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  3. CRIZALK 250MG CAPSULE

CRIZALK 250MG CAPSULE, Pack of 1 CAPSULE
CRIZALK 250MG CAPSULE, Pack of 1 CAPSULE
CRIZALK 250MG CAPSULE, Pack of 1 CAPSULE
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
Non returnable*
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Whats That

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Composition :

CRIZOTINIB-250MG

Manufacturer/Marketer :

Pfizer Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About CRIZALK 250MG CAPSULE

CRIZALK 250MG CAPSULE belongs to the group of medicines called anti-cancer medicines. It is used to treat lung cancer called non-small cell lung cancer (NSCLC) in adults. Non-small cell lung cancer is a condition in which malignant (cancer) cells develop in the lung tissues. Non-small cell lung cancer is classified into numerous categories. The most important risk factor for non-small cell lung cancer is smoking.

CRIZALK 250MG CAPSULE contains the active substance Crizotinib, a medicine used to treat adults with lung cancer called non-small cell lung cancer (NSCLC). It works by inhibiting a type of enzyme called tyrosine kinase and slowing down or stopping cancer cell growth. CRIZALK 250MG CAPSULE is only given to patients whose disease is due to an alteration in the gene for ALK tyrosine kinase.

Always use this medicine exactly as your doctor has told you. You must keep to your doctor's instructions to get the maximum benefit. Sometimes, you may experience specific common side effects, such as visual disturbances or stomach upset, including vomiting, diarrhoea, nausea, tiredness, and dizziness. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take CRIZALK 250MG CAPSULE if you are allergic to CRIZALK 250MG CAPSULE or any of its ingredients. CRIZALK 250MG CAPSULE may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with CRIZALK 250MG CAPSULE as it could lead to increased dizziness. CRIZALK 250MG CAPSULE is not recommended for children as safety and effectiveness have not been established. Inform your healthcare professional if you are a pregnant or breastfeeding woman so that your doctor decides whether CRIZALK 250MG CAPSULE can be taken or not. Keep your doctor informed about your health condition and medicines to rule out any side effects. While on CRIZALK 250MG CAPSULE treatment, you should avoid eating grapefruit or consuming grapefruit juice since they may alter the amount of CRIZALK 250MG CAPSULE in your body.

Uses of CRIZALK 250MG CAPSULE

Non-small cell lung cancer (NSCLC)

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

CRIZALK 250MG CAPSULE contains the active substance Crizotinib, a medicine used to treat adults with non-small cell lung cancer (NSCLC). CRIZALK 250MG CAPSULE is only given to patients whose disease is due to an alteration in the gene for ALK tyrosine kinase. It works by inhibiting a type of enzyme called tyrosine kinase and slowing down or stopping cancer cell growth.

Storage

Store in a cool and dry place away from sunlight
Side effects of Crizalk 250mg Capsule
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

Drug Warnings

Do not take CRIZALK 250MG CAPSULE if you are allergic to CRIZALK 250MG CAPSULE or any of its ingredients. CRIZALK 250MG CAPSULE may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol along with CRIZALK 250MG CAPSULE as it could lead to increased dizziness. CRIZALK 250MG CAPSULE is not recommended for children as safety and effectiveness have not been established. Consult your doctor if you are a pregnant or breastfeeding woman; your doctor will decide whether the CRIZALK 250MG CAPSULE can be taken or not. Keep your doctor informed about your health condition and medicines to rule out any side effects. It is essential to take CRIZALK 250MG CAPSULE every day, as long as your doctor prescribes it. Contact your doctor immediately if you cannot take medicine as your doctor prescribed or feel you do not need it anymore. Do not stop taking this medicine on your own. People with liver, kidney or heart disorders, lung inflammation, stomach or intestine problems, and vision disorders should consult the doctor before taking the CRIZALK 250MG CAPSULE.

Drug-Drug Interactions

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CrizotinibZiprasidone
Critical
CrizotinibCeritinib
Severe

Drug-Drug Interactions

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CrizotinibZiprasidone
Critical
How does the drug interact with Crizalk 250mg Capsule:
Coadministration of Crizalk 250mg Capsule with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Ziprasidone with Crizalk 250mg Capsule is not recommended,but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
CrizotinibCeritinib
Severe
How does the drug interact with Crizalk 250mg Capsule:
Taking Crizalk 250mg Capsule with Ceritinib may significantly increase the blood levels and effects of Crizalk 250mg Capsule.

How to manage the interaction:
Co-administration of Ceritinib with Crizalk 250mg Capsule can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you notice any symptoms like an irregular heart rhythm, dizziness, fainting, or a fast or pounding heartbeat, it is important to contact your doctor right away. Do not discontinue any medications without first consulting your doctor.
CrizotinibChlorpromazine
Severe
How does the drug interact with Crizalk 250mg Capsule:
Taking chlorpromazine and Crizalk 250mg Capsule together can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking chlorpromazine and Crizalk 250mg Capsule together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact your doctor. Do not discontinue any medications without first consulting your doctor.
CrizotinibGatifloxacin
Severe
How does the drug interact with Crizalk 250mg Capsule:
Taking Gatifloxacin with Crizalk 250mg Capsule can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Gatifloxacin with Crizalk 250mg Capsule together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
CrizotinibNorfloxacin
Severe
How does the drug interact with Crizalk 250mg Capsule:
Coadministration of Norfloxacin with Crizalk 250mg Capsule can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Norfloxacin with Crizalk 250mg Capsule together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
CrizotinibTetrabenazine
Severe
How does the drug interact with Crizalk 250mg Capsule:
Co-administration of Crizalk 250mg Capsule and Tetrabenazine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Crizalk 250mg Capsule and Tetrabenazine can lead to an interaction, but it can be taken if your doctor advises. However, contact your doctor immediately if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting. Do not discontinue any medications without consulting your doctor.
CrizotinibOndansetron
Severe
How does the drug interact with Crizalk 250mg Capsule:
Taking ondansetron with Crizalk 250mg Capsule increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Although taking ondansetron along with Crizalk 250mg Capsule can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
CrizotinibMirtazapine
Severe
How does the drug interact with Crizalk 250mg Capsule:
Using Crizalk 250mg Capsule together with mirtazapine can increase the risk of an irregular heart rhythm which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
There may be a possibility of interaction between Mirtazapine and Crizalk 250mg Capsule, but it can be taken if prescribed by a doctor. If you have any of these symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
CrizotinibOfloxacin
Severe
How does the drug interact with Crizalk 250mg Capsule:
Coadministration of Crizalk 250mg Capsule together with ofloxacin may raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although Ofloxacin and Crizalk 250mg Capsule interact, they can be used if prescribed by a doctor. Consult a doctor if you have sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
CrizotinibOxytocin
Severe
How does the drug interact with Crizalk 250mg Capsule:
Taking oxytocin with Crizalk 250mg Capsule can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Oxytocin with Crizalk 250mg Capsule together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience if you develop sudden dizziness, lightheadedness, fainting, shortness of breath contact your doctor immediately. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Watch out for triggers that worsen the cough, such as smoke, foods, air-conditioning, high altitude, etc.
  • Exercise moderately. Eat healthily.
  • Follow a pulmonary rehabilitation program. It includes exercise, disease education, and group therapy.
  • Quit smoking and alcohol.
  • Get ample rest.
  • Include green leafy vegetables, sweet potatoes, broccoli, tomatoes, carrots, mangoes, citrus fruits, berries, and cocoa.
  • Lean proteins such as fish, meat, and poultry are the best.
  • Hydration is important. Drink plenty of water, herbal tea, and vegetable and fruit juices.
  • Avoid processed and refined foods.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Veda MaddalaDoctor badge

Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Jul 8, 2025 | 9:44 AM IST

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Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Drug-Drug Interactions Checker List

  • KETOCONAZOLE
  • ITRACONAZOLE
  • POSACONAZOLE
  • VORICONAZOLE
  • CLARITHROMYCIN
  • TELITHROMYCIN
  • ERYTHROMYCIN
  • ATAZANAVIR
  • RITONAVIR
  • COBICISTAT
  • CARBAMAZEPINE
  • PHENOBARBITAL
  • RIFABUTIN
  • RIFAMPICIN
  • ST JOHN'S WORT

Special Advise

  • If you have a fever or an infection, call your doctor. Your doctor may perform blood tests, and if the findings are abnormal, your doctor may opt to cut the dose of CRIZALK 250MG CAPSULE.
  • Inform your doctor as soon as possible if you notice any vision loss or changes in your vision, such as difficulties seeing out of one or both eyes.
  • During your therapy with CRIZALK 250MG CAPSULE, your doctor may recommend electrocardiograms to ensure that your heart is not causing any difficulties.

Disease/Condition Glossary

Non-small cell lung cancer (NSCLC): Non-small cell lung cancer is a condition in which malignant (cancer) cells develop in the lung tissues. Non-small cell lung cancer is classified into numerous categories. The most important risk factor for non-small cell lung cancer is smoking. There are various forms of non-small cell lung cancer. Different types of cancer cells are found in non-small cell lung cancer. Cancer cells of different types grow and spread in different ways. The several types of non-small cell lung cancer are called after the types of cells found in cancer and how the cells appear under a microscope.

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