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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

About Cyramza 100 Injection 10 ml

Cyramza 100 Injection 10 ml is an anti-cancer medicine used alone or in combination with other combination medicines for the treatment of metastatic gastric or gastroesophageal junction adenocarcinoma, hepatocellular cancer, colorectal cancer, and non-small cell lung cancer. Cancer is a disease where the cells grow abnormally and divide uncontrollably. It can also be used when the cancer has spread to other parts of the body.

Cyramza 100 Injection 10 ml contains Ramucirumab as an active ingredient, which belongs to the class of monoclonal antibodies. It works by inhibiting the abnormal growth of cancer cells and, finally, causes the initiation of programmed cell death.

Cyramza 100 Injection 10 ml may cause some side effects, such as abdominal pain, dry mouth, mouth sores, increased blood pressure, diarrhoea, fatigue, nausea, headache, nose bleeds, vomiting, tiredness, and injection site reactions. If the side effects persist or bother you, please consult your doctor. Cyramza 100 Injection 10 ml will be administered by a doctor experienced in the administration of cancer medicine. Do not self-administer.

Avoid taking it and inform your doctor if you are allergic to Cyramza 100 Injection 10 ml or its components. Inform your doctor if you have any cardiovascular conditions, heart attack, stroke, increased blood pressure, any planned surgery, lung problems, or liver/kidney disease, as it can cause adverse effects. Cyramza 100 Injection 10 ml is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

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Non returnable*
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Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

Uses of Cyramza 100 Injection 10 ml

Colorectal Cancer, Stomach Cancer, Hepatocellular cancer, Non-small cell lung cancer.

Medicinal Benefits

Cyramza 100 Injection 10 ml contains Trastuzumab, which is used for treating patients with different types of cancer. This medicine works by inhibiting the excess production of a human vascular endothelial growth factor receptor 2, which is responsible for the growth and spread of cancer cells. This causes inhibition of the cancer cell growth and, finally, initiation of programmed cell death.

Side Effects of Cyramza 100 Injection 10 ml

  • Nausea
  • Vomiting
  • Diarrhoea
  • Nose bleeds
  • Headache
  • Fatigue
  • Injection site reactions
  • Pain at the site of injection
  • Increased blood pressure
  • Dry mouth
  • Mouth sores
  • Fever
  • Back pain

Directions for Use

A doctor who is trained or experienced in the administration of chemotherapeutic agents will administer Cyramza 100 Injection 10 ml. Do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Cyramza 100 Injection 10 ml should be avoided if you are allergic to it or any other components of this medicine. Before taking Cyramza 100 Injection 10 ml, inform your doctor if you have any history of cardiovascular conditions, heart attack, stroke, increased blood pressure, any planned surgery, lung problems, or liver or kidney disease, as it can cause adverse effects. Cyramza 100 Injection 10 ml may cause Cyramza 100 Injection 10 ml may cause reversible posterior leukoencephalopathy syndrome, arterial thromboembolic events, hypertension, an increased risk of hemorrhage, infusion-related reactions, gastrointestinal perforation, and clinical deterioration in patients with cirrhosis during the treatment. Hence, careful observation should be performed for any reactions in the patient. Cyramza 100 Injection 10 ml may cause embryo-fetal toxicity. Hence, if you are pregnant or planning to become pregnant, inform your doctor beforehand. Breastfeeding should be discontinued in nursing mothers during the treatment. Cyramza 100 Injection 10 ml is not recommended for use in children as the safety and efficacy are not established.

Therapeutic Class

ANTINEOPLASTIC

Drug-Drug Interactions

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RamucirumabDabigatran etexilate
Severe
RamucirumabApixaban
Severe

Drug-Drug Interactions

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RamucirumabDabigatran etexilate
Severe
How does the drug interact with Cyramza 100 Injection 10 ml:
Taking Dabigatran etexilate with Cyramza 100 Injection 10 ml can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Dabigatran etexilate with Cyramza 100 Injection 10 ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
RamucirumabApixaban
Severe
How does the drug interact with Cyramza 100 Injection 10 ml:
Using Cyramza 100 Injection 10 ml together with apixaban may increase the risk of bleeding.

How to manage the interaction:
Even though combining Cyramza 100 Injection 10 ml and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
RamucirumabAspirin
Severe
How does the drug interact with Cyramza 100 Injection 10 ml:
Combined use of aspirin with Cyramza 100 Injection 10 ml may result in gut ulcers and bleeding.

How to manage the interaction:
There may be a possibility of interaction between Aspirin and Cyramza 100 Injection 10 ml, but it can be taken if prescribed by a doctor. However, if you notice unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop using any medications without a doctor's advice.
RamucirumabFondaparinux
Severe
How does the drug interact with Cyramza 100 Injection 10 ml:
Using Cyramza 100 Injection 10 ml together with fondaparinux can increase the risk of bleeding.

How to manage the interaction:
There may be a possibility of interaction between Fondaparinux and Cyramza 100 Injection 10 ml, but it can be taken if prescribed by a doctor. However, if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
RamucirumabDiclofenac
Severe
How does the drug interact with Cyramza 100 Injection 10 ml:
Co-administration of Diclofenac and Cyramza 100 Injection 10 ml can cause bleeding and ulcers.

How to manage the interaction:
Co-administration of Diclofenac and Cyramza 100 Injection 10 ml can lead to an interaction; it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
RamucirumabKetorolac
Severe
How does the drug interact with Cyramza 100 Injection 10 ml:
Coadministration of ketorolac with Cyramza 100 Injection 10 ml can cause bleeding.

How to manage the interaction:
Although there is a interaction between Ketorolac and Cyramza 100 Injection 10 ml, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual bleeding, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not discontinue any medications without consulting a doctor.
RamucirumabPiroxicam
Severe
How does the drug interact with Cyramza 100 Injection 10 ml:
Coadministration of Piroxicam with Cyramza 100 Injection 10 ml can increase the risk of bleeding.

How to manage the interaction:
Taking Piroxicam with Cyramza 100 Injection 10 ml together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without talking to a doctor.
RamucirumabPrasugrel
Severe
How does the drug interact with Cyramza 100 Injection 10 ml:
Co-administration of Prasugrel with Cyramza 100 Injection 10 ml can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Prasugrel with Cyramza 100 Injection 10 ml together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
RamucirumabClopidogrel
Severe
How does the drug interact with Cyramza 100 Injection 10 ml:
The use of Cyramza 100 Injection 10 ml together with clopidogrel may raise the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Clopidogrel and Cyramza 100 Injection 10 ml, you can take these medicines together if prescribed by your doctor. If you notice these signs, contact your doctor immediately - feeling dizzy or lightheaded, dark or bloody stools, coughing, intense headaches, or weakness. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • ATAZANAVIR
  • NATALIZUMAB
  • ETANERCEPT

Diet & Lifestyle Advise

  • Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables, and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Special Advise

  • Avoid intercourse while on treatment with Cyramza 100 Injection 10 ml.
  • Regular, complete blood count monitoring is advised during the treatment.
  • Liver function tests (LFT) and kidney function tests (RFT) should be performed before starting the treatment and every 4 to 6 weeks during the treatment.
  • Regular ECG, blood pressure, and electrolytes should be monitored while taking the medicine.

Disease/Condition Glossary

Stomach Cancer (Gastric adenocarcinoma) is a type of cancer that develops from the stomach lining. When the cancer cells spread to other organs of the body, it is called metastatic. This condition can occur mainly due to smoking, a highly processed or salty diet, and severe bacterial infection of H. pylori. Symptoms of stomach cancer include feeling bloated after eating, feeling full after eating small amounts of food, nausea, heartburn or indigestion.

Non-Small Cell Lung Cancer (NSCLC): It is the most common form of lung cancer, which occurs when cells that form the lining of the lung start growing uncontrollably. It is mostly seen in persons who smoke. Symptoms may include chest pain, weight loss, hoarseness, and difficulty breathing.

Hepatocellular carcinoma: It occurs when the cancer/ malignant cells grow out of control in the liver. This infects the liver, destroys the liver cells and affects the ability of the liver to work properly. Symptoms may include abdominal pain, loss of appetite, weight loss, and pale bowel motions.

Colorectal cancer: Also known as colon cancer (growth of cancer cells in the colon) or rectal cancer (cancer cells grow in the rectum area), is a condition in which the cancerous or malignant cells grow out of control in the colon or rectum. Symptoms may include diarrhoea, constipation, bloody stools, change in bowel habits, abdominal discomfort, etc.

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