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  1. Home
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  3. Daplo M 10 mg/500 mg Tablet 10's

Daplo M 10 mg/500 mg Tablet 10's, Pack of 10 TabletS
Daplo M 10 mg/500 mg Tablet 10's, Pack of 10 TabletS
Written By Divya L , PharmaD
Reviewed By Sureshvarma D , MPharma
Non returnable*
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Whats That

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Composition :

DAPAGLIFLOZIN-10MG + METFORMIN-500MG

Manufacturer/Marketer :

Dr Reddy's Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About DAPLO-M 10/500 TABLETS

DAPLO-M 10/500 TABLETS belongs to the class of 'antidiabetic drugs', primarily used to treat type 2 diabetes mellitus with a proper diet and exercise. DAPLO-M 10/500 TABLETS also lowers the risk of heart failure in type 2 diabetic patients with heart diseases. Diabetes mellitus is a metabolic disease that causes high blood sugar levels. It occurs when the insulin (a hormone produced by the beta cells of the pancreas) is resistant in breaking the glucose to produce energy (insulin resistance) or the pancreas (an organ behind the stomach) produce little or no insulin at all. DAPLO-M 10/500 TABLETS is not indicated for use in type 1 diabetes.

DAPLO-M 10/500 TABLETS is composed of two antidiabetic medicines, namely: Metformin and Dapagliflozin. Metformin belongs to the class of biguanides and manages blood sugar levels, particularly in obese patients. It exhibits a nonpancreatic effect to reduce blood glucose levels without increasing insulin secretion. Dapagliflozin belongs to the class of gliflozins. It works by reducing blood sugar levels by eliminating excess sugars from the body through urine.

Take DAPLO-M 10/500 TABLETS as advised by your doctor. Some common side effects of DAPLO-M 10/500 TABLETS include nausea, vomiting, diarrhoea, headache, weakness, runny nose, genital infection, dizziness, taste changes, and sore throat. Sometimes, DAPLO-M 10/500 TABLETS can cause side effects like lactic acidosis (a rare, but serious metabolic complication of excess lactic acid in the blood that is caused by metformin accumulation) and diabetic ketoacidosis (excess production of blood acids (ketones)). These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor. 

DAPLO-M 10/500 TABLETS may cause hypoglycaemia (low blood sugar); hence it advised to take healthy food with enough calories and avoid heavy exercises. Do not take or stop this medicine, if the doctor did not advise you to do so. Before starting DAPLO-M 10/500 TABLETS , let your doctor know if you have any medical history of heart, kidney or liver diseases, breathing problems, blood disorders, dehydration, alcohol use, low blood pressure, and yeast infection of genitals. It is advised to avoid your alcohol intake while using DAPLO-M 10/500 TABLETS to decrease the risk of lactic acidosis. DAPLO-M 10/500 TABLETS is not recommended for use during the second or third trimester of pregnancy and breastfeeding.

Uses of DAPLO-M 10/500 TABLETS

Type 2 Diabetes mellitus.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it. Take it preferably with a meal since it lowers blood sugar levels and may cause gastrointestinal side effects. Your doctor may start the course with a low dose and gradually maintain an effective dose to achieve the required blood glucose control.

Medicinal Benefits

DAPLO-M 10/500 TABLETS treats type 2 diabetes mellitus and contains Metformin and Dapagliflozin. Metformin is a biguanide and manages blood sugar levels, particularly in obese patients. It exhibits a nonpancreatic effect to reduce blood glucose levels without increasing insulin secretion. It is also known as an insulin sensitizer as it increases the effects of insulin. Metformin is considered a unique antidiabetic drug since it does not cause hypoglycemia (lowered blood sugar levels). Dapagliflozin belongs to the class of gliflozins. It works by reducing blood sugar levels by eliminating excess sugars from the body through urine. DAPLO-M 10/500 TABLETS also reduces the risk of heart failure in patients with type 2 diabetes and heart disease. DAPLO-M 10/500 TABLETS may be advised with or without other medications along with diet and exercise to control blood sugar levels. 

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Inform your doctor if you take other antidiabetic drugs so that the dosage of DAPLO-M 10/500 TABLETS will be adjusted accordingly. Do not abruptly stop taking DAPLO-M 10/500 TABLETS midway if the doctor did not advise you. DAPLO-M 10/500 TABLETS may cause hypoglycaemia (low blood sugar); hence it is advised to make healthy food with enough calories and avoid heavy exercises. Brief your medical history to doctor if you have any heart, kidney or liver diseases, breathing problems (asthma, obstructive lung diseases), blood problems like anaemia (lack of blood cells), vitamin B12 deficiency, pancreas problems/surgery, dehydration, alcohol use, low blood pressure, and yeast infection of genitals before taking DAPLO-M 10/500 TABLETS . Avoid alcohol intake while using DAPLO-M 10/500 TABLETS since it may increase the risk of lactic acidosis. DAPLO-M 10/500 TABLETS is not recommended for use during the second or third trimester of pregnancy and breastfeeding. Your doctor may advise alternate medications to control your diabetic condition in such cases. DAPLO-M 10/500 TABLETS is not recommended for people younger than 18 years of age.

Drug-Drug Interactions

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DapagliflozinGatifloxacin
Critical
MetforminIopamidol
Critical

Drug-Drug Interactions

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DapagliflozinGatifloxacin
Critical
How does the drug interact with Daplo M 10 mg/500 mg Tablet:
Co-administration of Daplo M 10 mg/500 mg Tablet with Gatifloxacin may sometimes affect blood glucose levels. Both low blood glucose and, less frequently, high blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction, Gatifloxacin can be taken with Daplo M 10 mg/500 mg Tablet if prescribed by the doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremor, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Maintaining blood glucose levels is advised. Do not discontinue the medication without consulting a doctor.
MetforminIopamidol
Critical
How does the drug interact with Daplo M 10 mg/500 mg Tablet:
Co-administration of Iopamidol with Daplo M 10 mg/500 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Daplo M 10 mg/500 mg Tablet with Iopamidol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.
MetforminIopromide
Critical
How does the drug interact with Daplo M 10 mg/500 mg Tablet:
Co-administration of Iopromide with Daplo M 10 mg/500 mg Tablet can increase the risk of lactic acidosis.

How to manage the interaction:
Taking Iopromide with Daplo M 10 mg/500 mg Tablet is not recommended, please consult a doctor before taking it. Do not discontinue the medication without consulting a doctor.
MetforminIopanoic acid
Critical
How does the drug interact with Daplo M 10 mg/500 mg Tablet:
Co-administration of Iopanoic acid with Daplo M 10 mg/500 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Daplo M 10 mg/500 mg Tablet with Iopanoic acid is not recommended, please consult your doctor before taking it.
MetforminIodixanol
Critical
How does the drug interact with Daplo M 10 mg/500 mg Tablet:
Co-administration of Iodixanol with Daplo M 10 mg/500 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Daplo M 10 mg/500 mg Tablet with Iodixanol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.
MetforminIotroxic acid
Critical
How does the drug interact with Daplo M 10 mg/500 mg Tablet:
Co-administration of Iotroxic acid with Daplo M 10 mg/500 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Daplo M 10 mg/500 mg Tablet with Iotroxic acid is not recommended, please consult your doctor before taking it.
MetforminIoglycamic acid
Critical
How does the drug interact with Daplo M 10 mg/500 mg Tablet:
Co-administration of Ioglycamic acid with Daplo M 10 mg/500 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Daplo M 10 mg/500 mg Tablet with Ioglycamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIopentol
Critical
How does the drug interact with Daplo M 10 mg/500 mg Tablet:
Co-administration of Iopentol with Daplo M 10 mg/500 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Daplo M 10 mg/500 mg Tablet with Iopentol is not recommended, please consult your doctor before taking it.
MetforminIodamide
Critical
How does the drug interact with Daplo M 10 mg/500 mg Tablet:
Co-administration of Daplo M 10 mg/500 mg Tablet and Iodamide can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Daplo M 10 mg/500 mg Tablet with Iodamide is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIofendylate
Critical
How does the drug interact with Daplo M 10 mg/500 mg Tablet:
Co-administration of Iofendylate with Daplo M 10 mg/500 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Daplo M 10 mg/500 mg Tablet with Iofendylate is generally avoided as it can result in an interaction, please consult your doctor before taking it.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Take the medication as directed by the doctor and at regular intervals if you take DAPLO-M 10/500 TABLETS for more than once per day. Do not use other over the counter medications, herbal or vitamin supplements without informing your pharmacist or doctor when you take DAPLO-M 10/500 TABLETS .
  • Maintain a fibre-rich diet and include healthy carbohydrates from fruits, vegetables and whole grains to maintain your blood glucose levels.
  • Eat at regular intervals.
  • Keep a check on your weight and exercise regularly to keep your heart healthy.
  • Your doctor also guides you on noticing and managing the early symptoms of high/low blood sugar levels.
  • Gastrointestinal side effects can be managed with simple modifications in your lifestyle. These include cutting down on sugars and fatty foods, avoiding carbonated drinks and foods that cause gas. 

Habit Forming

No

Therapeutic Class

ANTIDIABETICS

DAPLO-M 10/500 TABLETS Substitute

Substitutes safety advice

Product Substitutes

Author Details

Doctor image

Written By

Divya L

PharmaD

Sureshvarma D

Reviewed By

Sureshvarma D

MPharma

Last Updated

Jul 8, 2025 | 9:37 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

DAPLO-M 10/500 TABLETS contains two antidiabetic medicines: Metformin and Dapagliflozin. These drugs lower the blood sugar levels in type 2 diabetes mellitus by eliminating excess sugars through urine and also by increasing the activity of insulin.

DAPLO-M 10/500 TABLETS may cause low blood sugar levels (hypoglycaemia) and can make you hungry, dizzy, irritable, confused, anxious, or shaky. Hence, it is advised to take DAPLO-M 10/500 TABLETS with a meal. To immediately treat hypoglycaemia, it is advised to eat or drink fast-acting sugar sources like fruit juices, hard candy, raisins or non-diet soda.

Your doctor may advise DAPLO-M 10/500 TABLETS with or without other medications to control your blood sugar levels. However, it is advised to maintain a proper diet and exercise to achieve the controlled blood sugar levels while using DAPLO-M 10/500 TABLETS with or without other antidiabetic drugs.

DAPLO-M 10/500 TABLETS should be used with caution in heart, kidney or liver diseases, breathing problems (asthma, obstructive lung disease), blood disorders (anaemia, vitamin B12 deficiency), dehydration, alcohol use, low blood pressure, pancreas problems/surgery, and yeast infection of genitals. DAPLO-M 10/500 TABLETS is contraindicated in patients with severe renal impairment and metabolic acidosis/diabetic ketoacidosis.

While using DAPLO-M 10/500 TABLETS , if you experience vomiting, stomach/abdominal pain, muscle cramps, sick feeling, severe tiredness, difficulty in breathing, or reduced body temperature and heartbeat, it is important to seek immediate medical help since these are the symptoms of lactic acidosis. Lactic acidosis is a rare but serious complication caused due to accumulation of metformin. It is a medical emergency and needs immediate treatment. Please consult your doctor for further information.

It is not recommended to use DAPLO-M 10/500 TABLETS along with water pills/diuretics. Simultaneous use of DAPLO-M 10/500 TABLETS and water pills causes dehydration and may increase the risk of lactic acidosis.

Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose.

Drug-Drug Interactions Checker List

  • HYDROCHLOROTHIAZIDE
  • IBUPROFEN
  • CELECOXIB
  • CIMETIDINE

Special Advise

  • It is advised to monitor your blood sugar levels regularly.
  • If you need to undergo any x-ray or CT scan using a dye that should be injected into your veins, your doctor may suggest you stop taking DAPLO-M 10/500 TABLETS temporarily.
  • Regular monitoring of kidney functioning is advised while using DAPLO-M 10/500 TABLETS .
  • DAPLO-M 10/500 TABLETS may make you test positive for a urine glucose test, hence inform your doctor in advance that you take DAPLO-M 10/500 TABLETS . 

Disease/Condition Glossary

Diabetes mellitus, also known as adult-onset diabetes, is a metabolic disease that causes high blood sugar levels. It is type 2 diabetes and occurs when the insulin (a hormone produced by the beta cells of the pancreas) is resistant in breaking the glucose to produce energy (insulin resistance) or the pancreas (an organ behind the stomach) produces little or no insulin at all. This disease mostly occurs in people aged above 40 years, but can also occur in childhood based on the risk factors. The treatment includes oral glucose-lowering medicines and insulin shots. 

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