in the blood. Avoid taking potassium-containing salt substitutes or potassium supplements while being treated with Coversyl-AM 8/5 Tablet.

Diet & Lifestyle Advise

  • You are advised to consume low salt and low-fat diet. 
  • Regular exercise is also recommended.
  • Eat a diet rich in whole grains, vegetables, and fruits.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight with proper diet and exercise.
  • Practice meditation or yoga as it helps in managing stress.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Coversyl-AM 8/5 Tablet contains Amlodipine and Perindopril erbumine. Amlodipine relaxes the blood vessels, thereby improving blood flow. Perindopril erbumine widens the blood vessels; this makes it easier for the heart to pump blood through them. Together, Coversyl-AM 8/5 Tablet helps treat high blood pressure.

Coversyl-AM 8/5 Tablet may cause palpitations, a sensation that the heart is racing, pounding, or fluttering. A minor fluctuation should not be a worry; however, if palpitations continue or you begin to feel unwell, speak with your doctor.

High blood pressure increases the workload on the arteries and heart. If untreated, it could damage the blood vessels of the heart, brain, and kidney and might result in stroke, heart failure or kidney failure. Hypertension increases the risk of heart attacks. Therefore, anti-hypertensives such as Coversyl-AM 8/5 Tablet are used to lower the blood pressure to normal; this reduces the risk of developing these disorders.

Do not stop taking Coversyl-AM 8/5 Tablet without consulting your doctor, as it may lead to a rise in blood pressure. To treat your condition effectually, continue taking Coversyl-AM 8/5 Tablet for as long as your doctor has prescribed it. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Coversyl-AM 8/5 Tablet .

Light-headedness could be a side-effect of Coversyl-AM 8/5 Tablet . It occurs due to low blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking; instead, lie down and get up slowly only when you feel better. People taking Coversyl-AM 8/5 Tablet are advised to regularly monitor their blood pressure levels to avoid unpleasant events.

Avoid consuming grapefruit and grapefruit juice whilst taking Coversyl-AM 8/5 Tablet as it might increase the blood levels of amlodipine; this can lead to an unpredictable increase in the blood pressure-lowering effect of Coversyl-AM 8/5 Tablet . Inform your doctor if you are on a salt-restricted diet, use salt substitutes or if you are taking potassium supplements.

Drug-Drug Interactions Checker List

  • LITHIUM
  • DANTROLENE
  • ESTRAMUSTINE
  • SACUBITRIL+VALSARTAN
  • TRIAMTERENE
  • AMILORIDE
  • ALISKIREN
  • HEPARIN
  • TRIMETHOPRIM+SULFAMETHOXAZOLE
  • EPLERENONE
  • SPIRONOLACTONE

Special Advise

  • Regular monitoring of blood pressure levels, kidney function and electrolyte levels while taking Coversyl-AM 8/5 Tablet is advised.
  • If you are due to undergo any surgery, inform the doctor that you are taking Coversyl-AM 8/5 Tablet .

Disease/Condition Glossary

High blood pressure (hypertension): It is a condition in which the blood exerts increased pressure on the walls of blood vessels leading to hypertension. This condition can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart. Raised blood pressure can cause chest pain (angina) and heart attack (when the blood supply to the heart is blocked). High blood pressure also causes brain damage (stroke) and kidney failure. Symptoms of high blood pressure include headache, dizziness, nose bleed, changes in vision, chest pain, weakness and dyspnoea (shortness of breath). However, most of the time, the signs and symptoms of hypertension are none.

Stable coronary artery disease: It is a condition in which the blood supply to the heart is blocked or reduced. Atherosclerosis (build-up of plaque in the arteries) is the main cause of stable coronary artery disease.

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