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  3. Depsonil PM 75 mg Capsule 10's

Depsonil PM 75 mg Capsule 10's, Pack of 10 TabletS
Depsonil PM 75 mg Capsule 10's, Pack of 10 TabletS
Not for online sale
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
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Composition :

IMIPRAMINE-75MG

Manufacturer/Marketer :

Abbott India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Depsonil PM 75 mg Capsule

Depsonil PM 75 mg Capsule belongs to a group of medicines called 'tricyclic anti-depressants' used to treat depression. Additionally, Depsonil PM 75 mg Capsule is also used to treat bed-wetting at night in children aged 6 years and older. Depression is a mood disorder characterised by sadness, unhappiness, anger, hopelessness or loss that interferes with a person’s daily activities.
 
Depsonil PM 75 mg Capsule contains ‘Imipramine’, which increases the activity of certain natural substances (neurotransmitters) in the brain required for mental balance, thereby regulating mood and treating depression. It also reduces childhood enuresis or bed-wetting in the children older than 6-7 years of age by relaxing the urinary bladder muscle, which lightens the sleep.
 
You are advised to take Depsonil PM 75 mg Capsule for as long as your doctor has prescribed it for you depending on your medical condition and response to the treatment. In some cases, you may experience certain common side-effects such as dry mouth, nausea, vomiting, increased blood pressure, lack of coordination, swelling of the breast and weakness.  You are advised to talk to your doctor if you experience these side-effects persistently.
 
Please do not stop taking Depsonil PM 75 mg Capsule without consulting your doctor as it could lead to withdrawal symptoms. Consult your doctor if you are pregnant or breastfeeding. Avoid driving or operating machinery as Depsonil PM 75 mg Capsule may cause impaired alertness, drowsiness or blurred vision. Depsonil PM 75 mg Capsule is not recommended for children below 6 years as safety and effectiveness have not been established. Avoid consuming alcohol with Depsonil PM 75 mg Capsule as it could lead to increased drowsiness. Keep your doctor informed about your health condition and medicines to rule out any side-effects.

Uses of Depsonil PM 75 mg Capsule

Depression, Nocturnal enuresis (bed-wetting in children)

Directions for Use

Swallow Depsonil PM 75 mg Capsule as a whole with a glass of water, do not chew or crush it.

Medicinal Benefits

Depsonil PM 75 mg Capsule belongs to a group of medicines called tricyclic anti-depressants. Depsonil PM 75 mg Capsule is used to treat depression. Depsonil PM 75 mg Capsule works by increasing the activity of certain natural substances in the brain needed for mental balance, thereby regulating mood and treating depression. Additionally, Depsonil PM 75 mg Capsule is used as an adjunct therapy in reducing bed-wetting at night in children aged 6-7 years and older. Depsonil PM 75 mg Capsule helps to control childhood enuresis or bed-wetting as a part of its anti-depressant effect.

Storage

Store in a cool and dry place away from sunlight
Side effects of Depsonil PM 75 mg Capsule
  • Do not stand up suddenly. Lie down and get up slowly only when you feel better.
  • Avoid alcohol and large meals.
  • Drink enough water before standing for long periods.
  • Exercise regularly; however, avoid exercising in extreme heat.
  • Eat small, low-carb meals.
  • Wear compression stockings.
  • Exercise regularly and maintain a healthy weight.
  • Manage cholesterol and blood pressure.
  • Limit intake of caffeine and alcohol.
  • Avoid vaping and tobacco smoke.
  • Get enough sleep.
  • Talk to your doctor about antiarrhythmic drugs or other medications to treat your condition.
  • Restlessness is related to mental health and needs medical attention if it's severe.
  • Regular practice of meditation and yoga can help calm your mind. This can reduce restlessness.
  • Prevent smoking as it can impact your calmness of body and mind.
  • Talk to your friends and family about restlessness, who can provide a solution for why you feel restless.
  • Get sufficient sleep for a minimum of 6-7 hours to reduce restlessness.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
Managing Medication-Triggered Anxiety: A Comprehensive Approach:
  • Inform your doctor about your anxiety symptoms so that you doctor may explore potential drug interactions and alter your treatment plan.
  • Work with your doctor to adjust your medication regimen or dosage to minimize anxiety symptoms.
  • Reduce anxiety symptoms by practicing relaxation techniques like meditation, deep breathing, or yoga.
  • Regular self-care activities, such as exercise, healthy food, and adequate sleep, can assist control anxiety.
  • Surround yourself with a supportive network of friends, family, or a support group to help manage anxiety and stay motivated.
  • Regularly track anxiety symptoms and report any changes to your doctor to ensure your treatment plan is effective and adjusted as needed.
  • Manage stress by practising deep breathing, yoga or meditation.
  • Participating in activities you enjoy, or exercising may also help manage agitation.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Exercise regularly. Try physical activities like walking, running, or dancing.

Drug Warnings

Do not take Depsonil PM 75 mg Capsule if you are allergic to any of its contents; if you are taking monoamine oxidase inhibitors (MAOI) or have taken them in the last 14 days, if you have heart diseases, mania, porphyria, glaucoma or are unable to pass urine. Avoid taking buprenorphine/opioids with Depsonil PM 75 mg Capsule as it could lead to serotonin syndrome. Inform your doctor if you have/had schizophrenia or manic depression, alcohol withdrawal, enlarged prostate, overactive thyroid, epilepsy, low blood pressure, poor circulation, panic attacks, a tumour of the adrenal gland, or if you are being given electroconvulsive therapy. Talk to your doctor immediately if you have suicidal thoughts such as killing or harming yourself. Consult your doctor if you are pregnant or breastfeeding. Avoid driving or operating machinery as Depsonil PM 75 mg Capsule may cause impaired alertness, drowsiness, or blurred vision. Depsonil PM 75 mg Capsule is not recommended for children below 6 years as safety and effectiveness have not been established. Avoid consuming alcohol with Depsonil PM 75 mg Capsule as it could lead to increased drowsiness. Rise slowly from sitting or lying position as Depsonil PM 75 mg Capsule causes dizziness on standing suddenly.

Drug-Drug Interactions

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ImipraminePotassium citrate
Critical
ImipramineZiprasidone
Critical

Drug-Drug Interactions

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ImipraminePotassium citrate
Critical
How does the drug interact with Depsonil PM 75 mg Capsule:
Taking Depsonil PM 75 mg Capsule and Potassium citrate (in tablet or capsule form) together can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Potassium citrate and Depsonil PM 75 mg Capsule is not recommended, as it may lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
ImipramineZiprasidone
Critical
How does the drug interact with Depsonil PM 75 mg Capsule:
Using ziprasidone together with Depsonil PM 75 mg Capsule can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Ziprasidone with Depsonil PM 75 mg Capsule is not recommended, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
ImipramineSelegiline
Critical
How does the drug interact with Depsonil PM 75 mg Capsule:
Co-administration of Depsonil PM 75 mg Capsule with Selegiline might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.

How to manage the interaction:
Taking Depsonil PM 75 mg Capsule and Selegiline together is not recommended as it can result in an interaction. It can be taken if a doctor has advised it. However, if you experience confusion, hallucinations, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, shaking, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ImipraminePhenelzine
Critical
How does the drug interact with Depsonil PM 75 mg Capsule:
Coadministration of Depsonil PM 75 mg Capsule with Phenelzine might raise serotonin hormone levels in the body, affecting the brain and nerve cells.

How to manage the interaction:
Taking Depsonil PM 75 mg Capsule and Phenelzine together is not recommended as it can result in an interaction. It can be taken if your doctor has advised it. However, if you experience confusion, hallucinations, seizures, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ImipramineSparfloxacin
Critical
How does the drug interact with Depsonil PM 75 mg Capsule:
Taking Sparfloxacin with Depsonil PM 75 mg Capsule can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Sparfloxacin and Depsonil PM 75 mg Capsule together is not recommended as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ImipramineLinezolid
Critical
How does the drug interact with Depsonil PM 75 mg Capsule:
Coadministration of Linezolid with Depsonil PM 75 mg Capsule might raise serotonin hormone levels in the body, affecting the brain and nerve cells.

How to manage the interaction:
Taking Linezolid and Depsonil PM 75 mg Capsule together is not recommended as it can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience confusion, hallucinations, seizures, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ImipramineTranylcypromine
Critical
How does the drug interact with Depsonil PM 75 mg Capsule:
Taking Tranylcypromine can increase the risk of Depsonil PM 75 mg Capsule on serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Tranylcypromine with Depsonil PM 75 mg Capsule is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
ImipramineDronedarone
Critical
How does the drug interact with Depsonil PM 75 mg Capsule:
Taking Depsonil PM 75 mg Capsule with Dronedarone can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Depsonil PM 75 mg Capsule with Dronedarone together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ImipramineThioridazine
Critical
How does the drug interact with Depsonil PM 75 mg Capsule:
When Thioridazine and Depsonil PM 75 mg Capsule are taken together, the body's ability to break down Thioridazine may be reduced. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Depsonil PM 75 mg Capsule with Thioridazine is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience extreme drowsiness, confusion, agitation, vomiting, blurred vision, feeling hot or cold, sweating, muscle stiffness, fainting, or seizure, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
ImipramineSafinamide
Critical
How does the drug interact with Depsonil PM 75 mg Capsule:
Coadministration of Safinamide with Depsonil PM 75 mg Capsule can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking safinamide and Depsonil PM 75 mg Capsule together is not recommended as it can result in an interaction, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly as it helps in improving overall health and boosts self-esteem.
  • Regularly attend therapy sessions.
  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.
  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.
  • Include foods rich in omega fatty acids such as fish, nuts, fresh fruits, vegetables and olive oils.
  • Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help in the proper maintenance of neurotransmitters. 
  • Complex carbohydrates help in stimulating serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges and pears.
  • Exercising helps in the production of the body’s natural anti-depressants. It also helps in relieving stress, improves mood, boosts self-esteem and provides restful sleep.
  • Avoid smoking and alcohol consumption.
  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Habit Forming

No

Therapeutic Class

PSYCHOTHERAPEUTICS

Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Sunny S

Reviewed By

Sunny S

MBBS

Last Updated

Jul 8, 2025 | 9:35 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Depsonil PM 75 mg Capsule works by increasing mood-enhancing chemical messengers (neurotransmitters) such as serotonin and norepinephrine in the brain that communicate between brain cells, thereby regulating mood and treating depression.

Do not discontinue Depsonil PM 75 mg Capsule without consulting your doctor as it could lead to withdrawal symptoms. To treat your condition effectually, continue taking Depsonil PM 75 mg Capsule for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Depsonil PM 75 mg Capsule . The doctor may reduce the dose gradually to prevent withdrawal symptoms.

Dry mouth could be a side-effect of Depsonil PM 75 mg Capsule . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.

Orthostatic hypotension could be a side-effect of Depsonil PM 75 mg Capsule . Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking, instead, lie down and get up slowly only when you feel better.

Depsonil PM 75 mg Capsule may cause photosensitivity or increased sensitivity to sunlight. Therefore, people taking Depsonil PM 75 mg Capsule should avoid excessive exposure to sunlight or tanning beds. Use effective sunscreen and wear protective clothing while going outside.

Consult your doctor before taking Depsonil PM 75 mg Capsule if you are diabetic, as Depsonil PM 75 mg Capsule may cause elevation or lower blood glucose levels. Regularly monitor blood sugar levels while taking Depsonil PM 75 mg Capsule .

Depsonil PM 75 mg Capsule may make your open-angle glaucoma worse. Your doctor may monitor your vision while you’re taking this medication.

Drug-Drug Interactions Checker List

  • FLUOXETINE
  • FLUVOXAMINE
  • DULOXETINE
  • ESCITALOPRAM
  • SERTRALINE
  • ARIPIPRAZOLE
  • QUETIAPINE
  • CARBAMAZEPINE
  • PHENYTOIN
  • PHENOBARBITAL
  • PREGABALIN
  • TOPIRAMATE
  • DIAZEPAM
  • NITRAZEPAM
  • OXAZEPAM
  • ALPRAZOLAM
  • CLONAZEPAM
  • ASPIRIN
  • TRAMADOL
  • CODEINE
  • DIHYDROCODEINE
  • RITONAVIR
  • CIMETIDINE
  • ESOMEPRAZOLE
  • WARFARIN
  • CYCLOBENZAPRINE
  • LEVOTHYROXINE

Special Advise

  • Close monitoring of patients taking Depsonil PM 75 mg Capsule for suicidal behaviour, clinical worsening, or unusual changes in behaviour is recommended. Consult the doctor immediately if the patient experiences suicidal thoughts such as killing or harming oneself.
  • Talk to your doctor before taking Depsonil PM 75 mg Capsule if you are due to have any surgery that involves an anaesthetic, including dental surgery. 
  • Your doctor may advise regular blood tests and liver functioning tests while taking Depsonil PM 75 mg Capsule .
  • Depsonil PM 75 mg Capsule may cause problems with your teeth, so a regular dental check-up is advised.

Disease/Condition Glossary

Depression: Depression is a mental health disorder characterised by a persistent and intense feeling of sadness for an extended duration of time. It mainly impacts mood, behaviour and other physical functions, such as sleep and appetite. Symptoms include sadness, loss of interest, appetite changes, sleep problems, restlessness, lack of energy, feeling worthless or guilty, thoughts of harming oneself, difficulty in concentrating, making decisions and thinking. The exact cause of depression is unknown. However, factors such as stress, changes in hormone levels, alcohol or drug abuse, abuse during childhood, certain medical conditions and medications might increase the risk of developing depression. 

Bed-wetting: Childhood enuresis is also known as bed-wetting in children. In most cases, children are toilet trained by the age of 5, but generally, there is no target date for complete bladder control development. A small number of children still wet the bed even after the age of 7 years. This may or may not be purposeful, and the condition is not diagnosed until the child is 5 years or older. The causes could be a small bladder, urinary tract infections, stress and developmental delays that could interfere with toilet training. Symptoms include repeated bed-wetting, wetting in the clothes and wetting at least twice a week for 3 months.

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