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Written By Veda Maddala , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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Consume Type

PARENTERAL

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Not Returnable

Expires on or after

Apr-24

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About Dixin 0.5 mg Injection 10 x 2 ml

Dixin 0.5 mg Injection 10 x 2 ml belongs to the group of medicines called cardiac glycosides used to treat heart failure and irregular heartbeats. Heart failure is a chronic condition in which the heart is unable to pump blood as effectively as it should. Irregular heartbeat is a condition in which the heart beats irregularly, i.e., too fast, or too slow. 

Dixin 0.5 mg Injection 10 x 2 ml contains Digoxin that works on the heart muscle and increases the force with which heart muscle contracts with each heartbeat. Thereby, it makes the heart efficient in pumping blood around the body and slows down the rate at which the heart beats.

Dixin 0.5 mg Injection 10 x 2 ml will be administered by a healthcare professional; do not self-administer. Some people may experience diarrhoea, nausea, dizziness, weakness, headache, or anxiety. Most of these side effects of Dixin 0.5 mg Injection 10 x 2 ml do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. 

If you are known to be allergic to Digoxin or any other medicines, please tell your doctor. Pregnant or breastfeeding women are advised to consult a doctor before taking Dixin 0.5 mg Injection 10 x 2 ml . If you have beriberi disease caused by vitamin B1 deficiency, malabsorption syndrome (unable to absorb minerals from food), or any lung or kidney disease, please inform your doctor before taking Dixin 0.5 mg Injection 10 x 2 ml so that the dose may be adjusted or an alternate medicine may be prescribed accordingly.

Uses of Dixin 0.5 mg Injection 10 x 2 ml

Prevention of heart failure, Irregular heartbeats

Directions for Use

Dixin 0.5 mg Injection 10 x 2 ml will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Dixin 0.5 mg Injection 10 x 2 ml is a cardiac glycoside that is used to treat heart failure and irregular heartbeats. Dixin 0.5 mg Injection 10 x 2 ml increases the force with which heart muscle contracts with each heartbeat and makes the heart efficient in pumping blood around the body. Thus, slows down the rate at which the heart beats and makes the heart rate normal. Dixin 0.5 mg Injection 10 x 2 ml improves heart failure symptoms such as exercise capacity and reduces the number of hospitalizations.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Dixin 0.5 mg Injection 10 x 2 ml

  • Diarrhoea
  • Nausea
  • Dizziness
  • Weakness
  • Headache
  • Anxiety

Drug Warnings

If you are known to be allergic to Dixin 0.5 mg Injection 10 x 2 ml or any other medicines, please tell your doctor. Pregnant or breastfeeding women are advised to consult a doctor before taking Dixin 0.5 mg Injection 10 x 2 ml . Avoid intake of alcohol with Dixin 0.5 mg Injection 10 x 2 ml as it may increase the risk of drowsiness. Dixin 0.5 mg Injection 10 x 2 ml may cause vision problems in some people; drive or operate machinery only if you are alert. If you have beriberi disease caused by vitamin B1 deficiency, malabsorption syndrome (unable to absorb minerals from food), thyroid, or any lung or kidney disease, please inform your doctor before taking Dixin 0.5 mg Injection 10 x 2 ml so that the dose may be adjusted or an alternate medicine may be prescribed accordingly. Dixin 0.5 mg Injection 10 x 2 ml has a narrow therapeutic index which makes its use limited and requires close monitoring as a small change in dose or blood concentration may lead to severe adverse effects and overdose may lead to life-threatening reactions.

Drug-Drug Interactions

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DigoxinDolasetron
Severe
DigoxinCalcium gluconate
Severe

Drug-Drug Interactions

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DigoxinDolasetron
Severe
How does the drug interact with Dixin 0.5 mg Injection 10 x 2 ml :
Co-administration of Dixin 0.5 mg Injection 10 x 2 ml with Dolasetron can increase the risk of irregular heart rhythm.

How to manage the interaction:
Co-administration of Dixin 0.5 mg Injection 10 x 2 ml with Dolasetron can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these risk factors or if you experience symptoms like an irregular heartbeat, dizziness, fainting, or a fast or irregular heartbeat, it is important to call a doctor right away. Do not discontinue any medications without consulting a doctor.
DigoxinCalcium gluconate
Severe
How does the drug interact with Dixin 0.5 mg Injection 10 x 2 ml :
Co-administration of Calcium gluconate with Dixin 0.5 mg Injection 10 x 2 ml may affect heart rhythm.

How to manage the interaction:
Although there is an interaction, Calcium gluconate can be taken with Dixin 0.5 mg Injection 10 x 2 ml if prescribed by the doctor. Consult the prescriber if you experience symptoms of irregular heartbeat, blurred vision, chest tightness, nausea, and seizures. Do not discontinue the medication without consulting a doctor.
DigoxinGlycopyrronium bromide
Severe
How does the drug interact with Dixin 0.5 mg Injection 10 x 2 ml :
Co-administration of Dixin 0.5 mg Injection 10 x 2 ml and Glycopyrronium bromide may increase the serum concentration of Dixin 0.5 mg Injection 10 x 2 ml and increase the risk or severity of adverse effects.

How to manage the interaction:
Although there is a possible interaction between Dixin 0.5 mg Injection 10 x 2 ml and Glycopyrronium bromide, you can take these medicines together if prescribed by a doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, confusion, loss of appetite, nausea, vomiting, diarrhea, change in vision such as blurry or yellow vision, fatigue, and fast or irregular heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DigoxinSaquinavir
Severe
How does the drug interact with Dixin 0.5 mg Injection 10 x 2 ml :
Co-administration of Dixin 0.5 mg Injection 10 x 2 ml and Saquinavir may increase the risk of severe irregular heart rhythm.

How to manage the interaction:
If you are supposed to take Dixin 0.5 mg Injection 10 x 2 ml and Saquinavir together, a doctor may adjust the dose or monitor more frequently to safely use both medications. However, if you develop lightheadedness, fainting, sudden dizziness, nausea, vomiting, loss of appetite, slow pulse, vision disturbances, or irregular heartbeat during treatment with these medications. Contact a doctor immediately. Do not discontinue the medication without consulting a doctor.
DigoxinFingolimod
Severe
How does the drug interact with Dixin 0.5 mg Injection 10 x 2 ml :
Co-administration of Fingolimod with Dixin 0.5 mg Injection 10 x 2 ml may increase the risk or severity of slowing down of the heart rate.

How to manage the interaction:
Although there is a possible interaction between Dixin 0.5 mg Injection 10 x 2 ml and Fingolimod, you can take these medicines together if prescribed by a doctor. It's important to monitor your heart rate and talk to a doctor about any alternative medications that don't interact. If you experience any symptoms like chest pain, shortness of breath, or fainting, it's important to call your doctor right away. Do not discontinue any medications without consulting a doctor.
DigoxinFamotidine
Severe
How does the drug interact with Dixin 0.5 mg Injection 10 x 2 ml :
Co-administration of Dixin 0.5 mg Injection 10 x 2 ml and Famotidine may increase the level or effect of Dixin 0.5 mg Injection 10 x 2 ml .

How to manage the interaction:
Although there is a possible interaction between Dixin 0.5 mg Injection 10 x 2 ml and Famotidine, you can take these medicines together if prescribed by a doctor. Do not discontinue the medication without consulting a doctor.
DigoxinSucralfate
Severe
How does the drug interact with Dixin 0.5 mg Injection 10 x 2 ml :
Co-administration of Sucralfate together with Dixin 0.5 mg Injection 10 x 2 ml may decrease the effects of Dixin 0.5 mg Injection 10 x 2 ml .

How to manage the interaction:
If you are supposed to take Dixin 0.5 mg Injection 10 x 2 ml and Sucralfate together, your doctor may adjust the dose to safely use both medications. Do not discontinue the medication without consulting a doctor.
DigoxinClarithromycin
Severe
How does the drug interact with Dixin 0.5 mg Injection 10 x 2 ml :
Co-administration of Clarithromycin with Dixin 0.5 mg Injection 10 x 2 ml may increase the blood levels and effects of Dixin 0.5 mg Injection 10 x 2 ml .

How to manage the interaction:
Although there is a possible interaction, Clarithromycin can be taken with Dixin 0.5 mg Injection 10 x 2 ml if prescribed by the doctor. Consult the prescriber if you experience signs and symptoms of excessive Dixin 0.5 mg Injection 10 x 2 ml levels such as diarrhea, nausea, loss of appetite, vomiting, visual disturbances, and an abnormally fast or slow or uneven heartbeat. Do not discontinue the medication without consulting a doctor.
DigoxinNadolol
Severe
How does the drug interact with Dixin 0.5 mg Injection 10 x 2 ml :
Co-administration of Dixin 0.5 mg Injection 10 x 2 ml and Nadolol may slow down the heart rate and lead to increased side effects.

How to manage the interaction:
If you are supposed to take Dixin 0.5 mg Injection 10 x 2 ml and Nadolol together, a doctor may adjust the dose to safely use both medications. However, if you experience decreased appetite, nausea, vomiting, confusion, diarrhea, seizures, visual changes, overtiredness, irregular heartbeats, and abnormally fast or slow heartbeats, contact a doctor. Do not discontinue the medication without consulting a doctor.
DigoxinAtazanavir
Severe
How does the drug interact with Dixin 0.5 mg Injection 10 x 2 ml :
Coadministration of Dixin 0.5 mg Injection 10 x 2 ml and Atazanavir may increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Dixin 0.5 mg Injection 10 x 2 ml and Atazanavir, you can take these medicines together if prescribed by a doctor. However, if you develop fainting, lightheadedness, sudden dizziness, or irregular heartbeat, contact a doctor immediately. Do not discontinue the medication without consulting a doctor.

Drug-Food Interactions

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DIGOXIN-0.5MGGrapefruit and Grapefruit Juice
Mild

Drug-Food Interactions

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DIGOXIN-0.5MGGrapefruit and Grapefruit Juice
Mild
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking Dixin 0.5 mg Injection 10 x 2 ml with Grapefruit and Grapefruit juice may increase the side effects of Dixin 0.5 mg Injection 10 x 2 ml . Consuming Grapefruit and grapefruit juice should be avoided while taking Dixin 0.5 mg Injection 10 x 2 ml .

Diet & Lifestyle Advise

  • Maintain a low salt diet and minimize eating processed foods as they contain more sodium. Try to replace salt with spices or herbs to add flavour to the food.
  • Regular exercise is advised as it helps to lower blood pressure and keeps blood vessels and the heart in good condition.
  • Quit smoking as smoking increases blood pressure and heart rate.
  • Eat a balanced and healthy diet which includes plenty of vegetables, fruits, and low-fat or fat-free products.

Habit Forming

No

Therapeutic Class

ANTIARRHYTHMICS

Author Details

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Drug-Diseases Interactions

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DIGOXIN-0.5MGOther conduction disorders
Severe
DIGOXIN-0.5MGAbnormalities of heart beat
Severe

Drug-Diseases Interactions

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DIGOXIN-0.5MGOther conduction disorders
Severe
How does the disease interact with Dixin 0.5 mg Injection 10 x 2 ml :
In cases like the Wolff-Parkinson-White syndrome, Dixin 0.5 mg Injection 10 x 2 ml may improve accessory route conduction.

How to manage the interaction:
Dixin 0.5 mg Injection 10 x 2 ml should be used with caution in patients with Wolff-Parkinson-White syndrome (a heart condition that causes rapid heartbeat).
DIGOXIN-0.5MGAbnormalities of heart beat
Severe
How does the disease interact with Dixin 0.5 mg Injection 10 x 2 ml :
Dixin 0.5 mg Injection 10 x 2 ml prolongs the PR interval by slowing sinoatrial and AV conduction. Dixin 0.5 mg Injection 10 x 2 ml therapy can cause severe sinus bradycardia or sinoatrial block in people with preexisting sinus node dysfunction, and it can cause progressive or full heart block in patients with incomplete AV block.

How to manage the interaction:
Dixin 0.5 mg Injection 10 x 2 ml may be administered to patients with complete, stable AV block (an electrical signal that controls your heartbeat is partially or completely blocked) who have congestive heart failure, provided the block was not induced by cardiac glycosides.
DIGOXIN-0.5MGDisorders of mineral metabolism
Severe
How does the disease interact with Dixin 0.5 mg Injection 10 x 2 ml :
Dixin 0.5 mg Injection 10 x 2 ml and calcium have cumulative effects on inotropy. As a result, Dixin 0.5 mg Injection 10 x 2 ml toxicity and dangerous arrhythmias are predisposed in patients with hypercalcemia from any source.

How to manage the interaction:
Hypercalcemia (too much calcium in the blood) should be corrected before starting treatment with Dixin 0.5 mg Injection 10 x 2 ml , and serum calcium levels should be monitored during therapy.
DIGOXIN-0.5MGDisorders of mineral metabolism
Severe
How does the disease interact with Dixin 0.5 mg Injection 10 x 2 ml :
Dixin 0.5 mg Injection 10 x 2 ml and calcium have cumulative effects on inotropy. As a result, Dixin 0.5 mg Injection 10 x 2 ml toxicity and dangerous arrhythmias are predisposed in patients with hypercalcemia from any source.

How to manage the interaction:
Hypercalcemia (too much calcium in the blood) should be corrected before starting treatment with Dixin 0.5 mg Injection 10 x 2 ml , and serum calcium levels should be monitored during therapy.
DIGOXIN-0.5MGOther disorders of fluid, electrolyte and acid-base balance
Severe
How does the disease interact with Dixin 0.5 mg Injection 10 x 2 ml :
Dixin 0.5 mg Injection 10 x 2 ml makes the myocardium more sensitive when potassium and/or magnesium are depleted. Despite Dixin 0.5 mg Injection 10 x 2 ml serum drug concentrations, Dixin 0.5 mg Injection 10 x 2 ml toxicity may happen in patients with hypokalemia or hypomagnesemia.

How to manage the interaction:
Dixin 0.5 mg Injection 10 x 2 ml should be used with caution in patients with or who are at risk of developing potassium and/or magnesium deficiency, including patients on diuretic therapy; those with primary or secondary aldosteronism (may have low potassium levels), severe or prolonged diarrhoea or vomiting, malnutrition; and renal dialysis patients. Electrolyte imbalances may be corrected before starting the treatment.
DIGOXIN-0.5MGThyrotoxicosis [hyperthyroidism]
Moderate
How does the disease interact with Dixin 0.5 mg Injection 10 x 2 ml :
Treatment of the underlying illness is the best way to control heart failure and/or atrial arrhythmias brought on by hypermetabolic or hyperdynamic conditions such hyperthyroidism, hypoxia, or arteriovenous shunt.

How to manage the interaction:
Dixin 0.5 mg Injection 10 x 2 ml should be used with caution in patients with hyperthyroidism. Your doctor may adjust the dose secondary to changes in the thyroid condition.

Drug-Drug Interactions Checker List

  • ADENOSINE
  • AMIODARONE
  • DOLASETRON
  • QUINIDINE
  • ARBUTAMINE
  • ATAZANAVIR
  • SAQUINAVIR
  • CERITINIB
  • LAPATINIB
  • CLARITHROMYCIN
  • FINGOLIMOD
  • FLIBANSERIN
  • ITRACONAZOLE
  • CALCIUM CHLORIDE
  • CALCIUM GLUCEPTATE
  • CALCIUM GLUCONATE

Special Advise

  • Regular blood tests are advised while taking Dixin 0.5 mg Injection 10 x 2 ml to monitor potassium levels and kidney functioning.
  • Digoxin levels in the blood should be monitored as digoxin toxicity can lead to several forms of heart rhythm disturbances, vomiting, nausea and visual disturbances.

Disease/Condition Glossary

Heart failure: It is a chronic condition in which heart is unable to pump blood as effectively as it should. Heart failure may occur due to certain conditions like high blood pressure, swelling or damage of heart muscle, faulty heart valves or narrow arteries in heart. Symptoms of heart failure include shortness of breath, tiredness, fast heartbeat and swollen legs.

Arrhythmia (irregular heartbeat): It is a condition in which the heart beats irregularly, i.e., too fast or too slow. Symptoms of irregular heartbeat include chest pain, shortness of breath, fast or slow heartbeat. 60 to 100 beats per minute is generally considered as normal heart rate. 

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