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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
COD available

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Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Cycloxan 500 mg Injection

Cycloxan 500 mg Injection belongs to the group of medicines called alkylating agents used to treat malignant diseases such as Hodgkin's disease, mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma, Burkitt's lymphoma, leukaemia,  neuroblastoma, retinoblastoma, adenocarcinoma of the ovary, mycosis fungoides, Ewing's sarcoma, small cell lung cancer, advanced/metastatic neuroblastoma and breast carcinoma. Additionally, Cycloxan 500 mg Injection is used to treat minimal change nephrotic syndrome (kidney disease) in paediatric patients.
 
Cycloxan 500 mg Injection contains 'Cyclophosphamide' that works by stopping or slowing the growth of cancer cells in the body. Thereby, Cycloxan 500 mg Injection helps treat cancer. Cycloxan 500 mg Injection suppresses the body's immune system and helps treat nephrotic syndrome.
 
In some cases, Cycloxan 500 mg Injection may cause nausea, vomiting, stomatitis (inflamed and sore mouth), weakness, malaise (general discomfort), fever, leukopenia (low white blood cell count), and alopecia (hair loss). You are advised to talk to your doctor if the side effects persist or worsen.
 
Consult your doctor if you are pregnant, planning pregnancy, or breastfeeding. Cycloxan 500 mg Injection may cause dizziness, so drive only if you are alert. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Cycloxan 500 mg Injection

Malignant diseases (cancer), nephrotic syndrome (kidney disease)

Directions for Use

Cycloxan 500 mg Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Cycloxan 500 mg Injection belongs to the group of medicines called alkylating agents used to treat malignant diseases such as Hodgkin's disease (cancer of the lymphatic system), mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma (cancer of plasma cells), Burkitt's lymphoma, leukaemia (blood cancer), neuroblastoma (cancer commonly found in the adrenal glands), retinoblastoma (eye cancer), adenocarcinoma of the ovary, mycosis fungoides, Ewing's sarcoma (cancer in and around the bones), small cell lung cancer, advanced/metastatic neuroblastoma and breast carcinoma. Cycloxan 500 mg Injection works by stopping or slowing the growth of cancer cells in the body. Thereby, Cycloxan 500 mg Injection helps treat cancer. Additionally, Cycloxan 500 mg Injection is used to treat minimal change nephrotic syndrome (kidney disease) in paediatric patients. Cycloxan 500 mg Injection suppresses the body's immune system, thereby helping treat nephrotic syndrome.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Cycloxan 500 mg Injection

  • Nausea
  • Vomiting
  • Stomatitis (inflamed and sore mouth)
  • Weakness
  • Malaise (general discomfort)
  • Fever
  • Leukopenia (low white blood cell count)
  • Alopecia (hair loss)

Drug Warnings

Do not take Cycloxan 500 mg Injection if you are allergic to any of its components. Inform your doctor if you have acute infections, bone marrow depression, urinary tract infections, urinary outflow/obstruction, liver or kidney problems, or urinary or respiratory symptoms. Consult your doctor if you are pregnant or breastfeeding. Cycloxan 500 mg Injection may cause myelosuppression, immunosuppression, bone marrow failure, and infections; consult your doctor if you have any concerns.

Drug-Drug Interactions

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CyclophosphamideNalidixic acid
Critical
CyclophosphamideCidofovir
Critical

Drug-Drug Interactions

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CyclophosphamideNalidixic acid
Critical
How does the drug interact with Cycloxan 500 mg Injection:
Co-administration of Nalidixic acid with Cycloxan 500 mg Injection may cause an increase in the risk of side effects.

How to manage the interaction:
Co-administration of Cycloxan 500 mg Injection and Nalidixic acid can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like bruising or bleeding, unusual weakness, nausea, stomach pain, low fever, or loss of appetite, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
CyclophosphamideCidofovir
Critical
How does the drug interact with Cycloxan 500 mg Injection:
Co-administration of Cycloxan 500 mg Injection and Cidofovir may increase the risk of kidney problems.

How to manage the interaction:
Taking Cyclophosphamine with Cidofovir is not recommended, please consult your doctor before taking it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm contact your doctor immediately. Do not discontinue any medications without consulting a doctor
CyclophosphamideThiotepa
Severe
How does the drug interact with Cycloxan 500 mg Injection:
When Thiotepa is taken with Cycloxan 500 mg Injection, can increase the blood levels or add to the medication side effects of Cycloxan 500 mg Injection.

How to manage the interaction:
Although taking Thiotepa and Cycloxan 500 mg Injection together can evidently cause an interaction, it can be taken if a doctor has suggested it. Do not discontinue any medications without consulting a doctor.
CyclophosphamideLidocaine
Severe
How does the drug interact with Cycloxan 500 mg Injection:
Taking Lidocaine with Cycloxan 500 mg Injection may increase the risk of methemoglobinemia (a rare condition that can lead to oxygen deprivation in tissues and vital organs due to reduced oxygen-carrying capacity of the blood).

How to manage the interaction:
Although there is a possible interaction, Cycloxan 500 mg Injection can be taken with lidocaine if prescribed by the doctor. However, consult the doctor if you experience gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, weakness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not discontinue the medication without consulting a doctor.
CyclophosphamideBusulfan
Severe
How does the drug interact with Cycloxan 500 mg Injection:
Co-administration of Cycloxan 500 mg Injection with Busulfan can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Busulfan and Cycloxan 500 mg Injection, they can be taken together if prescribed by a doctor. However, if you experience any vomiting, diarrhea, mouth sores, or stomach pain, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
CyclophosphamideThalidomide
Severe
How does the drug interact with Cycloxan 500 mg Injection:
Taking Cycloxan 500 mg Injection with Thalidomide may increase the risk of blood clots.

How to manage the interaction:
Although there is a possible interaction, Cycloxan 500 mg Injection can be taken with Thalidomide if prescribed by the doctor. However, consult the doctor if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, and/or pain, redness, or swelling in an arm or leg. Do not discontinue any medications without a doctor's advice.
CyclophosphamideRopivacaine
Severe
How does the drug interact with Cycloxan 500 mg Injection:
Co-administration of Ropivacaine with Cycloxan 500 mg Injection can cause methemoglobinemia (low levels of oxygen in the blood).

How to manage the interaction:
Although there is a possible interaction between Ropivacaine and Cycloxan 500 mg Injection, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
CyclophosphamideTenofovir alafenamide
Severe
How does the drug interact with Cycloxan 500 mg Injection:
Co-administration of Tenofovir alafenamide may cause kidney problems, and combining it with Cycloxan 500 mg Injection may increase the risk.

How to manage the interaction:
Although there is a possible interaction, Cycloxan 500 mg Injection can be taken with Tenofovir alafenamide if prescribed by the doctor. Consult the doctor if you develop signs and symptoms of kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop any medication without consulting a doctor.
CyclophosphamideLevobupivacaine
Severe
How does the drug interact with Cycloxan 500 mg Injection:
Co-administration of Cycloxan 500 mg Injection with Levobupivacaine can increase the risk of methemoglobinemia (low level of oxygen in the blood).

How to manage the interaction:
Co-administration of Levobupivacaine with Cycloxan 500 mg Injection can possibly result in an interaction, but it can be taken if a doctor has advised it. Keep a close eye on any signs or symptoms of Methemoglobinemia. If you notice any of these symptoms like gray skin, feeling sick, headaches, dizziness, tiredness, or trouble breathing, make sure to call a doctor right away. Do not stop using any medications without talking to a doctor.
CyclophosphamideVoclosporin
Severe
How does the drug interact with Cycloxan 500 mg Injection:
Co-administration of Cycloxan 500 mg Injection with Voclosporin can increase the risk of kidney damage.

How to manage the interaction:
Although there is a possible interaction between Cycloxan 500 mg Injection and Voclosporin, you can take these medicines together if prescribed by a doctor. It's important to keep an eye on how much you pee. Some other signs to watch out for are feeling sick, throwing up, not wanting to eat, gaining or losing weight suddenly, holding onto fluids, having a fever or chills, having diarrhea or a sore throat, feeling weak or dizzy, being confused, having trouble breathing, feeling pain or a burning sensation when you pee, or having an irregular heartbeat. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices in your food.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Cycloxan 500 mg Injection Substitute

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Drug-Diseases Interactions

verifiedApollotooltip
CYCLOPHOSPHAMIDE-500MGOther diseases of blood and blood-forming organs
Severe
CYCLOPHOSPHAMIDE-500MGObstructive and reflux uropathy
Severe

Drug-Diseases Interactions

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CYCLOPHOSPHAMIDE-500MGOther diseases of blood and blood-forming organs
Severe
How does the disease interact with Cycloxan 500 mg Injection:
Cycloxan 500 mg Injection usage can result in severe immunosuppression, bone marrow failure, myelosuppression (leukopenia, neutropenia, thrombocytopenia, and anaemia), and myelosuppression, which can all lead to serious and occasionally deadly infections including sepsis and septic shock. During Cycloxan 500 mg Injection treatment, complete blood counts must be closely monitored in order to determine whether the dose has to be changed. Patients should not be given Cycloxan 500 mg Injection if their neutrophil and platelet counts are below 1,500/mm3 and 50,000/mm3, respectively.

How to manage the interaction:
Close monitoring of complete blood count is advised during treatment with Cycloxan 500 mg Injection. Inform the doctor if you notice any signs or symptoms of bone marrow suppression such as fever, sore throat, local infection, or bleeding.
CYCLOPHOSPHAMIDE-500MGObstructive and reflux uropathy
Severe
How does the disease interact with Cycloxan 500 mg Injection:
Cycloxan 500 mg Injection should not be administered to individuals who have any type of urine outflow restriction. Urinary blockage should be ruled out or resolved before therapy is started. During Cycloxan 500 mg Injection treatment, hemorrhagic cystitis, pyelitis, and hematuria have all been mentioned.

How to manage the interaction:
Therapy with Cycloxan 500 mg Injection should be administered cautiously in patients with or predisposed to bladder inflammation, including patients with active urinary infections. Urinary sediment should be monitored regularly for presence or erythrocytes and other signs of toxicity.
CYCLOPHOSPHAMIDE-500MGObstructive and reflux uropathy
Severe
How does the disease interact with Cycloxan 500 mg Injection:
Cycloxan 500 mg Injection should not be administered to individuals who have any type of urine outflow restriction. Urinary blockage should be ruled out or resolved before therapy is started. During Cycloxan 500 mg Injection treatment, hemorrhagic cystitis, pyelitis, and hematuria have all been mentioned.

How to manage the interaction:
Therapy with Cycloxan 500 mg Injection should be administered cautiously in patients with or predisposed to bladder inflammation, including patients with active urinary infections. Urinary sediment should be monitored regularly for presence or erythrocytes and other signs of toxicity.
CYCLOPHOSPHAMIDE-500MGObstructive and reflux uropathy
Severe
How does the disease interact with Cycloxan 500 mg Injection:
Cycloxan 500 mg Injection should not be administered to individuals who have any type of urine outflow restriction. Urinary blockage should be ruled out or resolved before therapy is started. During Cycloxan 500 mg Injection treatment, hemorrhagic cystitis, pyelitis, and hematuria have all been mentioned.

How to manage the interaction:
Therapy with Cycloxan 500 mg Injection should be administered cautiously in patients with or predisposed to bladder inflammation, including patients with active urinary infections. Urinary sediment should be monitored regularly for presence or erythrocytes and other signs of toxicity.

Drug-Drug Interactions Checker List

  • NATALIZUMAB
  • PACLITAXEL
  • ZIDOVUDINE
  • AMIODARONE
  • AMPHOTERICIN B
  • INDOMETHACIN
  • AZATHIOPRINE
  • BUSULFAN

Special Advise

  • Monitoring of complete blood count whilst on treatment with Cycloxan 500 mg Injection is advised.
  • Women of childbearing potential must use highly effective contraception during treatment and for up to 1 year after the last dose.
  • Male patients who are sexually active with a female partner of child-bearing potential must use condoms during treatment and for up to 6 months after the last dose.

Disease/Condition Glossary

Cancer: It occurs due to mutations in genes that regulate cell growth. The mutations cause the cells to divide and multiply in an uncontrolled manner leading to the formation of tumours. The most common cancer treatment methods are surgery, chemotherapy, radiotherapy, bone marrow (stem cell) transplantation, immunotherapy and targeted drug therapy.

Nephrotic syndrome: It is a kidney disorder in which the body excretes too much protein in the urine. Symptoms include foamy urine, weight gain, and swelling around the eyes and in the ankles and feet.

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