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  3. D-Pressin Nasal Spray 5 ml

D-Pressin Nasal Spray 5 ml, Pack of 1 Nasal Spray
D-Pressin Nasal Spray 5 ml, Pack of 1 Nasal Spray
D-Pressin Nasal Spray 5 ml, Pack of 1 Nasal Spray
Written By Divya L , PharmaD
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
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Composition :

DESMOPRESSIN-0.1MG

Manufacturer/Marketer :

United Biotech Pvt Ltd

Consume Type :

NASAL

Return Policy :

Not Returnable

Expires on or after :

About D-Pressin Nasal Spray 5 ml

D-Pressin Nasal Spray 5 ml belongs to the class of 'antidiuretics', primarily used as replacement therapy in central cranial diabetes insipidus, a condition in which the body fails to control water balance, resulting in excessive urination. D-Pressin Nasal Spray 5 ml is also used to manage temporary polyuria (extreme urination) or polydipsia (extreme thirst) after head trauma or surgery in the pituitary gland.

D-Pressin Nasal Spray 5 ml contains Desmopressin, a human-made form (synthetic) of Vasopressin. Vasopressin is an antidiuretic (that controls fluid balance) hormone synthesized in the hypothalamus of the pituitary gland. When your body cannot produce enough vasopressin, D-Pressin Nasal Spray 5 ml is given to replace a low level of vasopressin. It mimics the natural hormone vasopressin and works by reabsorbing water from the kidneys, which controls excessive thirst and urination. Thus, it prevents dehydration. 

D-Pressin Nasal Spray 5 ml is for intranasal use only. Your doctor will decide the dosage depending on your medical condition. The common side effects of D-Pressin Nasal Spray 5 ml include conjunctivitis/red eyes, weakness, headache, nasal congestion/stuffy nose, rhinitis/runny nose, nose bleeds, nausea, upset stomach, abdominal pain, and flushing (sense of warmth) of the face. These side effects may not occur in every patient using this medication and gradually resolve over time. If the side effects persist longer or worsen, please seek a doctor's advice.

Before starting D-Pressin Nasal Spray 5 ml, let your doctor know if you have any medical history of severe kidney disease or hyponatremia (low sodium levels in your body), excessive fluid intake, high blood pressure, heart problems/failure, swelling or scarring of the nasal lining, and illnesses that cause fluid/mineral imbalance. While using D-Pressin Nasal Spray 5 ml, avoid drinking large amounts of fluid, including alcohol, since it could lead to the build-up of water in the body. Pregnant and breastfeeding women should consult their doctor before using D-Pressin Nasal Spray 5 ml. 

Uses of D-Pressin Nasal Spray 5 ml

Central cranial diabetes insipidus, polyuria, and polydipsia.

Directions for Use

Intranasal solution/Nasal spray: Read the instruction leaflet (if provided) carefully before using and prime the nozzle, if required. Blow your nose. Tilt your head back and insert the tip of the nozzle into your nostril. Spray into the nostril while breathing in slightly. When pressing down the pump, apply even pressure and press down quickly to produce a consistent spray. Repeat the same process for another nostril if required. Wipe off the tip with a clean tissue and replace the cap.Nasal drops: Read the instruction leaflet (if provided) carefully and use it as suggested by the doctor. Insert the tip of the dropper into the end of the medicine dispensing tube marked with measurements. Squeeze the dropper until the solution has reached the desired measurement. You can also use a syringe to fill the tube. Hold the tip of the tube, gently insert it into one nostril, and put the other end of the tube into your mouth. Hold your breath, tilt back your head, and blow slowly through your mouth into the tube so the solution reaches your nose.

Medicinal Benefits

D-Pressin Nasal Spray 5 ml is a hormone analogue that contains Desmopressin, a synthetic form of Vasopressin (an antidiuretic hormone that controls fluid balance). D-Pressin Nasal Spray 5 ml mimics the natural hormone vasopressin and works by limiting the amount of water eliminated in the urine, thus controlling excessive thirst and urination. D-Pressin Nasal Spray 5 ml is not indicated for the treatment of nephrogenic diabetes insipidus.

Storage

Store in a cool and dry place away from sunlight
Side effects of D-Pressin Nasal Spray 5 ml
Managing Medication-Triggered Rhinitis (Stuffy Nose): A Step-by-Step Guide
  • Consult your doctor if you experience nasal congestion, runny nose, or sinus pressure after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your rhinitis symptoms.
  • If advised by your doctor, use nasal decongestants or saline nasal sprays to help relieve nasal congestion.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of water and other fluids to help thin out mucus and soothe your nasal passages.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Rest well; get enough sleep.
  • Wear comfortable layers of clothes and get to a warm place.
  • Drink warm fluids like coffee, tea or hot chocolate.
  • Warm up using a blanket or heating pad.
  • Try eating smaller meals (4-5 times) instead of large ones to make it easier on your stomach.
  • Avoid foods that are spicy, fatty, or high in insoluble fibre.
  • Consuming soluble fibre (such as psyllium) can help with constipation, and probiotics may reduce bloating and discomfort.
  • Stay away from carbonated drinks, alcohol, caffeine, and smoking, as they can upset your stomach.
  • Reducing stress, losing weight, and exercising regularly for 20-30 minutes can help improve digestion and reduce stomach issues.
  • Poor sleep can worsen stomach problems, so focus on good sleep habits or use tools like Sleepio to improve your sleep.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Drug Warnings

Before starting D-Pressin Nasal Spray 5 ml, let your doctor know if you have any history of allergic reactions to antidiuretic hormones, severe kidney disease, hyponatremia (low sodium levels in your body), excessive fluid intake, high blood pressure, heart failure, illnesses that cause fluid/mineral imbalance (cystic fibrosis), and fluid retention. Please consult your doctor before starting D-Pressin Nasal Spray 5 ml if you are pregnant, planning to conceive or are a breastfeeding mother. Alcohol consumption may interfere with the working of D-Pressin Nasal Spray 5 ml; hence it is advised to limit or avoid its intake. D-Pressin Nasal Spray 5 ml should be used in children only when prescribed by the doctor.

Drug-Drug Interactions

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DesmopressinBumetanide
Critical
DesmopressinTriamcinolone
Critical

Drug-Drug Interactions

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DesmopressinBumetanide
Critical
How does the drug interact with D-Pressin Nasal Spray 5 ml:
Co-administration of Bumetanide and D-Pressin Nasal Spray 5 ml may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
If you have to use D-Pressin Nasal Spray 5 ml and Bumetanide together, your doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact your doctor immediately as these may be symptoms of water intoxication (water poisoning) and hyponatremia (low levels of salt in the blood). Do not discontinue the medication without consulting a doctor.
DesmopressinTriamcinolone
Critical
How does the drug interact with D-Pressin Nasal Spray 5 ml:
Co-administration of D-Pressin Nasal Spray 5 ml together with triamcinolone may increase the risk of hyponatremia (a condition associated with low levels of salt in the blood).

How to manage the interaction:
Taking Triamcinolone with D-Pressin Nasal Spray 5 ml is not recommended, but it should be taken if advised by a doctor. However, if you experience nausea, vomiting, headache, tiredness, irritability, difficulty concentrating, confusion, muscle spasm, weakness, , decreased urination and loss of appetite(less desire to eat), contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
DesmopressinTorasemide
Critical
How does the drug interact with D-Pressin Nasal Spray 5 ml:
Co-administration of Torasemide can make D-Pressin Nasal Spray 5 ml may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
If you have to use D-Pressin Nasal Spray 5 ml and Torasemide together, a doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact your doctor immediately as these may be symptoms of water intoxication (water poisoning) and hyponatremia (low levels of salt in the blood). Do not discontinue the medication without consulting a doctor.
DesmopressinFluticasone furoate
Critical
How does the drug interact with D-Pressin Nasal Spray 5 ml:
Co-administration of D-Pressin Nasal Spray 5 ml together with fluticasone may increase the risk of hyponatremia, a condition associated with low levels of salt in the blood.

How to manage the interaction:
If you have to use D-Pressin Nasal Spray 5 ml and Fluticasone together, your doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact your doctor immediately as these may be symptoms of water intoxication (water poisoning) and hyponatremia (low levels of salt in the blood). Do not discontinue the medication without consulting a doctor.
DesmopressinFludrocortisone
Critical
How does the drug interact with D-Pressin Nasal Spray 5 ml:
Using D-Pressin Nasal Spray 5 ml together with fludrocortisone may increase the risk of hyponatremia( a condition associated with low levels of salt in the blood).

How to manage the interaction:
Taking D-Pressin Nasal Spray 5 ml with Fludrocortisone is not recommended, but it can be taken if prescribed by a doctor. However, if you experience loss of appetite, nausea, vomiting, headache, lethargy, irritability, difficulty concentrating, memory impairment, confusion, muscle spasm, weakness, unsteadiness, decreased urination and sudden weight gain contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
DesmopressinCortisone
Critical
How does the drug interact with D-Pressin Nasal Spray 5 ml:
Co-administration of Cortisone and D-Pressin Nasal Spray 5 ml may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
If you have to use D-Pressin Nasal Spray 5 ml and Cortisone together, your doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact your doctor immediately as these may be symptoms of water intoxication (water poisoning) and hyponatremia (low levels of salt in the blood). Do not discontinue the medication without consulting a doctor.
DesmopressinCiclesonide
Critical
How does the drug interact with D-Pressin Nasal Spray 5 ml:
Co-administration of Bumetanide and D-Pressin Nasal Spray 5 ml may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
If you have to use D-Pressin Nasal Spray 5 ml and Ciclesonide together, a doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact your doctor immediately as these may be symptoms of water intoxication (water poisoning) and hyponatremia (low levels of salt in the blood). Do not discontinue the medication without consulting a doctor.
DesmopressinDeflazacort
Critical
How does the drug interact with D-Pressin Nasal Spray 5 ml:
Co-administration of Deflazacort and D-Pressin Nasal Spray 5 ml may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
Although co- administration of Daflazacort with Desmopression can possibly lead to an interaction, it can be taken in case a doctor advices you. You should seek medical attention if you experience loss of appetite, nausea, vomiting, headache, lethargy, irritability, difficulty in concentrating, memory impairment, confusion, muscle spasm, weakness, unsteadiness, decreased urination, or sudden weight gain. Do not stop using any medications without consulting a doctor.
DesmopressinFluticasone Propionate
Critical
How does the drug interact with D-Pressin Nasal Spray 5 ml:
Co-administration of D-Pressin Nasal Spray 5 ml together with fluticasone may increase the risk of hyponatremia, a condition associated with low levels of salt in the blood.

How to manage the interaction:
Coadministration of D-Pressin Nasal Spray 5 ml and Fluticasone Propionate is not recommended, but can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, headache, lethargy, irritability, difficulty concentrating, memory impairment, confusion, muscle spasm, weakness, unsteadiness, decreased urination and sudden weight gain contact doctor immediately. Do not discontinue any medications without consulting a doctor.
DesmopressinPrednisolone
Critical
How does the drug interact with D-Pressin Nasal Spray 5 ml:
Co-administration of Prednisolone and D-Pressin Nasal Spray 5 ml may increase the risk of hyponatremia (low levels of sodium in the blood).

How to manage the interaction:
Taking Prednisolone with D-Pressin Nasal Spray 5 ml is not generally advised as they lead to an interaction, they can be taken together if advised by a doctor. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact a doctor immediately. Do not discontinue the medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a fibre-rich diet and include healthy carbohydrates from fruits, vegetables and whole grains.
  • Reduce the amount of salt and protein in your diet, which will help your kidneys to produce less urine.
  • Avoid drinking coffee, tea, cola, energy drinks, or other caffeine sources before bedtime since it can lead to increased urination. 
  • Avoid activities that cause dehydration, such as excessive physical exercise or spending time in the heat.
  • Optimal water intake is recommended to prevent dehydration due to excessive urination.

Habit Forming

No

Therapeutic Class

HORMONES

Author Details

Doctor image

Written By

Divya L

PharmaD

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:46 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

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DESMOPRESSIN-0.1MGOther disorders of kidney and ureter, not elsewhere classified
Severe

Drug-Diseases Interactions

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DESMOPRESSIN-0.1MGOther disorders of kidney and ureter, not elsewhere classified
Severe
How does the disease interact with D-Pressin Nasal Spray 5 ml:
D-Pressin Nasal Spray 5 ml is not recommended for people with moderate to severe renal impairment (creatinine clearance less than 50 mL/min).

How to manage the interaction:
The use of D-Pressin Nasal Spray 5 ml is contraindicated in patients with moderate to severe kidney impairment.

FAQs

D-Pressin Nasal Spray 5 ml contains Desmopressin, a human-made form of vasopressin (antidiuretic hormone). When your body cannot produce enough vasopressin, D-Pressin Nasal Spray 5 ml is used to replace it. It helps treat cranial diabetes insipidus, polyuria, and polydipsia.

Do not use D-Pressin Nasal Spray 5 ml if you have polyuria that has not been diagnosed as diabetes insipidus. It is advised to use the D-Pressin Nasal Spray 5 ml only when the doctor has suggested it for you, depending on your medical condition.

Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and return to your regular dosing schedule.

Optimal intake of fluids is recommended to prevent dehydration. However, avoid excess intake of water and other liquids like coffee, tea, cola, and energy drinks during the treatment. Excessive fluid intake while using D-Pressin Nasal Spray 5 ml may lead to a build-up of water, which dilutes the salt in the body leading to serious problems.

Drug-Drug Interactions Checker List

  • LOPERAMIDE
  • CHLORPROPAMIDE
  • GLIBENCLAMIDE
  • CLOFIBRATE
  • NAPROXEN
  • IBUPROFEN
  • CARBAMAZEPINE
  • CHLORPROMAZINE
  • FUROSEMIDE
  • LITHIUM
  • FLUOXETINE
  • SERTRALINE

Special Advise

  • Regular monitoring of electrolytes is essential to rule out chances of fluid imbalance.
  • If you are more frequently urinating than usual, it is advised to consult your endocrinologist to check for any hormonal abnormalities.
  • Your doctor may advise kidney functioning tests to monitor for renal impairment.

Disease/Condition Glossary

Diabetes insipidus: It is a condition in which the body fails to control fluid balance, resulting in excessive urination. It is caused due to following: 

A) Central diabetes insipidus: It is caused when the pituitary gland cannot produce enough vasopressin (an antidiuretic hormone that maintains fluid balance). It is characterized by excessive thirst (polydipsia) and excessive urination (polyuria).

B) Nephrogenic diabetes insipidus: Though you make enough vasopressin, your kidneys may not respond to vasopressin that regulates fluid balance.

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