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  3. Depo-Provera 150 mg Injection 1 ml

Depo-Provera 150 mg Injection 1 ml, Pack of 1 Injection
Depo-Provera 150 mg Injection 1 ml, Pack of 1 Injection
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
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Whats That

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Synonym :

DEPOT MEDROXYPROGESTERONE ACETATE

Composition :

MEDROXYPROGESTERONE ACETATE-150MG

Manufacturer/Marketer :

DKT India Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About Depo-Provera 150 mg Injection 1 ml

Depo-Provera 150 mg Injection 1 ml belongs to a group of medicines called progestogens used as a long-acting contraceptive. Contraception is a procedure that aims to prevent unwanted pregnancy for safe family planning.

Depo-Provera 150 mg Injection 1 ml contains medroxyprogesterone acetate (DMPA), which is similar to (but not the same as) the natural hormone progesterone, which is produced in the ovaries during the second half of your menstrual cycle. During your menstrual cycle, Depo-Provera 150 mg Injection 1 ml prevents an egg from fully maturing and being discharged from the ovaries. If an egg is not released, it cannot be fertilised by sperm and result in pregnancy.

Depo-Provera 150 mg Injection 1 ml will be administered by your doctor or healthcare professional. In some cases, you may have nervousness, headache, stomach pain or discomfort, weight increase or decrease, libido decreased (reduced sex drive), dizziness, and feeling sick and depressed. Most of these side effects of Depo-Provera 150 mg Injection 1 ml do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Let your doctor know before prescribing Depo-Provera 150 mg Injection 1 ml if you have, or had migraine headaches, diabetes, Severe pain or swelling in the calf, eye disorders, depression, liver or kidney disorders, osteoporosis, asthma, or epilepsy. And also inform your doctor if you are pregnant or expecting pregnancy or breastfeeding or taking if you are using certain medicines such as high-dose glucocorticoids (steroids).

Uses of Depo-Provera 150 mg Injection 1 ml

Contraceptives

Directions for Use

Depo-Provera 150 mg Injection 1 ml will be administered by a qualified healthcare professional. Kindly do not self-administer.

Medicinal Benefits

Depo-Provera 150 mg Injection 1 ml contains medroxyprogesterone acetate (DMPA), which is close to (but not the same as) progesterone, a natural hormone secreted in the ovaries during the second half of your menstrual cycle. Depo-Provera 150 mg Injection 1 ml prevents an egg from fully developing and being released from the ovaries during your menstrual cycle. An egg that is not released cannot be fertilised by sperm and result in pregnancy. On the other hand, it also induces changes in the lining of your womb, making conception less likely. It also thickens the mucus at the womb's opening, making sperm entry more difficult.

Storage

Store in a cool and dry place away from sunlight
Side effects of Depo-Provera 150 mg Injection 1 ml
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Always wear loose-fitting clothes suitable for your activity during hot flashes.
  • Include a diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water and stay hydrated.
  • Stay calm and lower your anxiety by practising yoga or meditation.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Keep your skin clean by gently washing your face two times daily and after sweating. Choose a mild and non-abrasive cleanser.
  • Use gentle alcohol-free skin care products. Avoid products that might irritate your skin such as exfoliants, astringents and toners.
  • Acne may also occur due to oil in the hair. Thus, if you have oily hair, shampoo more frequently than you do now and keep your hair away from face.
  • Keep your hands off your face as touching face throughout the day might worsen acne. Also, do not pick, squeeze or pop acne as it will prolong the healing process and increase the risk of dark spots and scarring.
  • Avoid tanning by applying a broad spectrum sunscreen and wearing sun-protective clothing when outdoors.

Drug Warnings

Depo-Provera 150 mg Injection 1 ml should not be used if you are allergic to any of its components. Inform your doctor if you are allergic to any of the substances. Before taking Depo-Provera 150 mg Injection 1 ml, inform your healthcare provider if you have or have had migraine headaches, vaginal bleeding, blood disorders (such as deep vein thrombosis), diabetes, severe pain or swelling in the calf, eye diseases, depression, liver (such as jaundice) or kidney disorders, osteoporosis, asthma, or epilepsy and hormone-dependent cancer of the breast or sex organs. Also, tell your doctor if you are pregnant, expecting a pregnancy, breastfeeding, or using certain medications, such as high-dose glucocorticoids (steroids).

Drug-Drug Interactions

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MedroxyprogesteroneEtretinate
Critical
MedroxyprogesteroneTranexamic acid
Critical

Drug-Drug Interactions

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MedroxyprogesteroneEtretinate
Critical
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
Taking Depo-Provera 150 mg Injection 1 ml and Etretinate may cause severe birth defects if the mother takes the medication during pregnancy.

How to manage the interaction:
Using etretinate and Depo-Provera 150 mg Injection 1 ml together is not recommended, but can be taken if prescribed by a doctor. However, if you experience unusual symptoms contact your doctor. Do not discontinue any medications without consulting a doctor.
MedroxyprogesteroneTranexamic acid
Critical
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
Taking Depo-Provera 150 mg Injection 1 ml acetate with Tranexamic acid may increase the risk of blood clots.

How to manage the interaction:
Taking Depo-Provera 150 mg Injection 1 ml with Tranexamic acid is not recommended but can be taken if prescribed by a doctor. Consult your doctor immediately if you experience symptoms such as chest pain, shortness of breath, coughing up blood, blood in the urine, sudden loss of vision, and pain, redness, or swelling in your arm or leg. Do not stop using any medications without talking to your doctor.
MedroxyprogesteroneAcitretin
Critical
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
Coadministration of Acitretin with Depo-Provera 150 mg Injection 1 ml can increase the risk and severity of birth defects when taken by a pregnant woman.

How to manage the interaction:
Taking Acitretin with Depo-Provera 150 mg Injection 1 ml together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. Consult a doctor if you get pregnant while taking these medications. Do not discontinue any medications without consulting a doctor.
MedroxyprogesteroneDabrafenib
Severe
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
When Dabrafenib is taken with Depo-Provera 150 mg Injection 1 ml acetate, the amount of Depo-Provera 150 mg Injection 1 ml acetate in the blood may decrease.

How to manage the interaction:
Co-administration of Dabrafenib with Depo-Provera 150 mg Injection 1 ml can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience hot flashes(feeling of heat in the body), dryness, or unusual bleeding, don't hesitate to reach out to your doctor. Do not stop using any medications without a doctor's advice.
MedroxyprogesteroneFosamprenavir
Severe
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
Taking Depo-Provera 150 mg Injection 1 ml together with fosamprenavir may decrease the effects of fosamprenavir.

How to manage the interaction:
Although there is a possible interaction between Depo-Provera 150 mg Injection 1 ml and Fosamprenavir, you can take these medicines together if prescribed by your doctor. However, if you experience any unusual symptoms contact your doctor right away. Do not stop using any medications without a doctor's advice.
MedroxyprogesteroneMycophenolic acid
Severe
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
Coadministration of Depo-Provera 150 mg Injection 1 ml with mycophenolic acid may decrease the levels and effects of Depo-Provera 150 mg Injection 1 ml.

How to manage the interaction:
There could be a possible interaction between Mycophenolic acid and Depo-Provera 150 mg Injection 1 ml, but they can be taken together if your doctor has prescribed them. However, if you experience hot flashes, vaginal dryness, or abnormal bleeding consult a doctor. Do not discontinue any medications without a doctor's advice.
MedroxyprogesteroneGriseofulvin
Severe
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
Taking griseofulvin with Depo-Provera 150 mg Injection 1 ml may reduce blood levels and the effects of Depo-Provera 150 mg Injection 1 ml.

How to manage the interaction:
There may be a possibility of interaction between Griseofulvin and Depo-Provera 150 mg Injection 1 ml, but it can be taken if prescribed by a doctor. However, if you experience any of these symptoms like unexpected bleeding or abnormal bleeding, or if you think you might be pregnant while using birth control, it's important to contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MedroxyprogesteroneSugammadex
Severe
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
When Depo-Provera 150 mg Injection 1 ml is taken with sugammadex, the effect of Depo-Provera 150 mg Injection 1 ml in the blood may decrease.

How to manage the interaction:
Taking Sugammadex with Depo-Provera 150 mg Injection 1 ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any unusual symptoms consult your doctor immediately. Do not discontinue any medications without first consulting your doctor.
MedroxyprogesteroneBexarotene
Severe
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
Taking Depo-Provera 150 mg Injection 1 ml with bexarotene may decrease the effectiveness of Depo-Provera 150 mg Injection 1 ml.

How to manage the interaction:
Although taking Depo-Provera 150 mg Injection 1 ml and Bexarotene together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms consult your doctor immediately. Do not discontinue any medications without consulting a doctor.
MedroxyprogesteroneBrigatinib
Severe
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
Taking Depo-Provera 150 mg Injection 1 ml and Brigatinib may, reduce the blood levels and effects of Depo-Provera 150 mg Injection 1 ml.

How to manage the interaction:
Although taking Depo-Provera 150 mg Injection 1 ml and brigatinib together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience hot flashes(feeling of heat in the body), dryness, or unusual bleeding, don't hesitate to reach out to your doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Keep your weight under control with a body mass index (BMI) of 19.5-24.9.
  • Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.
  • Including heart-healthy omega-3 fatty acid-containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.
  • Do regular exercise to maintain weight fluctuations caused due to Depo-Provera 150 mg Injection 1 ml.
  • Avoid chronic stress and exercise like running, as it might increase vaginal bleeding.
  • Try to be stress-free to improve your mood swings due to hormonal fluctuations. 
  • Monitor your blood pressure daily and if there is too much fluctuation, immediately contact your doctor.
  • Monitor your blood sugar level and blood pressure regularly to avoid any complications.
  • Quitting smoking and not drinking alcohol is the best strategy to lower the risk of any complications.

Habit Forming

No

Therapeutic Class

HORMONES

Depo-Provera 150 mg Injection 1 ml Substitute

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:46 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Depo-Provera 150 mg Injection 1 ml prevents an egg from fully developing and being released from the ovaries during your menstrual cycle. An egg that is not released cannot be fertilised by sperm and result in pregnancy. On the other hand, it also induces changes in the lining of your womb, making conception less likely. It also thickens the mucus at the womb's opening, making sperm entry more difficult.

It is recommended not to take any other contraceptives with Depo-Provera 150 mg Injection 1 ml without a doctor's prescription.

Yes, the Depo-Provera 150 mg Injection 1 ml may cause hair loss. If you feel that you are experiencing a lot of hall falls while taking Depo-Provera 150 mg Injection 1 ml, please consult your doctor.

Do not use Depo-Provera 150 mg Injection 1 ml if you are allergic to medroxyprogesterone acetate, or any other similar hormonal medicines, if you have/had breast cancer, a blood clotting disorder such as deep vein thrombosis (blood clot in the legs) or pulmonary embolism (blood clot in the lung), severe liver disease such as jaundice, unexplained vaginal bleeding or if you are pregnant or think you may be pregnant or If you have not yet started your periods.

Depo-Provera 150 mg Injection 1 ml can be used for just one or two occasions in a few cases such as if your partner is having a vasectomy, Depo-Provera 150 mg Injection 1 ml can be used to protect you until the vasectomy takes place, or if you are being immunised against rubella, to prevent conception during the virus's active phase, or if you are awaiting sterilisation.

Drug-Drug Interactions Checker List

  • WARFARIN
  • TOPIRAMATE

Disease/Condition Glossary

Contraception: It is a procedure that aims to prevent pregnancy. A woman can only get pregnant if a man's sperm fertilizes her egg. Contraception aims to prevent this from happening by keeping egg and sperm apart by stopping egg production or not letting the uterus wall become thick. As a result, no fertilization takes place, so contraception is a safe method for family planning.

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