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Written By aquibnaseer ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
COD available

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Whats That

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Composition :

DEFLAZACORT-24MG

Manufacturer/Marketer :

Wallace Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Defza 24 Tablet

Defza 24 Tablet belongs to the class of medication called steroid primarily used to treat Duchene muscular dystrophy in adults and children above 2 years of age. Autoimmune disease is a health disorder in which the immune system doesn't work normally & is unable to distinguish between a foreign cell & a native cell. This condition results in an immune system that starts to attack native cells & organs, leading to medical problems like Duchenne muscular dystrophy, psoriasis & arthritis, etc.

Defza 24 Tablet is an immunosuppressive drug that works by binding to immune system cells and turns off the switches (receptors) that lead to their abnormal functioning or damaging effects. After taking the drug Defza 24 Tablet binds to immune cells, resulting in the inhibition of inflammation & autoimmune diseases that occur due to the production of chemicals called cytokines responsible for inflammation. Thus, a Defza 24 Tablet class of drugs is beneficial in autoimmune diseases and inflammation that causes harm in various organs, especially in joints in arthritis & skin psoriasis. Defza 24 Tablet make organ transplantation possible & treats muscle disorders like Duchenne muscular dystrophy.

Defza 24 Tablet is available in both oral tablet and suspension dosage forms. The tablet form of Defza 24 Tablet can be taken with or without food and swallowed whole with a water glass. Do not crush, chew or break it. The liquid form of Defza 24 Tablet can be taken as advised by your doctor with a measuring cup. Your doctor will recommend how often you take Defza 24 Tablet based on your medical condition. Some people may experience nausea, chest pain, vomiting, drowsiness, headache, dizziness, skin rash, tremor, nervousness, diarrhoea and fast heartbeats. Most of these side effects of Defza 24 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Do not quit taking deflazacort without consulting your physician. Symptoms such as loss of appetite, a disturbed stomach, vomiting, drowsiness, confusion, headache, fever, joint and muscle pain, peeling skin, and weight loss may be caused by stopping the medication suddenly.

Before starting Defza 24 Tablet, please inform your doctor that you are allergic (hypersensitive) to Defza 24 Tablet. Extra care is to be taken when a patient has an already existing infection being treated (systemic infection) or has recently had some live virus vaccines. Doctors' consultation is required as Defza 24 Tablet is not safe to use during pregnancy. 

Uses of Defza 24 Tablet

Duchenne muscular dystrophy (DMD) 

Directions for Use

Tablet: Swallow this tablet whole with a glass of water at the start of a meal or slightly before. Space the doses evenly during the course. Do not chew or crush it. If you cannot swallow the tablet as a whole, you may break the pill into half and take both halves one at a time.Suspension: Measure the suspension in the measuring cup provided with the pack and consume it in the doses as directed by your doctor.

Medicinal Benefits

Defza 24 Tablet is beneficial in inflammatory diseases, including asthma, arthritis, and allergies. It is used in the treatment of Duchenne muscular dystrophy (DMD). It raises the amount of glucocorticoid in the body. It works by reducing the formation of inflammatory substances and suppressing immunity to prevent self-damage caused by the immune system (auto-immune reactions occurring in organ transplants, autoimmune diseases, or cancer). Defza 24 Tablet is a steroid that interacts with overactive immune cells and slows their activity and decreases the damaging effects they cause in the body. 

Storage

Store in a cool and dry place away from sunlight

Side Effects of Defza 24 Tablet

Most of the side effects of Defza 24 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. Common side effects include upper respiratory tract infection, excessive abdominal fat, runny or stuffy nose, skin redness, irritability, abdominal discomfort or pain, irregular behaviour, fever, back pain, acne, nausea, restlessness, nosebleeds and stretch marks.

Drug Warnings

Patients with a history of tuberculosis (TB), heart disease or heart failure stomach disorders (gastritis, peptic ulcer), diabetes (including family history), osteoporosis (bone disease), myasthenia gravis (muscle weakness), depression, mental distress, history of muscular problems caused by corticosteroids, kidney & liver dysfunction (including hepatic insufficiency and cirrhosis), should consult a doctor before using Defza 24 Tablet.  This medicine is not recommended for children less than 5 years of age, lactating mothers and pregnant women. Avoid going near people who are sick or infected while using Defza 24 Tablet. Before taking Defza 24 Tablet for at least, 4-6 weeks do not take any live vaccine as it may cause severe allergic reactions. 

Drug-Drug Interactions

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DeflazacortDesmopressin
Critical
DeflazacortAmprenavir
Severe

Drug-Drug Interactions

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DeflazacortDesmopressin
Critical
How does the drug interact with Defza 24 Tablet:
Co-administration of Defza 24 Tablet and Desmopressin may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
Although co- administration of Daflazacort with Desmopression can possibly lead to an interaction, it can be taken in case a doctor advices you. You should seek medical attention if you experience loss of appetite, nausea, vomiting, headache, lethargy, irritability, difficulty in concentrating, memory impairment, confusion, muscle spasm, weakness, unsteadiness, decreased urination, or sudden weight gain. Do not stop using any medications without consulting a doctor.
DeflazacortAmprenavir
Severe
How does the drug interact with Defza 24 Tablet:
Coadministration of Amprenavir with Defza 24 Tablet can increase the levels of Defza 24 Tablet in the body.

How to manage the interaction:
Taking Amprenavir with Defza 24 Tablet together can result in an interaction. It can be taken if your doctor has advised it. However, if you experience symptoms like muscle weakness, excessive growth of facial or body hair, sudden dizziness, lightheadedness, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DeflazacortVerapamil
Severe
How does the drug interact with Defza 24 Tablet:
Coadministration of Verapamil with Defza 24 Tablet can increase the levels of Defza 24 Tablet in the body. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Verapamil with Defza 24 Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like swelling, weight gain, electrolyte abnormalities, high blood pressure, high blood glucose, muscle weakness, depression, mood swings, acne, thinning skin, stretch marks, easy bruising, bone density loss, cataracts, glaucoma, menstrual irregularities, excessive growth of facial or body hair, and abnormal distribution of body fat, especially in the face, neck, back, and waist. contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DeflazacortAprepitant
Severe
How does the drug interact with Defza 24 Tablet:
Aprepitant may significantly raise the blood levels of Defza 24 Tablet. This may lead to increased side effects.

How to manage the interaction:
Taking Aprepitant with Defza 24 Tablet together can result in an interaction, but it can be taken if your doctor has advised it. Consult a physician if you notice any signs of swelling, diarrhoea, muscle cramps, muscle weakness, depression, back pain, or excessive facial or body hair growth. Without consulting a doctor, never stop taking medicines.
DeflazacortGolimumab
Severe
How does the drug interact with Defza 24 Tablet:
Golimumab can cause tendinitis (inflammation of the thick fibrous cords that attach muscle to bone) and tendon rupture (injury to the soft tissue that connect muscle to bone), and the risk may be increased when combined with other drugs such as Defza 24 Tablet.

How to manage the interaction:
Although there is an interaction, Golimumab can be taken with Defza 24 Tablet if prescribed by the doctor. However, if you experience pain, swelling at the back of the ankle, biceps, shoulder, hand, or thumb, consult a doctor immediately. Avoid exercise or use of the affected area until further instruction from your doctor. Do not stop using any medications without first talking to your doctor.
DeflazacortCarbamazepine
Severe
How does the drug interact with Defza 24 Tablet:
Taking Carbamazepine with Defza 24 Tablet may significantly reduce the blood levels of Defza 24 Tablet, which may make the medication less effective in treating the condition.

How to manage the interaction:
Although using Carbamazepine and Defza 24 Tablet together can possibly result in an interaction, they can be taken together if advised by your doctor. Do not stop taking any medications without consulting a doctor.
DeflazacortNafcillin
Severe
How does the drug interact with Defza 24 Tablet:
Taking Nafcillin with Defza 24 Tablet may significantly reduce the blood levels of Defza 24 Tablet, which may make the medication less effective in treating the condition.

How to manage the interaction:
Although using Nafcillin and Defza 24 Tablet together can possibly result in an interaction, they can be taken together if advised by your doctor. However, consult your doctor if your condition worsens. Do not stop taking any medications without consulting a doctor.
DeflazacortCiprofloxacin
Severe
How does the drug interact with Defza 24 Tablet:
Co-administration of Defza 24 Tablet with Ciprofloxacin leads to tendinitis and tendon rupture.

How to manage the interaction:
Although there is an interaction, Ciprofloxacin can be taken with Defza 24 Tablet if prescribed by the doctor. However, if you experience pain or swelling consult a doctor immediately. Avoid exercise or use of the affected area until further instruction from the doctor. Do not stop using any medications without talking to a doctor.
DeflazacortAspirin
Severe
How does the drug interact with Defza 24 Tablet:
Using Aspirin together with Defza 24 Tablet may increase the risk of gastric and intestinal ulcers, bleeding and perforation.

How to manage the interaction:
Co-administration of Aspirin with Defza 24 Tablet can result in an interaction, but it can be taken if a doctor has advised it. If you have any symptoms unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without consulting a doctor.
DeflazacortInfliximab
Severe
How does the drug interact with Defza 24 Tablet:
Co-administration of Infliximab with Certolizumab may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction between Defza 24 Tablet and Infliximab, you can take these medicines together if prescribed by your doctor. If you have any of the symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you urinate, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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DEFLAZACORT-24MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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DEFLAZACORT-24MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consuming grapefruit juice while on Defza 24 Tablet therapy may elevate Defza 24 Tablet levels in the bloodstream. Avoid or limit the consumption of grapefruit and grapefruit juice.

Diet & Lifestyle Advise

A patient needs to take extra care of hygiene & stay away from places/people believed to be a cause of infection as this drug affects a patient's immune system & thus proper care is to be taken.

 

Habit Forming

No

Therapeutic Class

ANTI- INFLAMMATORY AGENTS

Defza 24 Tablet Substitute

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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Not recommended in mild allergies. Defza 24 Tablet is recommended only on consulting a doctor as Defza 24 Tablet is a strong medicine that produces considerable side effects & thus used only in moderate to severe cases.

It is not recommended to stop by a patient himself/herself, especially by a patient undergoing organ transplantation as it may worsen the situation.

It is not recommended to be taken Defza 24 Tablet with alcohol as it may cause stomach bleeding.

No its is not recommended to be used in seasonal allergy or mild cases. Only on doctors consultation, Defza 24 Tablet may be used in extreme cases of seasonal allergy.

You should not use Defza 24 Tablet if you have taken live vaccines of mumps, measles, rubella (MMR), polio, rotavirus, yellow fever, typhoid, nasal flu (influenza), varicella (chickenpox), and zoster (shingles). Do not take Defza 24 Tablet if you have a compromised immune system, eye problems or weak bones.

Drug-Drug Interactions Checker List

  • RIFAMPICIN
  • RIFABUTIN
  • CARBAMAZEPINE
  • PHENOBARBITONE
  • PHENYTOIN
  • PRIMIDONE

Special Advise

  • While taking Defza 24 Tablet and for at least 4-6 weeks before you start taking it. If you are taking Defza 24 Tablet, so do not receive a 'live' vaccine or you could develop a serious infection.  
  • Do not eat grapefruit or drink grapefruit juice while taking this medication as grapefruit has interaction with Defza 24 Tablet.
  • Regular eye check-ups, bone mineral test and liver function test is suggested while using Defza 24 Tablet. 

Disease/Condition Glossary

Autoimmune disease: These are a group of disorders in which the immune system doesn't work properly due to various genetic & environmental reasons that starts attacking normal cells, producing various chemicals resulting in unwanted and hazardous effects in patients. The overactive immune system leads to various symptoms that affect day to day life and promote diseases like arthritis, muscular weakness. The immune system can also damage the organ, which has been transplanted to the patient from another person due to having different blood groups/antigens of donor patients organ. The immune system considers it a foreign harmful body, leading to complications after transplanting an organ like a kidney, liver, or heart. 

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