Decapeptyl Depot Injection 1's

Written By Divya L , PharmaD

Reviewed By Sureshvarma D , MPharma

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MRP ₹6300

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About Decapeptyl Depot Injection

Decapeptyl Depot Injection belongs to the class of 'anti-neoplastic agents', primarily used to treat prostate cancer in men, endometriosis in women and precocious puberty (early puberty) in children. Prostate cancer is the prostate gland's cancer (a small gland under the bladder secretes fluid that nourishes and protects sperm) found only in men. Endometriosis is a disorder in which tissue lining the uterus grows outside the uterine cavity. Precocious puberty occurs when a child's body changes into that of an adult or experiences puberty too soon.

Decapeptyl Depot Injection contains Triptorelin that belongs to the class of gonadotropin-releasing hormone (GnRH) agonists. Triptorelin is a synthetic hormone that acts similar to the GnRH, produced by the hypothalamus gland in the brain. It works by inhibiting the synthesis of the natural male hormone, testosterone in men and oestrogen in women. The lowering of testosterone hormone levels in men helps slows down the growth of cancer cells in prostate cancer.

Use Decapeptyl Depot Injection as prescribed by your doctor. Your doctor will decide the dosage depending on your medical condition. The common side effects of Decapeptyl Depot Injection include hot flashes, decreased sexual interest, shrinking of the testicles, breast tenderness or swelling, dizziness, headache, flu symptoms, nausea, vomiting, diarrhoea, upset stomach and swelling in legs. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Do not take or stop this medicine, if the doctor did not advise you to do so. Before starting Decapeptyl Depot Injection, let your doctor know if you have any medical history of liver or kidney diseases, heart diseases, recent heart attack, depression, brain tumours, electrolyte imbalance, diabetes, fits, weak bones and high cholesterol levels. Decapeptyl Depot Injection is not indicated for use in pregnant and breastfeeding women. Decapeptyl Depot Injection may make you feel dizzy, hence drive when you are alert only. Decapeptyl Depot Injection is not recommended for children below two years of age.

Uses of Decapeptyl Depot Injection

Prostate cancer, endometriosis and precocious puberty.

Directions for Use

It will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Decapeptyl Depot Injection contains Triptorelin, a gonadotropin-releasing hormone (GnRH) agonist. It treats prostate cancer in men, endometriosis in women and precocious puberty (early puberty) in children. Decapeptyl Depot Injection is a synthetic hormone that acts similar to the GnRH, produced by the hypothalamus gland in the brain. Being an anti-neoplastic or anticancer agent, Decapeptyl Depot Injection works by lowering testosterone levels in men that help stop the growth of cancer cells in prostate cancer. Decapeptyl Depot Injection reduces oestrogen (a hormone required for the development and regulation of the female reproductive system and secondary sexual characteristics) levels in women, thus helps in shrinking of endometriosis. Decapeptyl Depot Injection also has the role of a contraceptive drug.

Storage

Keep out of sight and reach of children.

Side effects of Decapeptyl Depot Injection

Inflammation Of Air Passages In Lungs

Managing Medication-Triggered Bronchitis (Inflammation of the bronchial tubes): A Step-by-Step Guide:

If you experience symptoms like coughing, wheezing, chest tightness, or difficulty breathing after taking medication, seek medical attention immediately.
Your healthcare provider will work with you to stop the medication causing the reaction, start alternative treatments, and provide supportive therapy.
To manage symptoms and prevent complications, follow your doctor's advice to use inhalers or nebulizers as prescribed, practice good hygiene, avoid irritants, stay hydrated, and get plenty of rest.
Regularly track your symptoms and report any changes or concerns to your healthcare provider.

Stomach Flu

Get ample rest; this helps your stomach to settle.
Eat soft and easy-to-digest foods like white rice, bananas, crackers and apple sauce.
Include probiotics-rich food like yoghurt, kefir, or miso, as they help maintain gut functioning.
Wash your hands properly before preparing/eating food and after using the toilet.
Drink water, broth or diluted fruit juice to replace electrolytes and lost fluids.
Avoid caffeine, alcohol, high-fat, fried and fast foods, as well as sweetened beverages.

Flu

Rest well; get enough sleep. This helps the body fight infection.
Keep yourself hydrated by drinking enough water and other fluids.
Wash your hands often and avoid touching your eyes, mouth or nose.
Wear a mask whilst going out.
Warm steam or a hot shower may help with nose secretions.
Avoid contact with others to prevent contamination.

Common Cold

Here are the steps to manage the medication-triggered Common Cold:

Inform your doctor about the common cold symptoms you're experiencing due to medication.
Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.

Ear Infection

Boost immunity with vitamins by including foods rich in vitamins C (citrus fruits, bell peppers) and D (fortified milk, fatty fish).
Eat omega-3 rich foods like fatty fish like salmon, tuna, and sardines to reduce inflammation.
Stay hydrated by drinking plenty of fluids to thin mucus and aid drainage.
Consider probiotic-rich foods like yogurt to potentially help prevent future ear infections.
Limit dairy and sugar intake to manage mucus production.
Sleep with head elevated by using extra pillows to facilitate fluid drainage.
Apply warm compress for temporary pain relief.
Wash hands frequently to prevent spreading germs.
Use a humidifier to add moisture to the air to help with congestion and ear pressure.
Avoid secondhand smoke to reduce risk of ear infections.
Consult your doctor before making significant dietary or lifestyle changes, especially if taking medication for ear infection.

Sore Throat

Drink warm fluids such as warm water with honey, broth, soup or herbal tea to soothe sore throat.
Gargle with warm salt water.
Suck on lozenges to increase the production of saliva and soothe your throat.
Use a humidifier to soothe sore throat as it adds moisture to the air and makes breathing easier.

Inflammation Of Sinuses

Here are the steps to manage the medication-triggered Sinusitis (Sinus infection or Inflammation Of Sinuses):

Consult your doctor if you experience symptoms of sinusitis, such as nasal congestion, facial pain, or headaches, which may be triggered by your medication.
Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your sinusitis symptoms.
Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
If your doctor advises, you can use nasal decongestants or saline nasal sprays to help relieve nasal congestion and sinus pressure.
To help your body recover, get plenty of rest, stay hydrated, and engage in stress-reducing activities. If your symptoms persist or worsen, consult your doctor for further guidance.

Drug Warnings

Inform your doctor if you have any allergic reactions to Decapeptyl Depot Injection or other medications. Before starting Decapeptyl Depot Injection, let your doctor know if you have any medical history of liver or kidney diseases, heart diseases, recent heart attack, depression, brain tumours, electrolyte imbalance, diabetes, fits, weak bones and high cholesterol levels. Decapeptyl Depot Injection may cause QT prolongation (heart muscle takes longer than normal to recharge between beats) and may affect heart rhythm, hence heart patients should be cautious while taking Decapeptyl Depot Injection. Decapeptyl Depot Injection can affect the unborn baby when used in pregnancy. Hence, Decapeptyl Depot Injection is not indicated for use in pregnancy and breastfeeding women. If you are using Decapeptyl Depot Injection, make sure to use reliable forms of contraception to prevent pregnancy during the course. Decapeptyl Depot Injection may also affect fertility in men, hence discuss with your doctor if you have any plans to start a family in the future. Decapeptyl Depot Injection can make you feel dizzy and affects your mental ability to drive. Do not drive or operate machinery if you are not mentally alert and focused. Decapeptyl Depot Injection is not recommended for children younger than two years of age.

Drug-Drug Interactions

TriptorelinCeritinib

Severe

TriptorelinClozapine

Severe

Drug-Drug Interactions

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TriptorelinCeritinib

Severe

How does the drug interact with Decapeptyl Depot Injection:
Coadministration of Decapeptyl Depot Injection with ceritinib can increase the risk of irregular heart rhythm.

How to manage the interaction:
Co-administration of Ceritinib with Decapeptyl Depot Injection can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience any symptoms like irregular heart rhythm, dizziness, fainting, or shortness of breath, make sure to contact a doctor right away. Do not discontinue any medications without consulting a doctor.

TriptorelinClozapine

Severe

How does the drug interact with Decapeptyl Depot Injection:
Combining Decapeptyl Depot Injection with Clozapine can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Decapeptyl Depot Injection and Clozapine together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you notice any symptoms like an irregular heart rhythm, dizziness, shortness of breath, or heart palpitations, it's important to contact your doctor right away. Do not stop using any medications without first talking to your doctor.

TriptorelinMoxifloxacin

Severe

How does the drug interact with Decapeptyl Depot Injection:
Using moxifloxacin together with Decapeptyl Depot Injection can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Moxifloxacin with Decapeptyl Depot Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any symptoms like an irregular heart rhythm, prolonged diarrhea or vomiting, complications, sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, you should contact your doctor right away. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Take the medication as directed by the doctor and at regular intervals.
Maintain a fibre-rich diet and include healthy carbohydrates from fruits, vegetables and whole grains.
Include fish, soy, tomatoes, Brussels sprouts, kale, broccoli and oils containing omega-3 fatty acids such as olive oil as these foods may reduce the risk of prostate cancer.
Avoid grilled meat, red meat, saturated fat found in animal products, milk and dairy products.
Exercise regularly to lose weight as obesity is also considered as a risk factor for prostate cancer.
Eat at regular intervals.
Keep your weight under control with BMI 19.5-24.9.
Opt for a diet rich in whole grains, fruits, veggies and low-fat dairy products.

Side Effects of Decapeptyl Depot Injection

Hot flashes
Decreased sexual interest
Shrinking of the testicles
Breast tenderness or swelling
Dizziness
Headache
Flu
Nausea
Vomiting
Diarrhoea
Upset stomach
Swelling in legs

Habit Forming

No

Therapeutic Class

GONADOTROPHIN-RELEASING HORMONE AGONIST

Author Details

Written By

Divya L

PharmaD

Reviewed By

Sureshvarma D

MPharma

Last Updated

Jul 8, 2025 | 9:37 AM IST

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Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

How does Decapeptyl Depot Injection work?

Decapeptyl Depot Injection contains Triptorelin, a synthetic hormone. It helps reduce the testosterone and oestrogen hormones in men and women, respectively. This process of lowering hormone levels can decrease cancer cell's growth in prostate cancer in men and shrinks endometriosis in women.

What if I miss a dose of Decapeptyl Depot Injection?

Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose.

In what conditions should I stay cautious, while using Decapeptyl Depot Injection?

Decapeptyl Depot Injection should be used with caution and under doctor's supervision only if you have any medical history of liver or kidney diseases, heart diseases, recent heart attack, depression, brain tumours, electrolyte imbalance, diabetes, fits, weak bones and high cholesterol levels. Let your doctor know if you have any other medical concerns before using Decapeptyl Depot Injection.

What do I need to know before using Decapeptyl Depot Injection?

During treatment with Decapeptyl Depot Injection in the first few weeks, a temporary increase in hormones may occur before they decrease. This may cause new or worsening of side effects of Decapeptyl Depot Injection. This is a normal response of your body to Decapeptyl Depot Injection. However, if you notice any symptoms that are not manageable, please seek medical advice.

I am being treated for depression, can I use Decapeptyl Depot Injection?

Decapeptyl Depot Injection may worsen your mood disorders like depression. Hence it is advised to use Decapeptyl Depot Injection only when you are free from any kind of mental problems. Please consult your doctor for more information.

Does Decapeptyl Depot Injection affect fertility in men?

Decapeptyl Depot Injection may cause impotence and affect fertility in men. It is advised to speak to your doctor if you plan to have a family in the future before starting Decapeptyl Depot Injection.

Drug-Drug Interactions Checker List

QUINIDINE
PROCAINAMIDE
AMIODARONE
SOTALOL
MOXIFLOXACIN
METHADONE

Special Advise

Your doctor may advise liver function tests to monitor your liver health since Decapeptyl Depot Injection may cause increased liver enzymes (alanine aminotransferase, serum aspartate and serum transaminases).
Decapeptyl Depot Injection may cause increased serum glucose levels (hyperglycaemia), hence inform your doctor if you have diabetes before starting Decapeptyl Depot Injection.
Your doctor may advise blood tests and regular examinations of the prostate.
It is advised to get an electrocardiogram (ECG) done timely to monitor your heart health.

Disease/Condition Glossary

Prostate cancer: It is the cancer of the prostate gland (a small gland under the bladder that secretes fluid that nourishes and protects sperm) found only in men. The symptoms include difficulty in urination, pain, numbness or sexual problems. It is the most common type of cancer in men.

Endometriosis: It is a disorder in which tissue lining the uterus grows outside the uterine cavity. It commonly involves ovaries, fallopian tubes and the tissue lining the pelvis. Symptoms of endometriosis include pain and irregular periods.

Precocious puberty occurs when a child's body changes into that of an adult or experiences puberty too soon. If puberty begins before age 8 in girls and before age 9 in boys, it is considered precocious puberty. Symptoms in a girl include first period and breast development, whereas, in boy, it causes enlarged testicles and penis, deepening voice and facial hair.