Darba 25 mcg Injection 0.42 ml
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Darba 25 mcg Injection 0.42 ml belongs to the class of medication called 'blood-forming agent' primarily used to treat anaemia (low red blood cell count) in person with long-term serious (chronic) kidney disease and persons receiving chemotherapy for some types of cancer (except for bone marrow or blood cells' cancer). Darba 25 mcg Injection 0.42 ml helps to reverse anaemia and reduce the need for blood transfusion. Anaemia occurs when the body has a lower amount of red blood cells or haemoglobin. In chronic kidney disease, the kidney gets damaged and doesn't filter the blood, leading to anaemia.
Darba 25 mcg Injection 0.42 ml contains a protein 'Darbepoetin alfa' which works by providing signals to the bone marrow to make more red blood cells. Darba 25 mcg Injection 0.42 ml is a biologic response modifier and erythropoiesis-stimulating protein. In chronic kidney disease, when the kidney fails to produce sufficient 'erythropoietin protein' which aids in the formation of red blood cells, Darba 25 mcg Injection 0.42 ml stimulates the production of this protein in the bone marrow.
Darba 25 mcg Injection 0.42 ml will be injected by the healthcare provider. Do not self-administer. The most common side effects of Darba 25 mcg Injection 0.42 ml are shortness of breath, cough, low blood pressure during dialysis, headache, body aches, diarrhoea, injection site pain and abdominal pain. Most of these sides effects of Darba 25 mcg Injection 0.42 ml do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.
If you have uncontrolled/untreated high blood pressure or red cell aplasia (a type of anaemia) due to darbepoetin alfa or epoetin alfa, please inform your doctor before taking Darba 25 mcg Injection 0.42 ml to avoid any complications. Also, mention all the other medications you are taking to affect the way Darba 25 mcg Injection 0.42 ml works. Inform your doctor immediately, if you feel weak, lightheaded, tired, or short of breath, or if your skin looks pale as it may be signs that the body has stopped responding to Darba 25 mcg Injection 0.42 ml.
Darba 25 mcg Injection 0.42 ml is a human-made form of naturally occurring erythropoiesis-stimulating protein or erythropoietin (a hormone produced by the kidney's specialized cells and is responsible for protecting red blood cells against destruction and also stimulates the cells of bone marrow to produce more amount of red blood cells). Deficiency of erythropoietin happens when a person is suffering from chronic kidney diseases, which in turn cause low red blood cells count causing anaemia. This medicine is primarily indicated for treating anaemia (low red blood cell count) in persons with long-term serious (chronic) kidney disease and persons receiving chemotherapy for some types of cancer except for bone marrow or blood cells' cancer. Darba 25 mcg Injection 0.42 ml contains a protein 'Darbepoetin alfa' which works by providing signals to the bone marrow to make more red blood cells.
Darba 25 mcg Injection 0.42 ml can enhance the risk of serious heart problems including heart attack so tell your doctor immediately if you notice shortness of breath, sudden numbness or weakness, chest pain, or trouble speaking or understanding. This medicine may also shorten survival time in some people with certain types of cancer. Inform your doctor before taking Darba 25 mcg Injection 0.42 ml if you have heart disease, high blood pressure, kidney disease, stroke, heart attack, blood clot, seizure, or latex allergy. Do not take Darba 25 mcg Injection 0.42 ml if you are pregnant or breastfeeding unless prescribed by the doctor. Darba 25 mcg Injection 0.42 ml may affect a person's ability to drive as it may cause convulsion during initial days of treatment, so a person taking Darba 25 mcg Injection 0.42 ml should avoid driving or operating any machine. Darba 25 mcg Injection 0.42 ml should not be given to children below 12 years of age, as safety and effectiveness have not been established. Avoid consuming alcohol along with Darba 25 mcg Injection 0.42 ml as it could lead to increased dizziness and sleepiness.
Drug-Drug Interactions: Darba 25 mcg Injection 0.42 ml may have interaction with other chemotherapy drugs (thalidomide), immunosuppressant medication (cyclosporine), antihypertensive medicines (captopril).
Drug-Food Interactions: Avoid alcohol consumption while taking Darba 25 mcg Injection 0.42 ml as it might cause increased dizziness and sleepiness.
Drug-Disease Interactions: Darba 25 mcg Injection 0.42 ml may have interactions with disease conditions such as seizures, hemodialysis, hypertension, and thrombotic events
Anaemia: It occurs when the body has a lower amount of red blood cells or haemoglobin than normal haemoglobin (iron-rich the protein responsible for allowing red blood cells to carry more oxygen from the lungs to the rest of the body). In chronic kidney disease, the kidney gets damaged and doesn't filter the blood, leading to anaemia. Symptoms of anaemia in chronic kidney disease include fatigue or tiredness, shortness of breath, ashen skin, weakness, body aches, chest pain, dizziness, fainting, fast or irregular heartbeat, headache, sleep problems, and trouble in concentrating.
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Alcohol
Unsafe
Avoid consumption of alcohol while taking Darba 25 mcg Injection 0.42 ml as it may increase dizziness and sleepiness.
Pregnancy
Caution
Avoid taking Darba 25 mcg Injection 0.42 ml if you are pregnant unless prescribed by a doctor as Darba 25 mcg Injection 0.42 ml is a pregnancy category C drug. Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
Caution
Consult your doctor before taking Darba 25 mcg Injection 0.42 ml; your doctor will decide whether Darba 25 mcg Injection 0.42 ml can be taken by breastfeeding mothers or not.
Driving
Unsafe
Darba 25 mcg Injection 0.42 ml causes convulsions (seizures), especially during the initial months of treatment. So, it is better not to drive or operate machinery unless you are alert.
Liver
Caution
Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.
Kidney
Caution
Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.
Children
Caution
Darba 25 mcg Injection 0.42 ml should not be given to children as the safety and efficacy have not been established.
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