apollo
0
Written By aquibnaseer ,
Reviewed By Sunny S , MBBS
Non returnable*
COD available

Online payment accepted

rxMedicinePrescription drug

Whats That

tooltip
socialProofing21 people bought
in last 7 days

Composition

DISULFIRAM-250MG

Manufacturer/Marketer

Intas Pharmaceuticals Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Disulfiram 250 mg Tablet

Disulfiram 250 mg Tablet belongs to the class of medications called 'Antabuse' used to treat alcohol dependence or chronic alcoholism. Heavy long-term use of alcohol can cause addiction in an individual, thereby making changes in your brain. Long-term alcohol intake can severely damage your liver and cause liver cirrhosis or fatty liver syndrome.

Disulfiram 250 mg Tablet contains 'Disulfiram', which works by blocking an enzyme that breakdown alcohol in our body. When a patient drinks alcohol, it is changed into acetaldehyde, Disulfiram 250 mg Tablet blocks the enzyme that breaks down acetaldehyde. This results in a higher level of acetaldehyde in the blood, causing discomfort and physical reactions. Disulfiram 250 mg Tablet can help alcohol-addicted people who have decided to quit alcohol drinking by deterring them from drinking again. So, it acts as a supportive agent in the treatment of alcoholism. 

Disulfiram 250 mg Tablet should be taken as prescribed by your doctor, with or without a meal, to avoid stomach upset and at fixed daily intervals for best results. The common side effects of Disulfiram 250 mg Tablet include drowsiness, tiredness, headache, acne, flushing (warmth, redness, or tingly feeling), sweating, increased thirst, swelling, rapid weight gain, nausea, severe vomiting, neck pain, throbbing headache, blurred vision, fast or pounding heartbeats or fluttering in your chest, confusion, weakness, spinning sensation, feeling unsteady, or and metallic/garlic-like taste in the mouth may occur as your body gets used to the medication. Everyone need not experience the above side effects. If the Disulfiram 250 mg Tablet causes any serious case of discomfort, speak with a doctor.

Before starting Disulfiram 250 mg Tablet , do not take Disulfiram 250 mg Tablet if you have consumed alcohol within the past 12 hours. Do not consume alcohol while taking Disulfiram 250 mg Tablet and at least up to 14 days after you stop taking Disulfiram 250 mg Tablet . If your doctor prescribes, Disulfiram 250 mg Tablet is safe to use during pregnancy and breastfeeding. Unpleasant effects may occur after taking minimal amounts of alcohol used in cooking or even if rubbed into the skin. Avoid alcohol-containing aftershave, perfumes/colognes, body lotions, vinegar and alcohol-containing mouthwash and hand sanitiser. Even exposure to alcohol-based hand sanitisers in some people can trigger a serious side effect response. Hence hand-washing with water and soap is recommended instead.

Uses of Disulfiram 250 mg Tablet

Alcohol addiction

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Disulfiram 250 mg Tablet contains 'Disulfiram', which belongs to 'Antabuse' used to treat alcohol dependence. It works by blocking an enzyme (acetaldehyde) that helps break alcohol in the body. Disulfiram 250 mg Tablet helps alcohol-dependent people who have decided to quit alcohol drinking by deterring them from drinking again.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Disulfiram 250 mg Tablet

  • Drowsiness
  • Tiredness
  • Headache
  • Acne
  • Metallic/garlic-like taste in the mouth

Drug Warnings

Before taking the Disulfiram 250 mg Tablet , let your doctor know about all your medical conditions, sensitivities, and all medications you are using. Signs of an overdose of Disulfiram 250 mg Tablet include feeling or being sick, stomach pain, diarrhoea, drowsiness, mental disorders, tiredness, rapid heartbeat, rapid breathing, high body temperature, low blood pressure, loss of muscle control, high blood sugar, changes in the blood (as seen in blood tests). Certain foods, liquid medicines, remedies, tonics, toiletries, perfumes, and sprays may contain enough alcohol to cause a disulfiram tablet-alcohol reaction. So avoid using any alcohol-containing drugs, hand wash, mouth wash or alcoholic beverages as it may lead to an 'aldehyde reaction'.

Drug-Drug Interactions

verifiedApollotooltip
DisulfiramMetronidazole
Critical
DisulfiramAmprenavir
Critical

Drug-Drug Interactions

Login/Sign Up

DisulfiramMetronidazole
Critical
How does the drug interact with Disulfiram 250 mg Tablet 250 mg Tablet:
Coadministration of Disulfiram 250 mg Tablet with Metronidazole can increase the risk of side effects.

How to manage the interaction:
Taking Metronidazole and Disulfiram 250 mg Tablet together is generally avoided as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, confusion, weakness, shortness of breath, or palpitations, contact your doctor. Do not discontinue any medications without consulting a doctor.
DisulfiramAmprenavir
Critical
How does the drug interact with Disulfiram 250 mg Tablet 250 mg Tablet:
Coadministration of Amprenavir and Disulfiram 250 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Amprenavir and Disulfiram 250 mg Tablet together is generally avoided as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like difficulty breathing, vomiting, sweating, palpitation, or dizziness, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DisulfiramBenznidazole
Critical
How does the drug interact with Disulfiram 250 mg Tablet 250 mg Tablet:
Coadministration of Disulfiram 250 mg Tablet with Benznidazole can increase the risk of side effects.

How to manage the interaction:
Taking benznidazole and Disulfiram 250 mg Tablet together is advised as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, weakness, shortness of breath, or palpitations, contact your doctor immediately.
DisulfiramParaldehyde
Critical
How does the drug interact with Disulfiram 250 mg Tablet 250 mg Tablet:
Coadministration of Paraldehyde and Disulfiram 250 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Paraldehyde and Disulfiram 250 mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience palpitations, difficulty breathing, vomiting, sweating, chest pain, dizziness, or blurred vision contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DisulfiramLomitapide
Severe
How does the drug interact with Disulfiram 250 mg Tablet 250 mg Tablet:
Coadministration of Disulfiram 250 mg Tablet and Lomitapide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Disulfiram 250 mg Tablet and Lomitapide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DisulfiramTipranavir
Severe
How does the drug interact with Disulfiram 250 mg Tablet 250 mg Tablet:
Co-administration of Tipranavir with Disulfiram 250 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Co-administration of Tipranavir with Disulfiram 250 mg Tablet can lead to an interaction, it can be taken if your doctor advises. However, consult the doctor immediately if you experience any symptoms like palpitations, excessive sweating, chest pain, or ringing of the ears. Do not stop using any medications without a doctor's advice.
DisulfiramRitonavir
Severe
How does the drug interact with Disulfiram 250 mg Tablet 250 mg Tablet:
Co-administration of Ritonavir with Disulfiram 250 mg Tablet can increase the risk or severity of side effects.

How to manage the interaction:
Co-administration of Disulfiram 250 mg Tablet with ritonavir can lead to an interaction, but it can be taken if advised by your doctor. However, consult your doctor if you experience headaches, difficulty breathing, vomiting, excessive sweating, chest pain, palpitations, dizziness, or blurred vision. Do not stop using any medications without a doctor's advice.
DisulfiramLeflunomide
Severe
How does the drug interact with Disulfiram 250 mg Tablet 250 mg Tablet:
Coadministration of Disulfiram 250 mg Tablet and Leflunomide can increase the risk of liver problems.

How to manage the interaction:
There may be a possibility of interaction between Disulfiram 250 mg Tablet and Leflunomide, but it can be taken if prescribed by a doctor. If you have any of these symptoms fever, vomiting, stomach pain, dark urine, or yellowing of skin and eyes, contact your doctor right away. Do not discontinue any medications without consulting your doctor.
DisulfiramMipomersen
Severe
How does the drug interact with Disulfiram 250 mg Tablet 250 mg Tablet:
Co-administration of Disulfiram 250 mg Tablet and Mipomersen can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Disulfiram 250 mg Tablet and Mipomersen can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, weakness, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DisulfiramEthanol
Severe
How does the drug interact with Disulfiram 250 mg Tablet 250 mg Tablet:
Co-administration of Ethanol with Disulfiram 250 mg Tablet can increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Ethanol with Disulfiram 250 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any vomiting, blurred vision, shortness of breath, or palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Login/Sign Up

Diet & Lifestyle Advise

  • A patient is advised to have a diet that increases serotonin levels which makes a person feel good & involves eating foods high in carbohydrates, especially the complex carbohydrates present in starchy food items like legumes (e.g., beans, lentils and peas), root vegetables (e.g., potatoes and carrots), pasta and bread. Eating such foods in combination with protein in meals will benefit.
  • Deficiencies in B-complex vitamins such as thiamine, folate or folic acid, and B12 are common with alcoholism, and inadequate stores of other B vitamins and vitamin C frequently occur. A patient should take supplements and vitamins on consulting a doctor.
  • Malnutrition is common during alcohol consumption and is revealed slowly and gradually. The patient becomes tired and develops a weaker immune system—which means they are more susceptible to infections. These problems need to be identified and treated during the recovery process—ideally by a team of healthcare professionals.
  • The patient should change his drinking priorities and prefer drinks like apple cider, vanilla shake, mixing juice or lemonade with sparkling water etc.

Habit Forming

No

Therapeutic Class

ANTI-ALCOHOLIC AGENT

Disulfiram 250 mg Tablet Substitute

Substitutes safety advice
  • Dizone Tablet 10's

    by Others

    4.01per tablet
  • Esperal Tablet 10's

    by AYUR

    4.73per tablet
  • Tyfusin 250 Tablet 10's

    by Others

    9.36per tablet
  • D-Sulf 250 mg Tablet 10's

    by AYUR

    3.78per tablet
  • Recopress 250 Tablet 6's

    by Others

    6.75per tablet

Author Details

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

Login/Sign Up

FAQs

Disulfiram 250 mg Tablet contains 'Disulfiram', which belongs to 'Antabuse' used to treat alcohol dependence. It works by blocking an enzyme (acetaldehyde) that helps break alcohol in the body. Disulfiram 250 mg Tablet helps alcohol-dependent people who have decided to quit alcohol drinking by deterring them from drinking again.

An asthmatic patient, if already on cough-suppressing medications like diphenhydramine, is not recommended to take Disulfiram 250 mg Tablet . Disulfiram 250 mg Tablet and diphenhydramine are contraindicated and may result in harmful implications.

Not recommended in patients taking blood thinners like warfarin to prevent blood clot formation inside heart/brain vessels. Warfarin (blood thinner) and Disulfiram 250 mg Tablet are contraindicated and should not be taken together.

Yes, Disulfiram 250 mg Tablet has been implicated in altering the results of tests done for adrenal tumours & hence not recommended to be taken before any diagnostic test is done.

The common side effects of Disulfiram 250 mg Tablet are usually temporary, including headaches, nausea, a metallic taste in the mouth and feeling tired.

Take the missed dose as soon as you remember. Take the rest of the day's doses at evenly spaced intervals unless otherwise directed by your doctor.

Drug-Drug Interactions Checker List

  • THEOPHYLLINE
  • PHENYTOIN
  • WARFARIN
  • DICUMAROL
  • RIFAMPICIN
  • ISONIAZID
  • PIMOZIDE
  • AMITRIPTYLINE
  • CHLORPROMAZINE
  • METRONIDAZOLE+CHLORHEXIDINE

Special Advise

  • Disulfiram 250 mg Tablet may interfere with certain laboratory tests (including urine VMA/HVA tests), possibly causing false test results. It is a paramount priority for a patient to enlighten the laboratory personnel and all their doctors to know they use this drug.
  • Disulfiram 250 mg Tablet should never be given to a patient when they are in a state of alcohol intoxication or without his full knowledge.
  • After you stop taking Disulfiram 250 mg Tablet , do not drink alcohol for at least seven days as your body needs to start making the enzyme 'acetaldehyde' again. In case, drinking alcohol earlier than this may trigger an 'aldehyde reaction'.

Disease/Condition Glossary

Chronic alcoholism: Alcoholism is the addictive drinking of alcohol that results in physical & mental problems. A person can become an alcoholic out of stress, depression or just after developing a chronic habit. Excessive alcohol use can damage various organs like the brain, heart, kidneys and most importantly, the liver, which leads to liver cirrhosis (liver dysfunction). In most severe cases, there is an immediate need for liver transplantation. During pregnancy, drinking alcohol in large amounts affects the unborn baby and may lead to various birth complications.

whatsapp Floating Button