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Reviewed By Sureshvarma D , MPharma

About Depsol Plus Tablet 10's

Depsol Plus Tablet 10's belongs to the class of medications called ‘antidepressants’ used in the treatment of depression. Depression is a mood disorder that affects a person's daily life described as feelings of sadness, loss, or anger. These symptoms may interfere with your daily activities and affect your quality-of-life.

Depsol Plus Tablet 10's contains Imipramine and Diazepam. Imipramine is a tricyclic antidepressant. It works by increasing serotonin and noradrenalin levels, chemicals present in the brain responsible for energy, mood, and behavior. Diazepam is a benzodiazepine. It increases the levels of chemicals in the brain that produce a calming effect. Together, Depsol Plus Tablet 10's can effectively reduce the symptoms of depression.

You should take this medicine exactly as prescribed by the doctor. Depsol Plus Tablet 10's may cause side-effects such as drowsiness, fatigue (extreme tiredness), confusion, loss of coordination of body movements (ataxia), dryness in the mouth, constipation, difficulty in urination, difficulty passing urine, low blood pressure, decrease in sexual function, dilation of the pupil of the eye, vision problems, loss of appetite, and increased heart rate. These side-effects usually don’t require medical attention. However, if any of these side-effects persist or get worse, inform your doctor immediately.

It is not recommended to take Depsol Plus Tablet 10's if you are allergic to any contents of it. Do not take Depsol Plus Tablet 10's if you have severe liver disease, heart disease, mania (exaggerated behavior or hyperactivity), porphyria (an inherited blood disorder), difficulty passing urine, glaucoma (increased pressure inside the eye), severe breathing problems, phobia (a fear of particular object), myasthenia gravis (a condition in which muscles weaken), and sleep apnoea (a sleep disorder). Inform your doctor if you are pregnant or breastfeeding. It is not recommended for use in children below 6 years of age. In children and young adults below 25 years, this medicine should be used with caution as it may increase suicidal tendencies and worsen depression. It should be used with caution in elderly patients. Alcohol consumption may increase the risk of side-effects. Depsol Plus Tablet 10's may cause drowsiness or blurred vision, so do not drive or operate heavy machinery if you are not fully alert.

rxMedicinePrescription drug

Whats That

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Non returnable*
COD available

Online payment accepted

Manufacturer/Marketer

Int-Intas Laboratories Ltd

Consume Type

ORAL

Return Policy

3 Days Returnable

Expires on or after

Apr-24

for this medicine

Uses of Depsol Plus Tablet 10's

Depression

Medicinal Benefits

Depsol Plus Tablet 10's is used to treat depression. It decreases the number of episodes of depression and also reduces the duration of each depressive episode. It improves mood, behavior, sleep and decreases anxiety. This medicine is prescribed for longer durations as it may take several weeks to improve your overall condition. Depsol Plus Tablet 10's is highly effective if taken regularly as per the doctor’s advice.

Side Effects of Depsol Plus Tablet 10's

  • Drowsiness
  • Fatigue (extreme tiredness)
  • Confusion
  • Headache
  • Dizziness
  • Slurred speech
  • Loss of coordination of body movements (ataxia)
  • Dryness in mouth
  • Constipation
  • Difficulty passing urine
  • Low blood pressure
  • Disturbances in sexual function
  • Dilation of the pupil of the eye
  • Vision problems
  • Loss of appetite
  • Increased heart rate
  • Changes in libido
  • Weight increase

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

It is not recommended to take monoamine oxidase inhibitors (MAOI) and Depsol Plus Tablet 10's simultaneously. You should wait for at least 14 days after discontinuing MAOI before using Depsol Plus Tablet 10's. Before taking Depsol Plus Tablet 10's, inform your doctor if you have any mental illness, personality disorder, are withdrawing from alcohol or any other medicines, enlarged prostate gland, overactive thyroid, fits, brain damage, poor blood circulation, severe kidney disease, tumors in the adrenal gland, panic attacks, long-term constipation, low levels of albumin, and a habit of smoke. Inform your doctor if you have suicidal thoughts as Depsol Plus Tablet 10's may worsen suicidal tendencies, especially in young adults. While taking Depsol Plus Tablet 10's, inform your doctor if you experience agitation, restlessness, nightmares, and hallucinations as this medicine may cause these side-effects, especially in children and the elderly. Depsol Plus Tablet 10's may cause total or partial memory loss when taken in high doses. Depsol Plus Tablet 10's may cause dependence, so it should be used for the shortest time possible in patients with a history of alcohol or drug abuse. After a few weeks of treatment, if the tablets are not working for you, inform your doctor immediately, as it can be a sign of tolerance. Depsol Plus Tablet 10's should not be used in combination with an opioid pain killer (buprenorphine). Concomitant use of these drugs may lead to serotonin syndrome (a life-threatening condition that causes high blood pressure and fast heart rate).

Therapeutic Class

ANTIDEPRESSANT

Drug-Drug Interactions

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ImipramineDronedarone
Critical
ImipramineLinezolid
Critical

Drug-Drug Interactions

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ImipramineDronedarone
Critical
How does the drug interact with Depsol Plus Tablet 10's:
Taking Depsol Plus Tablet 10's with Dronedarone can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Depsol Plus Tablet 10's with Dronedarone together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ImipramineLinezolid
Critical
How does the drug interact with Depsol Plus Tablet 10's:
Coadministration of Linezolid with Depsol Plus Tablet 10's might raise serotonin hormone levels in the body, affecting the brain and nerve cells.

How to manage the interaction:
Taking Linezolid and Depsol Plus Tablet 10's together is not recommended as it can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience confusion, hallucinations, seizures, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ImipramineSelegiline
Critical
How does the drug interact with Depsol Plus Tablet 10's:
Co-administration of Depsol Plus Tablet 10's with Selegiline might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.

How to manage the interaction:
Taking Depsol Plus Tablet 10's and Selegiline together is not recommended as it can result in an interaction. It can be taken if a doctor has advised it. However, if you experience confusion, hallucinations, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, shaking, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ImipraminePhenelzine
Critical
How does the drug interact with Depsol Plus Tablet 10's:
Coadministration of Depsol Plus Tablet 10's with Phenelzine might raise serotonin hormone levels in the body, affecting the brain and nerve cells.

How to manage the interaction:
Taking Depsol Plus Tablet 10's and Phenelzine together is not recommended as it can result in an interaction. It can be taken if your doctor has advised it. However, if you experience confusion, hallucinations, seizures, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ImipramineSafinamide
Critical
How does the drug interact with Depsol Plus Tablet 10's:
Coadministration of Safinamide with Depsol Plus Tablet 10's can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking safinamide and Depsol Plus Tablet 10's together is not recommended as it can result in an interaction, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
ImipramineZiprasidone
Critical
How does the drug interact with Depsol Plus Tablet 10's:
Using ziprasidone together with Depsol Plus Tablet 10's can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Ziprasidone with Depsol Plus Tablet 10's is not recommended, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
ImipraminePotassium citrate
Critical
How does the drug interact with Depsol Plus Tablet 10's:
Taking Depsol Plus Tablet 10's and Potassium citrate (in tablet or capsule form) together can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Potassium citrate and Depsol Plus Tablet 10's is not recommended, as it may lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
ImipramineThioridazine
Critical
How does the drug interact with Depsol Plus Tablet 10's:
When Thioridazine and Depsol Plus Tablet 10's are taken together, the body's ability to break down Thioridazine may be reduced. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Depsol Plus Tablet 10's with Thioridazine is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience extreme drowsiness, confusion, agitation, vomiting, blurred vision, feeling hot or cold, sweating, muscle stiffness, fainting, or seizure, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
ImipramineSparfloxacin
Critical
How does the drug interact with Depsol Plus Tablet 10's:
Taking Sparfloxacin with Depsol Plus Tablet 10's can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Sparfloxacin and Depsol Plus Tablet 10's together is not recommended as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ImipramineTranylcypromine
Critical
How does the drug interact with Depsol Plus Tablet 10's:
Taking Tranylcypromine can increase the risk of Depsol Plus Tablet 10's on serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Tranylcypromine with Depsol Plus Tablet 10's is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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IMIPRAMINE-25MG+DIAZEPAM-2MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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IMIPRAMINE-25MG+DIAZEPAM-2MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Taking caffeine along with Depsol Plus Tablet 10's may increase the risk of undesired side effects. Limit or avoid caffeine intake while taking Depsol Plus Tablet 10's.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • BUPRENORPHINE
  • SODIUM OXYBATE
  • FLUVOXAMINE
  • FLUOXETINE
  • PHENELZINE
  • MOCLOBEMIDE
  • HYPERICUM PERFORATUM
  • CLOZAPINE
  • ALPRAZOLAM
  • ERYTHROMYCIN
  • RIFAMPICIN
  • SUXAMETHONIUM
  • TUBOCURARINE
  • MORPHINE
  • PHENOBARBITAL
  • CIMETIDINE
  • OMEPRAZOLE
  • ESOMEPRAZOLE
  • DISULFIRAM
  • PHENYTOIN
  • CARBAMAZEPINE
  • SODIUM VALPROATE
  • THEOPHYLLINE
  • ATAZANAVIR
  • RITONAVIR
  • EFAVIRENZ
  • INDINAVIR
  • ZIDOVUDINE
  • ISONIAZID
  • KETAMINE
  • NABILONE
  • DILTIAZEM
  • VERAPAMIL
  • QUINIDINE

Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly helps in improving overall health and boosts self-esteem.
  • Regularly attend therapy sessions.
  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.
  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.
  • Include foods rich in omega fatty acids such as fish, nuts, fresh fruits, vegetables, and olive oils.
  • Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help maintain neurotransmitter's proper maintenance.
  • Complex carbohydrates help in stimulating serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges, and pears.
  • Exercising helps in the production of the body’s natural antidepressants. It also helps in relieving stress, improving mood, boosts self-esteem, and provides restful sleep.
  • Avoid smoking and alcohol consumption.
  • Learn about your condition, understand the risk factors, and follow the doctor’s treatment plan.

Habit Forming

No

Special Advise

  • Depsol Plus Tablet 10's may reduce some blood cell counts and impair liver function. So, your doctor may monitor blood cell levels and liver function while using this medicine.
  • Depsol Plus Tablet 10's may cause problems with teeth, so your doctor may advise you to undergo regular dental check-ups throughout the treatment.
  • It is not recommended to abruptly stop Depsol Plus Tablet 10's, as it may cause withdrawal reactions such as irritability, excess sweating, nervousness, stomach upset, difficulty sleeping, and worsening of depression. Children may experience changes in behavior. Your doctor may gradually reduce the dose before completely stopping the medicine.
  • Depsol Plus Tablet 10's may cause orthostatic hypotension (sudden drop in blood pressure on standing). So, it is advised to rise-up slowly from a sitting or lying position.

Disease/Condition Glossary

Depression: It is a mood disorder characterized by the persistent feeling of sadness, unhappiness, anger, hopelessness, or loss that interferes with a person’s daily activities. Depression can also influence some chronic health conditions and relationships. In this condition, neurotransmitters (chemicals in the brain) such as dopamine, serotonin, and noradrenaline levels decrease, resulting in symptoms of depression. The exact cause of depression is unknown, but it may be associated with mental problems, trauma, family history, drug use, and medical conditions. Counseling (psychotherapy) and antidepressants can be used to treat depression.

Depsol Plus Tablet 10's Substitute

Substitutes safety advice
  • Imipam Tablet 10's

    1.71per tablet
  • Diamin Plus Tablet 10's

    by AYUR

    3.87per tablet
  • TALENDEP PLUS TABLET

    12.60per tablet
  • Tancodep 2 Mg Tablet 10's

    by AYUR

    2.75per tablet
  • Toframine-2/25 mg Tablet 10's

    2.52per tablet
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