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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
COD available

Online payment accepted

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Manufacturer/Marketer

Algen Healthcare Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Denol-P Tablet

Denol-P Tablet belongs to the class of combination medication called NSAIDs (non-steroidal anti-inflammatory drugs) used to relieve pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis. Besides this, it also helps treat muscle pain, tooth pain during dental surgery, menstrual period pain/cramps, ear pain and migraine headaches. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Arthritis is the tenderness and swelling in the joints which causes pain and joint stiffness.

Denol-P Tablet is a combination of three drugs, namely: Diclofenac, Paracetamol and Serratiopeptidase. Diclofenac and Paracetamol work by blocking the effect of a chemical messenger, known as cyclo-oxygenase (COX) enzymes that make other chemical prostaglandins. These prostaglandins are produced at injury sites and cause pain, swelling and fever. By blocking COX enzyme's effect, lesser prostaglandins are produced, which reduces mild to moderate pain, inflammation and fever. Serratiopeptidase acts as a mucolytic (dissolves thick protein at the injured/affected site) and anti-inflammatory agent thereby decreasing swelling at the painful site. 
 
You are advised to take Denol-P Tablet for as long as your doctor has prescribed it for you. In some cases, Denol-P Tablet may cause certain common side-effects such as nausea, vomiting, stomach pain, headache, indigestion and diarrhoea. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
 
Consult your doctor if you are pregnant or breastfeeding. Denol-P Tablet may cause drowsiness and dizziness, so drive with caution. Denol-P Tablet should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol with Denol-P Tablet as it could lead to increased drowsiness and dizziness; it might also increase the risk of stomach bleeding. Keep your doctor informed about your health condition and medicines to rule out any side-effects/interactions.

Uses of Denol-P Tablet

Pain and inflammation associated with osteoarthritis, muscle pain, joint pain, rheumatoid arthritis, mild migraine, dental pain, etc.

Directions for Use

Take Denol-P Tablet with food. Swallow Denol-P Tablet as a whole with a glass of water; do not chew or break it.

Medicinal Benefits

Denol-P Tablet is a combination of three drugs, namely: Diclofenac (pain killer), Paracetamol (fever reducer) and Serratiopeptidase (protein enzyme). Denol-P Tablet is used to relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, muscle pain, tooth pain, bone and joint pain, headache, swelling, period pain, ear pain, migraine, fever,  sore throat, nose pain, etc. Denol-P Tablet increases the pain threshold and blood flow across the skin. Diclofenac and Paracetamol work by blocking the effect of chemical messengers that cause pain and inflammation. Serratiopeptidase breaks down the abnormal proteins at the site of inflammation, thereby reduces inflammation. 

Storage

Store in a cool and dry place away from sunlight

Side Effects of Denol-P Tablet

  • Nausea
  • Vomiting
  • Stomach pain
  • Diarrhoea
  • Indigestion
  • Headache

Drug Warnings

Do not take Denol-P Tablet if you are allergic to paracetamol, diclofenac or serratiopeptidase, have/had severe heart problems, stomach ulcer or perforation, bleeding problems such as bleeding from the stomach, intestine or brain, have undergone any heart bypass surgery, have had a heart attack, blood circulation problems or inflammation of intestines. Consult your doctor if you are pregnant, planning for pregnancy or breastfeeding. Denol-P Tablet may cause drowsiness and dizziness, so drive only if you are alert. Denol-P Tablet is not recommended for children less than 10 years of age as safety and effectiveness have not been established. Avoid consuming alcohol with Denol-P Tablet as it could lead to increased drowsiness and increased risk of stomach bleeding. Stop taking Denol-P Tablet and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools. Do not take any other NSAIDs for pain relief along with Denol-P Tablet unless prescribed.

Drug-Drug Interactions

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DiclofenacMeloxicam
Critical
DiclofenacSirolimus
Severe

Drug-Drug Interactions

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DiclofenacMeloxicam
Critical
How does the drug interact with Denol-P Tablet:
Co-administration of Denol-P Tablet with Meloxicam can increase the risk or severity of gastrointestinal side effects.

How to manage the interaction:
Taking Meloxicam with Denol-P Tablet is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop any medication without doctor's advise.
DiclofenacSirolimus
Severe
How does the drug interact with Denol-P Tablet:
Co-administration of Denol-P Tablet with Sirolimus may increase the risk or severity of kidney problems.

How to manage the interaction:
Co-administration of Denol-P Tablet and Sirolimus can lead to an interaction, but it can be taken if advised by a doctor. However, consult a doctor if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
DiclofenacValdecoxib
Severe
How does the drug interact with Denol-P Tablet:
Taking Valdecoxib with Denol-P Tablet may increase risk of side effects.

How to manage the interaction:
There may be a possible interaction between Denol-P Tablet and Valdecoxib but can be taken if prescribed by doctor. However, consult your doctor immediately if you experience any unusual bleeding or bruising or have other signs and symptoms of bleeding such as dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop any medications without consulting a doctor.
DiclofenacKetorolac
Severe
How does the drug interact with Denol-P Tablet:
Co-administration of Denol-P Tablet and Ketorolac can increase the risk of side effects.

How to manage the interaction:
Co-administration of Denol-P Tablet and Ketorolac can lead to an interaction; it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
DiclofenacKetorolac
Severe
How does the drug interact with Denol-P Tablet:
Coadministration of Denol-P Tablet and Ketorolac can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding and ulceration.

How to manage the interaction:
Co-administration of Denol-P Tablet and Ketorolac can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
DiclofenacAmiloride
Severe
How does the drug interact with Denol-P Tablet:
Taking amiloride with Denol-P Tablet can increase the risk of kidney problems, hyperkalemia(high potassium levels in blood), and high blood pressure.

How to manage the interaction:
There could be a possible interaction between Denol-P Tablet and amiloride, but they can be taken together if your doctor has prescribed them. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
DiclofenacCidofovir
Severe
How does the drug interact with Denol-P Tablet:
Coadministration of Denol-P Tablet with cidofovir may increase the risk of kidney problems.

How to manage the interaction:
Although taking Denol-P Tablet and cidofovir together can possibly cause an interaction, it can be taken if your doctor has suggested it. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
DiclofenacNaproxen
Severe
How does the drug interact with Denol-P Tablet:
Coadministration of Denol-P Tablet and Naproxen can increase the risk or severity of side effects.

How to manage the interaction:
Taking Denol-P Tablet and Naproxen together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
DiclofenacVorapaxar
Severe
How does the drug interact with Denol-P Tablet:
Taking Denol-P Tablet with Vorapaxar can increase the risk of bleeding complications.

How to manage the interaction:
There may be a possible interaction between Denol-P Tablet and Vorapaxar, but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience any unusual bleeding, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headaches. Do not discontinue any medications without consulting your doctor.
DiclofenacTenofovir alafenamide
Severe
How does the drug interact with Denol-P Tablet:
Co-administration of Denol-P Tablet and tenofovir alafenamide may cause kidney problems.

How to manage the interaction:
There may be a possible interaction between Denol-P Tablet and Tenofovir alafenamide but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience symptoms such as such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Exercising regularly helps in muscle stretching so that they are less likely to spasm, tear and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.
  • Massages can also be helpful.
  • Avoid freezing and hot temperatures.
  • Avoid wearing tight-fitting clothes; instead, wear loose garments.
  • Rest well, and get plenty of sleep.
  • To avoid developing pressure sores, change your position every two hours.
  • Hot or cold therapy can help treat muscle spasms. Apply an ice-pack or hot-pack on the muscle for 15-20 minutes.
  • Stay hydrated, drink plenty of water.

Habit Forming

No

Therapeutic Class

ANALGESICS

Denol-P Tablet Substitute

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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Denol-P Tablet contains Diclofenac, Paracetamol and Serratiopeptidase. Diclofenac and Paracetamol work by blocking the effect of chemical messengers that cause pain and inflammation. Serratiopeptidase is a protein enzyme that helps break down and dissolves the abnormal proteins at the inflammation site, thereby reducing pain.

Denol-P Tablet is used to reduce and relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. Arthritis is the tenderness and swelling in the joints.

Diarrhoea might be a side-effect of Denol-P Tablet . Drink enough fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Denol-P Tablet should not be taken for longer durations unless prescribed by the doctor. If Denol-P Tablet has been prescribed for longer durations, regular monitoring of kidney function, liver function and blood count is advised, particularly in elderly patients.

Avoid taking Denol-P Tablet if you have ulcers in the stomach or intestines, bleeding problems or heart problems.

Drug-Drug Interactions Checker List

  • ASPIRIN
  • IBUPROFEN
  • CYCLOSPORINE
  • TACROLIMUS
  • LITHIUM
  • DIGOXIN
  • WARFARIN
  • METHOTREXATE
  • MAGNESIUM HYDROXIDE
  • KETOCONAZOLE
  • MICONAZOLE
  • VORICONAZOLE
  • FLUCONAZOLE
  • AMIDODARONE
  • SULFINPYRAZONE
  • METOCLOPRAMIDE
  • DOMPERIDONE
  • CHOLESTYRAMINE
  • IMATINIB
  • CHLORAMPHENICOL
  • MIFEPRESTONE

Disease/Condition Glossary

Pain: Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Pain may be dull or sharp, it might be constant or may come and go. The tolerance level of pain might vary from person to person. Pain can be generalized (overall body aches) or localized (affecting a specific area of the body). The common causes of pain include headache, muscle strain, cramps, cuts, bone fractures and arthritis.

Osteoarthritis: It is a joint disease in which the two ends of the joints come together due to the breakdown of a protective covering called cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms include pain, stiffness, inflammation and tenderness.

Rheumatoid arthritis: It is an auto-immune disease (the body's immune system attacks its tissue), leading to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities and loss of joint function. 

Ankylosing spondylitis: It causes pain and stiffness in the spine. The pain generally starts in the lower back and can spread to the neck, damaged joints or other body parts. Ankylosing spondylitis includes decreased flexibility which usually leads to a hunched-forward posture and pain in the back and joints.

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