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Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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Manufacturer/Marketer :

Torrent Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Domstal NP-250 mg Tablet

Domstal NP-250 mg Tablet belongs to the group of medications called analgesics. It treats migraine headaches. Besides this, it can also be used to reduce pain in rheumatoid arthritis, gout and dysmenorrhea (menstrual pain). Migraine is a condition characterized by intense headaches. Pain is a symptom that occurs due to various underlying conditions.

Domstal NP-250 mg Tablet is a combination of two drugs: Naproxen and Domperidone. Naproxen works by blocking the action of the cyclo-oxygenase (COX) enzyme in the body that produces certain chemical substances such as prostaglandins that cause pain and swelling. Domperidone is an antiemetic agent which prevents nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain.

Take Domstal NP-250 mg Tablet as prescribed by your doctor. You are advised to take Domstal NP-250 mg Tablet for as long as your doctor has prescribed it for you based on your medical condition. Common side-effects of Domstal NP-250 mg Tablet are dryness of the mouth, abdominal pain, constipation, drowsiness, dizziness, visual disturbances, hearing problems and headache. Consult your doctor if you feel any discomfort.

Before taking the Domstal NP-250 mg Tablet , let your doctor know about all your allergic or hypersensitivity reactions to medicines or food. If you are pregnant or breastfeeding, please tell your doctor so that your doctor will weigh the benefits and any potential risks before prescribing it to you. Also, inform the doctor if you have a history of heart rhythm problems or ulcers due to pain killers. Patients with age above 65 years, pre-existing cardiac diseases such as heart failure, hypertension or stroke, gastrointestinal bleeding (due to pain killers), gastric ulcers, respiratory diseases such as asthma, liver diseases, kidney diseases or bleeding disorders should use Domstal NP-250 mg Tablet only when prescribed by a doctor.

Uses of Domstal NP-250 mg Tablet

Migraine headache, Pain associated with conditions like rheumatoid arthritis, gout and dysmenorrhea (menstrual pain).

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Domstal NP-250 mg Tablet is a combination of naproxen and domperidone. Naproxen is an anti-inflammatory (reduce inflammation) and analgesic (reduce pain) agent. It inhibits the synthesis of prostaglandins, which are inflammatory mediators, thereby reducing pain and inflammation. Domperidone acts by enhancing gastric peristalsis (movements) to empty stomach. Easy movement of food through the stomach helps in relieving nausea and vomiting. It blocks the dopamine receptors present at the chemoreceptor trigger zone (responsible for regulating nausea and vomiting).

Storage

Keep Domstal NP-250 mg Tablet out of sight and reach of children.
Side effects of Domstal NP-250 mg Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Drug Warnings

Inform your doctor if you are taking any of the anticoagulants (warfarin), other NSAIDs (ibuprofen, ketorolac), corticosteroids (prednisolone), antidepressants (citalopram, fluoxetine, paroxetine, duloxetine, venlafaxine), or any other dietary or herbal supplements. Long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as naproxen may increase the risk of heart attack or stroke and stomach ulcers. The risk of developing ulcers is higher if you have a history of ulcers, have bleeding disorders, older in age, alcoholic or have multiple diseases. The risk of having a heart attack increases if you smoke, or you or your family has a history of heart failure, stroke, or hypertension. Call for medical help immediately, if you experience chest pain, shortness of breath, blood in the stool or dark stools, heartburn, or any other abnormal signs.

Drug-Drug Interactions

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OmeprazoleRilpivirine
Critical

Drug-Drug Interactions

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How does the drug interact with Domstal NP-250 mg Tablet:
Domstal NP-250 mg Tablet can make Erlotinib less effective by reducing its absorption in the body. This can lead to low treatment outcomes.

How to manage the interaction:
Taking Domstal NP-250 mg Tablet and Erlotinib together is not recommended as it can result in an interaction; it should be taken only if a doctor has advised it. Do not stop using any medications without talking to a doctor.
OmeprazoleRilpivirine
Critical
How does the drug interact with Domstal NP-250 mg Tablet:
Using rilpivirine together with Domstal NP-250 mg Tablet can decrease the absorption and blood levels of rilpivirine.

How to manage the interaction:
Taking Domstal NP-250 mg Tablet with Rilpivirine can cause an interaction, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Domstal NP-250 mg Tablet:
When Domstal NP-250 mg Tablet is used with citalopram the blood levels of citalopram may increase, increasing the risk of certain adverse effects, such as an abnormal heart rhythm, which can be serious.

How to manage the interaction:
Although taking Domstal NP-250 mg Tablet and citalopram together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid/pounding heartbeats while taking these medications, consult the doctor. Do not stop using any medications without talking to a doctor.
OmeprazoleNelfinavir
Severe
How does the drug interact with Domstal NP-250 mg Tablet:
Using Domstal NP-250 mg Tablet in conjunction with nelfinavir can reduce the effectiveness of nelfinavir.

How to manage the interaction:
Although taking Domstal NP-250 mg Tablet with nelfinavir can lead to interaction, they can be taken if recommended by a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Domstal NP-250 mg Tablet:
Taking Domstal NP-250 mg Tablet and carbamazepine may possibly reduce the effects of Domstal NP-250 mg Tablet, which could reduce its capacity to treat the condition.

How to manage the interaction:
Although taking Domstal NP-250 mg Tablet and carbamazepine together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Domstal NP-250 mg Tablet:
Co-administration of Domstal NP-250 mg Tablet with itraconazole can lessen the amount or effects of itraconazole.

How to manage the interaction:
Although taking Itraconazole along with Domstal NP-250 mg Tablet can cause an interaction, it can be taken if your doctor has suggested it. Do not stop using any medications without a doctor's advice.
How does the drug interact with Domstal NP-250 mg Tablet:
Domstal NP-250 mg Tablet may interfere with pazopanib absorption and reduces its effectiveness.

How to manage the interaction:
Although taking Domstal NP-250 mg Tablet with pazopanib can lead to interaction, they can be taken if recommended by a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Domstal NP-250 mg Tablet:
Domstal NP-250 mg Tablet, through decreasing stomach acidity, may interfere with the absorption of acalabrutinib capsules and reduce their effectiveness.

How to manage the interaction:
Although taking Domstal NP-250 mg Tablet with acalabrutinib can lead to interaction, they can be taken if recommended by a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Domstal NP-250 mg Tablet:
When taken together, Domstal NP-250 mg Tablet, through decreasing stomach acid, can reduce atazanavir absorption and blood levels, making the medication less effective.

How to manage the interaction:
Although taking Domstal NP-250 mg Tablet with atazanavir can lead to interaction, they can be taken if recommended by a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Domstal NP-250 mg Tablet:
Coadministration of Domstal NP-250 mg Tablet with methotrexate may increase the levels and side effects of Domstal NP-250 mg Tablet.

How to manage the interaction:
Although there is a possible interaction between Domstal NP-250 mg Tablet and methotrexate, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without consulting to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Drink plenty of fluids to avoid gastrointestinal problems.
  • Avoid triggers that can increase your migraine headache.
  • Take enough rest.
  • Acupuncture, massage and physical therapy may also be helpful.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listen to soothing music.
  • Avoid smoking and alcohol consumption.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.

Side Effects of Domstal NP-250 mg Tablet

  • Abdominal pain
  • Constipation
  • Indigestion
  • Flatulence
  • Dry mouth
  • Glossitis (inflammation of the tongue)
  • Diarrhoea
  • Drowsiness
  • Dizziness
  • Headache
  • Vision problems
  • Hearing problems

Habit Forming

No

Therapeutic Class

ANALGESICS

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Naproxen works by inhibiting the cyclo-oxygenase (COX) enzyme in the body, which creates chemical compounds such as prostaglandins, which induce pain and swelling. Domperidone is an antiemetic that blocks certain receptors (such as dopamine and serotonin) that stimulate the brain's vomiting centre (chemoreceptor trigger zone - CTZ).

Domstal NP-250 mg Tablet cannot permanently cure migraine. It can provide relief from pain and headache.

Domstal NP-250 mg Tablet on prolonged or frequent use can cause liver or kidney problems. Therefore, it should be only used for a duration as prescribed by the doctor.

Arthritis is a chronic condition of joints with pain and inflammation. Domstal NP-250 mg Tablet does not cure arthritis but relieves symptoms of arthritis-like joint pain, swelling and stiffness.

Yes, Domstal NP-250 mg Tablet may increase the risk of heart problems such as heart attack and stroke, especially when used in high doses or for a prolonged duration. It is advised to inform your doctor if you have any of these conditions or have a history of heart problems or stroke before taking the Domstal NP-250 mg Tablet .

Dry mouth may be caused by Domperidone in Domstal NP-250 mg Tablet . Chew a sugar-free sweet or sugar-free gum.

Drug-Drug Interactions Checker List

  • WARFARIN
  • KETOROLAC
  • PREDNISOLONE
  • RAMIPRIL
  • AMLODIPINE
  • AMIKACIN
  • ATORVASTATIN
  • CITALOPRAM
  • FLUOXETINE

Special Advise

  • Your doctor may monitor liver function and kidney function if you are taking Domstal NP-250 mg Tablet for long-term.
  • Taking meals at the same time every day and sufficient sleep might help in avoiding migraine attacks. You are recommended to avoid loud music, noisy place, extreme temperatures and bright light. Also, avoid consumption of chocolates, cheese, processed food, smoking and alcohol.

Disease/Condition Glossary

Migraine: Migraine is a condition characterized by intense headaches. It also causes nausea, vomiting, sensitivity to light and sound and difficulty speaking. Bright lights, strong smells, certain foods, loud sounds, stress and hormonal changes act as triggers for migraine. These triggers lead to acute attacks. Acute migraine attacks result in throbbing headaches and pain in the eyes, face or neck.

Pain: Pain is a widely used term used to describe unpleasant feelings or discomfort. It ranges from mild to severe. The severity of the pain depends on the underlying condition.

Rheumatoid arthritis: Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities and loss of joint function.

Gout: Gout is an inflammatory condition in which uric acid deposits and crystallizes in the joints. It is characterized by acute, severe, and recurring pain attacks, especially at night, redness and swelling in the affected joints.

Dysmenorrhea: Dysmenorrhea refers to abdominal cramps/pain and an unpleasant sensory/emotional experience associated with irregular periods. It occurs just before or during menses. Menstrual cramps that cause throbbing pain in the lower belly during periods may vary from mild to severe. Some of the common symptoms of menstrual cramps include an aching pain in your belly (sometimes severe), a feeling of pressure in your belly, pain in your hips, lower back, and inner thighs.

Have a query?

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Alcohol

Caution

It is advised not to take alcohol as Domstal NP-250 mg Tablet can cause dizziness or drowsiness.

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Pregnancy

Caution

Domstal NP-250 mg Tablet should be used in pregnant women only if clinically needed, and the benefits outweigh the risks.

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Breast Feeding

Caution

Domstal NP-250 mg Tablet should be used in breastfeeding mothers only if the benefits outweigh the risks.

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Driving

Unsafe

It is unsafe to drive after taking Domstal NP-250 mg Tablet as it impacts your ability to drive or operate machinery.

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Liver

Caution

Limited information was available for the use of Domstal NP-250 mg Tablet in patients suffering from liver impairment. Please consult your doctor if you have any concerns regarding using Domstal NP-250 mg Tablet in patients with liver impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Limited information was available for the use of Domstal NP-250 mg Tablet in patients suffering from kidney impairment. Please consult your doctor if you have any concerns regarding using Domstal NP-250 mg Tablet in patients with kidney impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Caution

Domstal NP-250 mg Tablet should be used in children below 12 years of age only when prescribed by a child specialist.

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