Crizalk 200 mg Capsule 60's

Written By Bayyarapu Mahesh Kumar , M Pharmacy

Reviewed By Veda Maddala , M Pharmacy

Prescription drug

MRP ₹1786

(Inclusive of all Taxes)

₹267.9 Cashback (15%)

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Whats That

About Crizalk 200 mg Capsule

Crizalk 200 mg Capsule belongs to the group of medicines called anti-cancer medicines. It is used to treat lung cancer called non-small cell lung cancer (NSCLC) in adults. Non-small cell lung cancer is a condition in which malignant (cancer) cells develop in the lung tissues. Non-small cell lung cancer is classified into numerous categories. The most important risk factor for non-small cell lung cancer is smoking.

Crizalk 200 mg Capsule contains the active substance Crizotinib, a medicine used to treat adults with lung cancer called non-small cell lung cancer (NSCLC). It works by inhibiting a type of enzyme called tyrosine kinase and slowing down or stopping cancer cell growth. Crizalk 200 mg Capsule is only given to patients whose disease is due to an alteration in the gene for ALK tyrosine kinase.

Always use this medicine exactly as your doctor has told you. You must keep to your doctor's instructions to get the maximum benefit. Sometimes, you may experience specific common side effects, such as visual disturbances or stomach upset, including vomiting, diarrhoea, nausea, tiredness, and dizziness. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Crizalk 200 mg Capsule if you are allergic to Crizalk 200 mg Capsule or any of its ingredients. Crizalk 200 mg Capsule may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with Crizalk 200 mg Capsule as it could lead to increased dizziness. Crizalk 200 mg Capsule is not recommended for children as safety and effectiveness have not been established. Inform your healthcare professional if you are a pregnant or breastfeeding woman so that your doctor decides whether Crizalk 200 mg Capsule can be taken or not. Keep your doctor informed about your health condition and medicines to rule out any side effects. While on Crizalk 200 mg Capsule treatment, you should avoid eating grapefruit or consuming grapefruit juice since they may alter the amount of Crizalk 200 mg Capsule in your body.

Uses of Crizalk 200 mg Capsule

Non-small cell lung cancer (NSCLC)

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Crizalk 200 mg Capsule contains the active substance Crizotinib, a medicine used to treat adults with non-small cell lung cancer (NSCLC). Crizalk 200 mg Capsule is only given to patients whose disease is due to an alteration in the gene for ALK tyrosine kinase. It works by inhibiting a type of enzyme called tyrosine kinase and slowing down or stopping cancer cell growth.

Storage

Keep Crizalk 200 mg Capsule out of sight and reach of children.

Side effects of Crizalk 200 mg Capsule

Nausea

Overcome Medication-Induced Nausea: A 9-Step Plan

Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
Divide your daily food intake into smaller, more frequent meals to reduce nausea.
Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
Use ginger (tea, ale, or candies) to help relieve nausea.
Get adequate rest and also avoid strenuous activities that can worsen nausea.
Talk to your doctor about taking anti-nausea medication if your nausea is severe.
Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Loose And Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Vomiting

To prevent, manage, and treat Constipation caused by medication usage, follow these steps:

Preventing Vomiting (Before it Happens)
Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
Having a small meal before taking your medication can help reduce nausea and vomiting.
Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
Managing Vomiting (If it Happens)
Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
What to Do if Vomiting Persists
Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Swelling

Reduce salt intake to minimize fluid buildup.
Use compression stockings, sleeves, or gloves.
Gently massage the affected area towards the heart.
Protect the swollen area from injury and keep it clean.
Use lotion or cream to keep the skin moisturized.

Constipation

Here are the steps to cope with constipation as a side effect of medication:

Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Abnormal liver function test

High levels of liver enzymes need immediate medical attention.
Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
Regularly do strengthening exercises to control your cholesterol levels.
Avoid drinking alcohol as it can affect your liver.
Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
Practice yoga and meditation to improve liver functioning and overall health.

Fatigue

Rest well; get enough sleep.
Eat a balanced diet and drink enough water.
Manage stress with yoga and meditation.
Limit alcohol and caffeine.
Physical activities like walking or jogging might help boost energy and make you feel less tired.

Drug Warnings

Do not take Crizalk 200 mg Capsule if you are allergic to Crizalk 200 mg Capsule or any of its ingredients. Crizalk 200 mg Capsule may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol along with Crizalk 200 mg Capsule as it could lead to increased dizziness. Crizalk 200 mg Capsule is not recommended for children as safety and effectiveness have not been established. Consult your doctor if you are a pregnant or breastfeeding woman; your doctor will decide whether the Crizalk 200 mg Capsule can be taken or not. Keep your doctor informed about your health condition and medicines to rule out any side effects. It is essential to take Crizalk 200 mg Capsule every day, as long as your doctor prescribes it. Contact your doctor immediately if you cannot take medicine as your doctor prescribed or feel you do not need it anymore. Do not stop taking this medicine on your own. People with liver, kidney or heart disorders, lung inflammation, stomach or intestine problems, and vision disorders should consult the doctor before taking the Crizalk 200 mg Capsule .

Drug-Drug Interactions

CrizotinibZiprasidone

Critical

CrizotinibGoserelin

Severe

Drug-Drug Interactions

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CrizotinibZiprasidone

Critical

How does the drug interact with Crizalk 200 mg Capsule:
Coadministration of Crizalk 200 mg Capsule with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Ziprasidone with Crizalk 200 mg Capsule is not recommended,but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.

CrizotinibGoserelin

Severe

How does the drug interact with Crizalk 200 mg Capsule:
Taking Goserelin and Crizalk 200 mg Capsule can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Goserelin and Crizalk 200 mg Capsule together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

CrizotinibRanolazine

Severe

How does the drug interact with Crizalk 200 mg Capsule:
When Crizalk 200 mg Capsule is taken with Ranolazine, may increase the blood levels and effects of ranolazine. High blood levels of ranolazine can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Crizalk 200 mg Capsule with Ranolazine can lead to an interaction, please consult a doctor before taking it. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not stop taking any medications without consulting a doctor.

CrizotinibBromocriptine

Severe

How does the drug interact with Crizalk 200 mg Capsule:
Crizalk 200 mg Capsule may considerably raise the blood levels of bromocriptine. This may enhance the risk of adverse effects of bromocriptine.

How to manage the interaction:
Although taking Bromocriptine and Crizalk 200 mg Capsule together can cause an interaction, it can be taken if your doctor has suggested it. Call your doctor immediately if you notice any of these symptoms - feeling dizzy or tired, suddenly falling asleep, or feeling lightheaded. Do not stop using any medications without talking to your doctor.

CrizotinibCeritinib

Severe

How does the drug interact with Crizalk 200 mg Capsule:
Taking Crizalk 200 mg Capsule with Ceritinib may significantly increase the blood levels and effects of Crizalk 200 mg Capsule.

How to manage the interaction:
Co-administration of Ceritinib with Crizalk 200 mg Capsule can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you notice any symptoms like an irregular heart rhythm, dizziness, fainting, or a fast or pounding heartbeat, it is important to contact your doctor right away. Do not discontinue any medications without first consulting your doctor.

CrizotinibMirtazapine

Severe

How does the drug interact with Crizalk 200 mg Capsule:
Using Crizalk 200 mg Capsule together with mirtazapine can increase the risk of an irregular heart rhythm which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
There may be a possibility of interaction between Mirtazapine and Crizalk 200 mg Capsule, but it can be taken if prescribed by a doctor. If you have any of these symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

CrizotinibGatifloxacin

Severe

How does the drug interact with Crizalk 200 mg Capsule:
Taking Gatifloxacin with Crizalk 200 mg Capsule can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Gatifloxacin with Crizalk 200 mg Capsule together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

CrizotinibAmitriptyline

Severe

How does the drug interact with Crizalk 200 mg Capsule:
Coadministration of Amitriptyline and Crizalk 200 mg Capsule may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amitriptyline with Crizalk 200 mg Capsule may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.

CrizotinibVenlafaxine

Severe

How does the drug interact with Crizalk 200 mg Capsule:
Taking Venlafaxine with Crizalk 200 mg Capsule increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Venlafaxine and Crizalk 200 mg Capsule, you can take these medicines together if prescribed by a doctor. However, consult your doctor immediately if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without consulting a doctor.

CrizotinibAtomoxetine

Severe

How does the drug interact with Crizalk 200 mg Capsule:
Taking Atomoxetine with Crizalk 200 mg Capsule can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Atomoxetine and Crizalk 200 mg Capsule, you can take these medicines together if prescribed by a doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Watch out for triggers that worsen the cough, such as smoke, foods, air-conditioning, high altitude, etc.
Exercise moderately. Eat healthily.
Follow a pulmonary rehabilitation program. It includes exercise, disease education, and group therapy.
Quit smoking and alcohol.
Get ample rest.
Include green leafy vegetables, sweet potatoes, broccoli, tomatoes, carrots, mangoes, citrus fruits, berries, and cocoa.
Lean proteins such as fish, meat, and poultry are the best.
Hydration is important. Drink plenty of water, herbal tea, and vegetable and fruit juices.
Avoid processed and refined foods.

Side Effects of Crizalk 200 mg Capsule

Visual disturbance
Stomach upset
Vomiting
Diarrhoea
Nausea
Constipation
Decreased appetite
Tiredness
Dizziness
Metallic taste
Abdomen pain

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Author Details

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Jul 8, 2025 | 9:44 AM IST

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Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

How does Crizalk 200 mg Capsule work?

Crizotinib is the active ingredient in Crizalk 200 mg Capsule . It works by inhibiting an enzyme called tyrosine kinase and causing cancer cells to die. Crizalk 200 mg Capsule is only provided to individuals whose condition is caused by an ALK tyrosine kinase gene mutation.

I am 65 years. Is it safe to take Crizalk 200 mg Capsule ?

In elderly patients, the risk of side effects is more if you take the Crizalk 200 mg Capsule . For the elderly, it might require dose adjustment, or your doctor might prescribe any other medication safe for the elderly.

Is it safe to smoke while taking Crizalk 200 mg Capsule ?

No, avoid smoking before starting the treatment and while taking Crizalk 200 mg Capsule as smoking might alter the effectiveness of Crizalk 200 mg Capsule .

What should I do if I forget to take Crizalk 200 mg Capsule ?

Take the missed dose as soon as you remember. Skip the missing dose and return to your regular dosing plan if it is time for the next dose. Do not take a double dose to make up for a missing dose.

Does Crizalk 200 mg Capsule cause vision disturbance?

Crizalk 200 mg Capsule may cause visual disturbances such as flashes of light, blurred vision, or double vision as a temporary side effect. If it continues or worsens your condition, seek medical advice immediately.

Drug-Drug Interactions Checker List

KETOCONAZOLE
ITRACONAZOLE
POSACONAZOLE
VORICONAZOLE
CLARITHROMYCIN
TELITHROMYCIN
ERYTHROMYCIN
ATAZANAVIR
RITONAVIR
COBICISTAT
CARBAMAZEPINE
PHENOBARBITAL
RIFABUTIN
RIFAMPICIN
ST JOHN'S WORT

Special Advise

If you have a fever or an infection, call your doctor. Your doctor may perform blood tests, and if the findings are abnormal, your doctor may opt to cut the dose of Crizalk 200 mg Capsule .
Inform your doctor as soon as possible if you notice any vision loss or changes in your vision, such as difficulties seeing out of one or both eyes.
During your therapy with Crizalk 200 mg Capsule , your doctor may recommend electrocardiograms to ensure that your heart is not causing any difficulties.

Disease/Condition Glossary

Non-small cell lung cancer (NSCLC): Non-small cell lung cancer is a condition in which malignant (cancer) cells develop in the lung tissues. Non-small cell lung cancer is classified into numerous categories. The most important risk factor for non-small cell lung cancer is smoking. There are various forms of non-small cell lung cancer. Different types of cancer cells are found in non-small cell lung cancer. Cancer cells of different types grow and spread in different ways. The several types of non-small cell lung cancer are called after the types of cells found in cancer and how the cells appear under a microscope.