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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
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Composition :

DEXAMETHASONE-4MG

Manufacturer/Marketer :

Searle India Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Dexadran Injection 2 ml

Dexadran Injection 2 ml belongs to a class of drugs called corticosteroids (hormones). When your body does not produce enough Dexamethasone, Dexadran Injection 2 ml is often utilized to replace it. It treats various medical conditions, including severe allergic conditions, collagen diseases, pulmonary disorders, blood disorders, rheumatic diseases, skin diseases, gastrointestinal disorders, oedema, eye disorders, neoplastic states and endocrine disorders. It is also used in preoperative and postoperative support. Furthermore, it is approved for the treatment of coronavirus disease 2019 (COVID-19) in adult and adolescent patients (aged 12 years and older with a body weight of at least 40 kg) who require supplemental oxygen therapy.

Dexadran Injection 2 ml contains dexamethasone, a steroid with both anti-inflammatory and immunosuppressant activity. Anti-inflammatory activity relieves the symptoms of inflammatory conditions such as redness, swelling, and tenderness caused by various medical conditions. On the other side, immunosuppressant activity helps to calm your immune system. As a result, it can aid in autoimmune diseases such as rheumatoid arthritis, in which your immune system erroneously destroys your own tissues.

Dexadran Injection 2 ml will be administered by a healthcare professional; do not self-administer. Some people may experience mood changes in personality, mental health problems, muscle weakness, increased appetite, irregular or absent menstrual periods, infections and infestations, impaired vision, difficulty falling asleep or staying asleep, heartburn, peptic ulcer, muscle weakness, nausea and injection site pain or redness as side effects of Dexadran Injection 2 ml. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Let your doctor know before prescribing Dexadran Injection 2 ml if you are allergic to any content of this medicine or sulphites. Inform your doctor if you are pregnant, planning for pregnancy or breastfeeding before receiving this medicine. Before obtaining the Dexadran Injection 2 ml, notify your doctor about your medical history and any other medications you are currently taking to rule out any potentially harmful effects.

Uses of Dexadran Injection 2 ml

Allergic or inflammatory conditions, Covid-19.

Directions for Use

Dexadran Injection 2 ml will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Dexadran Injection 2 ml is a steroid (corticosteroids) medication. Corticosteroids occur naturally in the body and contribute to overall health and well-being. Increasing your body's corticosteroid levels (such as dexamethasone) is an effective strategy for treating various disorders involving inflammation. Dexadran Injection 2 ml decreases inflammation, otherwise which might worsen your disease. You must take it daily to get the maximum benefits of Dexadran Injection 2 ml.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Before prescribing Dexadran Injection 2 ml, inform your doctor if you are allergic to any content of this medicine or other steroid medicines. You should disclose to your doctor if you have received any live virus vaccines. You should discuss with your doctor if you have fungal infections, amoebiasis, myasthenia gravis, peptic ulcer, osteoporosis, psychoses, eye infections, glaucoma, mental conditions, TB, bacteraemia (viable bacteria in the bloodstream), joint, liver, kidney, or heart conditions and septic arthritis resulting from gonorrhoea or tuberculosis. If you are pregnant, planning for pregnancy or breastfeeding, inform your doctor before receiving this medicine. Contact your doctor immediately if you notice mood changes or have depression and strange thoughts while Dexadran Injection 2 ml therapy.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Dexadran Injection 2 ml:
When Regorafenib is taken with Dexadran Injection 2 ml, may significantly reduce the blood levels of Regorafenib.

How to manage the interaction:
Co-administration of Regorafenib and Dexadran Injection 2 ml can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Dexadran Injection 2 ml:
Co-administration of Desmopressin with Dexadran Injection 2 ml may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
Co-administration of Dexadran Injection 2 ml and Desmopressin can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like confusion, hallucination, seizure, changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle stiffness, tremors, stomach cramps, nausea, vomiting, and diarrhea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DexamethasoneRilpivirine
Critical
How does the drug interact with Dexadran Injection 2 ml:
When Rilpivirine is taken with Dexadran Injection 2 ml, may significantly reduce the blood levels of Rilpivirine.

How to manage the interaction:
Co-administration of Rilpivirine and Dexadran Injection 2 ml can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Dexadran Injection 2 ml:
When Dexadran Injection 2 ml is taken with Ranolazine, may significantly reduce the blood levels of Ranolazine.

How to manage the interaction:
Co-administration of Ranolazine and Dexadran Injection 2 ml can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Dexadran Injection 2 ml:
Taking fentanyl with Dexadran Injection 2 ml may reduce the blood levels of fentanyl, which may make the medication less effective in treating your pain.

How to manage the interaction:
Although there is an interaction between diphenhydramine and ketamine, they can be taken together if prescribed by your doctor. However, consult your doctor if you experience watery eyes, excessive sweating, body aches, abdominal cramping, vomiting, diarrhea. Do not discontinue using any medications without consulting a doctor.
How does the drug interact with Dexadran Injection 2 ml:
When Dexadran Injection 2 ml is taken with Infliximab, it can increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Infliximab with Dexadran Injection 2 ml together can result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms, it's important to contact a doctor right away. These symptoms include fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee. Do not stop using any medications without a doctor's advice.
How does the drug interact with Dexadran Injection 2 ml:
Taking Dexadran Injection 2 ml with Bosutinib can decrease the blood levels of Bosutinib, reducing its effectiveness in treating your condition.

How to manage the interaction:
Although there is an interaction between Bosutinib and Dexadran Injection 2 ml, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Dexadran Injection 2 ml:
Taking Dexadran Injection 2 ml may lower the blood levels of Sunitinib in some patients, making the medication less effective.

How to manage the interaction:
Although there is a possible interaction, Dexadran Injection 2 ml can be taken with Sunitinib if prescribed by the doctor. Do not discontinue the medication without consulting a doctor.
How does the drug interact with Dexadran Injection 2 ml:
Taking Dexadran Injection 2 ml with Leflunomide may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction, Dexadran Injection 2 ml can be taken with Leflunomide if prescribed by the doctor. Consult the doctor immediately if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue the medication without consulting a doctor.
How does the drug interact with Dexadran Injection 2 ml:
Co-administration of Vigabatrin with Dexadran Injection 2 ml may increase the risk of serious side effects such as vision problems.

How to manage the interaction:
Taking Vigabatrin with Dexadran Injection 2 ml together can possibly result in an interaction, but it can be taken if a doctor has advised it. Routine vision testing is advised during treatment with vigabatrin. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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DEXAMETHASONE-4MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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DEXAMETHASONE-4MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Taking Dexadran Injection 2 ml with Caffeine may increase the side effects of Dexadran Injection 2 ml. Avoid consuming caffeine while taking Dexadran Injection 2 ml.

Diet & Lifestyle Advise

Diet & Lifestyle for Allergic or inflammatory conditions:

  • Consume antioxidant-rich food. Blueberries, tomatoes, cherries, squash, and bell peppers are highly antioxidants.
  • Consuming probiotic-rich foods aids in the development of the immune system's resistance to allergies.
  • Consume foods rich in quercetin (a flavonoid), such as apples, cherries, spinach, broccoli, and blueberries.
  • Include seasonal fruits, vegetables, whole grains, healthy fats, and fish in your daily diet.
  • Limit your intake of foods that may cause allergies, such as dairy products, soy, eggs, and nuts.
  • Limit the consumption of foods high in sugar that may aggravate inflammation.
  • Reducing stress and having a regular sleep schedule might be beneficial.
  • Avoid processed meats, refined carbohydrates, sugar, trans fats, and alcohol, as they may aggravate inflammation.

 

Diet & Lifestyle for Covid-19:

  • Remember always to wear a mask when you're around other people. Wearing a mask aids in the prevention of illness spread.
  • Take care of your mental health. Fear and anxiety can hamper the immune system as well. Therapy, yoga, and meditation effectively allow the mind a state of peace.
  • Keep a social distance and avoid social gatherings.
  • Please do not touch your eyes, nose or mouth if your hands are not clean.
  • Hands should be washed with soap and water or an alcohol-based sanitiser on a regular basis.
  • All surfaces should be cleaned and disinfected on a regular basis.
  • Gargling with salt water and inhaling steam would be beneficial.
  • Never exchange personal objects that have been contaminated with bodily fluids or blood, such as razor blades or toothbrushes.
  • Never share used needles and other injections or medical devices, as they may spread viruses.
  • Consume a well-balanced diet. Consume vitamin and nutrient-rich foods like dark green, yellow, orange, and red vegetables and fruits to enhance your immune system. Choose lean protein and whole carbohydrates over-processed foods.
  • Consume no raw meat or eggs. Consume boiled and cooked meat, poultry, or seafood.
  • If you have nausea or vomiting, eat bland, low-fat foods and avoid spicy or greasy foods.
  • Spending time with family or doing whatever makes you happy might help you minimise emotional and physical stress.

Habit Forming

No

Therapeutic Class

CORTICOSTEROIDS

Drug-Diseases Interactions

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DEXAMETHASONE-4MGOther and unspecified infectious diseases
Severe
DEXAMETHASONE-4MGDisorders related to short gestation and low birth weight, not elsewhere classified
Severe

Drug-Diseases Interactions

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DEXAMETHASONE-4MGOther and unspecified infectious diseases
Severe
How does the disease interact with Dexadran Injection 2 ml:
Corticosteroids' immunosuppressive and anti-inflammatory properties, especially when used in larger doses, have the potential to reduce host resistance to pathogens, impair the capacity to localise infections, and disguise infection-related symptoms. Perhaps secondary infections are more prone to occur. In general, corticosteroids should not be administered to patients with active infections, particularly systemic fungal infections, unless absolutely essential for medical reasons and after effective antimicrobial medication or another suitable course of treatment has been started.

How to manage the interaction:
Corticosteroids, particularly in higher dosages, may decrease host resistance to infectious agents, decrease the ability to localize infections, and mask the symptoms of infection.
DEXAMETHASONE-4MGDisorders related to short gestation and low birth weight, not elsewhere classified
Severe
How does the disease interact with Dexadran Injection 2 ml:
Manufacturers of the drugs believe that using some parenteral formulations of Dexadran Injection 2 ml, hydrocortisone, methylprednisolone, prednisolone, and triamcinolone in neonates, especially preterm newborns and infants with low birth weight, is contraindicated.

How to manage the interaction:
The use of certain parenteral formulations of Dexadran Injection 2 ml is contraindicated in neonates, particularly premature infants and infants of low birth weight.
DEXAMETHASONE-4MGFibrosis and cirrhosis of liver
Moderate
How does the disease interact with Dexadran Injection 2 ml:
Due to cirrhosis patients' lower metabolism, corticosteroids may have stronger effects on them. Patients with cirrhosis need to have their cortisol levels constantly checked. For certain people, dosage modifications may be necessary.

How to manage the interaction:
Patients with cirrhosis should be monitored more closely for excessive cortisol effects.
DEXAMETHASONE-4MGOther mental disorders due to brain damage and dysfunction and to physical disease
Moderate
How does the disease interact with Dexadran Injection 2 ml:
Psychotic and emotional instability symptoms may be made worse by corticosteroids. During corticosteroid medication, patients with these disorders should be monitored for any worsening or intensification of their symptoms.

How to manage the interaction:
Patients with psychosis and emotional instability should be monitored for increased or worsened symptoms during corticosteroid therapy.
DEXAMETHASONE-4MGUnspecified diabetes mellitus
Moderate
How does the disease interact with Dexadran Injection 2 ml:
By opposing the effect of insulin and inhibiting its production, corticosteroids can increase blood sugar levels. This inhibits peripheral glucose absorption and increases gluconeogenesis. Patients with diabetes mellitus, glucose intolerance, or a tendency for hyperglycemia should receive corticosteroid therapy with caution. During corticosteroid medication, patients with diabetes mellitus should be evaluated more carefully, and their anti-diabetic regimen should be changed correspondingly.

How to manage the interaction:
Patients with diabetes mellitus should be monitored more closely during corticosteroid therapy, and their antidiabetic regimen adjusted accordingly.

FAQs

Dexadran Injection 2 ml contains dexamethasone, a steroid with both anti-inflammatory and immunosuppressant activity. Anti-inflammatory activity relieves the symptoms of inflammatory conditions such as redness, swelling, and tenderness caused by various medical conditions. On the other side, immunosuppressant activity helps to calm your immune system. As a result, it can aid in autoimmune diseases such as rheumatoid arthritis, in which your immune system erroneously destroys your own tissues.

If you are about to be vaccinated, especially if it is a live vaccine, inform your doctor that you are taking Dexadran Injection 2 ml because taking Dexadran Injection 2 ml and getting immunised at the same time is not recommended.

Dexadran Injection 2 ml is not recommended to be used in fungal infections. If you have any concerns regarding this, please discuss them with your doctor.

Dexadran Injection 2 ml may increase the risk of Infections and infestations. Therefore, it is advised to stay away from people having chickenpox (herpes simplex), shingles (herpes zoster) or measles.

Dexadran Injection 2 ml is approved for the treatment of coronavirus disease 2019 (COVID-19) in adults and adolescents (aged 12 years and older with a body weight of at least 40 kg) who require supplemental oxygen therapy.

Caution is advised if you are taking anticoagulants while on Dexadran Injection 2 ml treatment. Checking your blood clotting time is recommended to lessen the risk of bleeding.

Drug-Drug Interactions Checker List

  • ASPIRIN
  • PHENYTOIN
  • PHENOBARBITAL
  • PRIMIDONE
  • RIFAMPICIN
  • RIFABUTIN
  • AMINOGLUTETHIMIDE
  • WARFARIN
  • RITONAVIR
  • DARUNAVIR
  • CARBAMAZEPINE

Special Advise

  • Dexadran Injection 2 ml may affect various laboratory tests. Therefore, inform your doctor/lab technician, that you are on treatment with Dexadran Injection 2 ml if you are undergoing any tests.

Disease/Condition Glossary

Allergy: Allergy is a condition that occurs when the immune system reacts to a foreign substance that is typically not harmful to your body. These foreign substances are known as 'allergens.' Allergic condition varies from person to person. Some might be allergic to certain foods, medications, and seasonal allergies like hay fever, pollen, or pet dander. The symptoms of an allergic reaction include itching, rash, scratchy throat, itchy or watery eyes, hives or itchy red spots on the skin, or allergic rhinitis (which causes sneezing or nasal congestion).

Inflammation: It is a response generated by damage to living tissues. This response is a defence mechanism to protect the body from injury, infection, or disease. The symptoms of inflammation include redness, pain, swelling, heat, or loss of function. Inflammation can be caused due to certain medications, acute and chronic conditions, exposure to foreign materials or irritants your body can't eliminate easily. 

Coronavirus disease (COVID-19): Covid-19 is an infectious disease caused by the SARS-CoV-2 virus. Most persons who become ill with Covid-19 will have mild to moderate symptoms and recover without specific therapy. Some, though, will become extremely unwell and require medical assistance. The virus can spread from an infected person's mouth or nose in microscopic liquid particles when they cough, sneeze, speak, sing, or breathe. Fever, cough, tiredness, and loss of taste or smell are the most common side effects of Covid-19.

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